Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GREM2
  • Mouse genes Grem2
  • Rat genes Grem2
  • Zfish genes grem2a,grem2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Grem2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0036122	BMP binding	Grem2	IMP		Mouse	MGI:MGI:5507937|PMID:23063586
Molecular Function	GO:0008201	heparin binding	Grem2	IDA		Mouse	MGI:MGI:5543884|PMID:23850456
Molecular Function	GO:0042802	identical protein binding	Grem2	IMP		Mouse	MGI:MGI:5507937|PMID:23063586
Molecular Function	GO:0042802	identical protein binding	Grem2	IPI	UniProtKB:O88273	Mouse	MGI:MGI:5543884|PMID:23850456
Cellular Component	GO:0005615	extracellular space	Grem2	IMP		Mouse	MGI:MGI:5507937|PMID:23063586
Biological Process	GO:0061312	BMP signaling pathway involved in heart development	grem2b	IMP	ZFIN:ZDB-MRPHLNO-130517-1	Zfish	PMID:23223679
Biological Process	GO:0003230	cardiac atrium development	grem2b	IMP	ZFIN:ZDB-MRPHLNO-130517-1	Zfish	PMID:23223679
Biological Process	GO:0003230	cardiac atrium development	grem2b	IDA		Zfish	PMID:23223679
Biological Process	GO:0003205	cardiac chamber development	grem2b	IMP	ZFIN:ZDB-MRPHLNO-130517-1	Zfish	PMID:23223679
Biological Process	GO:0051216	cartilage development	grem2b	IMP	ZFIN:ZDB-MRPHLNO-120215-5	Zfish	PMID:22031546
Biological Process	GO:0060536	cartilage morphogenesis	grem2b	IMP	ZFIN:ZDB-MRPHLNO-120215-5	Zfish	PMID:22031546
Biological Process	GO:0019221	cytokine-mediated signaling pathway	Grem2	IMP		Mouse	MGI:MGI:5543884|PMID:23850456
Biological Process	GO:0048263	determination of dorsal identity	Grem2	IMP		Mouse	MGI:MGI:5507937|PMID:23063586
Biological Process	GO:0010172	embryonic body morphogenesis	Grem2	IMP		Mouse	MGI:MGI:5543884|PMID:23850456
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	Grem2	IMP		Mouse	MGI:MGI:5507937|PMID:23063586
Biological Process	GO:0060300	regulation of cytokine activity	Grem2	IMP		Mouse	MGI:MGI:5543884|PMID:23850456
Biological Process	GO:0038098	sequestering of BMP from receptor via BMP binding	Grem2	IMP		Mouse	MGI:MGI:5507937|PMID:23063586

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern