Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GLRA4
  • Mouse genes Glra4
  • Rat genes Glra4
  • Zfish genes glra4a,glra4b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Glra4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0016934	extracellularly glycine-gated chloride channel activity	Glra4	IDA		Mouse	MGI:MGI:5751681|PMID:10762330
Molecular Function	GO:0016934	extracellularly glycine-gated chloride channel activity	glra4a	IDA		Zfish	PMID:11274795
Molecular Function	GO:0016933	extracellularly glycine-gated ion channel activity	glra4a	IDA		Zfish	PMID:30323738
Molecular Function	GO:0016933	extracellularly glycine-gated ion channel activity	glra4b	IDA		Zfish	PMID:30323738
Cellular Component	GO:0098690	glycinergic synapse	Glra4	IDA		Mouse	PMID:17154252
Cellular Component	GO:0005886	plasma membrane	Glra4	IDA		Mouse	MGI:MGI:5751681|PMID:10762330
Cellular Component	GO:0099634	postsynaptic specialization membrane	Glra4	IDA		Mouse	PMID:17154252
Biological Process	GO:0007417	central nervous system development	glra4a	IMP	ZFIN:ZDB-MRPHLNO-060706-1	Zfish	PMID:16763051
Biological Process	GO:1902476	chloride transmembrane transport	Glra4	IDA		Mouse	MGI:MGI:5751681|PMID:10762330
Biological Process	GO:0006821	chloride transport	glra4a	IDA		Zfish	PMID:11274795
Biological Process	GO:0060079	excitatory postsynaptic potential	glra4b	IDA		Zfish	PMID:30323738|ZFIN:ZDB-PUB-181017-7
Biological Process	GO:0034220	monoatomic ion transmembrane transport	glra4b	IDA		Zfish	PMID:30323738|ZFIN:ZDB-PUB-181017-7
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	glra4a	IGI	ZFIN:ZDB-GENE-990415-270	Zfish	PMID:30050902
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	glra4a	IMP	ZFIN:ZDB-MRPHLNO-060706-1	Zfish	PMID:30050902
Biological Process	GO:0045664	regulation of neuron differentiation	glra4a	IMP	ZFIN:ZDB-MRPHLNO-060706-1	Zfish	PMID:22234938
Biological Process	GO:0045664	regulation of neuron differentiation	glra4a	IMP	ZFIN:ZDB-MRPHLNO-060706-1	Zfish	PMID:16763051
Biological Process	GO:0043200	response to amino acid	Glra4	IDA		Mouse	MGI:MGI:5751681|PMID:10762330
Biological Process	GO:0043200	response to amino acid	glra4a	IDA		Zfish	PMID:11274795
Biological Process	GO:0001964	startle response	glra4a	IMP	ZFIN:ZDB-MRPHLNO-180718-1	Zfish	PMID:29445326
Biological Process	GO:0001966	thigmotaxis	glra4a	IMP	ZFIN:ZDB-MRPHLNO-180718-1	Zfish	PMID:29445326

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern