Fech
Gene Detail

Symbol Name ID

Fech ferrochelatase MGI:95513

Synonyms

fch, Fcl

Feature Type

protein coding gene

Genetic Map

Chromosome 18

37.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr18:64456550-64489066 bp, - strand From NCBI annotation of GRCm38   32517 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:113  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: ferrochelatase
Gene Tree: Fech

Human homologs

Human Homolog		FECH, ferrochelatase
NCBI Gene ID		2235
neXtProt AC		NX_P22830
Human Synonyms		EPP, FCE
Human Chr (Location)		18q21.3; chr18:55212073-55253969 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human FECH

Alleles and phenotypes

All alleles(4) : Targeted(1) Gene trapped(2) Chemically induced(1)
 

Homozygotes for an ENU-induced mutation exhibit hemolytic anemia, photosensitivity, cholestasis, and hepatic dysfunction. Homozygotes for a targeted null mutation die prior to embryonic day 3.5.

 
Human Diseases Modeled Using Mouse Fech (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (35 annotations)

Process	cholesterol metabolic process, detection of UV, ...
Component	membrane, mitochondrial inner membrane, ...
Function	2 iron, 2 sulfur cluster binding, ferrochelatase activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (147)    Tissues (98)    Images (31)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	147

cDNA source data(148)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(149) cDNA(148) Primer pair(1)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000024588 (Evidence)
Entrez Gene	14151 (Evidence)
UniGene	1070
DFCI	TC1574692, TC1607015, TC1623144, TC1634946
DoTS	DT.87069602, DT.91430047, DT.94138223, DT.94324993, DT.94324996, DT.99757948
NIA Mouse Gene Index	U084841
EC	4.99.1.1
Consensus CDS Project	CCDS29303.1
International Mouse Knockout Project Status	Fech

Sequences

Length	Strain/Species
genomic	14151	NCBI Gene Model | MGI Sequence Detail	32517	C57BL/6J
transcript	NM_007998	RefSeq | MGI Sequence Detail	2901	C57BL/6
polypeptide	P22315	UniProt | EBI | MGI Sequence Detail	420	Not Applicable

All sequences(43) RefSeq(2) UniProt(6)

Polymorphisms

SNPs(177 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001015	Ferrochelatase
InterPro	IPR019772	Ferrochelatase, active site
Protein Ontology	PR:000007453	ferrochelatase, mitochondrial

Graphical View of Protein Domain Structure

References

(Earliest) J:5439 Bannerman RM, et al., Hereditary disorders of the red cell in animals. Prog Hematol. 1973;8:131-79
(Latest) J:169473 McIntyre NR, et al., Nickel(II) Chelatase Variants Directly Evolved from Murine Ferrochelatase: Porphyrin Distortion and Kinetic Mechanism. Biochemistry. 2011 Mar 8;50(9):1535-44
All references(69)

Other accession IDs

MGD-MRK-9737, MGD-MRK-9755, MGI:2147283