Hcrtr2^tm1Ywa
Targeted Allele Detail

Summary

• Symbol: Hcrtr2^tm1Ywa
• Name: hypocretin (orexin) receptor 2; targeted mutation 1, Masashi Yanagisawa
• MGI ID: MGI:2664995
• Synonyms: OX2R-
• Gene: Hcrtr2 Location: Chr9:76133162-76230905 bp, - strand Genetic Position: Chr9, 42.48 cM
• Alliance: Hcrtr2^tm1Ywa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83817
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced in-frame with an nlacZ-neo cassette and homologous recombination was confirmed by PCR and Southern blots. Northern blots of whole brain RNA from homozygotes indicated the complete absence of gene transcripts. (J:83817)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hcrtr2 Mutation: 37 strains or lines available

References

• Original: J:83817 Willie JT, et al., Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processes. Neuron. 2003 Jun 5;38(5):715-30
• All: 17 reference(s)