Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FOXK2
  • Mouse genes Foxk2
  • Rat genes Foxk2
  • Zfish genes foxk2a,foxk2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Foxk2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	FOXK2	IDA		Human	PMID:9065434
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Foxk2	IDA		Mouse	MGI:MGI:6281052|PMID:30700909
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Foxk2	IDA		Mouse	MGI:MGI:6163926|PMID:29861159
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Foxk2	IDA		Mouse	MGI:MGI:5615527|PMID:25402684
Molecular Function	GO:0000287	magnesium ion binding	FOXK2	IDA		Human	PMID:16624804
Molecular Function	GO:0005515	protein binding	FOXK2	IPI	UniProtKB:P14316	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	FOXK2	IPI	UniProtKB:Q92560	Human	PMID:25451922
Molecular Function	GO:0005515	protein binding	FOXK2	IPI	UniProtKB:P14316	Human	PMID:25609649
Molecular Function	GO:0005515	protein binding	FOXK2	IPI	UniProtKB:P61244	Human	PMID:25609649
Molecular Function	GO:0005515	protein binding	FOXK2	IPI	UniProtKB:P14316	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	Foxk2	IPI	UniProtKB:Q60520	Mouse	MGI:MGI:5615527|PMID:25402684
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	FOXK2	IDA		Human	PMID:9065434
Molecular Function	GO:0043565	sequence-specific DNA binding	FOXK2	IDA		Human	PMID:12402362
Molecular Function	GO:0043565	sequence-specific DNA binding	FOXK2	IDA		Human	PMID:1339390
Molecular Function	GO:0043565	sequence-specific DNA binding	FOXK2	IDA		Human	PMID:16624804
Molecular Function	GO:0043565	sequence-specific DNA binding	FOXK2	IDA		Human	PMID:1909027
Molecular Function	GO:0000976	transcription cis-regulatory region binding	FOXK2	IDA		Human	PMID:22083952
Cellular Component	GO:0005737	cytoplasm	Foxk2	IDA		Mouse	MGI:MGI:5615527|PMID:25402684
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	FOXK2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	FOXK2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	FOXK2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	FOXK2	IDA		Human	PMID:20810654
Cellular Component	GO:0005634	nucleus	Foxk2	IDA		Mouse	MGI:MGI:5615527|PMID:25402684
Cellular Component	GO:0005634	nucleus	Foxk2	IDA		Mouse	MGI:MGI:3616943|PMID:16376864
Biological Process	GO:0061621	canonical glycolysis	Foxk2	IDA		Mouse	MGI:MGI:6281052|PMID:30700909
Biological Process	GO:0001678	intracellular glucose homeostasis	Foxk2	IDA		Mouse	MGI:MGI:6163926|PMID:29861159
Biological Process	GO:0001678	intracellular glucose homeostasis	Foxk2	IDA		Mouse	MGI:MGI:6281052|PMID:30700909
Biological Process	GO:0010507	negative regulation of autophagy	Foxk2	IDA		Mouse	MGI:MGI:5615527|PMID:25402684
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	FOXK2	IDA		Human	PMID:20810654
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	FOXK2	IDA		Human	PMID:25451922
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Foxk2	IDA		Mouse	MGI:MGI:5615527|PMID:25402684
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	FOXK2	IDA		Human	PMID:22083952
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Foxk2	IDA		Mouse	MGI:MGI:6281052|PMID:30700909
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Foxk2	IDA		Mouse	MGI:MGI:6163926|PMID:29861159
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	FOXK2	IDA		Human	PMID:9065434
Biological Process	GO:0010906	regulation of glucose metabolic process	Foxk2	IDA		Mouse	MGI:MGI:6281052|PMID:30700909
Biological Process	GO:0010906	regulation of glucose metabolic process	Foxk2	IDA		Mouse	MGI:MGI:6163926|PMID:29861159
Biological Process	GO:0042594	response to starvation	Foxk2	IDA		Mouse	MGI:MGI:5615527|PMID:25402684

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern