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Hoxd4 Gene Detail
Summary
  • Symbol
    Hoxd4
  • Name
    homeobox D4
  • Synonyms
    Hox-4.2, Hox-5.1
  • Feature Type
    protein coding gene
  • IDs
    MGI:96208
    NCBI Gene: 15436
  • Member of
    Hoxd cluster
  • Gene Overview
    MyGene.info: HOXD4
Location & Maps
more
  • Sequence Map
    Chr2:74711929-74729123 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      17195 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 44.13 cM, cytoband D
  • Mapping Data
    15 experiments
Homology
more
  • Human Ortholog
    HOXD4, homeobox D4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    HOXD4, homeobox D4
    Orthology source: HomoloGene
  • Synonyms
    HHO.C13, HOX4, Hox-4.2, HOX4B, HOX-5.1
  • Links
    NCBI Gene ID: 3233
    neXtProt AC: NX_P09016

  • Chr Location
    2q31.1; chr2:176150394-176153223 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    9 phenotypes from multigenic genotypes
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    20
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    17
  • Transgenic
    1
  • Genomic Mutations
    16 involving Hoxd4
  • Incidental Mutations
Both homozygotes and heterozygotes for a targeted null mutation exhibit homeotic transformations of the second cervical vertebrae and malformed neural arches of C1 to C3 and of the basioccipital bone. Mutants show variable penetrance and expressivity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019164 VEGA Gene Model | MGI Sequence Detail 17195 C57BL/6J ±  kb
transcript OTTMUST00000040129 VEGA | MGI Sequence Detail 1494 Not Applicable  
polypeptide OTTMUSP00000017904 VEGA | MGI Sequence Detail 250 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    40 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 58
    Genomic 25
    cDNA 28
    Primer pair 4
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-10849, MGD-MRK-10858, MGD-MRK-10909
References
more
  • Summaries
    All 135
    Developmental Gene Expression 87
    Gene Ontology 5
    Phenotypes 37
  • Earliest
    J:8920 Lonai P, et al., New murine homeoboxes: structure, chromosomal assignment, and differential expression in adult erythropoiesis. DNA. 1987 Oct;6(5):409-18
  • Latest
    J:231980 Tomas-Roca L, et al., Crypto-rhombomeres of the mouse medulla oblongata, defined by molecular and morphological features. Brain Struct Funct. 2016 Mar;221(2):815-38

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory