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Hoxd4
Gene Detail
 Symbol
Name
ID
Member of
Hoxd4
homeobox D4
MGI:96208
Hoxd cluster
Synonyms Hox-4.2, Hox-5.1
Feature Type protein coding gene
Genetic Map
Chromosome 2
44.13 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(15)
Sequence Map
Chr2:74711929-74729123 bp, + strand
From VEGA annotation of GRCm38

  17195 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7773  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: homeotic protein Hox A5/D4

Human
homologs
Human Homolog HOXD4, homeobox D4
NCBI Gene ID 3233
neXtProt AC  NX_P09016
Human Synonyms  HHO.C13, HOX4, Hox-4.2, HOX4B, HOX-5.1
Human Chr (Location)  2q31.1; chr2:176150394-176153223 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Targeted(16)
Genomic Mutations involving Hoxd4 (13)
 
Both homozygotes and heterozygotes for a targeted null mutation exhibit homeotic transformations of the second cervical vertebrae and malformed neural arches of C1 to C3 and of the basioccipital bone. Mutants show variable penetrance and expressivity.
 
Interactions
Hoxd4 interacts with 1 marker (Mir3544)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process anterior/posterior pattern specification, embryonic skeletal system morphogenesis, ...
External Resources: FuncBase
Expression
Literature Summary: (82 records)
Data Summary: Results (543)    Tissues (317)    Images (82)
Theiler Stages: 12, 13, 14, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 416
Northern blot 3
Western blot 4
RT-PCR 98
RNase protection 12
Nuclease S1 10
cDNA source data(24)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(58) Genomic(25) cDNA(28) Primer pair(4) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000019164 (Evidence)
Entrez Gene15436 (Evidence)
UniGene482194
DFCITC1589200, TC1668339
DoTSDT.55233707, DT.87067100
Consensus CDS ProjectCCDS16145.1
International Mouse Knockout Project StatusHoxd4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019164 VEGA Gene Model | MGI Sequence Detail 17195 C57BL/6J ±  kb
transcript OTTMUST00000040129 VEGA | MGI Sequence Detail 1494 Not Applicable 
polypeptide OTTMUSP00000017904 VEGA | MGI Sequence Detail 250 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2)
Polymorphisms RFLP(4) : SNPs within 2kb(41 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000008722 homeobox protein Hox-D4
References (Earliest) J:8920 Lonai P, et al., New murine homeoboxes: structure, chromosomal assignment, and differential expression in adult erythropoiesis. DNA. 1987 Oct;6(5):409-18
(Latest) J:208408 Prin F, et al., Hox proteins drive cell segregation and non-autonomous apical remodelling during hindbrain segmentation. Development. 2014 Apr;141(7):1492-502
All references(129)
Other
accession IDs
MGD-MRK-10849, MGD-MRK-10858, MGD-MRK-10909

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory