Glis3 MGI Mouse Gene Detail - MGI:2444289 - GLIS family zinc finger 3

Symbol

Glis3
Name

GLIS family zinc finger 3
Synonyms

4833409N03Rik, E330013K21Rik

Feature Type

protein coding gene
IDs

MGI:2444289
NCBI Gene: 226075
Alliance

gene page
Transcription Start Sites

10 TSS
Regulated by

Rr415 (1 regulatory region)

Sequence Map

Chr19:28236251-28657477 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 22.88 cM
Mapping Data

1 experiment

SNPs within 2kb

18615 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444289	protein coding gene	Chr19:28236251-28657684 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0025011	protein coding gene	Chr19:26661064-27097052 (-)
A/J	MGP_AJ_G0024988	protein coding gene	Chr19:25297632-25719313 (-)
AKR/J	MGP_AKRJ_G0024956	protein coding gene	Chr19:26243357-26663402 (-)
BALB/cJ	MGP_BALBcJ_G0024987	protein coding gene	Chr19:25332326-25763908 (-)
C3H/HeJ	MGP_C3HHeJ_G0024743	protein coding gene	Chr19:26186111-26623110 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025428	protein coding gene	Chr19:27409756-27847682 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022847	protein coding gene	Chr19:25289422-25710776 (-)
CAST/EiJ	MGP_CASTEiJ_G0024213	protein coding gene	Chr19:26004757-26451576 (-)
CBA/J	MGP_CBAJ_G0024721	protein coding gene	Chr19:28706187-29162013 (-)
DBA/2J	MGP_DBA2J_G0024853	protein coding gene	Chr19:25263578-25685681 (-)
FVB/NJ	MGP_FVBNJ_G0024815	protein coding gene	Chr19:25112450-25533782 (-)
LP/J	MGP_LPJ_G0024938	protein coding gene	Chr19:26642557-27089197 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024842	protein coding gene	Chr19:28656393-29100370 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025483	protein coding gene	Chr19:26243884-26674362 (-)
PWK/PhJ	MGP_PWKPhJ_G0023961	protein coding gene	Chr19:24910122-25342411 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023765	protein coding gene	Chr19:25489471-25926882 (-)
WSB/EiJ	MGP_WSBEiJ_G0024280	protein coding gene	Chr19:26278212-26710020 (-)

Human Ortholog

GLIS3, GLIS family zinc finger 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GLIS3, GLIS family zinc finger 3
Synonyms

NDH, ZNF515
Links

HGNC:28510

NCBI Gene ID: 169792

UniProt: Q8NEA6
Chr Location

9p24.2; chr9:3824127-4490465 (-) GRCh38

MGI Vertebrate Homology

Glis3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GLIS3
Gene Tree

Glis3

Diseases

1 with Glis3 mouse models; 1 with human GLIS3 associations

Human Disease

Mouse Models

neonatal diabetes mellitus with congenital hypothyroidism

IDs

View 2 models

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

2 with disease annotations

References

2 with disease annotations

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Phenotype Summary

29 phenotypes from 3 alleles in 3 genetic backgrounds
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

2
Gene trapped

2
Targeted

8
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

40 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for knock-out alleles exhibit postnatal lethality associated with neonatal diabetes and polycystic kidney disease.

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All GO Annotations

28
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

840
Tissues

89
cDNA Data

10
Literature Summary

16

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase glis3

ZFIN glis3

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All Sequences

68
RefSeq

14
UniProt

5
CCDS

CCDS37947.1

Ensembl

ENSMUSG00000052942 (Evidence)
NCBI Gene

226075

			Length	Strain/Species	Flank
genomic	ENSMUSG00000052942	Ensembl Gene Model \| MGI Sequence Detail	421227	C57BL/6J	± kb
transcript	ENSMUST00000162022	Ensembl \| MGI Sequence Detail	7514	Not Applicable
polypeptide	ENSMUSP00000124635	Ensembl \| MGI Sequence Detail	935	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000008036 zinc finger protein GLIS3

(term hierarchy)
InterPro Domains

IPR043359 C2H2-type zinc-finger protein GLI-like

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type
GlyGen

Q6XP49 1 site

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All nucleic 16

Genomic 2

cDNA 10

Primer pair 3

Other 1

Microarray probesets 3

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MGI:1918872

Summaries

All 58

Developmental Gene Expression 16

Diseases 2

Gene Ontology 9

Phenotypes 20
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:363327 Sepp M, et al., Cellular development and evolution of the mammalian cerebellum. Nature. 2024 Jan;625(7996):788-796

Glis3 expression regulated by:

Feature	Feature Type	Location	Reference
Rr415, regulatory region 415	enhancer	Chr19:28646768-28648496	J:23000

TSS for Glis3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr158732	Chr19:28657602-28657667 (-)	-158 bp
Tssr158731	Chr19:28657565-28657583 (-)	-97 bp
Tssr158730	Chr19:28657532-28657543 (-)	-61 bp
Tssr158729	Chr19:28657510-28657522 (-)	-39 bp
Tssr158728	Chr19:28538466-28538483 (-)	119,002 bp
Tssr158727	Chr19:28538417-28538425 (-)	119,056 bp
Tssr158726	Chr19:28538375-28538387 (-)	119,096 bp
Tssr158725	Chr19:28463691-28463694 (-)	193,784 bp
Tssr158724	Chr19:28261283-28261314 (-)	396,178 bp
Tssr158723	Chr19:28261261-28261282 (-)	396,205 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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