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Hcrtr2
Gene Detail
 Symbol
Name
ID
Hcrtr2
hypocretin (orexin) receptor 2
MGI:2680765
Synonyms mOX2aR, mOX2bR, mOXR2, OX2r
Feature Type protein coding gene
Genetic Map
Chromosome 9
42.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:76225880-76323856 bp, - strand
From VEGA annotation of GRCm38

  97977 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1168  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: orexin receptor
Gene Tree: Hcrtr2

Human
homologs
Human Homolog HCRTR2, hypocretin (orexin) receptor 2
NCBI Gene ID 3062
neXtProt AC  NX_O43614
Human Synonyms  OX2R
Human Chr (Location)  6p12; chr6:55106460-55282620 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Radiation induced(1) Targeted(4)
Genomic Mutations involving Hcrtr2 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice bearing targeted mutations in this gene exhibit fragmentation of sleep/wake states with similarity to narcolepsy and rare or very rare episodes of cataplexy. In addition, mice homozygous for a funtionally null allele display enhanced depression-like behavior.
 
Interactions
Hcrtr2 interacts with 296 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process circadian sleep/wake cycle process, feeding behavior, ...
Component integral component of membrane, membrane, ...
Function G-protein coupled receptor activity, orexin receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (24)    Tissues (12)   
Theiler Stages: 10, 18, 23, 25, 28
Assay TypeResults
RT-PCR 24
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) cDNA(9) Primer pair(4)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000044825 (Evidence)
Ensembl Gene ModelENSMUSG00000032360 (Evidence)
Entrez Gene387285 (Evidence)
UniGene335300
DFCITC1586497, TC1596984
DoTSDT.91283345, DT.94293331
Consensus CDS ProjectCCDS23350.1
International Mouse Knockout Project StatusHcrtr2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044825 VEGA Gene Model | MGI Sequence Detail 97977 C57BL/6J ±  kb
transcript OTTMUST00000117816 VEGA | MGI Sequence Detail 3761 Not Applicable 
polypeptide OTTMUSP00000065830 VEGA | MGI Sequence Detail 460 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(4) UniProt(3)
Polymorphisms SNPs within 2kb(626 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR004060 Orexin receptor 2
InterPro IPR000204 Orexin receptor family
Protein Ontology PR:000001634 orexin receptor type 2
References (Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:208001 Hasegawa E, et al., Orexin neurons suppress narcolepsy via 2 distinct efferent pathways. J Clin Invest. 2014 Feb 3;124(2):604-16
All references(40)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory