Grhl2
Gene Detail

Symbol

Name
ID

Grhl2
grainyhead-like 2 (Drosophila)
MGI:2182543

Synonyms

0610015A08Rik, BOM, grainyheadlike, Tcfcp2l3

Feature Type

protein coding gene

Genetic Map

Chromosome 15
14.84 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr15:37233036-37363569 bp, + strand From VEGA annotation of GRCm38   130534 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:32616  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Grhl2

Human
homologs

Human Homolog		GRHL2, grainyhead-like 2 (Drosophila)
NCBI Gene ID		79977
neXtProt AC		NX_Q6ISB3
Human Synonyms		BOM, DFNA28, ECTDS, TFCP2L3
Human Chr (Location)		8q22.3; chr8:101492440-101669726 (+)  GRCh38
Disease Associations		(2) Diseases Associated with Human GRHL2

Mutations,
alleles, and
phenotypes

All mutations/alleles(49) : Chemically induced (ENU)(1) Gene trapped(47) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a null mutation display embryonic lethality during organogenesis with cranioschisis, facial cleft, impaired neural fold elevation, and an open posterior neuropore.

 

Interactions

Grhl2 interacts with 331 markers (Mir7-1, Mir7-2, Mir7b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (34 annotations)

Process	brain development, camera-type eye development, ...
Component	cell-cell junction, nucleus
Function	DNA binding, sequence-specific DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (15 records)

Data Summary: Results (523)    Tissues (319)    Images (71)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	508
RT-PCR	15

cDNA source data(42)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(48) cDNA(45) Primer pair(2) Other(1)
Microarray probesets(6)

Other database
links

VEGA Gene Model	OTTMUSG00000030880 (Evidence)
Ensembl Gene Model	ENSMUSG00000022286 (Evidence)
Entrez Gene	252973 (Evidence)
UniGene	244612
DFCI	TC1586037, TC1687101, TC1588328, TC1632148
NIA Mouse Gene Index	U043436
Consensus CDS Project	CCDS27434.1
International Mouse Knockout Project Status	Grhl2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000030880	VEGA Gene Model | MGI Sequence Detail	130534	C57BL/6J
transcript	OTTMUST00000076417	VEGA | MGI Sequence Detail	4947	Not Applicable
polypeptide	OTTMUSP00000040224	VEGA | MGI Sequence Detail	625	Not Applicable

All sequences(62) RefSeq(13) UniProt(11)

Polymorphisms

SNPs within 2kb(1207 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR007604	CP2 transcription factor
Protein Ontology	PR:000008230	grainyhead-like protein 2

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:215592 Gao X, et al., Evidence for multiple roles for grainyheadlike 2 in the establishment and maintenance of human mucociliary airway epithelium. Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):9356-61
All references(50)

Other
accession IDs

MGI:1915242