Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HCRT
  • Mouse genes Hcrt
  • Rat genes Hcrt
  • Zfish genes hcrt
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hcrt

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005184	neuropeptide hormone activity	Hcrt	IDA		Rat	PMID:16247802|RGD:1600968
Molecular Function	GO:0031771	type 1 orexin receptor binding	Hcrt	IDA		Rat	PMID:12890892|RGD:1642020
Molecular Function	GO:0031772	type 2 orexin receptor binding	Hcrt	IDA		Rat	PMID:12890892|RGD:1642020
Cellular Component	GO:0005737	cytoplasm	Hcrt	IDA		Rat	PMID:16141395|RGD:1600965
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Hcrt	IDA		Mouse	PMID:11748295
Cellular Component	GO:0030141	secretory granule	Hcrt	IDA		Rat	PMID:9419374|RGD:1298943
Biological Process	GO:0042746	circadian sleep/wake cycle, wakefulness	hcrt	IMP	ZFIN:ZDB-GENO-070319-4	Zfish	PMID:17182791
Biological Process	GO:0042755	eating behavior	Hcrt	IDA		Rat	PMID:15961555|RGD:1600976
Biological Process	GO:0060079	excitatory postsynaptic potential	Hcrt	IDA		Rat	PMID:16247802|RGD:1600968
Biological Process	GO:0033555	multicellular organismal response to stress	hcrt	IEP		Zfish	PMID:25748166
Biological Process	GO:0008156	negative regulation of DNA replication	Hcrt	IDA		Rat	PMID:16141395|RGD:1600965
Biological Process	GO:0043267	negative regulation of potassium ion transport	Hcrt	IDA		Rat	PMID:16247802|RGD:1600968
Biological Process	GO:0051970	negative regulation of transmission of nerve impulse	Hcrt	IDA		Rat	PMID:15746258|RGD:1600996
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	Hcrt	IMP		Rat	PMID:16247802|RGD:1600968
Biological Process	GO:0051928	positive regulation of calcium ion transport	Hcrt	IMP		Rat	PMID:15858425|RGD:1600997
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	Hcrt	IMP		Mouse	MGI:MGI:6162310|PMID:23700511
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Hcrt	IDA		Rat	PMID:15858425|RGD:1600997
Biological Process	GO:0051971	positive regulation of transmission of nerve impulse	Hcrt	IDA		Rat	PMID:15746258|RGD:1600996
Biological Process	GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	Hcrt	IMP		Rat	PMID:16247802|RGD:1600968
Biological Process	GO:0046928	regulation of neurotransmitter secretion	Hcrt	IDA		Rat	PMID:15664710|RGD:1358371
Biological Process	GO:0042594	response to starvation	hcrt	IDA		Zfish	PMID:15936519
Biological Process	GO:0030431	sleep	hcrt	IGI	ZFIN:ZDB-GENE-990621-3	Zfish	PMID:26374985
Biological Process	GO:0030431	sleep	hcrt	IMP	ZFIN:ZDB-GENO-170823-4	Zfish	PMID:26374985
Biological Process	GO:0001659	temperature homeostasis	Hcrt	IDA		Rat	PMID:15479129|RGD:8693623

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern