Gpnmb
Gene Detail

Symbol Name ID

Gpnmb glycoprotein (transmembrane) nmb MGI:1934765

Synonyms

Dchil, Osteoactivin

Feature Type

protein coding gene

Genetic Map

Chromosome 6

23.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr6:49036518-49058182 bp, + strand From NCBI annotation of GRCm38   21665 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1880  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Gpnmb

Human homologs

Human Homolog		GPNMB, glycoprotein (transmembrane) nmb
NCBI Gene ID		10457
neXtProt AC		NX_Q14956
Human Synonyms		HGFIN, NMB
Human Chr (Location)		7p15; chr7:23286316-23314729 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(8) : Targeted(6) Gene trapped(1) Spontaneous(1)
 

Homozygous mutants exhibit dispersed pigmentation of the iris, deterioration of the posterior iris epithelium and slit-like transillumination defects. The mutation contributes to glaucoma, especially in combination with the brown coat color mutation.

 
Human Diseases Modeled Using Mouse Gpnmb (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	cell adhesion
Component	cytoplasmic membrane-bounded vesicle, cytoplasmic vesicle, ...
Function	heparin binding, integrin binding

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (162)    Tissues (25)    Images (86)
Theiler Stages: 15, 17, 19, 22, 23, 26, 28

Assay Type	Results
RNA in situ	162

cDNA source data(45)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(52) Genomic(4) cDNA(48)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000029816 (Evidence)
Entrez Gene	93695 (Evidence)
UniGene	302602
DFCI	TC1573833, TC1590730, TC1693064
DoTS	DT.101127109, DT.101409461, DT.110499636, DT.97411220, DT.99866817
NIA Mouse Gene Index	U006836
Consensus CDS Project	CCDS20122.1
International Mouse Knockout Project Status	Gpnmb

Sequences

Length	Strain/Species
genomic	93695	NCBI Gene Model | MGI Sequence Detail	21665	C57BL/6J
transcript	NM_053110	RefSeq | MGI Sequence Detail	3798	C57BL/6
polypeptide	Q99P91	UniProt | EBI | MGI Sequence Detail	574	Not Applicable

All sequences(81) RefSeq(2) UniProt(6)

Polymorphisms

SNPs(111 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR022409	PKD/Chitinase domain
InterPro	IPR000601	PKD domain
Protein Ontology	PR:000008183	transmembrane glycoprotein NMB

Graphical View of Protein Domain Structure

References

(Earliest) J:54013 Chang B, et al., Interacting loci cause severe iris atrophy and glaucoma in DBA/2J mice. Nat Genet. 1999 Apr;21(4):405-9
(Latest) J:193975 Crish SD, et al., Failure of axonal transport induces a spatially coincident increase in astrocyte BDNF prior to synapse loss in a central target. Neuroscience. 2013 Jan 15;229:55-70
All references(60)

Other accession IDs

MGI:1336203, MGI:1933809