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Fech
Gene Detail
 Symbol
Name
ID
Fech
ferrochelatase
MGI:95513
Synonyms fch, Fcl
Feature Type protein coding gene
Genetic Map
Chromosome 18
37.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr18:64456550-64489066 bp, - strand
From NCBI annotation of GRCm38

  32517 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:113  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: ferrochelatase
Gene Tree: Fech

Human
homologs
Human Homolog FECH, ferrochelatase
NCBI Gene ID 2235
neXtProt AC  NX_P22830
Human Synonyms  EPP, FCE
Human Chr (Location)  18q21.3; chr18:57544841-57586737 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human FECH
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Chemically induced (ENU)(1) Gene trapped(2) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for an ENU-induced mutation exhibit hemolytic anemia, photosensitivity, cholestasis, and hepatic dysfunction. Homozygotes for a targeted null mutation die prior to embryonic day 3.5.
 
Human Diseases Modeled Using Mouse Fech (1)    Alleles Annotated to Human Diseases(2)   
Interactions
Fech interacts with 218 markers (Mir1b, Mir10a, Mir10b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process cholesterol metabolic process, detection of UV, ...
Component membrane, mitochondrial inner membrane, ...
Function 2 iron, 2 sulfur cluster binding, ferrochelatase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (147)    Tissues (98)    Images (31)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 147
cDNA source data(150)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(151) cDNA(150) Primer pair(1)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000024588 (Evidence)
Entrez Gene14151 (Evidence)
UniGene1070
DFCITC1574692, TC1607015, TC1623144, TC1634946
DoTSDT.87069602, DT.91430047, DT.94138223, DT.94324993, DT.94324996, DT.99757948
NIA Mouse Gene IndexU084841
EC4.99.1.1
Consensus CDS ProjectCCDS29303.1
International Mouse Knockout Project StatusFech
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14151 NCBI Gene Model | MGI Sequence Detail 32517 C57BL/6J ±  kb
transcript NM_007998 RefSeq | MGI Sequence Detail 2901 C57BL/6 
polypeptide P22315 UniProt | EBI | MGI Sequence Detail 420 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(3) UniProt(6)
Polymorphisms SNPs within 2kb(186 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001015 Ferrochelatase
InterPro IPR019772 Ferrochelatase, active site
Protein Ontology PR:000007453 ferrochelatase, mitochondrial
Graphical View of Protein Domain Structure
References (Earliest) J:5439 Bannerman RM, et al., Hereditary disorders of the red cell in animals. Prog Hematol. 1973;8:131-79
(Latest) J:203507 White C, et al., HRG1 is essential for heme transport from the phagolysosome of macrophages during erythrophagocytosis. Cell Metab. 2013 Feb 5;17(2):261-70
All references(70)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-9737, MGD-MRK-9755, MGI:2147283

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory