Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GLS
  • Mouse genes Gls
  • Rat genes Gls
  • Zfish genes glsa,glsb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gls

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004359	glutaminase activity	GLS	IDA		Human	PMID:22049910
Molecular Function	GO:0004359	glutaminase activity	Gls	IDA		Mouse	MGI:MGI:5320252|PMID:22228304
Molecular Function	GO:0004359	glutaminase activity	Gls	IMP	MGI:MGI:3514104	Mouse	PMID:16641247
Molecular Function	GO:0004359	glutaminase activity	Gls	IMP	MGI:MGI:3514104	Mouse	PMID:22225880
Molecular Function	GO:0042802	identical protein binding	Gls	IPI	UniProtKB:D3Z7P3-2	Mouse	MGI:MGI:5320252|PMID:22228304
Molecular Function	GO:0005515	protein binding	GLS	IPI	UniProtKB:Q86WG3	Human	PMID:16899818
Molecular Function	GO:0005515	protein binding	Gls	IPI	UniProtKB:Q86WG3	Mouse	MGI:MGI:3654788|PMID:16899818
Molecular Function	GO:0005515	protein binding	Gls	IPI	UniProtKB:Q86WG3	Rat	PMID:16899818|RGD:8554105
Molecular Function	GO:0005515	protein binding	Gls	IPI	UniProtKB:Q86WG3	Rat	PMID:18628984|RGD:8553875
Cellular Component	GO:0005739	mitochondrion	GLS	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	GLS	IDA		Human	PMID:16899818
Cellular Component	GO:0005739	mitochondrion	Gls	IDA		Rat	PMID:1918000|RGD:728510
Cellular Component	GO:0045202	synapse	Gls	IMP	MGI:MGI:3514104	Mouse	MGI:MGI:3623875|PMID:16641247
Biological Process	GO:0007268	chemical synaptic transmission	Gls	IMP	MGI:MGI:3514104	Mouse	PMID:16641247
Biological Process	GO:0006537	glutamate biosynthetic process	GLS	IDA		Human	PMID:16899818
Biological Process	GO:0006537	glutamate biosynthetic process	GLS	IDA		Human	PMID:22049910
Biological Process	GO:0006537	glutamate biosynthetic process	Gls	IDA		Mouse	MGI:MGI:5320252|PMID:22228304
Biological Process	GO:0006543	glutamine catabolic process	GLS	IDA		Human	PMID:22049910
Biological Process	GO:0006543	glutamine catabolic process	Gls	IDA		Mouse	MGI:MGI:5320252|PMID:22228304
Biological Process	GO:0006543	glutamine catabolic process	Gls	IMP	MGI:MGI:3514104	Mouse	PMID:16641247
Biological Process	GO:0090461	intracellular glutamate homeostasis	GLS	IMP		Human	PMID:30239721
Biological Process	GO:0051289	protein homotetramerization	GLS	IDA		Human	PMID:22049910
Biological Process	GO:0051289	protein homotetramerization	Gls	IDA		Mouse	MGI:MGI:5320252|PMID:22228304
Biological Process	GO:0002087	regulation of respiratory gaseous exchange by nervous system process	Gls	IMP	MGI:MGI:3514104	Mouse	PMID:16641247
Biological Process	GO:0001967	suckling behavior	Gls	IMP	MGI:MGI:3514104	Mouse	PMID:16641247

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern