About   Help   FAQ
Fpr2 Gene Detail
Summary
  • Symbol
    Fpr2
  • Name
    formyl peptide receptor 2
  • Synonyms
    E330010I07Rik, Fpr-rs2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1278319
    NCBI Gene: 14289
  • Gene Overview
    MyGene.info: FPR2
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:17887824-17893952 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 10.66 cM, cytoband A3.1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    48 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1278319
protein coding gene Chr17:17887824-17893952 (.)
129S1/SvImJ MGP_129S1SvImJ_G0023187
protein coding gene Chr17:15894019-15906216 (+)
A/J MGP_AJ_G0023153
protein coding gene Chr17:15550244-15551581 (+)
AKR/J MGP_AKRJ_G0023122
protein coding gene Chr17:15614756-15621094 (+)
BALB/cJ MGP_BALBcJ_G0023152
protein coding gene Chr17:15485681-15491812 (+)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0023595
protein coding gene Chr17:16682921-16692946 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021107
protein coding gene Chr17:13387171-13393403 (+)
CAST/EiJ MGP_CASTEiJ_G0022431
protein coding gene Chr17:15650053-15695202 (+)
CBA/J MGP_CBAJ_G0022889
protein coding gene Chr17:17253292-17260043 (+)
DBA/2J MGP_DBA2J_G0023022
protein coding gene Chr17:15253630-15259481 (+)
FVB/NJ MGP_FVBNJ_G0022990
protein coding gene Chr17:15067902-15075819 (+)
LP/J MGP_LPJ_G0023096
protein coding gene Chr17:15887943-15894077 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023011
protein coding gene Chr17:16854773-16873078 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023632
protein coding gene Chr17:15808222-15814260 (+)
PWK/PhJ MGP_PWKPhJ_G0022181
protein coding gene Chr17:14907890-14921666 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022008
protein coding gene Chr17:14896691-14902811 (+)
WSB/EiJ MGP_WSBEiJ_G0022490
protein coding gene Chr17:16090415-16098587 (+)



Homology
more
  • Human Ortholog
    FPR2, formyl peptide receptor 2
  • Vertebrate Orthologs
    6
  • Human Ortholog
    FPR2, formyl peptide receptor 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ALXR, FMLP-R-II, FMLPX, FPR2A, FPRH1, FPRH2, FPRL1, HM63, LXA4R
  • Links
    NCBI Gene ID: 2358
    neXtProt AC: NX_P25090
    UniProt: P25090

  • Chr Location
    19q13.41; chr19:51752026-51770526 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 4 alleles in 6 genetic backgrounds
    8 images
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted reporter allele exhibit altered leukocyte responses and experimentally induced inflammation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 14289 NCBI Gene Model | MGI Sequence Detail 6129 C57BL/6J ±  kb
transcript NM_008039 RefSeq | MGI Sequence Detail 1296 C57BL/6  
polypeptide O88536 UniProt | EBI | MGI Sequence Detail 351 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR000826 Formyl peptide receptor-related
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
Molecular
Reagents
less
  • All nucleic 11
    Genomic 7
    cDNA 4

    Microarray probesets 2
Other
Accession IDs
less
MGI:2442028
References
more
  • Summaries
    All 69
    Gene Ontology 9
    Phenotypes 30
  • Earliest
    J:49567 Gao JL, et al., Differential expansion of the N-formylpeptide receptor gene cluster in human and mouse. Genomics. 1998 Jul 15;51(2):270-6
  • Latest
    J:266182 Hellmann J, et al., Biosynthesis of D-Series Resolvins in Skin Provides Insights into their Role in Tissue Repair. J Invest Dermatol. 2018 Sep;138(9):2051-2060

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/04/2018
MGI 6.13
The Jackson Laboratory