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Hcrtr2
Gene Detail
Symbol

Name
ID
Hcrtr2
hypocretin (orexin) receptor 2
MGI:2680765
Synonyms
mOX2aR, mOX2bR, mOXR2, OX2r
Feature Type
protein coding gene
Genetic Map
Chromosome 9
42.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:76225880-76323856 bp, - strand
From VEGA annotation of GRCm38

  97977 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1168  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HCRTR2
Protein SuperFamily: orexin receptor
Gene Tree: Hcrtr2

Human
homologs
HCRTR2, hypocretin (orexin) receptor 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 3062
neXtProt AC: NX_O43614

Human Synonyms: OX2R

Human Chr (Location): 6p12; chr6:55174273-55282620 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Radiation induced(1) Targeted(4)
Genomic Mutations involving Hcrtr2 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice bearing targeted mutations in this gene exhibit fragmentation of sleep/wake states with similarity to narcolepsy and rare or very rare episodes of cataplexy. In addition, mice homozygous for a funtionally null allele display enhanced depression-like behavior.
 
Interactions
Hcrtr2 interacts with 295 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (24)    Tissues (12)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 24
cDNA source data(8)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase hcrtr2 ; ZFIN hcrtr2    NEW 
Molecular
reagents
All nucleic(13) cDNA(9) Primer pair(4)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000044825 (Evidence)
Ensembl Gene Model ENSMUSG00000032360 (Evidence)
Entrez Gene 387285 (Evidence)
UniGene 335300
DFCI TC1586497, TC1596984
DoTS DT.91283345, DT.94293331
Consensus CDS Project CCDS23350.1
International Mouse Phenotyping Consortium Status Hcrtr2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044825 VEGA Gene Model | MGI Sequence Detail 97977 C57BL/6J ±  kb
transcript OTTMUST00000117816 VEGA | MGI Sequence Detail 3761 Not Applicable 
polypeptide OTTMUSP00000065830 VEGA | MGI Sequence Detail 460 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(626 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR004060 Orexin receptor 2
InterPro IPR000204 Orexin receptor family
Protein Ontology PR:000001634 orexin receptor type 2
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:215267 Wei W, et al., Orexin regulates bone remodeling via a dominant positive central action and a subordinate negative peripheral action. Cell Metab. 2014 Jun 3;19(6):927-40
All references(43)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory