Glis3
Gene Detail

Symbol Name ID

Glis3 GLIS family zinc finger 3 MGI:2444289

Synonyms

4833409N03Rik, E330013K21Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 19

22.88 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr19:28258851-28680077 bp, - strand From VEGA annotation of GRCm38   421227 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:34989  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Human homologs

Human Homolog		GLIS3, GLIS family zinc finger 3
NCBI Gene ID		169792
neXtProt AC		NX_Q8NEA6
Human Synonyms		ZNF515
Human Chr (Location)		9p24.2; chr9:3824128-4300035 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human GLIS3

Alleles and phenotypes

All alleles(10) : Targeted(5) Gene trapped(5)
 

Mice homozygous for knock-out alleles exhibit postnatal lethality associated with neonatal diabetes and polycystic kidney disease.

 
Human Diseases Modeled Using Mouse Glis3 (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	negative regulation of transcription from RNA polymerase II promoter, positive regulation of transcription from RNA polymerase II promoter, ...
Component	nuclear part, nucleus
Function	DNA binding, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (125)    Tissues (85)    Images (20)
Theiler Stages: 2, 3, 4, 5, 9, 11, 12, 13, 14, 15, 16, 17, 19, 20, 22, 23, 28

Assay Type	Results
RNA in situ	97
Northern blot	13
RT-PCR	15

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(12) Genomic(1) cDNA(9) Primer pair(1) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000033302 (Evidence)
Ensembl Gene Model	ENSMUSG00000052942 (Evidence), ENSMUSG00000091294 (Evidence)
Entrez Gene	226075 (Evidence)
DFCI	TC1587783, TC1590828, TC1649069
DoTS	DT.101722460, DT.110879248, DT.110879294, DT.94147083, DT.94174993, DT.97357739
NIA Mouse Gene Index	U038949, U116178
Consensus CDS Project	CCDS37947.1
International Mouse Knockout Project Status	Glis3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033302	VEGA Gene Model | MGI Sequence Detail	421227	C57BL/6J
transcript	OTTMUST00000083540	VEGA | MGI Sequence Detail	7514	Not Applicable
polypeptide	OTTMUSP00000044916	VEGA | MGI Sequence Detail	935	Not Applicable

All sequences(70) RefSeq(2) UniProt(6)

Polymorphisms

SNPs(3088 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007087	Zinc finger, C2H2
InterPro	IPR015880	Zinc finger, C2H2-like
InterPro	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology	PR:000008036	zinc finger protein GLIS3

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:185583 Metzakopian E, et al., Genome-wide characterization of Foxa2 targets reveals upregulation of floor plate genes and repression of ventrolateral genes in midbrain dopaminergic progenitors. Development. 2012 Jul;139(14):2625-34
All references(37)

Other accession IDs

MGI:1918872