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Gad1 Gene Detail
Summary
  • Symbol
    Gad1
  • Name
    glutamate decarboxylase 1
  • Synonyms
    EP10, Gad-1, GAD25, GAD44, GAD67, Z49976
  • Feature Type
    protein coding gene
  • IDs
    MGI:95632
    NCBI Gene: 14415
  • Gene Overview
    MyGene.info: GAD1
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr2:70553072-70602014 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      48943 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 41.63 cM, cytoband D
  • Mapping Data
    24 experiments
Homology
more
  • Human Ortholog
    GAD1, glutamate decarboxylase 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GAD1, glutamate decarboxylase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CPSQ1, GAD, SCP
  • Links
    NCBI Gene ID: 2571
    neXtProt AC: NX_Q99259
    UniProt: Q99259

  • Chr Location
    2q31.1; chr2:170813210-170861151 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with human GAD1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    39 phenotypes from 10 alleles in 8 genetic backgrounds
    21 phenotypes from multigenic genotypes
    3 images
    222 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations die at birth with cleft palate and apnea and exhibit reduced levels of glutamic acid decarboxylase and gamma-aminobutyric acid in the cerebral cortex.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    26
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1021
  • Tissues
    403
  • cDNA Data
    71
  • Literature Summary
    345
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000033269 VEGA Gene Model | MGI Sequence Detail 48943 C57BL/6J ±  kb
    transcript OTTMUST00000083419 VEGA | MGI Sequence Detail 3355 Not Applicable  
    polypeptide OTTMUSP00000044832 VEGA | MGI Sequence Detail 593 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      288 from dbSNP Build 142
    • RFLP
      3
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 134
      Genomic 20
      cDNA 80
      Primer pair 32
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-9953, MGD-MRK-9957, MGI:2152825
    References
    more
    • Summaries
      All 604
      Developmental Gene Expression 345
      Gene Ontology 14
      Phenotypes 222
    • Earliest
      J:16802 Maxson SC, et al., Electroencephalographic correlates of the audiogenic seizure response of inbred mice. Physiol Behav. 1976 May;16(5):623-9
    • Latest
      J:262197 Zechel S, et al., Cell-autonomous role of GFRalpha1 in the development of olfactory bulb GABAergic interneurons. Biol Open. 2018 May 18;7(5)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    07/31/2018
    MGI 6.12     		The Jackson Laboratory