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Fpr2 Gene Detail
Summary
  • Symbol
    Fpr2
  • Name
    formyl peptide receptor 2
  • Synonyms
    E330010I07Rik, Fpr-rs2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1278319
    NCBI Gene: 14289
  • Alliance
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:18108086-18114214 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 17, 10.66 cM, cytoband A3.1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    48 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1278319
protein coding gene Chr17:18108086-18114214 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023187
protein coding gene Chr17:15894019-15906216 (+)
A/J MGP_AJ_G0023153
protein coding gene Chr17:15550244-15551581 (+)
AKR/J MGP_AKRJ_G0023122
protein coding gene Chr17:15614756-15621094 (+)
BALB/cJ MGP_BALBcJ_G0023152
protein coding gene Chr17:15485681-15491812 (+)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0023595
protein coding gene Chr17:16682921-16692946 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021107
protein coding gene Chr17:13387171-13393403 (+)
CAST/EiJ MGP_CASTEiJ_G0022431
protein coding gene Chr17:15650053-15695202 (+)
CBA/J MGP_CBAJ_G0022889
protein coding gene Chr17:17253292-17260043 (+)
DBA/2J MGP_DBA2J_G0023022
protein coding gene Chr17:15253630-15259481 (+)
FVB/NJ MGP_FVBNJ_G0022990
protein coding gene Chr17:15067902-15075819 (+)
LP/J MGP_LPJ_G0023096
protein coding gene Chr17:15887943-15894077 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023011
protein coding gene Chr17:16854773-16873078 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023632
protein coding gene Chr17:15808222-15814260 (+)
PWK/PhJ MGP_PWKPhJ_G0022181
protein coding gene Chr17:14907890-14921666 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022008
protein coding gene Chr17:14896691-14902811 (+)
WSB/EiJ MGP_WSBEiJ_G0022490
protein coding gene Chr17:16090415-16098587 (+)



Homology
more
  • Human Ortholog
    FPR2, formyl peptide receptor 2
  • Vertebrate Orthologs
    10
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FPR2, formyl peptide receptor 2
  • Synonyms
    ALX, ALXR, FMLP-R-II, FMLPX, FPR2A, FPRH1, FPRH2, FPRL1, HM63, LXA4R
  • Links
    NCBI Gene ID: 2358
    neXtProt AC: NX_P25090
    UniProt: P25090

  • Chr Location
    19q13.41; chr19:51752026-51770531 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    34 phenotypes from 3 alleles in 5 genetic backgrounds
    2 phenotypes from multigenic genotypes
    8 images
    60 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted reporter allele exhibit altered leukocyte responses and experimentally induced inflammation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14289 NCBI Gene Model | MGI Sequence Detail 6129 C57BL/6J ±  kb
    transcript NM_008039 RefSeq | MGI Sequence Detail 1296 C57BL/6  
    polypeptide O88536 UniProt | EBI | MGI Sequence Detail 351 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR000826 Formyl peptide receptor-related
      IPR017452 GPCR, rhodopsin-like, 7TM
      IPR000276 G protein-coupled receptor, rhodopsin-like
    Molecular
    Reagents
    less
    • All nucleic 11
      Genomic 7
      cDNA 4

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2442028
    References
    more
    • Summaries
      All 103
      Gene Ontology 8
      Phenotypes 60
    • Earliest
      J:49567 Gao JL, et al., Differential expansion of the N-formylpeptide receptor gene cluster in human and mouse. Genomics. 1998 Jul 15;51(2):270-6
    • Latest
      J:340145 Ni C, et al., Fpr2 exacerbates Streptococcus suis-induced streptococcal toxic shock-like syndrome via attenuation of neutrophil recruitment. Front Immunol. 2023;14:1094331

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory