About   Help   FAQ
Gpnmb
Gene Detail
Symbol

Name
ID
Gpnmb
glycoprotein (transmembrane) nmb
MGI:1934765
Synonyms
Dchil, DC-HIL, Osteoactivin
Feature Type
protein coding gene
Genetic Map
Chromosome 6
23.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr6:49036518-49058182 bp, + strand
From NCBI annotation of GRCm38

  21665 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1880  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GPNMB
Gene Tree: Gpnmb

Human
homologs
GPNMB, glycoprotein (transmembrane) nmb
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 10457
neXtProt AC: NX_Q14956

Human Synonyms: HGFIN, NMB

Human Chr (Location): 7p15; chr7:23246686-23275110 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(1) Spontaneous(1) Targeted(7)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutants exhibit dispersed pigmentation of the iris, deterioration of the posterior iris epithelium and slit-like transillumination defects. The mutation contributes to glaucoma, especially in combination with the brown coat color mutation.
 
Human Diseases Modeled in Mice Using Gpnmb (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(3)
Interactions
Gpnmb interacts with 256 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process cell adhesion
Component cytoplasmic membrane-bounded vesicle, cytoplasmic vesicle, ...
Function heparin binding, integrin binding
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (162)    Tissues (25)    Images (86)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 162
cDNA source data(45)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase gpnmb    NEW 
Molecular
reagents
All nucleic(52) Genomic(4) cDNA(48)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000029816 (Evidence)
Entrez Gene 93695 (Evidence)
UniGene 302602
DFCI TC1573833, TC1590730, TC1693064
DoTS DT.101127109, DT.101409461, DT.110499636, DT.97411220, DT.99866817
NIA Mouse Gene Index U006836
Consensus CDS Project CCDS20122.1
International Mouse Phenotyping Consortium Status Gpnmb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 93695 NCBI Gene Model | MGI Sequence Detail 21665 C57BL/6J ±  kb
transcript NM_053110 RefSeq | MGI Sequence Detail 3798 C57BL/6 
polypeptide Q99P91 UniProt | EBI | MGI Sequence Detail 574 Not Applicable 

For the selected sequences
All sequences(88) RefSeq(2) UniProt(6)
Polymorphisms
SNPs within 2kb(135 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR022409 PKD/Chitinase domain
InterPro IPR000601 PKD domain
Protein Ontology PR:000008183 transmembrane glycoprotein NMB
Graphical View of Protein Domain Structure
References
(Earliest) J:54013 Chang B, et al., Interacting loci cause severe iris atrophy and glaucoma in DBA/2J mice. Nat Genet. 1999 Apr;21(4):405-9
(Latest) J:215931 Chung JS, et al., DC-HIL-expressing myelomonocytic cells are critical promoters of melanoma growth. J Invest Dermatol. 2014 Nov;134(11):2784-94
All references(66)
Disease annotation references (2)
Other
accession IDs
MGI:1336203, MGI:1933809

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory