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Grhl2 Gene Detail
Summary
  • Symbol
    Grhl2
  • Name
    grainyhead like transcription factor 2
  • Synonyms
    0610015A08Rik, BOM, clft3, grainyheadlike, Tcfcp2l3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2182543
    NCBI Gene: 252973
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:37233280-37363813 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 14.84 cM, cytoband C
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5266 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2182543
 protein coding gene Chr15:37233065-37363813 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021801
 protein coding gene Chr15:35664970-35809050 (+)
A/J MGP_AJ_G0021761
 protein coding gene Chr15:34310594-34445890 (+)
AKR/J MGP_AKRJ_G0021741
 protein coding gene Chr15:35296973-35436796 (+)
BALB/cJ MGP_BALBcJ_G0021768
 protein coding gene Chr15:34354378-34486013 (+)
C3H/HeJ MGP_C3HHeJ_G0021542
 protein coding gene Chr15:35259244-35401043 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022207
 protein coding gene Chr15:37065628-37221423 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019744
 protein coding gene Chr15:32106514-32238701 (+)
CAST/EiJ MGP_CASTEiJ_G0021059
 protein coding gene Chr15:35649299-35787278 (+)
CBA/J MGP_CBAJ_G0021511
 protein coding gene Chr15:38239914-38394850 (+)
DBA/2J MGP_DBA2J_G0021635
 protein coding gene Chr15:34150288-34282217 (+)
FVB/NJ MGP_FVBNJ_G0021613
 protein coding gene Chr15:33553287-33686706 (+)
LP/J MGP_LPJ_G0021705
 protein coding gene Chr15:35541945-35683881 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021637
 protein coding gene Chr15:41299231-41444189 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022230
 protein coding gene Chr15:35451016-35589335 (+)
PWK/PhJ MGP_PWKPhJ_G0020803
 protein coding gene Chr15:34168274-34309507 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020641
 protein coding gene Chr15:35142909-35276878 (+)
WSB/EiJ MGP_WSBEiJ_G0021114
 protein coding gene Chr15:35405430-35542936 (+)



Homology
more
  • Human Ortholog
    GRHL2, grainyhead like transcription factor 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRHL2, grainyhead like transcription factor 2
  • Synonyms
    BOM, DFNA28, ECTDS, PPCD4, TFCP2L3
  • Links
    NCBI Gene ID: 79977
    UniProt: Q6ISB3

  • Chr Location
    8q22.3; chr8:101492439-101681200 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human GRHL2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    50 phenotypes from 7 alleles in 7 genetic backgrounds
    10 phenotypes from multigenic genotypes
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display embryonic lethality during organogenesis with cranioschisis, facial cleft, impaired neural fold elevation, and an open posterior neuropore.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    88
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1379
  • Tissues
    372
  • cDNA Data
    44
  • Literature Summary
    36
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022286 Ensembl Gene Model | MGI Sequence Detail 130534 C57BL/6J ±  kb
    transcript ENSMUST00000022895 Ensembl | MGI Sequence Detail 4947 Not Applicable  
    polypeptide ENSMUSP00000022895 Ensembl | MGI Sequence Detail 625 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 54
      cDNA 47
      Primer pair 6
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1915242, MGI:5056362
    References
    more
    • Summaries
      All 91
      Developmental Gene Expression 36
      Gene Ontology 17
      Phenotypes 33
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:355461 Deng Z, et al., Single-cell transcriptomics reveals the cellular identity of a novel progenitor population crucial for murine neural tube closure. Heliyon. 2024 Sep 15;10(17):e37259
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory