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Hic1 Gene Detail
Summary
  • Symbol
    Hic1
  • Name
    hypermethylated in cancer 1
  • Synonyms
    HIC-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338010
    NCBI Gene: 15248
  • Gene Overview
    MyGene.info: HIC1
Location & Maps
more
  • Sequence Map
    Chr11:75164565-75169519 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4955 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 45.76 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    HIC1, hypermethylated in cancer 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    HIC1, hypermethylated in cancer 1
    Orthology source: HomoloGene
  • Synonyms
    hic-1, ZBTB29, ZNF901
  • Links
    NCBI Gene ID: 3090
    neXtProt AC: NX_Q14526

  • Chr Location
    17p13.3; chr17:2055099-2059687 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 4740
    1 human;1 mouse;1 rat;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: HIC1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Hic1 mouse models

Human Disease Mouse Models
       Miller-Dieker Lissencephaly Syndrome; MDLS   OMIM: 247200 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    28 phenotypes from 4 alleles in 2 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    7
  • Genomic Mutations
    2 involving Hic1
  • Incidental Mutations
Homozygotes for a targeted null mutation exhibit varying abnormalities, such as acrania, exencephaly, cleft palate, limb defects, and omphalocele, and die perinatally. Heterozygotes develop tumors, including lymphomas, sarcomas, and epithelial cancers.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006196 VEGA Gene Model | MGI Sequence Detail 4955 C57BL/6J ±  kb
transcript OTTMUST00000013968 VEGA | MGI Sequence Detail 3497 Not Applicable  
polypeptide OTTMUSP00000006488 VEGA | MGI Sequence Detail 893 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    15 from dbSNP Build 142
  • PCR
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 39
    Genomic 4
    cDNA 33
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGI:2143980
References
more
  • Summaries
    All 42
    Developmental Gene Expression 11
    Diseases 1
    Gene Ontology 5
    Phenotypes 22
  • Earliest
    J:55573 Deltour S, et al., The carboxy-terminal end of the candidate tumor suppressor gene HIC-1 is phylogenetically conserved. Biochim Biophys Acta. 1998 Nov 26;1443(1-2):230-2
  • Latest
    J:222772 Janeckova L, et al., HIC1 Tumor Suppressor Loss Potentiates TLR2/NF-kappaB Signaling and Promotes Tissue Damage-Associated Tumorigenesis. Mol Cancer Res. 2015 Jul;13(7):1139-48

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory