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Gad1 Gene Detail
Summary
  • Symbol
    Gad1
  • Name
    glutamate decarboxylase 1
  • Synonyms
    EP10, Gad-1, GAD25, GAD44, GAD67, Z49976
  • Feature Type
    protein coding gene
  • IDs
    MGI:95632
    NCBI Gene: 14415
  • Gene Overview
    MyGene.info: GAD1
  • Alliance
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:70561765-70602014 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 41.63 cM, cytoband D
  • Mapping Data
    24 experiments
Strain
Comparison
more
  • SNPs within 2kb
    245 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95632
protein coding gene Chr2:70553072-70602014 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025813
protein coding gene Chr2:70602773-70655317 (+)
A/J MGP_AJ_G0025790
protein coding gene Chr2:67857683-67907377 (+)
AKR/J MGP_AKRJ_G0025759
protein coding gene Chr2:69700817-69751120 (+)
BALB/cJ MGP_BALBcJ_G0025785
protein coding gene Chr2:68047140-68096470 (+)
C3H/HeJ MGP_C3HHeJ_G0025545
protein coding gene Chr2:69927039-69977976 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026232
protein coding gene Chr2:72727107-72781136 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023635
protein coding gene Chr2:65091616-65140520 (+)
CAST/EiJ MGP_CASTEiJ_G0025009
protein coding gene Chr2:70082935-70135779 (+)
CBA/J MGP_CBAJ_G0025525
protein coding gene Chr2:75419379-75474207 (+)
DBA/2J MGP_DBA2J_G0025656
protein coding gene Chr2:67492443-67541944 (+)
FVB/NJ MGP_FVBNJ_G0025619
protein coding gene Chr2:66867073-66918035 (+)
LP/J MGP_LPJ_G0025745
protein coding gene Chr2:70449816-70502855 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025648
protein coding gene Chr2:77443589-77495435 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026289
protein coding gene Chr2:69799956-69849827 (+)
PWK/PhJ MGP_PWKPhJ_G0024750
protein coding gene Chr2:67350339-67400889 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024557
protein coding gene Chr2:70008278-70056606 (+)
WSB/EiJ MGP_WSBEiJ_G0025077
protein coding gene Chr2:70232774-70284679 (+)



Homology
more
  • Human Ortholog
    GAD1, glutamate decarboxylase 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GAD1, glutamate decarboxylase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CPSQ1, GAD, SCP
  • Links
    NCBI Gene ID: 2571
    neXtProt AC: NX_Q99259
    UniProt: Q99259

  • Chr Location
    2q31.1; chr2:170813210-170861151 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human GAD1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    39 phenotypes from 10 alleles in 8 genetic backgrounds
    21 phenotypes from multigenic genotypes
    3 images
    233 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations die at birth with cleft palate and apnea and exhibit reduced levels of glutamic acid decarboxylase and gamma-aminobutyric acid in the cerebral cortex.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14415 NCBI Gene Model | MGI Sequence Detail 40250 C57BL/6J ±  kb
    transcript NM_008077 RefSeq | MGI Sequence Detail 3283 C57BL/6  
    polypeptide P48318 UniProt | EBI | MGI Sequence Detail 593 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 134
      Genomic 20
      cDNA 80
      Primer pair 32
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-9953, MGD-MRK-9957, MGI:2152825
    References
    more
    • Summaries
      All 625
      Developmental Gene Expression 357
      Gene Ontology 14
      Phenotypes 233
    • Earliest
      J:16802 Maxson SC, et al., Electroencephalographic correlates of the audiogenic seizure response of inbred mice. Physiol Behav. 1976 May;16(5):623-9
    • Latest
      J:266242 Desmaris E, et al., DMRT5, DMRT3, and EMX2 Cooperatively Repress Gsx2 at the Pallium-Subpallium Boundary to Maintain Cortical Identity in Dorsal Telencephalic Progenitors. J Neurosci. 2018 Oct 17;38(42):9105-9121

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory