Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Flt3

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes FLT3
- Mouse genes Flt3
- Rat genes Flt3
- Zfish genes flt3
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Flt3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004896	cytokine receptor activity	Flt3	IMP		Mouse	MGI:MGI:3795633\|PMID:18469816
Molecular Function	GO:0035259	nuclear glucocorticoid receptor binding	Flt3	IPI	RGD:2741	Rat	PMID:18261979\|RGD:2302206
Molecular Function	GO:0043548	phosphatidylinositol 3-kinase binding	Flt3	IDA		Mouse	PMID:8183574
Molecular Function	GO:0005515	protein binding	FLT3	IPI	UniProtKB:P27986	Human	PMID:16982329
Molecular Function	GO:0005515	protein binding	FLT3	IPI	UniProtKB:Q9Y6K9	Human	PMID:20098747
Molecular Function	GO:0005515	protein binding	FLT3	IPI	UniProtKB:Q13322	Human	PMID:23246379
Molecular Function	GO:0005515	protein binding	FLT3	IPI	UniProtKB:P43405	Human	PMID:24525236
Molecular Function	GO:0005515	protein binding	FLT3	IPI	UniProtKB:Q8R4L0	Human	PMID:27458164
Molecular Function	GO:0005515	protein binding	FLT3	IPI	UniProtKB:P00519	Human	PMID:28086240
Molecular Function	GO:0005515	protein binding	FLT3	IPI	UniProtKB:P06239	Human	PMID:28086240
Molecular Function	GO:0005515	protein binding	FLT3	IPI	UniProtKB:P06241	Human	PMID:28086240
Molecular Function	GO:0005515	protein binding	FLT3	IPI	UniProtKB:P20936	Human	PMID:28086240
Molecular Function	GO:0005515	protein binding	FLT3	IPI	UniProtKB:P42684	Human	PMID:28086240
Molecular Function	GO:0005515	protein binding	FLT3	IPI	UniProtKB:P43405	Human	PMID:28086240
Molecular Function	GO:0005515	protein binding	FLT3	IPI	UniProtKB:P46108	Human	PMID:28086240
Molecular Function	GO:0005515	protein binding	FLT3	IPI	UniProtKB:P46109	Human	PMID:28086240
Molecular Function	GO:0005515	protein binding	Flt3	IPI	PR:Q9WTJ4	Mouse	PMID:10409713
Molecular Function	GO:0005515	protein binding	Flt3	IPI	UniProtKB:P23727	Mouse	PMID:8183574
Molecular Function	GO:0005515	protein binding	Flt3	IPI	PR:P49772	Mouse	PMID:8896402
Molecular Function	GO:0005515	protein binding	Flt3	IPI	PR:Q9WTJ4	Mouse	PMID:20360400
Molecular Function	GO:0005515	protein binding	Flt3	IPI	PR:P49772	Mouse	PMID:7505204
Molecular Function	GO:0005515	protein binding	Flt3	IPI	PR:P49772	Mouse	PMID:7531700
Molecular Function	GO:0043621	protein self-association	FLT3	IMP		Human	PMID:14759363
Molecular Function	GO:0004713	protein tyrosine kinase activity	Flt3	IDA		Mouse	PMID:8384358
Molecular Function	GO:0044877	protein-containing complex binding	Flt3	IDA		Rat	PMID:18261979\|RGD:2302206
Molecular Function	GO:0031625	ubiquitin protein ligase binding	Flt3	IPI	UniProtKB:Q91YL2	Mouse	MGI:MGI:5582879\|PMID:23418353
Cellular Component	GO:0009986	cell surface	Flt3	IDA		Mouse	PMID:9620281
Cellular Component	GO:0009986	cell surface	Flt3	IDA		Mouse	PMID:7630197
Cellular Component	GO:0005737	cytoplasm	Flt3	IDA		Rat	PMID:18031378\|RGD:2302207
Cellular Component	GO:0005829	cytosol	Flt3	IDA		Rat	PMID:18261979\|RGD:2302206
Cellular Component	GO:0005783	endoplasmic reticulum	FLT3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0009897	external side of plasma membrane	Flt3	IDA		Mouse	PMID:23528453
Cellular Component	GO:0005634	nucleus	Flt3	IDA		Rat	PMID:18261979\|RGD:2302206
Cellular Component	GO:0005886	plasma membrane	Flt3	IDA		Rat	PMID:18031378\|RGD:2302207
Cellular Component	GO:0032991	protein-containing complex	Flt3	IDA		Rat	PMID:18261979\|RGD:2302206
Biological Process	GO:0031100	animal organ regeneration	Flt3	IEP		Rat	PMID:18031378\|RGD:2302207
Biological Process	GO:0019882	antigen processing and presentation	Flt3	IMP	MGI:MGI:3628823	Mouse	PMID:20457904
Biological Process	GO:0030183	B cell differentiation	Flt3	IMP		Mouse	MGI:MGI:4946600\|PMID:21228325
Biological Process	GO:0008283	cell population proliferation	Flt3	IMP		Mouse	PMID:7919361
Biological Process	GO:0071345	cellular response to cytokine stimulus	Flt3	IMP		Mouse	MGI:MGI:3795633\|PMID:18469816
Biological Process	GO:0071385	cellular response to glucocorticoid stimulus	Flt3	IEP		Rat	PMID:18261979\|RGD:2302206
Biological Process	GO:0098586	cellular response to virus	Flt3	IMP	MGI:MGI:3628823	Mouse	PMID:20457904
Biological Process	GO:0035726	common myeloid progenitor cell proliferation	Flt3	IMP		Mouse	MGI:MGI:5293565\|PMID:21813452
Biological Process	GO:0019221	cytokine-mediated signaling pathway	Flt3	IMP		Mouse	MGI:MGI:3795633\|PMID:18469816
Biological Process	GO:0097028	dendritic cell differentiation	Flt3	IMP		Mouse	MGI:MGI:3795633\|PMID:18469816
Biological Process	GO:0036145	dendritic cell homeostasis	Flt3	IMP	MGI:MGI:3628823	Mouse	PMID:20457904
Biological Process	GO:0030097	hemopoiesis	FLT3	IDA		Human	PMID:7507245
Biological Process	GO:0048873	homeostasis of number of cells within a tissue	Flt3	IGI	MGI:MGI:96995	Mouse	PMID:22674806
Biological Process	GO:0048873	homeostasis of number of cells within a tissue	Flt3	IMP	MGI:MGI:3628823	Mouse	PMID:20457904
Biological Process	GO:0001776	leukocyte homeostasis	Flt3	IMP		Mouse	MGI:MGI:3795633\|PMID:18469816
Biological Process	GO:0048535	lymph node development	Flt3	IMP	MGI:MGI:3628823	Mouse	PMID:20457904
Biological Process	GO:0030098	lymphocyte differentiation	Flt3	IDA		Mouse	PMID:12387740
Biological Process	GO:0046651	lymphocyte proliferation	Flt3	IMP		Mouse	MGI:MGI:3795633\|PMID:18469816
Biological Process	GO:0002320	lymphoid progenitor cell differentiation	Flt3	IGI	MGI:MGI:96677	Mouse	PMID:7621074
Biological Process	GO:0030225	macrophage differentiation	flt3	IMP	ZFIN:ZDB-MRPHLNO-140603-1	Zfish	PMID:24591202
Biological Process	GO:0061515	myeloid cell development	flt3	IMP	ZFIN:ZDB-MRPHLNO-140603-1	Zfish	PMID:24591202
Biological Process	GO:0002318	myeloid progenitor cell differentiation	Flt3	IMP		Mouse	MGI:MGI:3795633\|PMID:18469816
Biological Process	GO:0002318	myeloid progenitor cell differentiation	Flt3	IMP	MGI:MGI:2176073,MGI:MGI:3783339	Mouse	PMID:18245664
Biological Process	GO:0002318	myeloid progenitor cell differentiation	Flt3	IGI	MGI:MGI:96677	Mouse	PMID:7621074
Biological Process	GO:0045578	negative regulation of B cell differentiation	Flt3	IDA		Mouse	PMID:16618805
Biological Process	GO:0008285	negative regulation of cell population proliferation	Flt3	IMP		Mouse	PMID:7919361
Biological Process	GO:0032715	negative regulation of interleukin-6 production	Flt3	IMP	MGI:MGI:3628823	Mouse	PMID:20457904
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	Flt3	IMP	MGI:MGI:3628823	Mouse	PMID:20457904
Biological Process	GO:0032727	positive regulation of interferon-alpha production	Flt3	IMP	MGI:MGI:3628823	Mouse	PMID:20457904
Biological Process	GO:0032735	positive regulation of interleukin-12 production	Flt3	IMP	MGI:MGI:3628823	Mouse	PMID:20457904
Biological Process	GO:0040018	positive regulation of multicellular organism growth	Flt3	IMP	MGI:MGI:3628823	Mouse	PMID:20457904
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Flt3	IGI	MGI:MGI:1344336	Mouse	PMID:20360400
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Flt3	IGI	MGI:MGI:95560	Mouse	PMID:20360400
Biological Process	GO:0032729	positive regulation of type II interferon production	Flt3	IMP	MGI:MGI:3628823	Mouse	PMID:20457904
Biological Process	GO:0009791	post-embryonic development	Flt3	IGI	MGI:MGI:96995	Mouse	PMID:22674806
Biological Process	GO:0002328	pro-B cell differentiation	Flt3	IMP		Mouse	MGI:MGI:4946600\|PMID:21228325
Biological Process	GO:0002328	pro-B cell differentiation	Flt3	IMP	MGI:MGI:2384051	Mouse	PMID:7621074
Biological Process	GO:0002572	pro-T cell differentiation	Flt3	IMP	MGI:MGI:2384051	Mouse	PMID:7621074
Biological Process	GO:0046777	protein autophosphorylation	Flt3	IDA		Mouse	PMID:8183574
Biological Process	GO:0046777	protein autophosphorylation	Flt3	IDA		Mouse	PMID:8384358
Biological Process	GO:0006468	protein phosphorylation	Flt3	IGI	MGI:MGI:1344336	Mouse	PMID:20360400
Biological Process	GO:0006468	protein phosphorylation	Flt3	IGI	MGI:MGI:95560	Mouse	PMID:20360400
Biological Process	GO:0010243	response to organonitrogen compound	Flt3	IEP		Rat	PMID:18031378\|RGD:2302207
Biological Process	GO:0048536	spleen development	Flt3	IGI	MGI:MGI:96995	Mouse	PMID:22674806

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.