Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FPR2
  • Mouse genes Fpr2
  • Rat genes Fpr2,Fpr3
  • Zfish genes si:ch211-137j23.9,si:ch73-160i9.1,si:ch73-160i9.2,si:dkey-211g8.1,si:dkey-42l23.4,si:dkey-42l23.5,si:dkey-42l23.7
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fpr2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001540	amyloid-beta binding	FPR2	IPI	UniProtKB:P05067:PRO_0000000092	Human	PMID:11316806
Molecular Function	GO:0001540	amyloid-beta binding	Fpr2	IPI	UniProtKB:P05067:PRO_0000000092	Mouse	MGI:MGI:5905278|PMID:11316806
Molecular Function	GO:0004982	N-formyl peptide receptor activity	Fpr2	IDA		Mouse	PMID:22859307
Molecular Function	GO:0005515	protein binding	FPR2	IPI	UniProtKB:Q8IVG9	Human	PMID:15465011
Molecular Function	GO:0005515	protein binding	FPR2	IPI	UniProtKB:P05090	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FPR2	IPI	UniProtKB:Q8N386	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FPR2	IPI	UniProtKB:Q8WWF3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FPR2	IPI	UniProtKB:Q9H0Q3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FPR2	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0050786	RAGE receptor binding	Fpr2	IPI	RGD:69258	Rat	PMID:23164356|RGD:7244287
Molecular Function	GO:0005124	scavenger receptor binding	FPR2	IPI	UniProtKB:Q9UEW3	Human	PMID:20141570
Molecular Function	GO:0038023	signaling receptor activity	FPR2	IDA		Human	PMID:25505240
Molecular Function	GO:0038023	signaling receptor activity	Fpr2	IDA		Mouse	PMID:12218158
Cellular Component	GO:0005737	cytoplasm	FPR2	IDA		Human	PMID:11689470
Cellular Component	GO:0005886	plasma membrane	FPR2	IDA		Human	PMID:11689470
Cellular Component	GO:0005886	plasma membrane	FPR2	IDA		Human	PMID:15465011
Biological Process	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	FPR2	IGI	UniProtKB:P05067:PRO_0000000092,UniProtKB:Q9UEW3	Human	PMID:20141570
Biological Process	GO:0019722	calcium-mediated signaling	FPR2	IGI	UniProtKB:P05067:PRO_0000000092	Human	PMID:11160457
Biological Process	GO:0007166	cell surface receptor signaling pathway	FPR2	IDA		Human	PMID:25505240
Biological Process	GO:1904646	cellular response to amyloid-beta	FPR2	IDA		Human	PMID:11316806
Biological Process	GO:1904646	cellular response to amyloid-beta	Fpr2	IDA		Mouse	MGI:MGI:5905278|PMID:11316806
Biological Process	GO:0042742	defense response to bacterium	FPR2	IDA		Human	PMID:25505240
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	FPR2	IGI	UniProtKB:P05067:PRO_0000000092	Human	PMID:11160457
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Fpr2	IDA		Mouse	MGI:MGI:5467169|PMID:22859307
Biological Process	GO:0002768	immune response-regulating cell surface receptor signaling pathway	FPR2	IDA		Human	PMID:25505240
Biological Process	GO:0050728	negative regulation of inflammatory response	FPR2	IDA		Human	PMID:25505240
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	Fpr2	IDA		Mouse	PMID:22859307
Biological Process	GO:0050918	positive chemotaxis	Fpr2	IGI	UniProtKB:O88536	Mouse	MGI:MGI:5905278|PMID:11316806
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	FPR2	IGI	UniProtKB:P05067:PRO_0000000092,UniProtKB:Q9UEW3	Human	PMID:20141570
Biological Process	GO:0045089	positive regulation of innate immune response	FPR2	IDA		Human	PMID:25505240
Biological Process	GO:0090026	positive regulation of monocyte chemotaxis	FPR2	IGI	UniProtKB:P05067:PRO_0000000092	Human	PMID:11160457
Biological Process	GO:0050766	positive regulation of phagocytosis	FPR2	IDA		Human	PMID:25505240
Biological Process	GO:0001934	positive regulation of protein phosphorylation	FPR2	IGI	UniProtKB:P05067:PRO_0000000092,UniProtKB:Q9UEW3	Human	PMID:20141570
Biological Process	GO:0032930	positive regulation of superoxide anion generation	Fpr2	IGI	UniProtKB:P05067:PRO_0000000092	Mouse	MGI:MGI:5905278|PMID:11316806

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern