Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HIC1
  • Mouse genes Hic1
  • Rat genes Hic1
  • Zfish genes hic1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hic1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	hic1	IDA		Zfish	PMID:15093138
Molecular Function	GO:0003700	DNA-binding transcription factor activity	HIC1	IDA		Human	PMID:15231840
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	HIC1	IDA		Human	PMID:15231840
Molecular Function	GO:0042826	histone deacetylase binding	HIC1	IDA		Human	PMID:12052894
Molecular Function	GO:0005515	protein binding	HIC1	IPI	UniProtKB:O88712	Human	PMID:12052894
Molecular Function	GO:0005515	protein binding	HIC1	IPI	UniProtKB:O88712	Human	PMID:16724116
Molecular Function	GO:0005515	protein binding	HIC1	IPI	UniProtKB:Q9NQB0	Human	PMID:16724116
Molecular Function	GO:0005515	protein binding	HIC1	IPI	UniProtKB:O88712	Human	PMID:16762039
Molecular Function	GO:0005515	protein binding	HIC1	IPI	UniProtKB:P56546	Human	PMID:16762039
Molecular Function	GO:0005515	protein binding	HIC1	IPI	UniProtKB:Q13363	Human	PMID:16762039
Molecular Function	GO:0005515	protein binding	HIC1	IPI	UniProtKB:O14497	Human	PMID:19486893
Molecular Function	GO:0005515	protein binding	HIC1	IPI	UniProtKB:P56545	Human	PMID:19486893
Molecular Function	GO:0005515	protein binding	HIC1	IPI	UniProtKB:Q13363	Human	PMID:19486893
Molecular Function	GO:0005515	protein binding	Hic1	IPI	UniProtKB:Q924A0	Mouse	MGI:MGI:3701023|PMID:16724116
Molecular Function	GO:0005515	protein binding	Hic1	IPI	UniProtKB:Q923E4	Mouse	MGI:MGI:5297787|PMID:16269335
Molecular Function	GO:0043565	sequence-specific DNA binding	HIC1	IDA		Human	PMID:15231840
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	HIC1	IDA		Human	PMID:28473536
Cellular Component	GO:0000785	chromatin	Hic1	IDA		Mouse	MGI:MGI:5297787|PMID:16269335
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	HIC1	IDA		Human	PMID:16269335
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	Hic1	IDA		Mouse	MGI:MGI:5297787|PMID:16269335
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	HIC1	IDA		Human	PMID:12052894
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	HIC1	IDA		Human	PMID:15231840
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Hic1	IDA		Mouse	MGI:MGI:5297787|PMID:16269335
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	HIC1	IDA		Human	PMID:16724116
Biological Process	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	Hic1	IMP		Mouse	MGI:MGI:5297787|PMID:16269335

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern