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Gpnmb Gene Detail
Summary
  • Symbol
    Gpnmb
  • Name
    glycoprotein (transmembrane) nmb
  • Synonyms
    Dchil, DC-HIL, Osteoactivin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1934765
    NCBI Gene: 93695
  • Gene Overview
    MyGene.info: GPNMB
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr6:49036546-49070929 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      34384 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 23.82 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    GPNMB, glycoprotein nmb
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GPNMB, glycoprotein nmb
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HGFIN, NMB, PLCA3
  • Links
    NCBI Gene ID: 10457
    neXtProt AC: NX_Q14956
    UniProt: Q14956

  • Chr Location
    7p15.3; chr7:23246206-23275110 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 1880
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GPNMB
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Gpnmb mouse models

Human Disease Mouse Models
      
IDs
View 5 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 3 alleles in 5 genetic backgrounds
    9 phenotypes from multigenic genotypes
    3 images
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants exhibit dispersed pigmentation of the iris, deterioration of the posterior iris epithelium and slit-like transillumination defects. The mutation contributes to glaucoma, especially in combination with the brown coat color mutation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000057401 VEGA Gene Model | MGI Sequence Detail 34384 C57BL/6J ±  kb
    transcript OTTMUST00000141205 VEGA | MGI Sequence Detail 3701 Not Applicable  
    polypeptide OTTMUSP00000073829 VEGA | MGI Sequence Detail 574 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      159 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 52
      Genomic 4
      cDNA 48

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1336203, MGI:1933809
    References
    more
    • Summaries
      All 91
      Developmental Gene Expression 8
      Diseases 2
      Gene Ontology 7
      Phenotypes 39
    • Earliest
      J:54013 Chang B, et al., Interacting loci cause severe iris atrophy and glaucoma in DBA/2J mice. Nat Genet. 1999 Apr;21(4):405-9
    • Latest
      J:259404 Yu B, et al., Glycoprotein Nonmelanoma Clone B Regulates the Crosstalk between Macrophages and Mesenchymal Stem Cells toward Wound Repair. J Invest Dermatol. 2018 Jan;138(1):219-227

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory