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Hoxd4 Gene Detail
Summary
  • Symbol
    Hoxd4
  • Name
    homeobox D4
  • Synonyms
    Hox-4.2, Hox-5.1
  • Feature Type
    protein coding gene
  • IDs
    MGI:96208
    NCBI Gene: 15436
  • Member of
    Hoxd cluster
  • Gene Overview
    MyGene.info: HOXD4
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:74721978-74729160 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 44.13 cM, cytoband D
  • Mapping Data
    15 experiments
Strain
Comparison
more
  • SNPs within 2kb
    15 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96208
protein coding gene Chr2:74711929-74729160 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025852
protein coding gene Chr2:75025755-75042959 (+)
A/J MGP_AJ_G0025830
protein coding gene Chr2:72093078-72110245 (+)
AKR/J MGP_AKRJ_G0025798
protein coding gene Chr2:74046433-74063609 (+)
BALB/cJ MGP_BALBcJ_G0025824
protein coding gene Chr2:72280342-72297570 (+)
C3H/HeJ MGP_C3HHeJ_G0025584
protein coding gene Chr2:74234485-74251711 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026271
protein coding gene Chr2:77262797-77280014 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023674
protein coding gene Chr2:69516327-69533661 (+)
CAST/EiJ MGP_CASTEiJ_G0025048
protein coding gene Chr2:74551552-74568727 (+)
CBA/J MGP_CBAJ_G0025565
protein coding gene Chr2:80085610-80104075 (+)
DBA/2J MGP_DBA2J_G0025696
protein coding gene Chr2:71700571-71717740 (+)
FVB/NJ MGP_FVBNJ_G0025658
protein coding gene Chr2:71089045-71106237 (+)
LP/J MGP_LPJ_G0025784
protein coding gene Chr2:74890135-74907311 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025689
protein coding gene Chr2:81996493-82013710 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026328
protein coding gene Chr2:74162944-74180130 (+)
PWK/PhJ MGP_PWKPhJ_G0024789
protein coding gene Chr2:71630920-71648243 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024597
protein coding gene Chr2:74395594-74412799 (+)
WSB/EiJ MGP_WSBEiJ_G0025116
protein coding gene Chr2:74600660-74617844 (+)



Homology
more
  • Human Ortholog
    HOXD4, homeobox D4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    HOXD4, homeobox D4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HHO.C13, HOX4, Hox-4.2, HOX4B, HOX-5.1
  • Links
    NCBI Gene ID: 3233
    neXtProt AC: NX_P09016
    UniProt: P09016

  • Chr Location
    2q31.1; chr2:176150394-176156078 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    9 phenotypes from multigenic genotypes
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Both homozygotes and heterozygotes for a targeted null mutation exhibit homeotic transformations of the second cervical vertebrae and malformed neural arches of C1 to C3 and of the basioccipital bone. Mutants show variable penetrance and expressivity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15436 NCBI Gene Model | MGI Sequence Detail 7183 C57BL/6J ±  kb
    transcript NM_010469 RefSeq | MGI Sequence Detail 2560 Not Specified  
    polypeptide P10628 UniProt | EBI | MGI Sequence Detail 250 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 61
      Genomic 25
      cDNA 31
      Primer pair 4
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10849, MGD-MRK-10858, MGD-MRK-10909
    References
    more
    • Summaries
      All 174
      Developmental Gene Expression 96
      Gene Ontology 7
      Phenotypes 42
    • Earliest
      J:8920 Lonai P, et al., New murine homeoboxes: structure, chromosomal assignment, and differential expression in adult erythropoiesis. DNA. 1987 Oct;6(5):409-18
    • Latest
      J:266434 Hong SH, et al., Corepressor SMRT is required to maintain Hox transcriptional memory during somitogenesis. Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10381-10386

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    last database update
    10/08/2019
    MGI 6.14
    The Jackson Laboratory