Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GLIS3
  • Mouse genes Glis3
  • Rat genes Glis3
  • Zfish genes glis3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Glis3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Glis3	IDA		Mouse	PMID:14500813
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Glis3	IDA		Mouse	MGI:MGI:5004770|PMID:18263616
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Glis3	IDA		Mouse	MGI:MGI:3033266|PMID:14500813
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Glis3	IDA		Mouse	MGI:MGI:5009496|PMID:19264802
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Glis3	IDA		Mouse	PMID:14500813
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Glis3	IDA		Mouse	MGI:MGI:3033266|PMID:14500813
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Glis3	IMP		Mouse	MGI:MGI:5009496|PMID:19264802
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Glis3	IDA		Mouse	MGI:MGI:5009496|PMID:19264802
Molecular Function	GO:0005515	protein binding	GLIS3	IPI	UniProtKB:Q9UMX1	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	GLIS3	IPI	UniProtKB:Q9UMX1	Human	PMID:20211142
Molecular Function	GO:0005515	protein binding	GLIS3	IPI	UniProtKB:P46937	Human	PMID:35044719
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Glis3	IDA		Mouse	MGI:MGI:3033266|PMID:14500813
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Glis3	IDA		Mouse	MGI:MGI:5009496|PMID:19264802
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Glis3	IDA		Mouse	MGI:MGI:5004770|PMID:18263616
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	Glis3	IDA		Mouse	PMID:18298960
Cellular Component	GO:0005634	nucleus	Glis3	IDA		Mouse	PMID:14500813
Biological Process	GO:0042593	glucose homeostasis	glis3	IMP	ZFIN:ZDB-MRPHLNO-160621-27	Zfish	PMID:26963759
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Glis3	IMP		Mouse	MGI:MGI:5009496|PMID:19264802
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Glis3	IDA		Mouse	PMID:14500813
Biological Process	GO:1990798	pancreas regeneration	glis3	IMP	ZFIN:ZDB-MRPHLNO-160621-27	Zfish	PMID:26963759
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Glis3	IDA		Mouse	MGI:MGI:5004770|PMID:18263616
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Glis3	IDA		Mouse	MGI:MGI:5009496|PMID:19264802
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Glis3	IDA		Mouse	PMID:14500813
Biological Process	GO:0007224	smoothened signaling pathway	glis3	IMP	ZFIN:ZDB-MRPHLNO-200914-1	Zfish	PMID:31797737
Biological Process	GO:0030878	thyroid gland development	glis3	IMP	ZFIN:ZDB-MRPHLNO-200914-1	Zfish	PMID:31797737
Biological Process	GO:0006366	transcription by RNA polymerase II	Glis3	IDA		Mouse	MGI:MGI:3033266|PMID:14500813
Biological Process	GO:0003323	type B pancreatic cell development	glis3	IMP	ZFIN:ZDB-MRPHLNO-160621-27	Zfish	PMID:26963759

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern