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Glra4 Gene Detail
Summary
  • Symbol
    Glra4
  • Name
    glycine receptor, alpha 4 subunit
  • Feature Type
    protein coding gene
  • IDs
    MGI:95750
    NCBI Gene: 14657
  • Gene Overview
    MyGene.info: GLRA4
Location & Maps
more
  • Sequence Map
    ChrX:136757674-136780141 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      22468 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 59.10 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    GLRA4, glycine receptor alpha 4
  • Vertebrate Orthologs
    8
  • Human Ortholog
    GLRA4, glycine receptor alpha 4
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 441509
    neXtProt AC: NX_Q5JXX5

  • Chr Location
    Xq22.2; chrX:103707344-103728624 (-)  GRCh38.p2

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotype references
  • All Mutations and Alleles
    5
  • Gene trapped
    1
  • Targeted
    4
  • Genomic Mutations
    1 involving Glra4
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018721 VEGA Gene Model | MGI Sequence Detail 22468 C57BL/6J ±  kb
transcript OTTMUST00000045027 VEGA | MGI Sequence Detail 1831 Not Applicable  
polypeptide OTTMUSP00000020235 VEGA | MGI Sequence Detail 456 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    196 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000008045 glycine receptor subunit alpha-4
  • InterPro Domains
    IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
    IPR008127 Glycine receptor alpha
    IPR006201 Neurotransmitter-gated ion-channel
    IPR018000 Neurotransmitter-gated ion-channel, conserved site
    IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
    IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
Molecular
Reagents
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  • All nucleic 6
    Genomic 2
    cDNA 4

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-10133
References
more
  • Summaries
    All 27
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 4
    Phenotypes 5
  • Earliest
    J:16637 Matzenbach B, et al., Structural analysis of mouse glycine receptor alpha subunit genes. Identification and chromosomal localization of a novel variant. J Biol Chem. 1994 Jan 28;269(4):2607-12
  • Latest
    J:203021 Kunz PA, et al., Glycine receptors support excitatory neurotransmitter release in developing mouse visual cortex. J Physiol. 2012 Nov 15;590(Pt 22):5749-64

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory