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Glis3
Gene Detail
 Symbol
Name
ID
Glis3
GLIS family zinc finger 3
MGI:2444289
Synonyms 4833409N03Rik, E330013K21Rik
Feature Type protein coding gene
Genetic Map
Chromosome 19
22.88 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr19:28258851-28680077 bp, - strand
From VEGA annotation of GRCm38

  421227 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:34989  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Human
homologs
Human Homolog GLIS3, GLIS family zinc finger 3
NCBI Gene ID 169792
neXtProt AC  NX_Q8NEA6
Human Synonyms  ZNF515
Human Chr (Location)  9p24.2; chr9:3824128-4300036 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human GLIS3
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(5) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for knock-out alleles exhibit postnatal lethality associated with neonatal diabetes and polycystic kidney disease.
 
Human Diseases Modeled Using Mouse Glis3 (1)    Alleles Annotated to Human Diseases(2)   
Interactions
Glis3 interacts with 424 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process negative regulation of transcription from RNA polymerase II promoter, positive regulation of transcription from RNA polymerase II promoter, ...
Component Golgi apparatus, nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (118)    Tissues (80)    Images (20)
Theiler Stages: 2, 3, 4, 5, 9, 11, 12, 13, 14, 15, 16, 17, 19, 20, 22, 23, 28
Assay TypeResults
RNA in situ 97
Northern blot 13
RT-PCR 8
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) Genomic(1) cDNA(9) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000033302 (Evidence)
Ensembl Gene ModelENSMUSG00000052942 (Evidence), ENSMUSG00000091294 (Evidence)
Entrez Gene226075 (Evidence)
DFCITC1587783, TC1590828, TC1649069
DoTSDT.101722460, DT.110879248, DT.110879294, DT.94147083, DT.94174993, DT.97357739
NIA Mouse Gene IndexU038949, U116178
Consensus CDS ProjectCCDS37947.1
International Mouse Knockout Project StatusGlis3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033302 VEGA Gene Model | MGI Sequence Detail 421227 C57BL/6J ±  kb
transcript OTTMUST00000083540 VEGA | MGI Sequence Detail 7514 Not Applicable 
polypeptide OTTMUSP00000044916 VEGA | MGI Sequence Detail 935 Not Applicable 

For the selected sequences
All sequences(80) RefSeq(12) UniProt(6)
Polymorphisms SNPs within 2kb(3541 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000008036 zinc finger protein GLIS3
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:198394 Ejarque M, et al., Neurogenin3 cooperates with Foxa2 to autoactivate its own expression. J Biol Chem. 2013 Apr 26;288(17):11705-17
All references(39)
Disease annotation references (2)
Other
accession IDs
MGI:1918872

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory