Glis3
Gene Detail

Symbol

Name
ID

Glis3
GLIS family zinc finger 3
MGI:2444289

Synonyms

4833409N03Rik, E330013K21Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 19
22.88 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr19:28258851-28680077 bp, - strand From VEGA annotation of GRCm38   421227 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:34989  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Glis3

Human
homologs

Human Homolog		GLIS3, GLIS family zinc finger 3
NCBI Gene ID		169792
neXtProt AC		NX_Q8NEA6
Human Synonyms		ZNF515
Human Chr (Location)		9p24.2; chr9:3824128-4300036 (-)  GRCh38
Disease Associations		(1) Diseases Associated with Human GLIS3

Mutations,
alleles, and
phenotypes

All mutations/alleles(10) : Gene trapped(5) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for knock-out alleles exhibit postnatal lethality associated with neonatal diabetes and polycystic kidney disease.

 
Human Diseases Modeled in Mice Using Glis3 (1)    Mutations Annotated to Human Diseases (2)   

Interactions

Glis3 interacts with 424 markers (Mir7-1, Mir7-2, Mir7b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (19 annotations)

Process	negative regulation of transcription from RNA polymerase II promoter, positive regulation of transcription from RNA polymerase II promoter, ...
Component	Golgi apparatus, nucleoplasm, ...
Function	DNA binding, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)

Data Summary: Results (118)    Tissues (80)    Images (20)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	97
Northern blot	13
RT-PCR	8

cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(12) Genomic(1) cDNA(9) Primer pair(1) Other(1)
Microarray probesets(3)

Other database
links

VEGA Gene Model	OTTMUSG00000033302 (Evidence)
Ensembl Gene Model	ENSMUSG00000052942 (Evidence)
Entrez Gene	226075 (Evidence)
DFCI	TC1587783, TC1649069, TC1590828
DoTS	DT.94174993, DT.110879294, DT.110879248, DT.94147083, DT.101722460, DT.97357739
NIA Mouse Gene Index	U116178, U038949
Consensus CDS Project	CCDS37947.1
International Mouse Knockout Project Status	Glis3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033302	VEGA Gene Model | MGI Sequence Detail	421227	C57BL/6J
transcript	OTTMUST00000083540	VEGA | MGI Sequence Detail	7514	Not Applicable
polypeptide	OTTMUSP00000044916	VEGA | MGI Sequence Detail	935	Not Applicable

All sequences(80) RefSeq(12) UniProt(9)

Polymorphisms

SNPs within 2kb(3541 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR007087	Zinc finger, C2H2
InterPro	IPR015880	Zinc finger, C2H2-like
InterPro	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology	PR:000008036	zinc finger protein GLIS3

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:210543 Flanagan SE, et al., Analysis of transcription factors key for mouse pancreatic development establishes NKX2-2 and MNX1 mutations as causes of neonatal diabetes in man. Cell Metab. 2014 Jan 7;19(1):146-54
All references(40)
Disease annotation references (3)

Other
accession IDs

MGI:1918872