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Fech Gene Detail
Summary
  • Symbol
    Fech
  • Name
    ferrochelatase
  • Synonyms
    fch, Fcl
  • Feature Type
    protein coding gene
  • IDs
    MGI:95513
    NCBI Gene: 14151
  • Gene Overview
    MyGene.info: FECH
Location & Maps
more
  • Sequence Map
    Chr18:64456550-64489066 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      32517 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 37.43 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    FECH, ferrochelatase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FECH, ferrochelatase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EPP, FCE
  • Links
    NCBI Gene ID: 2235
    neXtProt AC: NX_P22830

  • Chr Location
    18q21.31; chr18:57544841-57586737 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Fech mouse models; 1 with human FECH associations

Human Disease Mouse Models
       Protoporphyria, Erythropoietic; EPP   OMIM: 177000 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (ENU)
    1
  • Gene trapped
    2
  • Targeted
    1
  • Incidental Mutations
Homozygotes for an ENU-induced mutation exhibit hemolytic anemia, photosensitivity, cholestasis, and hepatic dysfunction. Homozygotes for a targeted null mutation die prior to embryonic day 3.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024588 Ensembl Gene Model | MGI Sequence Detail 32517 C57BL/6J ±  kb
transcript ENSMUST00000025484 Ensembl | MGI Sequence Detail 2901 Not Applicable  
polypeptide ENSMUSP00000025484 Ensembl | MGI Sequence Detail 422 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    186 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 151
    cDNA 150
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-9737, MGD-MRK-9755, MGI:2147283
References
more
  • Summaries
    All 68
    Developmental Gene Expression 7
    Diseases 2
    Gene Ontology 20
    Phenotypes 20
  • Earliest
    J:5439 Bannerman RM, et al., Hereditary disorders of the red cell in animals. Prog Hematol. 1973;8:131-79
  • Latest
    J:229390 Doty RT, et al., Coordinate expression of heme and globin is essential for effective erythropoiesis. J Clin Invest. 2015 Dec;125(12):4681-91

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory