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Glis3 Gene Detail
Summary
  • Symbol
    Glis3
  • Name
    GLIS family zinc finger 3
  • Synonyms
    4833409N03Rik, E330013K21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444289
    NCBI Gene: 226075
Location & Maps
more
  • Sequence Map
    Chr19:28258851-28680077 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      421227 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 22.88 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    GLIS3, GLIS family zinc finger 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GLIS3, GLIS family zinc finger 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    NDH, ZNF515
  • Links
    NCBI Gene ID: 169792
    neXtProt AC: NX_Q8NEA6

  • Chr Location
    9p24.2; chr9:3824127-4310506 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 34989
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: GLIS3
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Glis3 mouse models; 1 with human GLIS3 associations

Human Disease Mouse Models
       Diabetes Mellitus, Neonatal, with Congenital Hypothyroidism; NDH   OMIM: 610199 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 3 alleles in 3 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Gene trapped
    5
  • Targeted
    5
  • Incidental Mutations
Mice homozygous for knock-out alleles exhibit postnatal lethality associated with neonatal diabetes and polycystic kidney disease.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033302 VEGA Gene Model | MGI Sequence Detail 421227 C57BL/6J ±  kb
transcript OTTMUST00000083540 VEGA | MGI Sequence Detail 7514 Not Applicable  
polypeptide OTTMUSP00000044916 VEGA | MGI Sequence Detail 935 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    3534 from dbSNP Build 142
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000008036 zinc finger protein GLIS3
  • InterPro Domains
    IPR007087 Zinc finger, C2H2
    IPR015880 Zinc finger, C2H2-like
    IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
    IPR030405 Zinc finger protein GLIS3
Molecular
Reagents
less
  • All nucleic 13
    Genomic 1
    cDNA 10
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1918872
References
more
  • Summaries
    All 38
    Developmental Gene Expression 8
    Diseases 3
    Gene Ontology 6
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:231303 Cordi S, et al., Role of beta-catenin in development of bile ducts. Differentiation. 2016 Jan-Mar;91(1-3):42-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory