Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FECH
  • Mouse genes Fech
  • Rat genes Fech
  • Zfish genes fech
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fech

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004325	ferrochelatase activity	FECH	IDA		Human	PMID:15123683
Molecular Function	GO:0004325	ferrochelatase activity	FECH	IDA		Human	PMID:27599036
Molecular Function	GO:0004325	ferrochelatase activity	FECH	IDA		Human	PMID:8973195
Molecular Function	GO:0004325	ferrochelatase activity	Fech	IMP	MGI:MGI:2384729	Mouse	PMID:9989256
Molecular Function	GO:0004325	ferrochelatase activity	Fech	IMP	MGI:MGI:1858114	Mouse	PMID:17003376
Molecular Function	GO:0004325	ferrochelatase activity	Fech	IDA		Mouse	PMID:16503645
Molecular Function	GO:0004325	ferrochelatase activity	Fech	IMP	MGI:MGI:1858114	Mouse	PMID:16306232
Molecular Function	GO:0004325	ferrochelatase activity	Fech	IDA		Mouse	PMID:15496139
Molecular Function	GO:0004325	ferrochelatase activity	Fech	IMP	MGI:MGI:1858114	Mouse	PMID:8325637
Molecular Function	GO:0004325	ferrochelatase activity	Fech	IDA		Mouse	PMID:14981080
Molecular Function	GO:0004325	ferrochelatase activity	Fech	IDA		Mouse	PMID:12149233
Molecular Function	GO:0004325	ferrochelatase activity	Fech	IDA		Rat	PMID:1316128|RGD:1598931
Molecular Function	GO:0004325	ferrochelatase activity	fech	IMP	ZFIN:ZDB-GENO-980202-296	Zfish	PMID:10985389
Molecular Function	GO:0020037	heme binding	Fech	IDA		Mouse	PMID:16503645
Molecular Function	GO:0005506	iron ion binding	Fech	IDA		Mouse	PMID:14981080
Molecular Function	GO:0030350	iron-responsive element binding	Fech	IDA		Mouse	PMID:7575558
Molecular Function	GO:0005515	protein binding	FECH	IPI	UniProtKB:Q16595	Human	PMID:15123683
Molecular Function	GO:0005515	protein binding	FECH	IPI	UniProtKB:O00264	Human	PMID:27599036
Molecular Function	GO:0005515	protein binding	FECH	IPI	UniProtKB:O75027,UniProtKB:Q9JI39	Human	PMID:30765471
Molecular Function	GO:0005515	protein binding	FECH	IPI	UniProtKB:Q9NRK6	Human	PMID:30765471
Molecular Function	GO:0005515	protein binding	Fech	IPI	UniProtKB:Q61102,UniProtKB:Q9JI39	Mouse	MGI:MGI:6695684|PMID:30765471
Molecular Function	GO:0005515	protein binding	Fech	IPI	UniProtKB:Q920G8|UniProtKB:Q9JI39	Mouse	MGI:MGI:4819907|PMID:20427704
Molecular Function	GO:0005515	protein binding	Fech	IPI	UniProtKB:O15173	Mouse	MGI:MGI:5810216|PMID:27599036
Molecular Function	GO:0042803	protein homodimerization activity	FECH	IDA		Human	PMID:30765471
Molecular Function	GO:0046906	tetrapyrrole binding	Fech	IDA		Mouse	PMID:16503645
Molecular Function	GO:0046906	tetrapyrrole binding	Fech	IDA		Mouse	PMID:15496139
Molecular Function	GO:0046906	tetrapyrrole binding	Fech	IDA		Mouse	PMID:14981080
Cellular Component	GO:0005743	mitochondrial inner membrane	Fech	IDA		Mouse	MGI:MGI:5810216|PMID:27599036
Cellular Component	GO:0005739	mitochondrion	Fech	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Fech	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Fech	IDA		Rat	PMID:3741431|RGD:4145287
Biological Process	GO:0071549	cellular response to dexamethasone stimulus	Fech	IEP		Rat	PMID:7917467|RGD:4144799
Biological Process	GO:0008203	cholesterol metabolic process	Fech	IMP	MGI:MGI:1858114	Mouse	PMID:11160364
Biological Process	GO:0009589	detection of UV	Fech	IMP	MGI:MGI:2384729	Mouse	PMID:12149233
Biological Process	GO:0030218	erythrocyte differentiation	Fech	IMP	MGI:MGI:1858114	Mouse	PMID:1939658
Biological Process	GO:0043249	erythrocyte maturation	fech	IMP	ZFIN:ZDB-GENO-091118-1	Zfish	PMID:9007250
Biological Process	GO:0043249	erythrocyte maturation	fech	IMP	ZFIN:ZDB-GENO-120312-30	Zfish	PMID:9007250
Biological Process	GO:0043249	erythrocyte maturation	fech	IMP	ZFIN:ZDB-GENO-120312-32	Zfish	PMID:9007250
Biological Process	GO:0043249	erythrocyte maturation	fech	IMP	ZFIN:ZDB-GENO-980202-296	Zfish	PMID:9007250
Biological Process	GO:0006783	heme biosynthetic process	FECH	IDA		Human	PMID:27599036
Biological Process	GO:0006783	heme biosynthetic process	Fech	IDA		Mouse	PMID:16503645
Biological Process	GO:0006783	heme biosynthetic process	Fech	IMP	MGI:MGI:2384729	Mouse	PMID:9989256
Biological Process	GO:0006783	heme biosynthetic process	Fech	IDA		Mouse	PMID:15496139
Biological Process	GO:0006783	heme biosynthetic process	Fech	IMP	MGI:MGI:1858114	Mouse	PMID:16306232
Biological Process	GO:0006783	heme biosynthetic process	Fech	IMP		Mouse	PMID:8611576
Biological Process	GO:0006783	heme biosynthetic process	Fech	IDA		Rat	PMID:3955059|RGD:1600961
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	Fech	IMP	MGI:MGI:1858114	Mouse	PMID:17003376
Biological Process	GO:0006779	porphyrin-containing compound biosynthetic process	Fech	IMP	MGI:MGI:2384729	Mouse	PMID:12149233
Biological Process	GO:0046501	protoporphyrinogen IX metabolic process	FECH	IDA		Human	PMID:15123683
Biological Process	GO:0046501	protoporphyrinogen IX metabolic process	Fech	IGI	MGI:MGI:1353448	Mouse	PMID:15931390
Biological Process	GO:0046501	protoporphyrinogen IX metabolic process	Fech	IGI	MGI:MGI:95513	Mouse	PMID:15931390
Biological Process	GO:0010999	regulation of eIF2 alpha phosphorylation by heme	Fech	IGI	MGI:MGI:1353448	Mouse	PMID:15931390
Biological Process	GO:0010999	regulation of eIF2 alpha phosphorylation by heme	Fech	IMP	MGI:MGI:1858114	Mouse	PMID:15931390
Biological Process	GO:0010999	regulation of eIF2 alpha phosphorylation by heme	Fech	IGI	MGI:MGI:95513	Mouse	PMID:15931390
Biological Process	GO:0010468	regulation of gene expression	Fech	IMP		Mouse	PMID:23395172
Biological Process	GO:0046984	regulation of hemoglobin biosynthetic process	Fech	IGI	MGI:MGI:95513	Mouse	PMID:15931390
Biological Process	GO:0046984	regulation of hemoglobin biosynthetic process	Fech	IGI	MGI:MGI:1353448	Mouse	PMID:15931390
Biological Process	GO:0046685	response to arsenic-containing substance	Fech	IEP		Rat	PMID:908300|RGD:4145284
Biological Process	GO:0045471	response to ethanol	Fech	IEP		Rat	PMID:12426626|RGD:4144182
Biological Process	GO:0017085	response to insecticide	Fech	IEP		Rat	PMID:6626236|RGD:1600962
Biological Process	GO:0010288	response to lead ion	Fech	IEP		Rat	PMID:4065316|RGD:4144206
Biological Process	GO:0009416	response to light stimulus	Fech	IMP	MGI:MGI:1858114	Mouse	PMID:1939658
Biological Process	GO:0010038	response to metal ion	Fech	IEP		Rat	PMID:3629603|RGD:4144818
Biological Process	GO:0051597	response to methylmercury	Fech	IEP		Rat	PMID:3327437|RGD:4145123
Biological Process	GO:0070541	response to platinum ion	Fech	IEP		Rat	PMID:4040350|RGD:4144805
Biological Process	GO:0009410	response to xenobiotic stimulus	Fech	IEP		Rat	PMID:6721832|RGD:4144806
Biological Process	GO:0034379	very-low-density lipoprotein particle assembly	Fech	IMP	MGI:MGI:1858114	Mouse	PMID:11160364

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern