Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GPNMB
  • Mouse genes Gpnmb
  • Rat genes Gpnmb
  • Zfish genes gpnmb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gpnmb

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008201	heparin binding	GPNMB	IDA		Human	PMID:19350579
Molecular Function	GO:0008201	heparin binding	Gpnmb	IDA		Mouse	PMID:11114299
Molecular Function	GO:0005178	integrin binding	Gpnmb	IDA		Mouse	PMID:11114299
Molecular Function	GO:0005515	protein binding	GPNMB	IPI	UniProtKB:P20366:PRO_0000033530	Human	PMID:12609765
Molecular Function	GO:0005515	protein binding	GPNMB	IPI	UniProtKB:P00533	Human	PMID:26751287
Molecular Function	GO:0048018	receptor ligand activity	GPNMB	IMP		Human	PMID:19350579
Molecular Function	GO:0045545	syndecan binding	GPNMB	IPI	UniProtKB:P31431	Human	PMID:19350579
Cellular Component	GO:0031410	cytoplasmic vesicle	Gpnmb	IDA		Mouse	PMID:12638126
Cellular Component	GO:0016020	membrane	GPNMB	IDA		Human	PMID:12609765
Cellular Component	GO:0005886	plasma membrane	Gpnmb	IDA		Mouse	PMID:11114299
Biological Process	GO:0030282	bone mineralization	Gpnmb	IEP		Rat	PMID:11746512|RGD:632991
Biological Process	GO:0007155	cell adhesion	Gpnmb	IDA		Mouse	PMID:11114299
Biological Process	GO:0007267	cell-cell signaling	GPNMB	IMP		Human	PMID:19350579
Biological Process	GO:0001818	negative regulation of cytokine production	GPNMB	IDA		Human	PMID:19350579
Biological Process	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	GPNMB	IDA		Human	PMID:19350579
Biological Process	GO:1901215	negative regulation of neuron death	GPNMB	IGI	UniProtKB:P00441	Human	PMID:22891158
Biological Process	GO:0050868	negative regulation of T cell activation	GPNMB	IMP		Human	PMID:19350579
Biological Process	GO:0042130	negative regulation of T cell proliferation	GPNMB	IDA		Human	PMID:19350579
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	Gpnmb	IMP		Mouse	MGI:MGI:3836695|PMID:17475886
Biological Process	GO:0001649	osteoblast differentiation	Gpnmb	IEP		Rat	PMID:11746512|RGD:632991
Biological Process	GO:0030335	positive regulation of cell migration	GPNMB	IDA		Human	PMID:20711474
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Gpnmb	IDA		Mouse	MGI:MGI:3768878|PMID:18036345
Biological Process	GO:0031954	positive regulation of protein autophosphorylation	GPNMB	IDA		Human	PMID:19350579
Biological Process	GO:0001934	positive regulation of protein phosphorylation	GPNMB	IDA		Human	PMID:22891158
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Gpnmb	IDA		Mouse	MGI:MGI:3768878|PMID:18036345
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Gpnmb	IMP		Mouse	MGI:MGI:5605931|PMID:25010402
Biological Process	GO:0034103	regulation of tissue remodeling	GPNMB	IDA		Human	PMID:25010402
Biological Process	GO:0034103	regulation of tissue remodeling	Gpnmb	IMP		Mouse	MGI:MGI:5605931|PMID:25010402
Biological Process	GO:0007165	signal transduction	GPNMB	IMP		Human	PMID:19350579

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern