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Gpnmb
Gene Detail
 Symbol
Name
ID
Gpnmb
glycoprotein (transmembrane) nmb
MGI:1934765
Synonyms Dchil, Osteoactivin
Feature Type protein coding gene
Genetic Map
Chromosome 6
23.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr6:49036518-49058182 bp, + strand
From NCBI annotation of GRCm38

  21665 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1880  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Gpnmb

Human
homologs
Human Homolog GPNMB, glycoprotein (transmembrane) nmb
NCBI Gene ID 10457
neXtProt AC  NX_Q14956
Human Synonyms  HGFIN, NMB
Human Chr (Location)  7p15; chr7:23246686-23275110 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(1) Spontaneous(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants exhibit dispersed pigmentation of the iris, deterioration of the posterior iris epithelium and slit-like transillumination defects. The mutation contributes to glaucoma, especially in combination with the brown coat color mutation.
 
Human Diseases Modeled Using Mouse Gpnmb (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)
Interactions
Gpnmb interacts with 257 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process cell adhesion
Component cytoplasmic membrane-bounded vesicle, cytoplasmic vesicle, ...
Function heparin binding, integrin binding
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (162)    Tissues (25)    Images (86)
Theiler Stages: 15, 17, 19, 22, 23, 26, 28
Assay TypeResults
RNA in situ 162
cDNA source data(45)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(52) Genomic(4) cDNA(48)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000029816 (Evidence)
Entrez Gene93695 (Evidence)
UniGene302602
DFCITC1573833, TC1590730, TC1693064
DoTSDT.101127109, DT.101409461, DT.110499636, DT.97411220, DT.99866817
NIA Mouse Gene IndexU006836
Consensus CDS ProjectCCDS20122.1
International Mouse Knockout Project StatusGpnmb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 93695 NCBI Gene Model | MGI Sequence Detail 21665 C57BL/6J ±  kb
transcript NM_053110 RefSeq | MGI Sequence Detail 3798 C57BL/6 
polypeptide Q99P91 UniProt | EBI | MGI Sequence Detail 574 Not Applicable 

For the selected sequences
All sequences(81) RefSeq(2) UniProt(6)
Polymorphisms SNPs within 2kb(135 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR022409 PKD/Chitinase domain
InterPro IPR000601 PKD domain
Protein Ontology PR:000008183 transmembrane glycoprotein NMB
Graphical View of Protein Domain Structure
References (Earliest) J:54013 Chang B, et al., Interacting loci cause severe iris atrophy and glaucoma in DBA/2J mice. Nat Genet. 1999 Apr;21(4):405-9
(Latest) J:206565 Abdelmagid SM, et al., Mutation in Osteoactivin Decreases Bone Formation in Vivo and Osteoblast Differentiation in Vitro. Am J Pathol. 2014 Mar;184(3):697-713
All references(64)
Disease annotation references (2)
Other
accession IDs
MGI:1336203, MGI:1933809

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory