Hoxd4
Gene Detail

Symbol Name ID

Hoxd4 homeobox D4 MGI:96208

Synonyms

Hox-4.2, Hox-5.1

Feature Type

protein coding gene

Genetic Map

Chromosome 2

44.13 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(15)

Sequence Map

Chr2:74727074-74729093 bp, + strand From VEGA annotation of GRCm38   2020 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7773  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: homeotic protein Hox A5/D4
Gene Tree: Hoxd4

Human homologs

Human Homolog		HOXD4, homeobox D4
NCBI Gene ID		3233
neXtProt AC		NX_P09016
Human Synonyms		HHO.C13, HOX4, Hox-4.2, HOX4B, HOX-5.1
Human Chr (Location)		2q31.1; chr2:177016113-177017951 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human HOXD4

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Both homozygotes and heterozygotes for a targeted null mutation exhibit homeotic transformations of the second cervical vertebrae and malformed neural arches of C1 to C3 and of the basioccipital bone. Mutants show variable penetrance and expressivity.

 

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	anterior/posterior pattern specification, embryonic skeletal system morphogenesis, ...
Component	nucleus
Function	DNA binding, sequence-specific DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (79 records)
Data Summary: Results (533)    Tissues (309)    Images (82)
Theiler Stages: 12, 13, 14, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	406
Northern blot	3
Western blot	4
RT-PCR	98
RNase protection	12
Nuclease S1	10

cDNA source data(24)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(57) Genomic(25) cDNA(27) Primer pair(4) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000016600 (Evidence)
Ensembl Gene Model	ENSMUSG00000042464 (Evidence)
Entrez Gene	15436 (Evidence)
UniGene	482194
DFCI	TC1589200, TC1668339
DoTS	DT.55233707, DT.87067100
Consensus CDS Project	CCDS16145.1
International Mouse Knockout Project Status	Hoxd4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016600	VEGA Gene Model | MGI Sequence Detail	2020	C57BL/6J
transcript	OTTMUST00000040129	VEGA | MGI Sequence Detail	1464	Not Applicable
polypeptide	OTTMUSP00000017904	VEGA | MGI Sequence Detail	250	Not Applicable

All sequences(25) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(4) : SNPs(11 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR017995	Homeobox protein, antennapedia type
InterPro	IPR001827	Homeobox protein, antennapedia type, conserved site
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR020479	Homeodomain, metazoa
Protein Ontology	PR:000008722	homeobox protein Hox-D4

References

(Earliest) J:8920 Lonai P, et al., New murine homeoboxes: structure, chromosomal assignment, and differential expression in adult erythropoiesis. DNA. 1987 Oct;6(5):409-18
(Latest) J:194424 Yasunaga S, et al., Scmh1 has E3 ubiquitin ligase activity for geminin and histone H2A and regulates geminin stability directly or indirectly via transcriptional repression of Hoxa9 and Hoxb4. Mol Cell Biol. 2013 Feb;33(4):644-60
All references(129)

Other accession IDs

MGD-MRK-10849, MGD-MRK-10858, MGD-MRK-10909