Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Grhl2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes GRHL2
- Mouse genes Grhl2
- Rat genes Grhl2
- Zfish genes grhl2a,grhl2b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Grhl2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Grhl2	IDA		Mouse	PMID:25758223
Molecular Function	GO:0031490	chromatin DNA binding	GRHL2	IDA		Human	PMID:21081122
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GRHL2	IDA		Human	PMID:23814079
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GRHL2	IMP		Human	PMID:29309642
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Grhl2	IDA		Mouse	MGI:MGI:5613464\|PMID:22955271
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Grhl2	IDA		Mouse	MGI:MGI:4867118\|PMID:20978075
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Grhl2	IDA		Mouse	MGI:MGI:5499697\|PMID:22696678
Molecular Function	GO:0001161	intronic transcription regulatory region sequence-specific DNA binding	Grhl2	IDA		Mouse	MGI:MGI:4867118\|PMID:20978075
Molecular Function	GO:0005515	protein binding	GRHL2	IPI	UniProtKB:P61968	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	GRHL2	IPI	UniProtKB:P61968	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	GRHL2	IPI	UniProtKB:O75928-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GRHL2	IPI	UniProtKB:P26367	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GRHL2	IPI	UniProtKB:P61968	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GRHL2	IPI	UniProtKB:Q02548	Human	PMID:32296183
Molecular Function	GO:0043565	sequence-specific DNA binding	GRHL2	IDA		Human	PMID:19015635
Molecular Function	GO:0043565	sequence-specific DNA binding	GRHL2	IDA		Human	PMID:20938050
Molecular Function	GO:0043565	sequence-specific DNA binding	Grhl2	IDA		Mouse	MGI:MGI:4881608\|PMID:21081122
Molecular Function	GO:0000976	transcription cis-regulatory region binding	grhl2b	IDA		Zfish	PMID:22223680
Cellular Component	GO:0005911	cell-cell junction	GRHL2	IDA		Human	PMID:25152456
Cellular Component	GO:0005654	nucleoplasm	GRHL2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	GRHL2	IDA		Human	PMID:20938050
Cellular Component	GO:0005634	nucleus	GRHL2	IDA		Human	PMID:21081122
Cellular Component	GO:0005634	nucleus	GRHL2	IDA		Human	PMID:23814079
Cellular Component	GO:0005634	nucleus	GRHL2	IDA		Human	PMID:25152456
Cellular Component	GO:0005634	nucleus	Grhl2	IDA		Mouse	MGI:MGI:5613464\|PMID:22955271
Biological Process	GO:0061713	anterior neural tube closure	Grhl2	IMP	MGI:5056365	Mouse	PMID:21515572
Biological Process	GO:0060561	apoptotic process involved in morphogenesis	grhl2b	IGI	ZFIN:ZDB-MRPHLNO-060930-2,ZFIN:ZDB-MRPHLNO-120207-2	Zfish	PMID:22223680
Biological Process	GO:0070830	bicellular tight junction assembly	GRHL2	IMP		Human	PMID:25152456
Biological Process	GO:0007420	brain development	Grhl2	IMP	MGI:MGI:4942413	Mouse	PMID:21377456
Biological Process	GO:0043010	camera-type eye development	Grhl2	IMP	MGI:MGI:4942413	Mouse	PMID:21377456
Biological Process	GO:0003208	cardiac ventricle morphogenesis	Grhl2	IMP	MGI:MGI:4942413	Mouse	PMID:21377456
Biological Process	GO:0007155	cell adhesion	GRHL2	IMP		Human	PMID:25152456
Biological Process	GO:0034329	cell junction assembly	GRHL2	IMP		Human	PMID:25152456
Biological Process	GO:0008283	cell population proliferation	GRHL2	IMP		Human	PMID:20938050
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	Grhl2	IMP	MGI:MGI:4942413	Mouse	PMID:21377456
Biological Process	GO:0042733	embryonic digit morphogenesis	Grhl2	IMP	MGI:MGI:4942413	Mouse	PMID:21377456
Biological Process	GO:0048568	embryonic organ development	Grhl2	IMP	MGI:MGI:4942413	Mouse	PMID:21377456
Biological Process	GO:0008544	epidermis development	GRHL2	IDA		Human	PMID:23254293
Biological Process	GO:0008544	epidermis development	Grhl2	IMP		Mouse	MGI:MGI:4881608\|PMID:21081122
Biological Process	GO:0003382	epithelial cell morphogenesis	GRHL2	IMP		Human	PMID:25152456
Biological Process	GO:0003382	epithelial cell morphogenesis	Grhl2	IMP		Mouse	MGI:MGI:5499697\|PMID:22696678
Biological Process	GO:0060672	epithelial cell morphogenesis involved in placental branching	Grhl2	IMP	MGI:MGI:4340678	Mouse	PMID:25758223
Biological Process	GO:0090132	epithelium migration	Grhl2	IMP		Mouse	MGI:MGI:5613464\|PMID:22955271
Biological Process	GO:0060324	face development	Grhl2	IMP	MGI:MGI:4942413	Mouse	PMID:21377456
Biological Process	GO:0001701	in utero embryonic development	Grhl2	IMP	MGI:MGI:4331210	Mouse	PMID:21262862
Biological Process	GO:0048839	inner ear development	grhl2b	IMP	ZFIN:ZDB-GENO-111024-1	Zfish	PMID:21610158
Biological Process	GO:0060487	lung epithelial cell differentiation	Grhl2	IMP		Mouse	MGI:MGI:5613464\|PMID:22955271
Biological Process	GO:0060463	lung lobe morphogenesis	Grhl2	IMP	MGI:MGI:4942413	Mouse	PMID:21377456
Biological Process	GO:0030917	midbrain-hindbrain boundary development	grhl2b	IGI	ZFIN:ZDB-MRPHLNO-120207-2,ZFIN:ZDB-MRPHLNO-141230-25	Zfish	PMID:29242584
Biological Process	GO:0021555	midbrain-hindbrain boundary morphogenesis	grhl2b	IGI	ZFIN:ZDB-MRPHLNO-120207-2,ZFIN:ZDB-MRPHLNO-120207-4	Zfish	PMID:22223680
Biological Process	GO:0021555	midbrain-hindbrain boundary morphogenesis	grhl2b	IGI	ZFIN:ZDB-MRPHLNO-050714-1,ZFIN:ZDB-MRPHLNO-120207-2	Zfish	PMID:22223680
Biological Process	GO:0021555	midbrain-hindbrain boundary morphogenesis	grhl2b	IGI	ZFIN:ZDB-GENE-980526-167,ZFIN:ZDB-MRPHLNO-120207-2	Zfish	PMID:22223680
Biological Process	GO:0021555	midbrain-hindbrain boundary morphogenesis	grhl2b	IMP	ZFIN:ZDB-MRPHLNO-120207-2	Zfish	PMID:22223680
Biological Process	GO:0035264	multicellular organism growth	Grhl2	IMP	MGI:MGI:4942413	Mouse	PMID:21377456
Biological Process	GO:0045617	negative regulation of keratinocyte differentiation	GRHL2	IDA		Human	PMID:23254293
Biological Process	GO:0001843	neural tube closure	Grhl2	IMP		Mouse	MGI:MGI:4867118\|PMID:20978075
Biological Process	GO:0001843	neural tube closure	Grhl2	IMP		Mouse	MGI:MGI:4835348\|PMID:20654612
Biological Process	GO:0001843	neural tube closure	Grhl2	IMP	MGI:MGI:4331210	Mouse	PMID:21262862
Biological Process	GO:0021915	neural tube development	Grhl2	IMP	MGI:MGI:4942413	Mouse	PMID:21377456
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Grhl2	IMP		Mouse	MGI:MGI:5613464\|PMID:22955271
Biological Process	GO:0051973	positive regulation of telomerase activity	GRHL2	IMP		Human	PMID:19015635
Biological Process	GO:0051973	positive regulation of telomerase activity	GRHL2	IMP		Human	PMID:20938050
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	GRHL2	IDA		Human	PMID:23814079
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	GRHL2	IMP		Human	PMID:29309642
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Grhl2	IDA		Mouse	MGI:MGI:4867118\|PMID:20978075
Biological Process	GO:0044030	regulation of DNA methylation	GRHL2	IMP		Human	PMID:20938050
Biological Process	GO:0044030	regulation of DNA methylation	GRHL2	IDA		Human	PMID:23254293
Biological Process	GO:0010468	regulation of gene expression	Grhl2	IMP	MGI:MGI:4942413	Mouse	PMID:21377456
Biological Process	GO:0030323	respiratory tube development	Grhl2	IMP	MGI:MGI:4942413	Mouse	PMID:21377456

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.