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Hcrt
Gene Detail
Symbol

Name
ID
Hcrt
hypocretin
MGI:1202306
Synonyms
orexin A, orexin B
Feature Type
protein coding gene
Genetic Map
Chromosome 11
63.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr11:100761069-100762931 bp, - strand
From VEGA annotation of GRCm38

  1863 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1166  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: orexin
Gene Tree: Hcrt

Human
homologs
Human Homolog HCRT, hypocretin (orexin) neuropeptide precursor
NCBI Gene ID 3060
neXtProt AC  NX_O43612
Human Synonyms  NRCLP1, OX, PPOX
Human Chr (Location)  17q21; chr17:42184060-42185452 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human HCRT
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
 
Homozygotes for a targeted null mutation exhibit altered sleep patterns, frequent periods of behavioral arrest resembling human narcolepsy, and attenuated morphine dependence.
 
Human Diseases Modeled Using Mouse Hcrt (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Hcrt interacts with 7 markers (Mir92-1, Mir92-2, Mir92b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process eating behavior, feeding behavior, ...
Component cell junction, cytoplasm, ...
Function neuropeptide hormone activity, type 1 hypocretin receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (124)    Tissues (123)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 124
cDNA source data(7)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(9) Genomic(2) cDNA(7)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000002123 (Evidence)
Ensembl Gene ModelENSMUSG00000045471 (Evidence)
Entrez Gene15171 (Evidence)
UniGene10096
DFCITC1591142
DoTSDT.87048332
NIA Mouse Gene IndexU033435
Consensus CDS ProjectCCDS25436.1
International Mouse Knockout Project StatusHcrt
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002123 VEGA Gene Model | MGI Sequence Detail 1863 C57BL/6J ±  kb
transcript OTTMUST00000004304 VEGA | MGI Sequence Detail 586 Not Applicable 
polypeptide OTTMUSP00000002040 VEGA | MGI Sequence Detail 130 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(29 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001704 Prepro-orexin
Protein Ontology PR:000008476 orexin
References
(Earliest) J:45976 de Lecea L, et al., The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci U S A. 1998 Jan 6;95(1):322-7
(Latest) J:208001 Hasegawa E, et al., Orexin neurons suppress narcolepsy via 2 distinct efferent pathways. J Clin Invest. 2014 Feb 3;124(2):604-16
All references(84)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory