Hcrt
Gene Detail

Symbol Name ID

Hcrt hypocretin MGI:1202306

Synonyms

orexin A, orexin B

Feature Type

protein coding gene

Genetic Map

Chromosome 11

63.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr11:100761069-100762931 bp, - strand From VEGA annotation of GRCm38   1863 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1166  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: orexin
Gene Tree: Hcrt

Human homologs

Human Homolog		HCRT, hypocretin (orexin) neuropeptide precursor
NCBI Gene ID		3060
neXtProt AC		NX_O43612
Human Synonyms		NRCLP1, OX, PPOX
Human Chr (Location)		17q21; chr17:40336078-40337470 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human HCRT

Alleles and phenotypes

All alleles(3) : Targeted(2) Gene trapped(1)
 

Homozygotes for a targeted null mutation exhibit altered sleep patterns, frequent periods of behavioral arrest resembling human narcolepsy, and attenuated morphine dependence.

 
Human Diseases Modeled Using Mouse Hcrt (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	eating behavior, elevation of cytosolic calcium ion concentration, ...
Component	cell junction, cytoplasm, ...
Function	neuropeptide hormone activity, type 1 hypocretin receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (124)    Tissues (123)    Images (15)
Theiler Stages: 19, 22, 23, 26, 28

Assay Type	Results
RNA in situ	124

cDNA source data(7)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(9) Genomic(2) cDNA(7)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000002123 (Evidence)
Ensembl Gene Model	ENSMUSG00000045471 (Evidence)
Entrez Gene	15171 (Evidence)
UniGene	10096
DFCI	TC1591142
DoTS	DT.87048332
NIA Mouse Gene Index	U033435
Consensus CDS Project	CCDS25436.1
International Mouse Knockout Project Status	Hcrt

Sequences

Length	Strain/Species
genomic	OTTMUSG00000002123	VEGA Gene Model | MGI Sequence Detail	1863	C57BL/6J
transcript	OTTMUST00000004304	VEGA | MGI Sequence Detail	586	Not Applicable
polypeptide	OTTMUSP00000002040	VEGA | MGI Sequence Detail	130	Not Applicable

All sequences(24) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(11 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001704	Prepro-orexin
Protein Ontology	PR:000008476	orexin

References

(Earliest) J:45976 de Lecea L, et al., The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci U S A. 1998 Jan 6;95(1):322-7
(Latest) J:177647 Sellayah D, et al., Orexin is required for brown adipose tissue development, differentiation, and function. Cell Metab. 2011 Oct 5;14(4):478-90
All references(77)