Gad1
Gene Detail

Symbol Name ID

Gad1 glutamate decarboxylase 1 MGI:95632

Synonyms

EP10, Gad-1, GAD25, GAD44, GAD67, Z49976

Feature Type

protein coding gene

Genetic Map

Chromosome 2

41.63 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(24)

Sequence Map

Chr2:70553072-70602014 bp, + strand From VEGA annotation of GRCm38   48943 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:635  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: glutamate decarboxylase
Gene Tree: Gad1

Human homologs

Human Homolog		GAD1, glutamate decarboxylase 1 (brain, 67kDa)
NCBI Gene ID		2571
neXtProt AC		NX_Q99259
Human Synonyms		CPSQ1, GAD, SCP
Human Chr (Location)		2q31; chr2:170816690-170861151 (+)  GRCh38
Disease Associations		(1) Diseases Associated with Human GAD1

Mutations, alleles, and phenotypes

All mutations/alleles(17) : Gene trapped(2) Targeted(15)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygotes for targeted null mutations die at birth with cleft palate and apnea and exhibit reduced levels of glutamic acid decarboxylase and gamma-aminobutyric acid in the cerebral cortex.

 
Phenotype Images(3)

Interactions

Gad1 interacts with 295 markers (Mir1a-1, Mir1a-2, Mir1b, ...)

View All

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	carboxylic acid metabolic process, gamma-aminobutyric acid biosynthetic process, ...
Component	axon, axon terminus, ...
Function	carboxy-lyase activity, catalytic activity, ...

External Resources: FuncBase

Expression

Literature Summary: (256 records)

Data Summary: Results (743)    Tissues (335)    Images (203)
Theiler Stages: 13, 14, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	64
RNA in situ	499
In situ reporter (knock in)	11
Northern blot	17
Western blot	49
RT-PCR	97
RNase protection	6

cDNA source data(66)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular reagents

All nucleic(103) Genomic(20) cDNA(75) Primer pair(7) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000033269 (Evidence)
Ensembl Gene Model	ENSMUSG00000070880 (Evidence)
Entrez Gene	14415 (Evidence)
UniGene	272120
DFCI	TC1574972, TC1646801
DoTS	DT.101234151, DT.101378097, DT.110693445, DT.40168125
NIA Mouse Gene Index	U329555, U355679
EC	4.1.1.15
Consensus CDS Project	CCDS16108.1
International Mouse Knockout Project Status	Gad1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033269	VEGA Gene Model | MGI Sequence Detail	48943	C57BL/6J
transcript	OTTMUST00000083419	VEGA | MGI Sequence Detail	3355	Not Applicable
polypeptide	OTTMUSP00000044832	VEGA | MGI Sequence Detail	593	Not Applicable

All sequences(76) RefSeq(12) UniProt(6)

Polymorphisms

RFLP(3) : SNPs within 2kb(291 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR021115	Pyridoxal-phosphate binding site
InterPro	IPR002129	Pyridoxal phosphate-dependent decarboxylase
InterPro	IPR015424	Pyridoxal phosphate-dependent transferase
InterPro	IPR015421	Pyridoxal phosphate-dependent transferase, major region, subdomain 1
InterPro	IPR015422	Pyridoxal phosphate-dependent transferase, major region, subdomain 2
Protein Ontology	PR:000007785	glutamate decarboxylase 1

References

(Earliest) J:16802 Maxson SC, et al., Electroencephalographic correlates of the audiogenic seizure response of inbred mice. Physiol Behav. 1976 May;16(5):623-9
(Latest) J:209605 Easton CR, et al., Genetic elimination of GABAergic neurotransmission reveals two distinct pacemakers for spontaneous waves of activity in the developing mouse cortex. J Neurosci. 2014 Mar 12;34(11):3854-63
All references(422)

Other accession IDs

MGD-MRK-9953, MGD-MRK-9957, MGI:2152825