Hic1
Gene Detail

Symbol Name ID

Hic1 hypermethylated in cancer 1 MGI:1338010

Synonyms

HIC-1

Feature Type

protein coding gene

Genetic Map

Chromosome 11

45.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr11:75164565-75169519 bp, - strand From VEGA annotation of GRCm38   4955 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4740  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Hic1

Human homologs

Human Homolog		HIC1, hypermethylated in cancer 1
NCBI Gene ID		3090
neXtProt AC		NX_Q14526
Human Synonyms		hic-1, ZBTB29, ZNF901
Human Chr (Location)		17p13.3; chr17:1958393-1962981 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(7) : Targeted(6) Gene trapped(1)
 

Homozygotes for a targeted null mutation exhibit varying abnormalities, such as acrania, exencephaly, cleft palate, limb defects, and omphalocele, and die perinatally. Heterozygotes develop tumors, including lymphomas, sarcomas, and epithelial cancers.

 

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	intrinsic apoptotic signaling pathway in response to DNA damage, multicellular organismal development, ...
Component	chromatin, cytoplasm, ...
Function	DNA binding, histone deacetylase binding, ...

External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (75)    Tissues (51)    Images (9)
Theiler Stages: 17, 20, 21, 23, 28

Assay Type	Results
RNA in situ	72
RT-PCR	3

cDNA source data(33)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(39) Genomic(4) cDNA(33) Primer pair(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000006196 (Evidence)
Ensembl Gene Model	ENSMUSG00000043099 (Evidence)
Entrez Gene	15248 (Evidence)
UniGene	57250
DFCI	TC1597390, TC1667066
DoTS	DT.536173, DT.91593828
NIA Mouse Gene Index	U033074
Consensus CDS Project	CCDS36226.1
International Mouse Knockout Project Status	Hic1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006196	VEGA Gene Model | MGI Sequence Detail	4955	C57BL/6J
transcript	OTTMUST00000013968	VEGA | MGI Sequence Detail	3497	Not Applicable
polypeptide	OTTMUSP00000006488	VEGA | MGI Sequence Detail	893	Not Applicable

All sequences(32) RefSeq(4) UniProt(2)

Polymorphisms

PCR(1) : SNPs(7 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013069	BTB/POZ
InterPro	IPR011333	BTB/POZ fold
InterPro	IPR000210	BTB/POZ-like
InterPro	IPR007087	Zinc finger, C2H2
InterPro	IPR015880	Zinc finger, C2H2-like
InterPro	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology	PR:000008551	hypermethylated in cancer 1 protein

References

(Earliest) J:55573 Deltour S, et al., The carboxy-terminal end of the candidate tumor suppressor gene HIC-1 is phylogenetically conserved. Biochim Biophys Acta. 1998 Nov 26;1443(1-2):230-2
(Latest) J:173699 Mohammad HP, et al., Loss of a single Hic1 allele accelerates polyp formation in Apc(Delta716) mice. Oncogene. 2011 Jun 9;30(23):2659-69
All references(43)

Other accession IDs

MGI:2143980