Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FFAR1
  • Mouse genes Ffar1
  • Rat genes Ffar1
  • Zfish genes si:dkey-211g8.9
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ffar1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0045125	bioactive lipid receptor activity	FFAR1	IDA		Human	PMID:24130766
Molecular Function	GO:0045125	bioactive lipid receptor activity	Ffar1	IDA		Mouse	MGI:MGI:5607397|PMID:24130766
Molecular Function	GO:0005504	fatty acid binding	Ffar1	IDA		Rat	PMID:12496284|RGD:632951
Molecular Function	GO:0004930	G protein-coupled receptor activity	Ffar1	IDA		Mouse	PMID:31664108
Molecular Function	GO:0005096	GTPase activator activity	Ffar1	IDA		Mouse	PMID:31664108
Cellular Component	GO:0005886	plasma membrane	FFAR1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	FFAR1	IDA		Human	PMID:24130766
Cellular Component	GO:0005886	plasma membrane	FFAR1	IDA		Human	PMID:25043059
Cellular Component	GO:0005886	plasma membrane	Ffar1	IDA		Mouse	MGI:MGI:5607397|PMID:24130766
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Ffar1	IDA		Rat	PMID:12496284|RGD:632951
Biological Process	GO:0042593	glucose homeostasis	Ffar1	IMP		Mouse	MGI:MGI:5607397|PMID:24130766
Biological Process	GO:0042593	glucose homeostasis	Ffar1	IMP	MGI:MGI:3713759	Mouse	PMID:17395749
Biological Process	GO:0030073	insulin secretion	Ffar1	IMP	MGI:MGI:3713759	Mouse	PMID:17395749
Biological Process	GO:0099105	ion channel modulating, G protein-coupled receptor signaling pathway	Ffar1	IDA		Mouse	PMID:31664108
Biological Process	GO:1990806	ligand-gated ion channel signaling pathway	Ffar1	IDA		Mouse	PMID:31664108
Biological Process	GO:0032691	negative regulation of interleukin-1 beta production	FFAR1	IMP		Human	PMID:23809162
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	Ffar1	IDA		Mouse	PMID:31664108
Biological Process	GO:0051928	positive regulation of calcium ion transport	FFAR1	IDA		Human	PMID:24130766
Biological Process	GO:0051928	positive regulation of calcium ion transport	Ffar1	IDA		Mouse	MGI:MGI:5607397|PMID:24130766
Biological Process	GO:0010524	positive regulation of calcium ion transport into cytosol	Ffar1	IMP		Rat	PMID:15914509|RGD:2315052
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	FFAR1	IDA		Human	PMID:24742677
Biological Process	GO:0032024	positive regulation of insulin secretion	Ffar1	IMP		Mouse	MGI:MGI:5607397|PMID:24130766
Biological Process	GO:0032024	positive regulation of insulin secretion	Ffar1	IDA		Mouse	PMID:31664108
Biological Process	GO:0032024	positive regulation of insulin secretion	Ffar1	IMP		Rat	PMID:16081037|RGD:2315053
Biological Process	GO:0070542	response to fatty acid	FFAR1	IDA		Human	PMID:24130766
Biological Process	GO:0070542	response to fatty acid	Ffar1	IDA		Mouse	MGI:MGI:5607397|PMID:24130766

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern