Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HLA-DRB1,HLA-DRB3,HLA-DRB4,HLA-DRB5
  • Mouse genes H2-Eb1
  • Rat genes RT1-Db1
  • Zfish genes mhc2bl,mhc2d4b,mhc2d8.35b2,mhc2d8.37b2,mhc2dab,mhc2dgb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set H2-Eb1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042609	CD4 receptor binding	HLA-DRB1	IPI	UniProtKB:P01730,UniProtKB:P04233	Human	PMID:24942581
Molecular Function	GO:0023026	MHC class II protein complex binding	HLA-DRB1	HDA		Human	PMID:20458337
Molecular Function	GO:0032395	MHC class II receptor activity	HLA-DRB1	IDA		Human	PMID:15795121
Molecular Function	GO:0042605	peptide antigen binding	HLA-DRB1	IDA		Human	PMID:1448172
Molecular Function	GO:0042605	peptide antigen binding	HLA-DRB1	IDA		Human	PMID:20543955
Molecular Function	GO:0042605	peptide antigen binding	HLA-DRB1	IDA		Human	PMID:21502329
Molecular Function	GO:0042605	peptide antigen binding	HLA-DRB1	IDA		Human	PMID:22733780
Molecular Function	GO:0042605	peptide antigen binding	HLA-DRB1	IDA		Human	PMID:7477400
Molecular Function	GO:0042605	peptide antigen binding	HLA-DRB1	IDA		Human	PMID:7606781
Molecular Function	GO:0042605	peptide antigen binding	HLA-DRB3	IDA		Human	PMID:17583734
Molecular Function	GO:0042605	peptide antigen binding	HLA-DRB3	IDA		Human	PMID:18697946
Molecular Function	GO:0030247	polysaccharide binding	HLA-DRB1	IDA		Human	PMID:21502329
Molecular Function	GO:0005515	protein binding	HLA-DRB1	IPI	UniProtKB:P0A0M0	Human	PMID:21081917
Molecular Function	GO:0005515	protein binding	HLA-DRB1	IPI	UniProtKB:P01730	Human	PMID:27114505
Molecular Function	GO:0005515	protein binding	HLA-DRB1	IPI	UniProtKB:P01903,UniProtKB:P02458	Human	PMID:9354468
Molecular Function	GO:0005515	protein binding	HLA-DRB3	IPI	UniProtKB:P27797	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HLA-DRB3	IPI	UniProtKB:P36957	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	HLA-DRB3	IPI	UniProtKB:Q8TDX7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	H2-Eb1	IPI	PR:Q9Z324	Mouse	PMID:11591653
Molecular Function	GO:0042608	T cell receptor binding	HLA-DRB1	IDA		Human	PMID:29884618
Cellular Component	GO:0009986	cell surface	HLA-DRB1	IDA		Human	PMID:21502329
Cellular Component	GO:0009897	external side of plasma membrane	HLA-DRB1	IDA		Human	PMID:20543955
Cellular Component	GO:0070062	extracellular exosome	HLA-DRB1	HDA		Human	PMID:12519789
Cellular Component	GO:0070062	extracellular exosome	HLA-DRB1	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	HLA-DRB1	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	HLA-DRB5	HDA		Human	PMID:12519789
Cellular Component	GO:0070062	extracellular exosome	HLA-DRB5	HDA		Human	PMID:20458337
Cellular Component	GO:0005615	extracellular space	HLA-DRB1	HDA		Human	PMID:16502470
Cellular Component	GO:0001772	immunological synapse	HLA-DRB1	IDA		Human	PMID:15322540
Cellular Component	GO:0001772	immunological synapse	HLA-DRB1	IDA		Human	PMID:29884618
Cellular Component	GO:0031902	late endosome membrane	HLA-DRB1	IDA		Human	PMID:18305173
Cellular Component	GO:0031902	late endosome membrane	HLA-DRB1	IDA		Human	PMID:9075930
Cellular Component	GO:0031902	late endosome membrane	HLA-DRB4	IDA		Human	PMID:18305173
Cellular Component	GO:0031902	late endosome membrane	HLA-DRB4	IDA		Human	PMID:19117940
Cellular Component	GO:0031902	late endosome membrane	HLA-DRB3	IDA		Human	PMID:18305173
Cellular Component	GO:0031902	late endosome membrane	HLA-DRB5	IDA		Human	PMID:18305173
Cellular Component	GO:0005765	lysosomal membrane	HLA-DRB1	IDA		Human	PMID:18305173
Cellular Component	GO:0005765	lysosomal membrane	HLA-DRB1	IDA		Human	PMID:9075930
Cellular Component	GO:0005765	lysosomal membrane	HLA-DRB4	IDA		Human	PMID:18305173
Cellular Component	GO:0005765	lysosomal membrane	HLA-DRB3	IDA		Human	PMID:18305173
Cellular Component	GO:0005765	lysosomal membrane	HLA-DRB5	IDA		Human	PMID:18305173
Cellular Component	GO:0016020	membrane	HLA-DRB1	HDA		Human	PMID:19946888
Cellular Component	GO:0016020	membrane	HLA-DRB3	HDA		Human	PMID:19946888
Cellular Component	GO:0042613	MHC class II protein complex	HLA-DRB1	IDA		Human	PMID:1448172
Cellular Component	GO:0042613	MHC class II protein complex	HLA-DRB1	IDA		Human	PMID:21502329
Cellular Component	GO:0042613	MHC class II protein complex	HLA-DRB1	IDA		Human	PMID:22733780
Cellular Component	GO:0042613	MHC class II protein complex	HLA-DRB1	IDA		Human	PMID:7477400
Cellular Component	GO:0042613	MHC class II protein complex	HLA-DRB1	IDA		Human	PMID:7606781
Cellular Component	GO:0042613	MHC class II protein complex	HLA-DRB1	IMP		Human	PMID:9354468
Cellular Component	GO:0005886	plasma membrane	HLA-DRB3	IDA		Human	PMID:19531622
Biological Process	GO:0002491	antigen processing and presentation of endogenous peptide antigen via MHC class II	HLA-DRB1	IDA		Human	PMID:15322540
Biological Process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	HLA-DRB1	IDA		Human	PMID:15265931
Biological Process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	HLA-DRB1	IDA		Human	PMID:32341563
Biological Process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	HLA-DRB3	IDA		Human	PMID:19531622
Biological Process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	HLA-DRB3	IDA		Human	PMID:32341563
Biological Process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	H2-Eb1	IDA		Mouse	PMID:11714799
Biological Process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	H2-Eb1	IDA		Mouse	PMID:11027433
Biological Process	GO:0016045	detection of bacterium	HLA-DRB1	IMP		Human	PMID:22321387
Biological Process	GO:0006959	humoral immune response	HLA-DRB1	IMP		Human	PMID:17050030
Biological Process	GO:0006955	immune response	HLA-DRB1	IDA		Human	PMID:20543955
Biological Process	GO:0006955	immune response	HLA-DRB1	IDA		Human	PMID:21569485
Biological Process	GO:0006955	immune response	HLA-DRB1	IMP		Human	PMID:22321387
Biological Process	GO:0002437	inflammatory response to antigenic stimulus	HLA-DRB1	IDA		Human	PMID:15795121
Biological Process	GO:0030225	macrophage differentiation	HLA-DRB1	IDA		Human	PMID:24942581
Biological Process	GO:0002469	myeloid dendritic cell antigen processing and presentation	HLA-DRB1	IDA		Human	PMID:29884618
Biological Process	GO:0002469	myeloid dendritic cell antigen processing and presentation	HLA-DRB1	IDA		Human	PMID:30282837
Biological Process	GO:0002469	myeloid dendritic cell antigen processing and presentation	HLA-DRB3	IDA		Human	PMID:19531622
Biological Process	GO:0002469	myeloid dendritic cell antigen processing and presentation	HLA-DRB3	IDA		Human	PMID:30282837
Biological Process	GO:0002862	negative regulation of inflammatory response to antigenic stimulus	HLA-DRB1	IDA		Human	PMID:18039812
Biological Process	GO:0042130	negative regulation of T cell proliferation	HLA-DRB1	IMP		Human	PMID:15795121
Biological Process	GO:0032689	negative regulation of type II interferon production	HLA-DRB1	IMP		Human	PMID:15795121
Biological Process	GO:0002503	peptide antigen assembly with MHC class II protein complex	HLA-DRB1	IDA		Human	PMID:1448172
Biological Process	GO:0002503	peptide antigen assembly with MHC class II protein complex	HLA-DRB1	IDA		Human	PMID:22733780
Biological Process	GO:0002503	peptide antigen assembly with MHC class II protein complex	HLA-DRB1	IDA		Human	PMID:7606781
Biological Process	GO:2000516	positive regulation of CD4-positive, alpha-beta T cell activation	HLA-DRB1	IDA		Human	PMID:15265931
Biological Process	GO:2000516	positive regulation of CD4-positive, alpha-beta T cell activation	HLA-DRB3	IDA		Human	PMID:19531622
Biological Process	GO:0032831	positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation	HLA-DRB1	IDA		Human	PMID:28467828
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	HLA-DRB1	IDA		Human	PMID:24942581
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	HLA-DRB1	IDA		Human	PMID:24942581
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	HLA-DRB1	IDA		Human	PMID:24942581
Biological Process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	HLA-DRB1	IMP		Human	PMID:21484216
Biological Process	GO:0033674	positive regulation of kinase activity	HLA-DRB1	IDA		Human	PMID:24942581
Biological Process	GO:0043410	positive regulation of MAPK cascade	HLA-DRB1	IDA		Human	PMID:24942581
Biological Process	GO:0043382	positive regulation of memory T cell differentiation	HLA-DRB1	IDA		Human	PMID:27591323
Biological Process	GO:0045657	positive regulation of monocyte differentiation	HLA-DRB1	IDA		Human	PMID:24942581
Biological Process	GO:0001934	positive regulation of protein phosphorylation	HLA-DRB1	IDA		Human	PMID:24942581
Biological Process	GO:0001916	positive regulation of T cell mediated cytotoxicity	HLA-DRB1	IDA		Human	PMID:29884618
Biological Process	GO:0002842	positive regulation of T cell mediated immune response to tumor cell	HLA-DRB1	IDA		Human	PMID:30282837
Biological Process	GO:0002842	positive regulation of T cell mediated immune response to tumor cell	HLA-DRB3	IDA		Human	PMID:30282837
Biological Process	GO:0046598	positive regulation of viral entry into host cell	HLA-DRB1	IDA		Human	PMID:24942581
Biological Process	GO:0051262	protein tetramerization	HLA-DRB1	IDA		Human	PMID:20543955
Biological Process	GO:0032653	regulation of interleukin-10 production	HLA-DRB1	IDA		Human	PMID:20543955
Biological Process	GO:0032673	regulation of interleukin-4 production	HLA-DRB1	IDA		Human	PMID:20543955
Biological Process	GO:0045622	regulation of T-helper cell differentiation	HLA-DRB1	IDA		Human	PMID:15322540
Biological Process	GO:0071548	response to dexamethasone	RT1-Db1	IEP		Rat	PMID:20377877|RGD:4144112
Biological Process	GO:0010033	response to organic substance	RT1-Db1	IEP		Rat	PMID:23717070|RGD:10448994
Biological Process	GO:0034341	response to type II interferon	H2-Eb1	IDA		Mouse	MGI:MGI:5009185|PMID:11465104
Biological Process	GO:0007165	signal transduction	HLA-DRB1	IMP		Human	PMID:15795121
Biological Process	GO:0050852	T cell receptor signaling pathway	HLA-DRB1	IDA		Human	PMID:32341563
Biological Process	GO:0050852	T cell receptor signaling pathway	HLA-DRB3	IDA		Human	PMID:32341563
Biological Process	GO:0042088	T-helper 1 type immune response	HLA-DRB1	IMP		Human	PMID:15795121

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern