Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Hmgcr

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes HMGCR
- Mouse genes Hmgcr
- Rat genes Hmgcr
- Zfish genes hmgcra,hmgcrb
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hmgcr

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0120225	coenzyme A binding	HMGCR	IDA		Human	PMID:10698924
Molecular Function	GO:0030695	GTPase regulator activity	Hmgcr	IGI	MGI:MGI:97306	Mouse	PMID:16271875
Molecular Function	GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity	HMGCR	IDA		Human	PMID:21357570
Molecular Function	GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity	HMGCR	IDA		Human	PMID:2991281
Molecular Function	GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity	Hmgcr	IDA		Mouse	PMID:15845870
Molecular Function	GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity	Hmgcr	IDA		Mouse	PMID:1352323
Molecular Function	GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity	Hmgcr	IDA		Mouse	PMID:8647961
Molecular Function	GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity	Hmgcr	IDA		Mouse	PMID:9186920
Molecular Function	GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity	Hmgcr	IDA		Mouse	PMID:7798939
Molecular Function	GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity	Hmgcr	IDA		Mouse	PMID:12114517
Molecular Function	GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity	Hmgcr	IDA		Mouse	PMID:16100574
Molecular Function	GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity	Hmgcr	IDA		Mouse	PMID:12920113
Molecular Function	GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity	Hmgcr	IDA		Mouse	PMID:11792727
Molecular Function	GO:0042802	identical protein binding	Hmgcr	IPI	RGD:2803	Rat	PMID:4019513\|RGD:1625194
Molecular Function	GO:0070402	NADPH binding	HMGCR	IDA		Human	PMID:10698924
Molecular Function	GO:0005515	protein binding	HMGCR	IPI	UniProtKB:Q9Y5Z9	Human	PMID:23169578
Molecular Function	GO:0005515	protein binding	HMGCR	IPI	UniProtKB:Q9Y5Z9-1	Human	PMID:23169578
Molecular Function	GO:0051721	protein phosphatase 2A binding	Hmgcr	IPI	RGD:3380	Rat	PMID:18031790\|RGD:8693702
Cellular Component	GO:0005783	endoplasmic reticulum	HMGCR	IDA		Human	PMID:17180682
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Hmgcr	IDA		Rat	PMID:12841361\|RGD:1300058
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Hmgcr	IDA		Rat	PMID:16140414\|RGD:2316848
Cellular Component	GO:0005778	peroxisomal membrane	HMGCR	IDA		Human	PMID:17180682
Biological Process	GO:0007568	aging	Hmgcr	IEP		Rat	PMID:15491682\|RGD:5508699
Biological Process	GO:0007568	aging	Hmgcr	IEP		Rat	PMID:19267214\|RGD:2317945
Biological Process	GO:0038183	bile acid signaling pathway	Hmgcr	IEP		Rat	PMID:25263431\|RGD:15045610
Biological Process	GO:0001955	blood vessel maturation	hmgcrb	IMP	ZFIN:ZDB-MRPHLNO-130322-1	Zfish	PMID:23206891
Biological Process	GO:0001955	blood vessel maturation	hmgcrb	IMP	ZFIN:ZDB-MRPHLNO-130322-2	Zfish	PMID:23206891
Biological Process	GO:0006695	cholesterol biosynthetic process	HMGCR	IDA		Human	PMID:23063590
Biological Process	GO:0006695	cholesterol biosynthetic process	Hmgcr	IDA		Mouse	PMID:7798939
Biological Process	GO:0006695	cholesterol biosynthetic process	Hmgcr	IDA		Mouse	PMID:15845870
Biological Process	GO:0006695	cholesterol biosynthetic process	Hmgcr	IDA		Mouse	PMID:8647961
Biological Process	GO:0042632	cholesterol homeostasis	Hmgcr	IEP		Rat	PMID:23117815\|RGD:15045604
Biological Process	GO:0009790	embryo development	Hmgcr	IMP	MGI:MGI:2682329	Mouse	PMID:12920113
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	hmgcrb	IMP	ZFIN:ZDB-GENO-110609-7	Zfish	PMID:27488927
Biological Process	GO:0003007	heart morphogenesis	hmgcrb	IMP	ZFIN:ZDB-GENO-070308-5	Zfish	PMID:17276918
Biological Process	GO:0003007	heart morphogenesis	hmgcrb	IMP	ZFIN:ZDB-MRPHLNO-070308-2	Zfish	PMID:17276918
Biological Process	GO:0060291	long-term synaptic potentiation	Hmgcr	IGI	MGI:MGI:97306	Mouse	PMID:16271875
Biological Process	GO:0045445	myoblast differentiation	Hmgcr	IEP		Rat	PMID:20336669\|RGD:5508688
Biological Process	GO:1900222	negative regulation of amyloid-beta clearance	Hmgcr	IMP		Mouse	MGI:MGI:6270905\|PMID:20876579
Biological Process	GO:0043066	negative regulation of apoptotic process	Hmgcr	IMP		Rat	PMID:15385411\|RGD:5508700
Biological Process	GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus	Hmgcr	IMP		Rat	PMID:20610886\|RGD:5508687
Biological Process	GO:0043407	negative regulation of MAP kinase activity	Hmgcr	IGI	MGI:MGI:97306	Mouse	PMID:16271875
Biological Process	GO:0043407	negative regulation of MAP kinase activity	Hmgcr	IGI	MGI:MGI:97306	Mouse	PMID:12409258
Biological Process	GO:0042177	negative regulation of protein catabolic process	Hmgcr	IMP		Mouse	MGI:MGI:6270905\|PMID:20876579
Biological Process	GO:0050709	negative regulation of protein secretion	Hmgcr	IMP		Mouse	MGI:MGI:6270905\|PMID:20876579
Biological Process	GO:0010664	negative regulation of striated muscle cell apoptotic process	Hmgcr	IMP		Rat	PMID:19505369\|RGD:5508691
Biological Process	GO:0061045	negative regulation of wound healing	Hmgcr	IMP		Rat	PMID:19578821\|RGD:5508683
Biological Process	GO:0014032	neural crest cell development	hmgcrb	IMP	ZFIN:ZDB-GENO-110609-7	Zfish	PMID:27488927
Biological Process	GO:0001755	neural crest cell migration	hmgcrb	IMP	ZFIN:ZDB-GENO-110609-7	Zfish	PMID:27488927
Biological Process	GO:0010666	positive regulation of cardiac muscle cell apoptotic process	Hmgcr	IMP		Rat	PMID:19298698\|RGD:5508693
Biological Process	GO:0008284	positive regulation of cell population proliferation	Hmgcr	IMP		Rat	PMID:12713866\|RGD:5508702
Biological Process	GO:0008284	positive regulation of cell population proliferation	Hmgcr	IMP		Rat	PMID:21907337\|RGD:5508684
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Hmgcr	IMP		Rat	PMID:17161379\|RGD:5508698
Biological Process	GO:0048643	positive regulation of skeletal muscle tissue development	Hmgcr	IMP		Rat	PMID:19388010\|RGD:2317940
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	Hmgcr	IMP		Rat	PMID:18413661\|RGD:5508694
Biological Process	GO:0032874	positive regulation of stress-activated MAPK cascade	Hmgcr	IMP		Rat	PMID:17161379\|RGD:5508698
Biological Process	GO:0045907	positive regulation of vasoconstriction	Hmgcr	IMP		Rat	PMID:19221211\|RGD:2316498
Biological Process	GO:0070372	regulation of ERK1 and ERK2 cascade	Hmgcr	IGI	MGI:MGI:97306	Mouse	PMID:16271875
Biological Process	GO:0070723	response to cholesterol	Hmgcr	IEP		Rat	PMID:25263431\|RGD:15045610
Biological Process	GO:0045471	response to ethanol	Hmgcr	IEP		Rat	PMID:20041784\|RGD:5508451
Biological Process	GO:0007584	response to nutrient	Hmgcr	IEP		Rat	PMID:16702306\|RGD:2313754
Biological Process	GO:0031667	response to nutrient levels	Hmgcr	IEP		Rat	PMID:23117815\|RGD:15045604
Biological Process	GO:0031667	response to nutrient levels	Hmgcr	IEP		Rat	PMID:25263431\|RGD:15045610
Biological Process	GO:0007519	skeletal muscle tissue development	hmgcra	IMP	ZFIN:ZDB-MRPHLNO-080202-1,ZFIN:ZDB-MRPHLNO-080202-2	Zfish	PMID:17992259
Biological Process	GO:0070328	triglyceride homeostasis	Hmgcr	IEP		Rat	PMID:23117815\|RGD:15045604
Biological Process	GO:0006743	ubiquinone metabolic process	Hmgcr	IMP		Rat	PMID:17192694\|RGD:5508697
Biological Process	GO:0008542	visual learning	Hmgcr	IGI	MGI:MGI:97306	Mouse	PMID:16271875

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.