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Gls Gene Detail
Summary
  • Symbol
    Gls
  • Name
    glutaminase
  • Synonyms
    B230365M23Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:95752
    NCBI Gene: 14660
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:52163448-52233232 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 26.86 cM
  • Mapping Data
    23 experiments
Strain
Comparison
more
  • SNPs within 2kb
    486 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95752
protein coding gene Chr1:52163448-52233719 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016007
protein coding gene Chr1:51673367-51743091 (-)
A/J MGP_AJ_G0015989
protein coding gene Chr1:49943585-50012965 (-)
AKR/J MGP_AKRJ_G0015945
protein coding gene Chr1:50996317-51067415 (-)
BALB/cJ MGP_BALBcJ_G0015946
protein coding gene Chr1:49759325-49829145 (-)
C3H/HeJ MGP_C3HHeJ_G0015778
protein coding gene Chr1:51404778-51476550 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016397
protein coding gene Chr1:53844333-53930651 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014127
protein coding gene Chr1:41843246-41913074 (+)
CAST/EiJ MGP_CASTEiJ_G0015359
protein coding gene Chr1:50883414-50954625 (-)
CBA/J MGP_CBAJ_G0015749
protein coding gene Chr1:55279312-55357715 (-)
DBA/2J MGP_DBA2J_G0015850
protein coding gene Chr1:49195146-49264685 (-)
FVB/NJ MGP_FVBNJ_G0015852
protein coding gene Chr1:48659895-48730980 (-)
LP/J MGP_LPJ_G0015921
protein coding gene Chr1:52168861-52241042 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015872
protein coding gene Chr1:58307146-58413265 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016445
protein coding gene Chr1:51128884-51200578 (-)
PWK/PhJ MGP_PWKPhJ_G0015145
protein coding gene Chr1:49076483-49147944 (-)
SPRET/EiJ MGP_SPRETEiJ_G0014925
protein coding gene Chr1:50781744-50855311 (-)
WSB/EiJ MGP_WSBEiJ_G0015422
protein coding gene Chr1:50938562-51010614 (-)



Homology
more
  • Human Ortholog
    GLS, glutaminase
  • Vertebrate Orthologs
    11
  • Human Ortholog
    GLS, glutaminase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AAD20, CASGID, EIEE71, GAC, GAM, GDPAG, GLS1, KGA
  • Links
    NCBI Gene ID: 2744
    neXtProt AC: NX_O94925
    UniProt: O94925

  • Chr Location
    2q32.2; chr2:190880821-190965552 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 22726
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GLS
  • Gene Tree
    Gls
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 3 alleles in 4 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations die within 1 day postnatally with abnormal respiratory function and goal-oriented behavior toward dam. Mice homozygous for another allele exhibit abnormal TNFA-stimulated astrocyte extracellular vesicle release.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026103 Ensembl Gene Model | MGI Sequence Detail 69785 C57BL/6J ±  kb
transcript ENSMUST00000114513 Ensembl | MGI Sequence Detail 4966 Not Applicable  
polypeptide ENSMUSP00000110158 Ensembl | MGI Sequence Detail 674 Not Applicable  
For the selected sequence
Protein
Information
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Molecular
Reagents
less
  • All nucleic 222
    Genomic 4
    cDNA 214
    Primer pair 3
    Other 1

    Microarray probesets 7
Other
Accession IDs
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MGD-MRK-10135, MGI:2138193, MGI:2444416
References
more
  • Summaries
    All 78
    Developmental Gene Expression 7
    Gene Ontology 9
    Phenotypes 21
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:275108 Yu Y, et al., Glutamine Metabolism Regulates Proliferation and Lineage Allocation in Skeletal Stem Cells. Cell Metab. 2019 Apr 2;29(4):966-978.e4

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
06/11/2019
MGI 6.14
The Jackson Laboratory