Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II and transcription by RNA polymerase II. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including brain ventricular layer; embryo ectoderm; eye; genitourinary system; and limb. Used to study neonatal diabetes mellitus with congenital hypothyroidism. Human ortholog(s) of this gene implicated in neonatal diabetes mellitus with congenital hypothyroidism. Orthologous to human GLIS3 (GLIS family zinc finger 3).