Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GAD1
  • Mouse genes Gad1
  • Rat genes Gad1
  • Zfish genes gad1a,gad1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gad1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0016595	glutamate binding	Gad1	IDA		Rat	PMID:10812196|RGD:6480261
Molecular Function	GO:0004351	glutamate decarboxylase activity	GAD1	IDA		Human	PMID:10671565
Molecular Function	GO:0004351	glutamate decarboxylase activity	GAD1	IDA		Human	PMID:17384644
Molecular Function	GO:0004351	glutamate decarboxylase activity	Gad1	IMP		Mouse	MGI:MGI:892697|PMID:9177246
Molecular Function	GO:0004351	glutamate decarboxylase activity	Gad1	IDA		Rat	PMID:10812196|RGD:6480261
Molecular Function	GO:0004351	glutamate decarboxylase activity	Gad1	IDA		Rat	PMID:17712632|RGD:6480258
Molecular Function	GO:0004351	glutamate decarboxylase activity	Gad1	IDA		Rat	PMID:1924335|RGD:728511
Molecular Function	GO:0042802	identical protein binding	GAD1	IDA		Human	PMID:17384644
Molecular Function	GO:0005515	protein binding	GAD1	IPI	UniProtKB:Q05329	Human	PMID:10671565
Molecular Function	GO:0005515	protein binding	GAD1	IPI	UniProtKB:P46952	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	GAD1	IPI	UniProtKB:P16333	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	GAD1	IPI	UniProtKB:Q96DZ9	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	GAD1	IPI	UniProtKB:P46952	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	GAD1	IPI	UniProtKB:Q13188	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	GAD1	IPI	UniProtKB:Q6RW13	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	GAD1	IPI	UniProtKB:Q96DZ9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	GAD1	IPI	UniProtKB:Q6RW13-2	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	GAD1	IPI	UniProtKB:Q969L2	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	GAD1	IPI	UniProtKB:Q96DZ9-2	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	GAD1	IPI	UniProtKB:P46952	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	GAD1	IPI	UniProtKB:P46952	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GAD1	IPI	UniProtKB:Q6RW13-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GAD1	IPI	UniProtKB:Q969L2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GAD1	IPI	UniProtKB:Q96DZ9-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Gad1	IPI	RGD:2653	Rat	PMID:7836456|RGD:6480262
Molecular Function	GO:0044877	protein-containing complex binding	Gad1	IDA		Rat	PMID:7836456|RGD:6480262
Molecular Function	GO:0030170	pyridoxal phosphate binding	Gad1	IDA		Rat	PMID:1880546|RGD:6480263
Cellular Component	GO:0030424	axon	Gad1	IDA		Mouse	PMID:12074840
Cellular Component	GO:0030424	axon	Gad1	IDA		Mouse	PMID:15479642
Cellular Component	GO:0043679	axon terminus	Gad1	IDA		Mouse	PMID:11064363
Cellular Component	GO:0005938	cell cortex	Gad1	IDA		Mouse	PMID:11064363
Cellular Component	GO:0005737	cytoplasm	Gad1	IDA		Mouse	PMID:15347806
Cellular Component	GO:0005737	cytoplasm	Gad1	IDA		Mouse	PMID:20096683
Cellular Component	GO:0098982	GABA-ergic synapse	Gad1	IDA		Mouse	PMID:21584649
Cellular Component	GO:0098982	GABA-ergic synapse	Gad1	IMP		Mouse	PMID:21584649
Cellular Component	GO:0060077	inhibitory synapse	Gad1	IDA		Mouse	PMID:24613359
Cellular Component	GO:0005739	mitochondrion	Gad1	HDA		Mouse	PMID:14651853
Cellular Component	GO:0044306	neuron projection terminus	Gad1	IDA		Mouse	PMID:12074840
Cellular Component	GO:0098793	presynapse	Gad1	IMP		Mouse	PMID:21584649
Cellular Component	GO:0098793	presynapse	Gad1	IDA		Mouse	PMID:21584649
Cellular Component	GO:0048786	presynaptic active zone	Gad1	IDA		Mouse	PMID:23258346
Cellular Component	GO:0048786	presynaptic active zone	Gad1	IDA		Mouse	PMID:12074840
Cellular Component	GO:0048786	presynaptic active zone	Gad1	IDA		Mouse	PMID:18165320
Cellular Component	GO:0048786	presynaptic active zone	Gad1	IDA		Rat	PMID:24613359|RGD:10047247
Cellular Component	GO:0045202	synapse	Gad1	IDA		Mouse	PMID:15479642
Biological Process	GO:0009449	gamma-aminobutyric acid biosynthetic process	Gad1	IMP		Mouse	MGI:MGI:892697|PMID:9177246
Biological Process	GO:0009449	gamma-aminobutyric acid biosynthetic process	Gad1	IDA		Rat	PMID:17712632|RGD:6480258
Biological Process	GO:0009449	gamma-aminobutyric acid biosynthetic process	Gad1	IDA		Rat	PMID:1924335|RGD:728511
Biological Process	GO:0009449	gamma-aminobutyric acid biosynthetic process	gad1b	IEP		Zfish	PMID:9634146
Biological Process	GO:0006538	glutamate catabolic process	GAD1	IDA		Human	PMID:17384644
Biological Process	GO:0035641	locomotory exploration behavior	Gad1	IMP	MGI:MGI:3762150	Mouse	PMID:24952328
Biological Process	GO:0042136	neurotransmitter biosynthetic process	GAD1	IDA		Human	PMID:17384644
Biological Process	GO:0042136	neurotransmitter biosynthetic process	GAD1	IDA		Human	PMID:8336154
Biological Process	GO:0042136	neurotransmitter biosynthetic process	GAD1	IMP		Human	PMID:8336154
Biological Process	GO:0042136	neurotransmitter biosynthetic process	Gad1	IMP		Mouse	MGI:MGI:892697|PMID:9177246
Biological Process	GO:0042136	neurotransmitter biosynthetic process	Gad1	IDA		Rat	PMID:1924335|RGD:728511
Biological Process	GO:0042136	neurotransmitter biosynthetic process	gad1b	IEP		Zfish	PMID:9634146
Biological Process	GO:0018352	protein-pyridoxal-5-phosphate linkage	GAD1	IDA		Human	PMID:17384644
Biological Process	GO:0009410	response to xenobiotic stimulus	Gad1	IEP		Rat	PMID:19359144|RGD:2317787
Biological Process	GO:0035176	social behavior	Gad1	IMP	MGI:MGI:3762150	Mouse	PMID:24952328

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern