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Fech
Gene Detail
Symbol

Name
ID
Fech
ferrochelatase
MGI:95513
Synonyms
fch, Fcl
Feature Type
protein coding gene
Genetic Map
Chromosome 18
37.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr18:64456550-64489066 bp, - strand
From Ensembl annotation of GRCm38

  32517 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:113  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FECH
Protein SuperFamily: ferrochelatase
Gene Tree: Fech

Human
homologs
FECH, ferrochelatase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2235
neXtProt AC: NX_P22830

Human Synonyms: EPP, FCE

Human Chr (Location): 18q21.3; chr18:57544841-57586737 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human FECH

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Chemically induced (ENU)(1) Gene trapped(2) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for an ENU-induced mutation exhibit hemolytic anemia, photosensitivity, cholestasis, and hepatic dysfunction. Homozygotes for a targeted null mutation die prior to embryonic day 3.5.
 
Human Diseases Modeled in Mice Using Fech (1)    Mutations Annotated to Human Diseases (2)   
Interactions
Fech interacts with 218 markers (Mir1b, Mir10a, Mir10b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process cholesterol metabolic process, detection of UV, ...
Component membrane, mitochondrial inner membrane, ...
Function 2 iron, 2 sulfur cluster binding, ferrochelatase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (147)    Tissues (98)    Images (31)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 147
cDNA source data(150)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase fech    NEW 
Molecular
reagents
All nucleic(151) cDNA(150) Primer pair(1)
Microarray probesets(6)
Other database
links
Ensembl Gene Model ENSMUSG00000024588 (Evidence)
Entrez Gene 14151 (Evidence)
UniGene 1070
DFCI TC1574692, TC1607015, TC1623144, TC1634946
DoTS DT.87069602, DT.91430047, DT.94138223, DT.94324993, DT.94324996, DT.99757948
NIA Mouse Gene Index U084841
EC 4.99.1.1
Consensus CDS Project CCDS29303.1
International Mouse Phenotyping Consortium Status Fech
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024588 Ensembl Gene Model | MGI Sequence Detail 32517 C57BL/6J ±  kb
transcript ENSMUST00000025484 Ensembl | MGI Sequence Detail 2901 Not Applicable 
polypeptide ENSMUSP00000025484 Ensembl | MGI Sequence Detail 422 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(3) UniProt(6)
Polymorphisms
SNPs within 2kb(186 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001015 Ferrochelatase
InterPro IPR019772 Ferrochelatase, active site
Protein Ontology PR:000007453 ferrochelatase, mitochondrial
References
(Earliest) J:5439 Bannerman RM, et al., Hereditary disorders of the red cell in animals. Prog Hematol. 1973;8:131-79
(Latest) J:221206 Smith CM, et al., Red cells from ferrochelatase-deficient erythropoietic protoporphyria patients are resistant to growth of malarial parasites. Blood. 2015 Jan 15;125(3):534-41
All references(69)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-9737, MGD-MRK-9755, MGI:2147283

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory