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Fech Gene Detail
Summary
  • Symbol
    Fech
  • Name
    ferrochelatase
  • Synonyms
    fch, Fcl
  • Feature Type
    protein coding gene
  • IDs
    MGI:95513
    NCBI Gene: 14151
  • Gene Overview
    MyGene.info: FECH
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:64456550-64489066 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 37.43 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    186 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95513
protein coding gene Chr18:64456542-64489097 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024503
protein coding gene Chr18:64505332-64539833 (-)
A/J MGP_AJ_G0024470
protein coding gene Chr18:61730871-61762986 (-)
AKR/J MGP_AKRJ_G0024440
protein coding gene Chr18:63457441-63490243 (-)
BALB/cJ MGP_BALBcJ_G0024469
protein coding gene Chr18:61875779-61908876 (-)
C3H/HeJ MGP_C3HHeJ_G0024237
protein coding gene Chr18:63674995-63708859 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024916
protein coding gene Chr18:66242503-66275218 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022347
protein coding gene Chr18:61173701-61208144 (-)
CAST/EiJ MGP_CASTEiJ_G0023710
protein coding gene Chr18:63592685-63625134 (-)
CBA/J MGP_CBAJ_G0024207
protein coding gene Chr18:68388319-68420669 (-)
DBA/2J MGP_DBA2J_G0024337
protein coding gene Chr18:61397543-61430126 (-)
FVB/NJ MGP_FVBNJ_G0024303
protein coding gene Chr18:60774315-60808182 (-)
LP/J MGP_LPJ_G0024421
protein coding gene Chr18:64373515-64407068 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024332
protein coding gene Chr18:69885551-69919965 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024963
protein coding gene Chr18:63671268-63703674 (-)
PWK/PhJ MGP_PWKPhJ_G0023453
protein coding gene Chr18:61625105-61658269 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023258
protein coding gene Chr18:63819455-63854795 (-)
WSB/EiJ MGP_WSBEiJ_G0023774
protein coding gene Chr18:63527213-63561633 (-)



Homology
more
  • Human Ortholog
    FECH, ferrochelatase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FECH, ferrochelatase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EPP, EPP1, FCE
  • Links
    NCBI Gene ID: 2235
    neXtProt AC: NX_P22830
    UniProt: P22830

  • Chr Location
    18q21.31; chr18:57544841-57586737 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Fech mouse models; 1 with human FECH associations

Human Disease Mouse Models
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for an ENU-induced mutation exhibit hemolytic anemia, photosensitivity, cholestasis, and hepatic dysfunction. Homozygotes for a targeted null mutation die prior to embryonic day 3.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024588 Ensembl Gene Model | MGI Sequence Detail 32517 C57BL/6J ±  kb
    transcript ENSMUST00000025484 Ensembl | MGI Sequence Detail 2901 Not Applicable  
    polypeptide ENSMUSP00000025484 Ensembl | MGI Sequence Detail 422 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 152
      cDNA 151
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-9737, MGD-MRK-9755, MGI:2147283
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 7
      Diseases 2
      Gene Ontology 23
      Phenotypes 23
    • Earliest
      J:5439 Bannerman RM, et al., Hereditary disorders of the red cell in animals. Prog Hematol. 1973;8:131-79
    • Latest
      J:262449 Basavarajappa HD, et al., Ferrochelatase is a therapeutic target for ocular neovascularization. EMBO Mol Med. 2017 Jun;9(6):786-801

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    03/13/2019
    MGI 6.13
    The Jackson Laboratory