Fgf23
Gene Detail

Symbol Name ID

Fgf23 fibroblast growth factor 23 MGI:1891427

Feature Type

protein coding gene

Genetic Map

Chromosome 6

61.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr6:127072902-127081408 bp, + strand From NCBI annotation of GRCm38   8507 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:10771  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Fgf23

Human homologs

Human Homolog		FGF23, Fibroblast growth factor 23
NCBI Gene ID		8074
neXtProt AC		NX_Q9GZV9
Human Synonyms		ADHR, FGFN, HPDR2, HYPF, PHPTC
Human Chr (Location)		12p13.3; chr12:4477393-4488894 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human FGF23

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Homozygous mutant mice are severely growth retarded and die prematurely. They exhibit hypophosphatemia, abnormal vitamin D metabolism, renal defects, skeletal defects, and are infertile.

 
Human Diseases Modeled Using Mouse Fgf23 (1)    Alleles Annotated to Human Diseases(3)    Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	cell differentiation, cellular phosphate ion homeostasis, ...
Component	extracellular region, extracellular region part, ...
Function	fibroblast growth factor receptor binding, growth factor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (98)    Tissues (98)    Images (2)
Theiler Stages: 22, 24, 25

Assay Type	Results
RNA in situ	97
RT-PCR	1

cDNA source data(5)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(8) cDNA(5) Primer pair(2) Other(1)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000000182 (Evidence)
Entrez Gene	64654 (Evidence)
UniGene	347933
DFCI	TC1584511
DoTS	DT.99565441
NIA Mouse Gene Index	U007432
Consensus CDS Project	CCDS20562.1
International Mouse Knockout Project Status	Fgf23

Sequences

Length	Strain/Species
genomic	64654	NCBI Gene Model | MGI Sequence Detail	8507	C57BL/6J
transcript	NM_022657	RefSeq | MGI Sequence Detail	2702	C57BL/6
polypeptide	Q9EPC2	UniProt | EBI | MGI Sequence Detail	251	Not Applicable

All sequences(16) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(19 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008996	Cytokine, IL-1-like
InterPro	IPR002348	Interleukin 1/heparin-binding growth factor
Protein Ontology	PR:000007493	fibroblast growth factor 23

Graphical View of Protein Domain Structure

References

(Earliest) J:65463 White KE, et al., Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23. Nat Genet. 2000 Nov;26(3):345-8
(Latest) J:188437 Krieger NS, et al., Metabolic acidosis increases fibroblast growth factor 23 in neonatal mouse bone. Am J Physiol Renal Physiol. 2012 Aug 1;303(3):F431-6
All references(64)