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Hcrtr2 Gene Detail
Summary
  • Symbol
    Hcrtr2
  • Name
    hypocretin (orexin) receptor 2
  • Synonyms
    mOX2aR, mOX2bR, mOXR2, OX2r
  • Feature Type
    protein coding gene
  • IDs
    MGI:2680765
    NCBI Gene: 387285
  • Gene Overview
    MyGene.info: HCRTR2
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:76225880-76323578 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 42.48 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    814 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2680765
protein coding gene Chr9:76225880-76323856 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035048
protein coding gene Chr9:76586594-76693124 (-)
A/J MGP_AJ_G0035029
protein coding gene Chr9:73900083-74010104 (-)
AKR/J MGP_AKRJ_G0034958
protein coding gene Chr9:75678069-75786477 (-)
BALB/cJ MGP_BALBcJ_G0035021
protein coding gene Chr9:73569983-73682055 (-)
C3H/HeJ MGP_C3HHeJ_G0034730
protein coding gene Chr9:76136246-76248554 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035539
protein coding gene Chr9:78619298-78733213 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032450
protein coding gene Chr9:73228862-73327145 (-)
CAST/EiJ MGP_CASTEiJ_G0034052
protein coding gene Chr9:76490817-76601342 (-)
CBA/J MGP_CBAJ_G0034702
protein coding gene Chr9:81317586-81441761 (-)
DBA/2J MGP_DBA2J_G0034862
protein coding gene Chr9:73565536-73676418 (-)
FVB/NJ MGP_FVBNJ_G0034804
protein coding gene Chr9:72859696-72962012 (-)
LP/J MGP_LPJ_G0034943
protein coding gene Chr9:76817926-76924813 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034845
protein coding gene Chr9:82417108-82548364 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035562
protein coding gene Chr9:75835109-75947536 (-)
PWK/PhJ MGP_PWKPhJ_G0033756
protein coding gene Chr9:73835567-73935825 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033589
protein coding gene Chr9:76073476-76180090 (-)
WSB/EiJ MGP_WSBEiJ_G0034164
protein coding gene Chr9:75757026-75861409 (-)



Homology
more
  • Human Ortholog
    HCRTR2, hypocretin receptor 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HCRTR2, hypocretin receptor 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    OX2R
  • Links
    NCBI Gene ID: 3062
    neXtProt AC: NX_O43614
    UniProt: O43614

  • Chr Location
    6p12.1; chr6:55174273-55284698 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Hcrtr2 mouse models

Human Disease Mouse Models
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 3 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice bearing targeted mutations in this gene exhibit fragmentation of sleep/wake states with similarity to narcolepsy and rare or very rare episodes of cataplexy. In addition, mice homozygous for a funtionally null allele display enhanced depression-likebehavior.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 387285 NCBI Gene Model | MGI Sequence Detail 97699 C57BL/6J ±  kb
    transcript NM_198962 RefSeq | MGI Sequence Detail 3773 C57BL/6  
    polypeptide P58308 UniProt | EBI | MGI Sequence Detail 460 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 10
      Primer pair 4
      Other 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 3
      Diseases 2
      Gene Ontology 8
      Phenotypes 26
    • Earliest
      J:12013 Russell LB, Definition of functional units in a small chromosomal segment of the mouse and its use in interpreting the nature of radiation-induced mutations. Mutat Res. 1971 Jan;11(1):107-23
    • Latest
      J:263007 Kaushik MK, et al., Continuous intrathecal orexin delivery inhibits cataplexy in a murine model of narcolepsy. Proc Natl Acad Sci U S A. 2018 Jun 5;115(23):6046-6051

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory