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Gad1
Gene Detail
 Symbol
Name
ID
Gad1
glutamate decarboxylase 1
MGI:95632
Synonyms EP10, Gad-1, GAD25, GAD44, GAD67, Z49976
Feature Type protein coding gene
Genetic Map
Chromosome 2
41.63 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(24)
Sequence Map
Chr2:70553072-70602014 bp, + strand
From VEGA annotation of GRCm38

  48943 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:635  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: glutamate decarboxylase
Gene Tree: Gad1

Human
homologs
Human Homolog GAD1, glutamate decarboxylase 1 (brain, 67kDa)
NCBI Gene ID 2571
neXtProt AC  NX_Q99259
Human Synonyms  CPSQ1, GAD, SCP
Human Chr (Location)  2q31; chr2:170816690-170861151 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human GAD1
Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(2) Targeted(15)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations die at birth with cleft palate and apnea and exhibit reduced levels of glutamic acid decarboxylase and gamma-aminobutyric acid in the cerebral cortex.
 
Phenotype Images(3)
Interactions
Gad1 interacts with 295 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process carboxylic acid metabolic process, gamma-aminobutyric acid biosynthetic process, ...
Component axon, axon terminus, ...
Function carboxy-lyase activity, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (258 records)
Data Summary: Results (747)    Tissues (342)    Images (210)
Theiler Stages: 13, 14, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 68
RNA in situ 499
In situ reporter (knock in) 11
Northern blot 17
Western blot 49
RT-PCR 97
RNase protection 6
cDNA source data(66)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(103) Genomic(20) cDNA(75) Primer pair(7) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000033269 (Evidence)
Ensembl Gene ModelENSMUSG00000070880 (Evidence)
Entrez Gene14415 (Evidence)
UniGene272120
DFCITC1574972, TC1646801
DoTSDT.101234151, DT.101378097, DT.110693445, DT.40168125
NIA Mouse Gene IndexU329555, U355679
EC4.1.1.15
Consensus CDS ProjectCCDS16108.1
International Mouse Knockout Project StatusGad1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033269 VEGA Gene Model | MGI Sequence Detail 48943 C57BL/6J ±  kb
transcript OTTMUST00000083419 VEGA | MGI Sequence Detail 3355 Not Applicable 
polypeptide OTTMUSP00000044832 VEGA | MGI Sequence Detail 593 Not Applicable 

For the selected sequences
All sequences(76) RefSeq(12) UniProt(6)
Polymorphisms RFLP(3) : SNPs within 2kb(291 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR021115 Pyridoxal-phosphate binding site
InterPro IPR002129 Pyridoxal phosphate-dependent decarboxylase
InterPro IPR015424 Pyridoxal phosphate-dependent transferase
InterPro IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1
InterPro IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2
Protein Ontology PR:000007785 glutamate decarboxylase 1
References (Earliest) J:16802 Maxson SC, et al., Electroencephalographic correlates of the audiogenic seizure response of inbred mice. Physiol Behav. 1976 May;16(5):623-9
(Latest) J:213058 Golding B, et al., Retinal input directs the recruitment of inhibitory interneurons into thalamic visual circuits. Neuron. 2014 Mar 5;81(5):1057-69
All references(426)
Other
accession IDs
MGD-MRK-9953, MGD-MRK-9957, MGI:2152825

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory