Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FGF23
  • Mouse genes Fgf23
  • Rat genes Fgf23
  • Zfish genes fgf23
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fgf23

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005104	fibroblast growth factor receptor binding	Fgf23	IPI	PR:O35082	Mouse	PMID:16436388
Molecular Function	GO:0005104	fibroblast growth factor receptor binding	Fgf23	IPI	PR:P16092	Mouse	PMID:16436388
Molecular Function	GO:0005515	protein binding	FGF23	IPI	UniProtKB:O35082	Human	PMID:17086194
Molecular Function	GO:0005515	protein binding	FGF23	IPI	UniProtKB:O35082	Human	PMID:19966287
Molecular Function	GO:0005515	protein binding	FGF23	IPI	UniProtKB:P11362	Human	PMID:19966287
Molecular Function	GO:0005515	protein binding	Fgf23	IPI	UniProtKB:O35082	Mouse	MGI:MGI:3696596|PMID:17086194
Molecular Function	GO:0005105	type 1 fibroblast growth factor receptor binding	Fgf23	IPI	UniProtKB:P16092	Mouse	MGI:MGI:3696596|PMID:17086194
Cellular Component	GO:0005615	extracellular space	FGF23	IDA		Human	PMID:16638743
Cellular Component	GO:0005615	extracellular space	Fgf23	IDA		Mouse	PMID:24259513
Cellular Component	GO:0005615	extracellular space	Fgf23	IDA		Rat	PMID:15531762|RGD:1598934
Cellular Component	GO:0005615	extracellular space	Fgf23	IDA		Rat	PMID:20016468|RGD:10044210
Biological Process	GO:0055074	calcium ion homeostasis	Fgf23	IDA		Mouse	PMID:23523568
Biological Process	GO:0055074	calcium ion homeostasis	fgf23	IMP	ZFIN:ZDB-MRPHLNO-171024-3	Zfish	PMID:28323996
Biological Process	GO:0071354	cellular response to interleukin-6	Fgf23	IEP		Rat	PMID:23263654|RGD:10044209
Biological Process	GO:0044320	cellular response to leptin stimulus	Fgf23	IEP		Rat	PMID:23263654|RGD:10044209
Biological Process	GO:0071374	cellular response to parathyroid hormone stimulus	Fgf23	IEP		Rat	PMID:20685823|RGD:10044214
Biological Process	GO:0071305	cellular response to vitamin D	Fgf23	IEP		Rat	PMID:23263654|RGD:10044209
Biological Process	GO:0070371	ERK1 and ERK2 cascade	Fgf23	IDA		Mouse	PMID:23523568
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	Fgf23	IPI	PR:O35082	Mouse	PMID:16436388
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	Fgf23	IPI	PR:P16092	Mouse	PMID:16436388
Biological Process	GO:0030643	intracellular phosphate ion homeostasis	Fgf23	IMP	MGI:MGI:3512143	Mouse	PMID:15579309
Biological Process	GO:0000165	MAPK cascade	Fgf23	IDA		Mouse	PMID:24259513
Biological Process	GO:0030502	negative regulation of bone mineralization	FGF23	IDA		Human	PMID:18282132
Biological Process	GO:0046888	negative regulation of hormone secretion	Fgf23	IDA		Rat	PMID:17992255|RGD:8554413
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	FGF23	IDA		Human	PMID:18282132
Biological Process	GO:0055062	phosphate ion homeostasis	FGF23	IMP		Human	PMID:11062477
Biological Process	GO:0006796	phosphate-containing compound metabolic process	Fgf23	IEP		Rat	PMID:15531762|RGD:1598934
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Fgf23	IDA		Mouse	MGI:MGI:3696596|PMID:17086194
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Fgf23	IDA		Mouse	MGI:MGI:3696596|PMID:17086194
Biological Process	GO:0090080	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway	Fgf23	IGI	MGI:MGI:1101771	Mouse	PMID:16436388
Biological Process	GO:0010980	positive regulation of vitamin D 24-hydroxylase activity	FGF23	IDA		Human	PMID:15040831
Biological Process	GO:0030500	regulation of bone mineralization	Fgf23	IMP	MGI:MGI:3512143	Mouse	PMID:15579309
Biological Process	GO:0010966	regulation of phosphate transport	FGF23	IDA		Human	PMID:11409890
Biological Process	GO:0032026	response to magnesium ion	Fgf23	IEP		Rat	PMID:23608165|RGD:10044234
Biological Process	GO:1904383	response to sodium phosphate	Fgf23	IDA		Mouse	PMID:23523568
Biological Process	GO:1904383	response to sodium phosphate	Fgf23	IEP		Rat	PMID:24625659|RGD:10044230
Biological Process	GO:0042369	vitamin D catabolic process	FGF23	IDA		Human	PMID:15040831
Biological Process	GO:0042359	vitamin D metabolic process	Fgf23	IEP		Rat	PMID:15531762|RGD:1598934

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern