About   Help   FAQ
Grhl2
Gene Detail
Symbol

Name
ID
Grhl2
grainyhead-like 2 (Drosophila)
MGI:2182543
Synonyms
0610015A08Rik, BOM, grainyheadlike, Tcfcp2l3
Feature Type
protein coding gene
Genetic Map
Chromosome 15
14.84 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:37233036-37363569 bp, + strand
From VEGA annotation of GRCm38

  130534 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32616  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GRHL2
Gene Tree: Grhl2

Human
homologs
GRHL2, grainyhead-like 2 (Drosophila)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 79977
neXtProt AC: NX_Q6ISB3

Human Synonyms: BOM, DFNA28, ECTDS, TFCP2L3

Human Chr (Location): 8q22.3; chr8:101492406-101678098 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human GRHL2

Mutations,
alleles, and
phenotypes
All mutations/alleles(49) : Chemically induced (ENU)(1) Gene trapped(47) Targeted(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null mutation display embryonic lethality during organogenesis with cranioschisis, facial cleft, impaired neural fold elevation, and an open posterior neuropore.
 
Interactions
Grhl2 interacts with 330 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (44 annotations)
Process bicellular tight junction assembly, brain development, ...
Component cell-cell junction, membrane, ...
Function chromatin binding, chromatin DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (523)    Tissues (319)    Images (71)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 508
RT-PCR 15
cDNA source data(42)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase grhl2 ; ZFIN grhl2a, grhl2b    NEW 
Molecular
reagents
All nucleic(48) cDNA(45) Primer pair(2) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000030880 (Evidence)
Ensembl Gene Model ENSMUSG00000022286 (Evidence)
Entrez Gene 252973 (Evidence)
UniGene 244612
DFCI TC1632148, TC1588328, TC1586037, TC1687101
NIA Mouse Gene Index U043436
Consensus CDS Project CCDS27434.1
International Mouse Phenotyping Consortium Status Grhl2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030880 VEGA Gene Model | MGI Sequence Detail 130534 C57BL/6J ±  kb
transcript OTTMUST00000076417 VEGA | MGI Sequence Detail 4947 Not Applicable 
polypeptide OTTMUSP00000040224 VEGA | MGI Sequence Detail 625 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(10) UniProt(6)
Polymorphisms
SNPs within 2kb(1207 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007604 CP2 transcription factor
Protein Ontology PR:000008230 grainyhead-like protein 2
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:220468 Walentin K, et al., A Grhl2-dependent gene network controls trophoblast branching morphogenesis. Development. 2015 Mar 15;142(6):1125-36
All references(50)
Other
accession IDs
MGI:1915242

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory