Grhl2
Gene Detail

Symbol Name ID

Grhl2 grainyhead-like 2 (Drosophila) MGI:2182543

Synonyms

0610015A08Rik, BOM, Tcfcp2l3

Feature Type

protein coding gene

Genetic Map

Chromosome 15

14.84 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr15:37233036-37363569 bp, + strand From VEGA annotation of GRCm38   130534 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:32616  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Grhl2

Human homologs

Human Homolog		GRHL2, grainyhead-like 2 (Drosophila)
NCBI Gene ID		79977
neXtProt AC		NX_Q6ISB3
Human Synonyms		BOM, DFNA28, TFCP2L3
Human Chr (Location)		8q22.3; chr8:101492440-101669726 (+)  GRCh38
Disease Associations		(1) Diseases Associated with Human GRHL2

Alleles and phenotypes

All alleles(49) : Chemically induced (ENU)(1) Gene trapped(47) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a null mutation display embryonic lethality during organogenesis with cranioschisis, facial cleft, impaired neural fold elevation, and an open posterior neuropore.

 

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	brain development, camera-type eye development, ...
Component	nucleus
Function	DNA binding, sequence-specific DNA binding transcription factor activity

External Resources: FuncBase

Expression

Literature Summary: (15 records)

Data Summary: Results (530)    Tissues (324)    Images (71)
Theiler Stages: 2, 3, 4, 5, 13, 15, 17, 19, 20, 21, 22, 23, 24, 25, 28

Assay Type	Results
RNA in situ	508
RT-PCR	22

cDNA source data(42)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(48) cDNA(45) Primer pair(2) Other(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000030880 (Evidence)
Ensembl Gene Model	ENSMUSG00000022286 (Evidence)
Entrez Gene	252973 (Evidence)
UniGene	244612
DFCI	TC1586037, TC1588328, TC1632148, TC1687101
NIA Mouse Gene Index	U043436
Consensus CDS Project	CCDS27434.1
International Mouse Knockout Project Status	Grhl2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000030880	VEGA Gene Model | MGI Sequence Detail	130534	C57BL/6J
transcript	OTTMUST00000076417	VEGA | MGI Sequence Detail	4947	Not Applicable
polypeptide	OTTMUSP00000040224	VEGA | MGI Sequence Detail	625	Not Applicable

All sequences(57) RefSeq(13) UniProt(6)

Polymorphisms

SNPs within 2kb(1207 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR007604	CP2 transcription factor
Protein Ontology	PR:000008230	grainyhead-like protein 2

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:198191 Li C, et al., Apc deficiency alters pulmonary epithelial cell fate and inhibits Nkx2.1 via triggering TGF-beta signaling. Dev Biol. 2013 Jun 1;378(1):13-24
All references(47)

Other accession IDs

MGI:1915242