Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HCRTR2
  • Mouse genes Hcrtr2
  • Rat genes Hcrtr2
  • Zfish genes hcrtr2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hcrtr2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004930	G protein-coupled receptor activity	Hcrtr2	IDA		Rat	PMID:9491897|RGD:728644
Molecular Function	GO:0016499	orexin receptor activity	HCRTR2	IDA		Human	PMID:26950369
Molecular Function	GO:0016499	orexin receptor activity	Hcrtr2	IDA		Mouse	PMID:15256537
Molecular Function	GO:0016499	orexin receptor activity	Hcrtr2	IDA		Rat	PMID:12890892|RGD:1642020
Molecular Function	GO:0016499	orexin receptor activity	Hcrtr2	IDA		Rat	PMID:9491897|RGD:728644
Molecular Function	GO:0017046	peptide hormone binding	Hcrtr2	IDA		Rat	PMID:12890892|RGD:1642020
Molecular Function	GO:0005515	protein binding	HCRTR2	IPI	UniProtKB:P62937	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Hcrtr2	IPI	PR:P51807	Mouse	PMID:22028875
Cellular Component	GO:0005886	plasma membrane	HCRTR2	IDA		Human	PMID:26950369
Biological Process	GO:0048512	circadian behavior	hcrtr2	IMP	ZFIN:ZDB-GENO-080103-1	Zfish	PMID:19966231
Biological Process	GO:0007631	feeding behavior	Hcrtr2	IDA		Rat	PMID:9491897|RGD:728644
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Hcrtr2	IDA		Rat	PMID:12890892|RGD:1642020
Biological Process	GO:0040011	locomotion	Hcrtr2	IGI	UniProtKB:G5EEB1|UniProtKB:Q18534	Mouse	MGI:MGI:6827197|PMID:27585848
Biological Process	GO:0030186	melatonin metabolic process	hcrtr2	IMP	ZFIN:ZDB-GENO-080103-1	Zfish	PMID:19966231
Biological Process	GO:0007218	neuropeptide signaling pathway	HCRTR2	IDA		Human	PMID:26950369
Biological Process	GO:0007218	neuropeptide signaling pathway	Hcrtr2	IDA		Rat	PMID:9491897|RGD:728644
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	Hcrtr2	IDA		Mouse	PMID:15256537
Biological Process	GO:0045187	regulation of circadian sleep/wake cycle, sleep	hcrtr2	IMP	ZFIN:ZDB-GENO-080103-1	Zfish	PMID:17941721
Biological Process	GO:0051480	regulation of cytosolic calcium ion concentration	HCRTR2	IDA		Human	PMID:26950369

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern