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Grhl2
Gene Detail
Symbol

Name
ID
Grhl2
grainyhead-like 2 (Drosophila)
MGI:2182543
Synonyms
0610015A08Rik, BOM, Tcfcp2l3
Feature Type
protein coding gene
Genetic Map
Chromosome 15
14.84 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:37233036-37363569 bp, + strand
From VEGA annotation of GRCm38

  130534 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32616  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Grhl2

Human
homologs
Human Homolog GRHL2, grainyhead-like 2 (Drosophila)
NCBI Gene ID 79977
neXtProt AC  NX_Q6ISB3
Human Synonyms  BOM, DFNA28, ECTDS, TFCP2L3
Human Chr (Location)  8q22.3; chr8:101492440-101669726 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human GRHL2
Mutations,
alleles, and
phenotypes
All mutations/alleles(49) : Chemically induced (ENU)(1) Gene trapped(47) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display embryonic lethality during organogenesis with cranioschisis, facial cleft, impaired neural fold elevation, and an open posterior neuropore.
 
Interactions
Grhl2 interacts with 331 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process brain development, camera-type eye development, ...
Component nucleus
Function DNA binding, sequence-specific DNA binding transcription factor activity
External Resources: FuncBase
Expression
Literature Summary: (15 records)
Data Summary: Results (523)    Tissues (319)    Images (71)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 508
RT-PCR 15
cDNA source data(42)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(48) cDNA(45) Primer pair(2) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000030880 (Evidence)
Ensembl Gene ModelENSMUSG00000022286 (Evidence)
Entrez Gene252973 (Evidence)
UniGene244612
DFCITC1632148, TC1687101, TC1588328, TC1586037
NIA Mouse Gene IndexU043436
Consensus CDS ProjectCCDS27434.1
International Mouse Knockout Project StatusGrhl2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030880 VEGA Gene Model | MGI Sequence Detail 130534 C57BL/6J ±  kb
transcript OTTMUST00000076417 VEGA | MGI Sequence Detail 4947 Not Applicable 
polypeptide OTTMUSP00000040224 VEGA | MGI Sequence Detail 625 Not Applicable 

For the selected sequences
All sequences(62) RefSeq(13) UniProt(11)
Polymorphisms
SNPs within 2kb(1207 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007604 CP2 transcription factor
Protein Ontology PR:000008230 grainyhead-like protein 2
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:198191 Li C, et al., Apc deficiency alters pulmonary epithelial cell fate and inhibits Nkx2.1 via triggering TGF-beta signaling. Dev Biol. 2013 Jun 1;378(1):13-24
All references(47)
Other
accession IDs
MGI:1915242

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory