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Fgf23
Gene Detail
 Symbol
Name
ID
Fgf23
fibroblast growth factor 23
MGI:1891427
Feature Type protein coding gene
Genetic Map
Chromosome 6
61.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr6:127072902-127081408 bp, + strand
From NCBI annotation of GRCm38

  8507 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10771  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Fgf23

Human
homologs
Human Homolog FGF23, Fibroblast growth factor 23
NCBI Gene ID 8074
neXtProt AC  NX_Q9GZV9
Human Synonyms  ADHR, FGFN, HPDR2, HYPF, PHPTC
Human Chr (Location)  12p13.3; chr12:4368227-4379728 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human FGF23
Alleles
and
phenotypes
All alleles(6) : Targeted(6)
 
Homozygous mutant mice are severely growth retarded and die prematurely. They exhibit hypophosphatemia, abnormal vitamin D metabolism, renal defects, skeletal defects, and are infertile.
 
Human Diseases Modeled Using Mouse Fgf23 (1)    Alleles Annotated to Human Diseases(3)    Phenotype Images(2)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process cell differentiation, cellular phosphate ion homeostasis, ...
Component extracellular region, extracellular space
Function fibroblast growth factor receptor binding, growth factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (147)    Tissues (147)    Images (4)
Theiler Stages: 22, 24, 25, 26, 28
Assay TypeResults
RNA in situ 146
RT-PCR 1
cDNA source data(5)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(8) cDNA(5) Primer pair(2) Other(1)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000000182 (Evidence)
Entrez Gene64654 (Evidence)
UniGene347933
DFCITC1584511
DoTSDT.99565441
NIA Mouse Gene IndexU007432
Consensus CDS ProjectCCDS20562.1
International Mouse Knockout Project StatusFgf23
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 64654 NCBI Gene Model | MGI Sequence Detail 8507 C57BL/6J ±  kb
transcript NM_022657 RefSeq | MGI Sequence Detail 2702 C57BL/6 
polypeptide Q9EPC2 UniProt | EBI | MGI Sequence Detail 251 Not Applicable 

For the selected sequences
All sequences(16) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(109 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008996 Cytokine, IL-1-like
InterPro IPR002209 Heparin-binding growth factor/Fibroblast growth factor
Protein Ontology PR:000007493 fibroblast growth factor 23
Graphical View of Protein Domain Structure
References (Earliest) J:65463 White KE, et al., Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23. Nat Genet. 2000 Nov;26(3):345-8
(Latest) J:206448 Andrukhova O, et al., FGF23 promotes renal calcium reabsorption through the TRPV5 channel. EMBO J. 2014 Feb 3;33(3):229-46
All references(66)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory