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Glra4
Gene Detail
Symbol

Name
ID
Glra4
glycine receptor, alpha 4 subunit
MGI:95750
Feature Type
protein coding gene
Genetic Map
Chromosome X
59.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
ChrX:136757674-136780141 bp, - strand
From VEGA annotation of GRCm38

  22468 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:69070  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Glra4

Human
homologs
Human Homolog GLRA4, glycine receptor, alpha 4
NCBI Gene ID 441509
neXtProt AC  NX_Q5JXX5
Human Chr (Location)  Xq22.2; chrX:103707344-103728624 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Genomic Mutations involving Glra4 (1)
Alleles Annotated to Human Diseases(1)   
Interactions
Glra4 interacts with 9 markers (Mir300, Mir344d-2, Mir370, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process chloride transport, ion transport, ...
Component cell junction, chloride channel complex, ...
Function chloride channel activity, extracellular ligand-gated ion channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
cDNA source data(4)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(6) Genomic(2) cDNA(4)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000018721 (Evidence)
Ensembl Gene ModelENSMUSG00000018595 (Evidence)
Entrez Gene14657 (Evidence)
UniGene215168
DFCITC1592825, TC1593669
DoTSDT.91387005, DT.97370528
NIA Mouse Gene IndexU039723
Consensus CDS ProjectCCDS53195.1
International Mouse Knockout Project StatusGlra4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018721 VEGA Gene Model | MGI Sequence Detail 22468 C57BL/6J ±  kb
transcript OTTMUST00000045027 VEGA | MGI Sequence Detail 1831 Not Applicable 
polypeptide OTTMUSP00000020235 VEGA | MGI Sequence Detail 456 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(8) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(121 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006028 Gamma-aminobutyric acid A receptor
InterPro IPR008127 Glycine receptor alpha
InterPro IPR006201 Neurotransmitter-gated ion-channel
InterPro IPR018000 Neurotransmitter-gated ion-channel, conserved site
InterPro IPR006202 Neurotransmitter-gated ion-channel ligand-binding
InterPro IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
Protein Ontology PR:000008045 glycine receptor subunit alpha-4
References
(Earliest) J:16637 Matzenbach B, et al., Structural analysis of mouse glycine receptor alpha subunit genes. Identification and chromosomal localization of a novel variant. J Biol Chem. 1994 Jan 28;269(4):2607-12
(Latest) J:203021 Kunz PA, et al., Glycine receptors support excitatory neurotransmitter release in developing mouse visual cortex. J Physiol. 2012 Nov 15;590(Pt 22):5749-64
All references(28)
Other
accession IDs
MGD-MRK-10133

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory