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Gene Ontology Browser
Term Detail
GO term:heme biosynthetic process
Synonym: haem biosynthesis
Synonym: haem biosynthetic process
Synonym: heme anabolism
Synonym: heme biosynthesis
Synonym: heme formation
Synonym: heme synthesis
GO id:GO:0006783
Definition:The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors.
Number of paths to term: 62

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular metabolic process
                                is-acellular aromatic compound metabolic process
                                        is-aaromatic compound biosynthetic process
                                                is-atetrapyrrole biosynthetic process
                                                        is-aporphyrin-containing compound biosynthetic process
                                                                is-achlorophyll biosynthetic process +
                                                                is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                                        is-aheme a biosynthetic process
                                                                        is-aheme b biosynthetic process
                                                                        is-aheme c biosynthetic process
                                                                        is-aheme O biosynthetic process
                                                                        negatively-regulatesnegative regulation of heme biosynthetic process
                                                                        positively-regulatespositive regulation of heme biosynthetic process
                                                                        part-ofprotoporphyrinogen IX biosynthetic process +
                                                                        regulatesregulation of heme biosynthetic process +
                                                                        is-asiroheme biosynthetic process
                                                                is-aprotoporphyrinogen IX biosynthetic process +
                                                                is-asuccinyl-CoA pathway
                                                                is-auroporphyrinogen III biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular metabolic process
                                is-acellular aromatic compound metabolic process
                                        is-atetrapyrrole metabolic process
                                                is-aporphyrin-containing compound metabolic process
                                                        is-aheme metabolic process
                                                                is-aheme a metabolic process +
                                                                is-aheme b metabolic process +
                                                                is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                                        is-aheme a biosynthetic process
                                                                        is-aheme b biosynthetic process
                                                                        is-aheme c biosynthetic process
                                                                        is-aheme O biosynthetic process
                                                                        negatively-regulatesnegative regulation of heme biosynthetic process
                                                                        positively-regulatespositive regulation of heme biosynthetic process
                                                                        part-ofprotoporphyrinogen IX biosynthetic process +
                                                                        regulatesregulation of heme biosynthetic process +
                                                                        is-asiroheme biosynthetic process
                                                                is-aheme c metabolic process +
                                                                is-aheme catabolic process +
                                                                is-aheme o metabolic process +
                                                                is-aheme oxidation
                                                                is-asiroheme metabolic process +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular metabolic process
                                is-acellular aromatic compound metabolic process
                                        is-atetrapyrrole metabolic process
                                                is-aporphyrin-containing compound metabolic process
                                                        is-aporphyrin-containing compound biosynthetic process
                                                                is-achlorophyll biosynthetic process +
                                                                is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                                        is-aheme a biosynthetic process
                                                                        is-aheme b biosynthetic process
                                                                        is-aheme c biosynthetic process
                                                                        is-aheme O biosynthetic process
                                                                        negatively-regulatesnegative regulation of heme biosynthetic process
                                                                        positively-regulatespositive regulation of heme biosynthetic process
                                                                        part-ofprotoporphyrinogen IX biosynthetic process +
                                                                        regulatesregulation of heme biosynthetic process +
                                                                        is-asiroheme biosynthetic process
                                                                is-aprotoporphyrinogen IX biosynthetic process +
                                                                is-asuccinyl-CoA pathway
                                                                is-auroporphyrinogen III biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular metabolic process
                                is-acellular aromatic compound metabolic process
                                        is-atetrapyrrole metabolic process
                                                is-atetrapyrrole biosynthetic process
                                                        is-aporphyrin-containing compound biosynthetic process
                                                                is-achlorophyll biosynthetic process +
                                                                is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                                        is-aheme a biosynthetic process
                                                                        is-aheme b biosynthetic process
                                                                        is-aheme c biosynthetic process
                                                                        is-aheme O biosynthetic process
                                                                        negatively-regulatesnegative regulation of heme biosynthetic process
                                                                        positively-regulatespositive regulation of heme biosynthetic process
                                                                        part-ofprotoporphyrinogen IX biosynthetic process +
                                                                        regulatesregulation of heme biosynthetic process +
                                                                        is-asiroheme biosynthetic process
                                                                is-aprotoporphyrinogen IX biosynthetic process +
                                                                is-asuccinyl-CoA pathway
                                                                is-auroporphyrinogen III biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular metabolic process
                                is-acellular biosynthetic process
                                        is-aaromatic compound biosynthetic process
                                                is-atetrapyrrole biosynthetic process
                                                        is-aporphyrin-containing compound biosynthetic process
                                                                is-achlorophyll biosynthetic process +
                                                                is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                                        is-aheme a biosynthetic process
                                                                        is-aheme b biosynthetic process
                                                                        is-aheme c biosynthetic process
                                                                        is-aheme O biosynthetic process
                                                                        negatively-regulatesnegative regulation of heme biosynthetic process
                                                                        positively-regulatespositive regulation of heme biosynthetic process
                                                                        part-ofprotoporphyrinogen IX biosynthetic process +
                                                                        regulatesregulation of heme biosynthetic process +
                                                                        is-asiroheme biosynthetic process
                                                                is-aprotoporphyrinogen IX biosynthetic process +
                                                                is-asuccinyl-CoA pathway
                                                                is-auroporphyrinogen III biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular metabolic process
                                is-acellular biosynthetic process
                                        is-acellular nitrogen compound biosynthetic process
                                                is-atetrapyrrole biosynthetic process
                                                        is-aporphyrin-containing compound biosynthetic process
                                                                is-achlorophyll biosynthetic process +
                                                                is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                                        is-aheme a biosynthetic process
                                                                        is-aheme b biosynthetic process
                                                                        is-aheme c biosynthetic process
                                                                        is-aheme O biosynthetic process
                                                                        negatively-regulatesnegative regulation of heme biosynthetic process
                                                                        positively-regulatespositive regulation of heme biosynthetic process
                                                                        part-ofprotoporphyrinogen IX biosynthetic process +
                                                                        regulatesregulation of heme biosynthetic process +
                                                                        is-asiroheme biosynthetic process
                                                                is-aprotoporphyrinogen IX biosynthetic process +
                                                                is-asuccinyl-CoA pathway
                                                                is-auroporphyrinogen III biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular metabolic process
                                is-acellular biosynthetic process
                                        is-acofactor biosynthetic process
                                                is-aporphyrin-containing compound biosynthetic process
                                                        is-achlorophyll biosynthetic process +
                                                        is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                                is-aheme a biosynthetic process
                                                                is-aheme b biosynthetic process
                                                                is-aheme c biosynthetic process
                                                                is-aheme O biosynthetic process
                                                                negatively-regulatesnegative regulation of heme biosynthetic process
                                                                positively-regulatespositive regulation of heme biosynthetic process
                                                                part-ofprotoporphyrinogen IX biosynthetic process +
                                                                regulatesregulation of heme biosynthetic process +
                                                                is-asiroheme biosynthetic process
                                                        is-aprotoporphyrinogen IX biosynthetic process +
                                                        is-asuccinyl-CoA pathway
                                                        is-auroporphyrinogen III biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular metabolic process
                                is-acellular biosynthetic process
                                        is-aheterocycle biosynthetic process
                                                is-atetrapyrrole biosynthetic process
                                                        is-aporphyrin-containing compound biosynthetic process
                                                                is-achlorophyll biosynthetic process +
                                                                is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                                        is-aheme a biosynthetic process
                                                                        is-aheme b biosynthetic process
                                                                        is-aheme c biosynthetic process
                                                                        is-aheme O biosynthetic process
                                                                        negatively-regulatesnegative regulation of heme biosynthetic process
                                                                        positively-regulatespositive regulation of heme biosynthetic process
                                                                        part-ofprotoporphyrinogen IX biosynthetic process +
                                                                        regulatesregulation of heme biosynthetic process +
                                                                        is-asiroheme biosynthetic process
                                                                is-aprotoporphyrinogen IX biosynthetic process +
                                                                is-asuccinyl-CoA pathway
                                                                is-auroporphyrinogen III biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular metabolic process
                                is-acellular nitrogen compound metabolic process
                                        is-acellular nitrogen compound biosynthetic process
                                                is-atetrapyrrole biosynthetic process
                                                        is-aporphyrin-containing compound biosynthetic process
                                                                is-achlorophyll biosynthetic process +
                                                                is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                                        is-aheme a biosynthetic process
                                                                        is-aheme b biosynthetic process
                                                                        is-aheme c biosynthetic process
                                                                        is-aheme O biosynthetic process
                                                                        negatively-regulatesnegative regulation of heme biosynthetic process
                                                                        positively-regulatespositive regulation of heme biosynthetic process
                                                                        part-ofprotoporphyrinogen IX biosynthetic process +
                                                                        regulatesregulation of heme biosynthetic process +
                                                                        is-asiroheme biosynthetic process
                                                                is-aprotoporphyrinogen IX biosynthetic process +
                                                                is-asuccinyl-CoA pathway
                                                                is-auroporphyrinogen III biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular metabolic process
                                is-acofactor metabolic process
                                        is-acofactor biosynthetic process
                                                is-aporphyrin-containing compound biosynthetic process
                                                        is-achlorophyll biosynthetic process +
                                                        is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                                is-aheme a biosynthetic process
                                                                is-aheme b biosynthetic process
                                                                is-aheme c biosynthetic process
                                                                is-aheme O biosynthetic process
                                                                negatively-regulatesnegative regulation of heme biosynthetic process
                                                                positively-regulatespositive regulation of heme biosynthetic process
                                                                part-ofprotoporphyrinogen IX biosynthetic process +
                                                                regulatesregulation of heme biosynthetic process +
                                                                is-asiroheme biosynthetic process
                                                        is-aprotoporphyrinogen IX biosynthetic process +
                                                        is-asuccinyl-CoA pathway
                                                        is-auroporphyrinogen III biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular metabolic process
                                is-acofactor metabolic process
                                        is-aporphyrin-containing compound metabolic process
                                                is-aheme metabolic process
                                                        is-aheme a metabolic process +
                                                        is-aheme b metabolic process +
                                                        is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                                is-aheme a biosynthetic process
                                                                is-aheme b biosynthetic process
                                                                is-aheme c biosynthetic process
                                                                is-aheme O biosynthetic process
                                                                negatively-regulatesnegative regulation of heme biosynthetic process
                                                                positively-regulatespositive regulation of heme biosynthetic process
                                                                part-ofprotoporphyrinogen IX biosynthetic process +
                                                                regulatesregulation of heme biosynthetic process +
                                                                is-asiroheme biosynthetic process
                                                        is-aheme c metabolic process +
                                                        is-aheme catabolic process +
                                                        is-aheme o metabolic process +
                                                        is-aheme oxidation
                                                        is-asiroheme metabolic process +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular metabolic process
                                is-acofactor metabolic process
                                        is-aporphyrin-containing compound metabolic process
                                                is-aporphyrin-containing compound biosynthetic process
                                                        is-achlorophyll biosynthetic process +
                                                        is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                                is-aheme a biosynthetic process
                                                                is-aheme b biosynthetic process
                                                                is-aheme c biosynthetic process
                                                                is-aheme O biosynthetic process
                                                                negatively-regulatesnegative regulation of heme biosynthetic process
                                                                positively-regulatespositive regulation of heme biosynthetic process
                                                                part-ofprotoporphyrinogen IX biosynthetic process +
                                                                regulatesregulation of heme biosynthetic process +
                                                                is-asiroheme biosynthetic process
                                                        is-aprotoporphyrinogen IX biosynthetic process +
                                                        is-asuccinyl-CoA pathway
                                                        is-auroporphyrinogen III biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular metabolic process
                                is-aheterocycle metabolic process
                                        is-aheterocycle biosynthetic process
                                                is-atetrapyrrole biosynthetic process
                                                        is-aporphyrin-containing compound biosynthetic process
                                                                is-achlorophyll biosynthetic process +
                                                                is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                                        is-aheme a biosynthetic process
                                                                        is-aheme b biosynthetic process
                                                                        is-aheme c biosynthetic process
                                                                        is-aheme O biosynthetic process
                                                                        negatively-regulatesnegative regulation of heme biosynthetic process
                                                                        positively-regulatespositive regulation of heme biosynthetic process
                                                                        part-ofprotoporphyrinogen IX biosynthetic process +
                                                                        regulatesregulation of heme biosynthetic process +
                                                                        is-asiroheme biosynthetic process
                                                                is-aprotoporphyrinogen IX biosynthetic process +
                                                                is-asuccinyl-CoA pathway
                                                                is-auroporphyrinogen III biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular metabolic process
                                is-aheterocycle metabolic process
                                        is-atetrapyrrole metabolic process
                                                is-aporphyrin-containing compound metabolic process
                                                        is-aheme metabolic process
                                                                is-aheme a metabolic process +
                                                                is-aheme b metabolic process +
                                                                is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                                        is-aheme a biosynthetic process
                                                                        is-aheme b biosynthetic process
                                                                        is-aheme c biosynthetic process
                                                                        is-aheme O biosynthetic process
                                                                        negatively-regulatesnegative regulation of heme biosynthetic process
                                                                        positively-regulatespositive regulation of heme biosynthetic process
                                                                        part-ofprotoporphyrinogen IX biosynthetic process +
                                                                        regulatesregulation of heme biosynthetic process +
                                                                        is-asiroheme biosynthetic process
                                                                is-aheme c metabolic process +
                                                                is-aheme catabolic process +
                                                                is-aheme o metabolic process +
                                                                is-aheme oxidation
                                                                is-asiroheme metabolic process +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular metabolic process
                                is-aheterocycle metabolic process
                                        is-atetrapyrrole metabolic process
                                                is-aporphyrin-containing compound metabolic process
                                                        is-aporphyrin-containing compound biosynthetic process
                                                                is-achlorophyll biosynthetic process +
                                                                is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                                        is-aheme a biosynthetic process
                                                                        is-aheme b biosynthetic process
                                                                        is-aheme c biosynthetic process
                                                                        is-aheme O biosynthetic process
                                                                        negatively-regulatesnegative regulation of heme biosynthetic process
                                                                        positively-regulatespositive regulation of heme biosynthetic process
                                                                        part-ofprotoporphyrinogen IX biosynthetic process +
                                                                        regulatesregulation of heme biosynthetic process +
                                                                        is-asiroheme biosynthetic process
                                                                is-aprotoporphyrinogen IX biosynthetic process +
                                                                is-asuccinyl-CoA pathway
                                                                is-auroporphyrinogen III biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular metabolic process
                                is-aheterocycle metabolic process
                                        is-atetrapyrrole metabolic process
                                                is-atetrapyrrole biosynthetic process
                                                        is-aporphyrin-containing compound biosynthetic process
                                                                is-achlorophyll biosynthetic process +
                                                                is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                                        is-aheme a biosynthetic process
                                                                        is-aheme b biosynthetic process
                                                                        is-aheme c biosynthetic process
                                                                        is-aheme O biosynthetic process
                                                                        negatively-regulatesnegative regulation of heme biosynthetic process
                                                                        positively-regulatespositive regulation of heme biosynthetic process
                                                                        part-ofprotoporphyrinogen IX biosynthetic process +
                                                                        regulatesregulation of heme biosynthetic process +
                                                                        is-asiroheme biosynthetic process
                                                                is-aprotoporphyrinogen IX biosynthetic process +
                                                                is-asuccinyl-CoA pathway
                                                                is-auroporphyrinogen III biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-aheme metabolic process
                                        is-aheme a metabolic process +
                                        is-aheme b metabolic process +
                                        is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                is-aheme a biosynthetic process
                                                is-aheme b biosynthetic process
                                                is-aheme c biosynthetic process
                                                is-aheme O biosynthetic process
                                                negatively-regulatesnegative regulation of heme biosynthetic process
                                                positively-regulatespositive regulation of heme biosynthetic process
                                                part-ofprotoporphyrinogen IX biosynthetic process +
                                                regulatesregulation of heme biosynthetic process +
                                                is-asiroheme biosynthetic process
                                        is-aheme c metabolic process +
                                        is-aheme catabolic process +
                                        is-aheme o metabolic process +
                                        is-aheme oxidation
                                        is-asiroheme metabolic process +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-abiosynthetic process
                                is-acellular biosynthetic process
                                        is-aaromatic compound biosynthetic process
                                                is-atetrapyrrole biosynthetic process
                                                        is-aporphyrin-containing compound biosynthetic process
                                                                is-achlorophyll biosynthetic process +
                                                                is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                                        is-aheme a biosynthetic process
                                                                        is-aheme b biosynthetic process
                                                                        is-aheme c biosynthetic process
                                                                        is-aheme O biosynthetic process
                                                                        negatively-regulatesnegative regulation of heme biosynthetic process
                                                                        positively-regulatespositive regulation of heme biosynthetic process
                                                                        part-ofprotoporphyrinogen IX biosynthetic process +
                                                                        regulatesregulation of heme biosynthetic process +
                                                                        is-asiroheme biosynthetic process
                                                                is-aprotoporphyrinogen IX biosynthetic process +
                                                                is-asuccinyl-CoA pathway
                                                                is-auroporphyrinogen III biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-abiosynthetic process
                                is-acellular biosynthetic process
                                        is-acellular nitrogen compound biosynthetic process
                                                is-atetrapyrrole biosynthetic process
                                                        is-aporphyrin-containing compound biosynthetic process
                                                                is-achlorophyll biosynthetic process +
                                                                is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                                        is-aheme a biosynthetic process
                                                                        is-aheme b biosynthetic process
                                                                        is-aheme c biosynthetic process
                                                                        is-aheme O biosynthetic process
                                                                        negatively-regulatesnegative regulation of heme biosynthetic process
                                                                        positively-regulatespositive regulation of heme biosynthetic process
                                                                        part-ofprotoporphyrinogen IX biosynthetic process +
                                                                        regulatesregulation of heme biosynthetic process +
                                                                        is-asiroheme biosynthetic process
                                                                is-aprotoporphyrinogen IX biosynthetic process +
                                                                is-asuccinyl-CoA pathway
                                                                is-auroporphyrinogen III biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-abiosynthetic process
                                is-acellular biosynthetic process
                                        is-acofactor biosynthetic process
                                                is-aporphyrin-containing compound biosynthetic process
                                                        is-achlorophyll biosynthetic process +
                                                        is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                                is-aheme a biosynthetic process
                                                                is-aheme b biosynthetic process
                                                                is-aheme c biosynthetic process
                                                                is-aheme O biosynthetic process
                                                                negatively-regulatesnegative regulation of heme biosynthetic process
                                                                positively-regulatespositive regulation of heme biosynthetic process
                                                                part-ofprotoporphyrinogen IX biosynthetic process +
                                                                regulatesregulation of heme biosynthetic process +
                                                                is-asiroheme biosynthetic process
                                                        is-aprotoporphyrinogen IX biosynthetic process +
                                                        is-asuccinyl-CoA pathway
                                                        is-auroporphyrinogen III biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-abiosynthetic process
                                is-acellular biosynthetic process
                                        is-aheterocycle biosynthetic process
                                                is-atetrapyrrole biosynthetic process
                                                        is-aporphyrin-containing compound biosynthetic process
                                                                is-achlorophyll biosynthetic process +
                                                                is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                                        is-aheme a biosynthetic process
                                                                        is-aheme b biosynthetic process
                                                                        is-aheme c biosynthetic process
                                                                        is-aheme O biosynthetic process
                                                                        negatively-regulatesnegative regulation of heme biosynthetic process
                                                                        positively-regulatespositive regulation of heme biosynthetic process
                                                                        part-ofprotoporphyrinogen IX biosynthetic process +
                                                                        regulatesregulation of heme biosynthetic process +
                                                                        is-asiroheme biosynthetic process
                                                                is-aprotoporphyrinogen IX biosynthetic process +
                                                                is-asuccinyl-CoA pathway
                                                                is-auroporphyrinogen III biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-abiosynthetic process
                                is-aorganic substance biosynthetic process
                                        is-aorganic cyclic compound biosynthetic process
                                                is-atetrapyrrole biosynthetic process
                                                        is-aporphyrin-containing compound biosynthetic process
                                                                is-achlorophyll biosynthetic process +
                                                                is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                                        is-aheme a biosynthetic process
                                                                        is-aheme b biosynthetic process
                                                                        is-aheme c biosynthetic process
                                                                        is-aheme O biosynthetic process
                                                                        negatively-regulatesnegative regulation of heme biosynthetic process
                                                                        positively-regulatespositive regulation of heme biosynthetic process
                                                                        part-ofprotoporphyrinogen IX biosynthetic process +
                                                                        regulatesregulation of heme biosynthetic process +
                                                                        is-asiroheme biosynthetic process
                                                                is-aprotoporphyrinogen IX biosynthetic process +
                                                                is-asuccinyl-CoA pathway
                                                                is-auroporphyrinogen III biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-abiosynthetic process
                                is-aorganic substance biosynthetic process
                                        is-aorganonitrogen compound biosynthetic process
                                                is-atetrapyrrole biosynthetic process
                                                        is-aporphyrin-containing compound biosynthetic process
                                                                is-achlorophyll biosynthetic process +
                                                                is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                                        is-aheme a biosynthetic process
                                                                        is-aheme b biosynthetic process
                                                                        is-aheme c biosynthetic process
                                                                        is-aheme O biosynthetic process
                                                                        negatively-regulatesnegative regulation of heme biosynthetic process
                                                                        positively-regulatespositive regulation of heme biosynthetic process
                                                                        part-ofprotoporphyrinogen IX biosynthetic process +
                                                                        regulatesregulation of heme biosynthetic process +
                                                                        is-asiroheme biosynthetic process
                                                                is-aprotoporphyrinogen IX biosynthetic process +
                                                                is-asuccinyl-CoA pathway
                                                                is-auroporphyrinogen III biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-abiosynthetic process
                                is-asingle-organism biosynthetic process
                                        is-apigment biosynthetic process
                                                is-aanthocyanin-containing compound biosynthetic process +
                                                is-aaurone biosynthetic process
                                                is-acarotenoid biosynthetic process +
                                                is-achlorophyll biosynthetic process +
                                                is-aeye pigment biosynthetic process +
                                                is-aflavone biosynthetic process +
                                                is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                        is-aheme a biosynthetic process
                                                        is-aheme b biosynthetic process
                                                        is-aheme c biosynthetic process
                                                        is-aheme O biosynthetic process
                                                        negatively-regulatesnegative regulation of heme biosynthetic process
                                                        positively-regulatespositive regulation of heme biosynthetic process
                                                        part-ofprotoporphyrinogen IX biosynthetic process +
                                                        regulatesregulation of heme biosynthetic process +
                                                        is-asiroheme biosynthetic process
                                                is-amelanin biosynthetic process +
                                                is-aocellus pigment biosynthetic process +
                                                is-aphlobaphene biosynthetic process
                                                is-aphytochrome chromophore biosynthetic process
                                                is-apigment biosynthetic process involved in pigment accumulation +
                                                is-apteridine biosynthetic process
                                                is-apurine nucleobase biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-acellular metabolic process
                                is-acellular aromatic compound metabolic process
                                        is-aaromatic compound biosynthetic process
                                                is-atetrapyrrole biosynthetic process
                                                        is-aporphyrin-containing compound biosynthetic process
                                                                is-achlorophyll biosynthetic process +
                                                                is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                                        is-aheme a biosynthetic process
                                                                        is-aheme b biosynthetic process
                                                                        is-aheme c biosynthetic process
                                                                        is-aheme O biosynthetic process
                                                                        negatively-regulatesnegative regulation of heme biosynthetic process
                                                                        positively-regulatespositive regulation of heme biosynthetic process
                                                                        part-ofprotoporphyrinogen IX biosynthetic process +
                                                                        regulatesregulation of heme biosynthetic process +
                                                                        is-asiroheme biosynthetic process
                                                                is-aprotoporphyrinogen IX biosynthetic process +
                                                                is-asuccinyl-CoA pathway
                                                                is-auroporphyrinogen III biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-acellular metabolic process
                                is-acellular aromatic compound metabolic process
                                        is-atetrapyrrole metabolic process
                                                is-aporphyrin-containing compound metabolic process
                                                        is-aheme metabolic process
                                                                is-aheme a metabolic process +
                                                                is-aheme b metabolic process +
                                                                is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                                        is-aheme a biosynthetic process
                                                                        is-aheme b biosynthetic process
                                                                        is-aheme c biosynthetic process
                                                                        is-aheme O biosynthetic process
                                                                        negatively-regulatesnegative regulation of heme biosynthetic process
                                                                        positively-regulatespositive regulation of heme biosynthetic process
                                                                        part-ofprotoporphyrinogen IX biosynthetic process +
                                                                        regulatesregulation of heme biosynthetic process +
                                                                        is-asiroheme biosynthetic process
                                                                is-aheme c metabolic process +
                                                                is-aheme catabolic process +
                                                                is-aheme o metabolic process +
                                                                is-aheme oxidation
                                                                is-asiroheme metabolic process +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-acellular metabolic process
                                is-acellular aromatic compound metabolic process
                                        is-atetrapyrrole metabolic process
                                                is-aporphyrin-containing compound metabolic process
                                                        is-aporphyrin-containing compound biosynthetic process
                                                                is-achlorophyll biosynthetic process +
                                                                is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                                        is-aheme a biosynthetic process
                                                                        is-aheme b biosynthetic process
                                                                        is-aheme c biosynthetic process
                                                                        is-aheme O biosynthetic process
                                                                        negatively-regulatesnegative regulation of heme biosynthetic process
                                                                        positively-regulatespositive regulation of heme biosynthetic process
                                                                        part-ofprotoporphyrinogen IX biosynthetic process +
                                                                        regulatesregulation of heme biosynthetic process +
                                                                        is-asiroheme biosynthetic process
                                                                is-aprotoporphyrinogen IX biosynthetic process +
                                                                is-asuccinyl-CoA pathway
                                                                is-auroporphyrinogen III biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-acellular metabolic process
                                is-acellular aromatic compound metabolic process
                                        is-atetrapyrrole metabolic process
                                                is-atetrapyrrole biosynthetic process
                                                        is-aporphyrin-containing compound biosynthetic process
                                                                is-achlorophyll biosynthetic process +
                                                                is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                                        is-aheme a biosynthetic process
                                                                        is-aheme b biosynthetic process
                                                                        is-aheme c biosynthetic process
                                                                        is-aheme O biosynthetic process
                                                                        negatively-regulatesnegative regulation of heme biosynthetic process
                                                                        positively-regulatespositive regulation of heme biosynthetic process
                                                                        part-ofprotoporphyrinogen IX biosynthetic process +
                                                                        regulatesregulation of heme biosynthetic process +
                                                                        is-asiroheme biosynthetic process
                                                                is-aprotoporphyrinogen IX biosynthetic process +
                                                                is-asuccinyl-CoA pathway
                                                                is-auroporphyrinogen III biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-acellular metabolic process
                                is-acellular biosynthetic process
                                        is-aaromatic compound biosynthetic process
                                                is-atetrapyrrole biosynthetic process
                                                        is-aporphyrin-containing compound biosynthetic process
                                                                is-achlorophyll biosynthetic process +
                                                                is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                                        is-aheme a biosynthetic process
                                                                        is-aheme b biosynthetic process
                                                                        is-aheme c biosynthetic process
                                                                        is-aheme O biosynthetic process
                                                                        negatively-regulatesnegative regulation of heme biosynthetic process
                                                                        positively-regulatespositive regulation of heme biosynthetic process
                                                                        part-ofprotoporphyrinogen IX biosynthetic process +
                                                                        regulatesregulation of heme biosynthetic process +
                                                                        is-asiroheme biosynthetic process
                                                                is-aprotoporphyrinogen IX biosynthetic process +
                                                                is-asuccinyl-CoA pathway
                                                                is-auroporphyrinogen III biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-acellular metabolic process
                                is-acellular biosynthetic process
                                        is-acellular nitrogen compound biosynthetic process
                                                is-atetrapyrrole biosynthetic process
                                                        is-aporphyrin-containing compound biosynthetic process
                                                                is-achlorophyll biosynthetic process +
                                                                is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                                        is-aheme a biosynthetic process
                                                                        is-aheme b biosynthetic process
                                                                        is-aheme c biosynthetic process
                                                                        is-aheme O biosynthetic process
                                                                        negatively-regulatesnegative regulation of heme biosynthetic process
                                                                        positively-regulatespositive regulation of heme biosynthetic process
                                                                        part-ofprotoporphyrinogen IX biosynthetic process +
                                                                        regulatesregulation of heme biosynthetic process +
                                                                        is-asiroheme biosynthetic process
                                                                is-aprotoporphyrinogen IX biosynthetic process +
                                                                is-asuccinyl-CoA pathway
                                                                is-auroporphyrinogen III biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-acellular metabolic process
                                is-acellular biosynthetic process
                                        is-acofactor biosynthetic process
                                                is-aporphyrin-containing compound biosynthetic process
                                                        is-achlorophyll biosynthetic process +
                                                        is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                                is-aheme a biosynthetic process
                                                                is-aheme b biosynthetic process
                                                                is-aheme c biosynthetic process
                                                                is-aheme O biosynthetic process
                                                                negatively-regulatesnegative regulation of heme biosynthetic process
                                                                positively-regulatespositive regulation of heme biosynthetic process
                                                                part-ofprotoporphyrinogen IX biosynthetic process +
                                                                regulatesregulation of heme biosynthetic process +
                                                                is-asiroheme biosynthetic process
                                                        is-aprotoporphyrinogen IX biosynthetic process +
                                                        is-asuccinyl-CoA pathway
                                                        is-auroporphyrinogen III biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-acellular metabolic process
                                is-acellular biosynthetic process
                                        is-aheterocycle biosynthetic process
                                                is-atetrapyrrole biosynthetic process
                                                        is-aporphyrin-containing compound biosynthetic process
                                                                is-achlorophyll biosynthetic process +
                                                                is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                                        is-aheme a biosynthetic process
                                                                        is-aheme b biosynthetic process
                                                                        is-aheme c biosynthetic process
                                                                        is-aheme O biosynthetic process
                                                                        negatively-regulatesnegative regulation of heme biosynthetic process
                                                                        positively-regulatespositive regulation of heme biosynthetic process
                                                                        part-ofprotoporphyrinogen IX biosynthetic process +
                                                                        regulatesregulation of heme biosynthetic process +
                                                                        is-asiroheme biosynthetic process
                                                                is-aprotoporphyrinogen IX biosynthetic process +
                                                                is-asuccinyl-CoA pathway
                                                                is-auroporphyrinogen III biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-acellular metabolic process
                                is-acellular nitrogen compound metabolic process
                                        is-acellular nitrogen compound biosynthetic process
                                                is-atetrapyrrole biosynthetic process
                                                        is-aporphyrin-containing compound biosynthetic process
                                                                is-achlorophyll biosynthetic process +
                                                                is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                                        is-aheme a biosynthetic process
                                                                        is-aheme b biosynthetic process
                                                                        is-aheme c biosynthetic process
                                                                        is-aheme O biosynthetic process
                                                                        negatively-regulatesnegative regulation of heme biosynthetic process
                                                                        positively-regulatespositive regulation of heme biosynthetic process
                                                                        part-ofprotoporphyrinogen IX biosynthetic process +
                                                                        regulatesregulation of heme biosynthetic process +
                                                                        is-asiroheme biosynthetic process
                                                                is-aprotoporphyrinogen IX biosynthetic process +
                                                                is-asuccinyl-CoA pathway
                                                                is-auroporphyrinogen III biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-acellular metabolic process
                                is-acofactor metabolic process
                                        is-acofactor biosynthetic process
                                                is-aporphyrin-containing compound biosynthetic process
                                                        is-achlorophyll biosynthetic process +
                                                        is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                                is-aheme a biosynthetic process
                                                                is-aheme b biosynthetic process
                                                                is-aheme c biosynthetic process
                                                                is-aheme O biosynthetic process
                                                                negatively-regulatesnegative regulation of heme biosynthetic process
                                                                positively-regulatespositive regulation of heme biosynthetic process
                                                                part-ofprotoporphyrinogen IX biosynthetic process +
                                                                regulatesregulation of heme biosynthetic process +
                                                                is-asiroheme biosynthetic process
                                                        is-aprotoporphyrinogen IX biosynthetic process +
                                                        is-asuccinyl-CoA pathway
                                                        is-auroporphyrinogen III biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-acellular metabolic process
                                is-acofactor metabolic process
                                        is-aporphyrin-containing compound metabolic process
                                                is-aheme metabolic process
                                                        is-aheme a metabolic process +
                                                        is-aheme b metabolic process +
                                                        is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                                is-aheme a biosynthetic process
                                                                is-aheme b biosynthetic process
                                                                is-aheme c biosynthetic process
                                                                is-aheme O biosynthetic process
                                                                negatively-regulatesnegative regulation of heme biosynthetic process
                                                                positively-regulatespositive regulation of heme biosynthetic process
                                                                part-ofprotoporphyrinogen IX biosynthetic process +
                                                                regulatesregulation of heme biosynthetic process +
                                                                is-asiroheme biosynthetic process
                                                        is-aheme c metabolic process +
                                                        is-aheme catabolic process +
                                                        is-aheme o metabolic process +
                                                        is-aheme oxidation
                                                        is-asiroheme metabolic process +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-acellular metabolic process
                                is-acofactor metabolic process
                                        is-aporphyrin-containing compound metabolic process
                                                is-aporphyrin-containing compound biosynthetic process
                                                        is-achlorophyll biosynthetic process +
                                                        is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                                is-aheme a biosynthetic process
                                                                is-aheme b biosynthetic process
                                                                is-aheme c biosynthetic process
                                                                is-aheme O biosynthetic process
                                                                negatively-regulatesnegative regulation of heme biosynthetic process
                                                                positively-regulatespositive regulation of heme biosynthetic process
                                                                part-ofprotoporphyrinogen IX biosynthetic process +
                                                                regulatesregulation of heme biosynthetic process +
                                                                is-asiroheme biosynthetic process
                                                        is-aprotoporphyrinogen IX biosynthetic process +
                                                        is-asuccinyl-CoA pathway
                                                        is-auroporphyrinogen III biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-acellular metabolic process
                                is-aheterocycle metabolic process
                                        is-aheterocycle biosynthetic process
                                                is-atetrapyrrole biosynthetic process
                                                        is-aporphyrin-containing compound biosynthetic process
                                                                is-achlorophyll biosynthetic process +
                                                                is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                                        is-aheme a biosynthetic process
                                                                        is-aheme b biosynthetic process
                                                                        is-aheme c biosynthetic process
                                                                        is-aheme O biosynthetic process
                                                                        negatively-regulatesnegative regulation of heme biosynthetic process
                                                                        positively-regulatespositive regulation of heme biosynthetic process
                                                                        part-ofprotoporphyrinogen IX biosynthetic process +
                                                                        regulatesregulation of heme biosynthetic process +
                                                                        is-asiroheme biosynthetic process
                                                                is-aprotoporphyrinogen IX biosynthetic process +
                                                                is-asuccinyl-CoA pathway
                                                                is-auroporphyrinogen III biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-acellular metabolic process
                                is-aheterocycle metabolic process
                                        is-atetrapyrrole metabolic process
                                                is-aporphyrin-containing compound metabolic process
                                                        is-aheme metabolic process
                                                                is-aheme a metabolic process +
                                                                is-aheme b metabolic process +
                                                                is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                                        is-aheme a biosynthetic process
                                                                        is-aheme b biosynthetic process
                                                                        is-aheme c biosynthetic process
                                                                        is-aheme O biosynthetic process
                                                                        negatively-regulatesnegative regulation of heme biosynthetic process
                                                                        positively-regulatespositive regulation of heme biosynthetic process
                                                                        part-ofprotoporphyrinogen IX biosynthetic process +
                                                                        regulatesregulation of heme biosynthetic process +
                                                                        is-asiroheme biosynthetic process
                                                                is-aheme c metabolic process +
                                                                is-aheme catabolic process +
                                                                is-aheme o metabolic process +
                                                                is-aheme oxidation
                                                                is-asiroheme metabolic process +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-acellular metabolic process
                                is-aheterocycle metabolic process
                                        is-atetrapyrrole metabolic process
                                                is-aporphyrin-containing compound metabolic process
                                                        is-aporphyrin-containing compound biosynthetic process
                                                                is-achlorophyll biosynthetic process +
                                                                is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                                        is-aheme a biosynthetic process
                                                                        is-aheme b biosynthetic process
                                                                        is-aheme c biosynthetic process
                                                                        is-aheme O biosynthetic process
                                                                        negatively-regulatesnegative regulation of heme biosynthetic process
                                                                        positively-regulatespositive regulation of heme biosynthetic process
                                                                        part-ofprotoporphyrinogen IX biosynthetic process +
                                                                        regulatesregulation of heme biosynthetic process +
                                                                        is-asiroheme biosynthetic process
                                                                is-aprotoporphyrinogen IX biosynthetic process +
                                                                is-asuccinyl-CoA pathway
                                                                is-auroporphyrinogen III biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-acellular metabolic process
                                is-aheterocycle metabolic process
                                        is-atetrapyrrole metabolic process
                                                is-atetrapyrrole biosynthetic process
                                                        is-aporphyrin-containing compound biosynthetic process
                                                                is-achlorophyll biosynthetic process +
                                                                is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                                        is-aheme a biosynthetic process
                                                                        is-aheme b biosynthetic process
                                                                        is-aheme c biosynthetic process
                                                                        is-aheme O biosynthetic process
                                                                        negatively-regulatesnegative regulation of heme biosynthetic process
                                                                        positively-regulatespositive regulation of heme biosynthetic process
                                                                        part-ofprotoporphyrinogen IX biosynthetic process +
                                                                        regulatesregulation of heme biosynthetic process +
                                                                        is-asiroheme biosynthetic process
                                                                is-aprotoporphyrinogen IX biosynthetic process +
                                                                is-asuccinyl-CoA pathway
                                                                is-auroporphyrinogen III biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-anitrogen compound metabolic process
                                is-acellular nitrogen compound metabolic process
                                        is-acellular nitrogen compound biosynthetic process
                                                is-atetrapyrrole biosynthetic process
                                                        is-aporphyrin-containing compound biosynthetic process
                                                                is-achlorophyll biosynthetic process +
                                                                is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                                        is-aheme a biosynthetic process
                                                                        is-aheme b biosynthetic process
                                                                        is-aheme c biosynthetic process
                                                                        is-aheme O biosynthetic process
                                                                        negatively-regulatesnegative regulation of heme biosynthetic process
                                                                        positively-regulatespositive regulation of heme biosynthetic process
                                                                        part-ofprotoporphyrinogen IX biosynthetic process +
                                                                        regulatesregulation of heme biosynthetic process +
                                                                        is-asiroheme biosynthetic process
                                                                is-aprotoporphyrinogen IX biosynthetic process +
                                                                is-asuccinyl-CoA pathway
                                                                is-auroporphyrinogen III biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-anitrogen compound metabolic process
                                is-aorganonitrogen compound metabolic process
                                        is-aorganonitrogen compound biosynthetic process
                                                is-atetrapyrrole biosynthetic process
                                                        is-aporphyrin-containing compound biosynthetic process
                                                                is-achlorophyll biosynthetic process +
                                                                is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                                        is-aheme a biosynthetic process
                                                                        is-aheme b biosynthetic process
                                                                        is-aheme c biosynthetic process
                                                                        is-aheme O biosynthetic process
                                                                        negatively-regulatesnegative regulation of heme biosynthetic process
                                                                        positively-regulatespositive regulation of heme biosynthetic process
                                                                        part-ofprotoporphyrinogen IX biosynthetic process +
                                                                        regulatesregulation of heme biosynthetic process +
                                                                        is-asiroheme biosynthetic process
                                                                is-aprotoporphyrinogen IX biosynthetic process +
                                                                is-asuccinyl-CoA pathway
                                                                is-auroporphyrinogen III biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-anitrogen compound metabolic process
                                is-aorganonitrogen compound metabolic process
                                        is-atetrapyrrole metabolic process
                                                is-aporphyrin-containing compound metabolic process
                                                        is-aheme metabolic process
                                                                is-aheme a metabolic process +
                                                                is-aheme b metabolic process +
                                                                is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                                        is-aheme a biosynthetic process
                                                                        is-aheme b biosynthetic process
                                                                        is-aheme c biosynthetic process
                                                                        is-aheme O biosynthetic process
                                                                        negatively-regulatesnegative regulation of heme biosynthetic process
                                                                        positively-regulatespositive regulation of heme biosynthetic process
                                                                        part-ofprotoporphyrinogen IX biosynthetic process +
                                                                        regulatesregulation of heme biosynthetic process +
                                                                        is-asiroheme biosynthetic process
                                                                is-aheme c metabolic process +
                                                                is-aheme catabolic process +
                                                                is-aheme o metabolic process +
                                                                is-aheme oxidation
                                                                is-asiroheme metabolic process +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-anitrogen compound metabolic process
                                is-aorganonitrogen compound metabolic process
                                        is-atetrapyrrole metabolic process
                                                is-aporphyrin-containing compound metabolic process
                                                        is-aporphyrin-containing compound biosynthetic process
                                                                is-achlorophyll biosynthetic process +
                                                                is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                                        is-aheme a biosynthetic process
                                                                        is-aheme b biosynthetic process
                                                                        is-aheme c biosynthetic process
                                                                        is-aheme O biosynthetic process
                                                                        negatively-regulatesnegative regulation of heme biosynthetic process
                                                                        positively-regulatespositive regulation of heme biosynthetic process
                                                                        part-ofprotoporphyrinogen IX biosynthetic process +
                                                                        regulatesregulation of heme biosynthetic process +
                                                                        is-asiroheme biosynthetic process
                                                                is-aprotoporphyrinogen IX biosynthetic process +
                                                                is-asuccinyl-CoA pathway
                                                                is-auroporphyrinogen III biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-anitrogen compound metabolic process
                                is-aorganonitrogen compound metabolic process
                                        is-atetrapyrrole metabolic process
                                                is-atetrapyrrole biosynthetic process
                                                        is-aporphyrin-containing compound biosynthetic process
                                                                is-achlorophyll biosynthetic process +
                                                                is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                                        is-aheme a biosynthetic process
                                                                        is-aheme b biosynthetic process
                                                                        is-aheme c biosynthetic process
                                                                        is-aheme O biosynthetic process
                                                                        negatively-regulatesnegative regulation of heme biosynthetic process
                                                                        positively-regulatespositive regulation of heme biosynthetic process
                                                                        part-ofprotoporphyrinogen IX biosynthetic process +
                                                                        regulatesregulation of heme biosynthetic process +
                                                                        is-asiroheme biosynthetic process
                                                                is-aprotoporphyrinogen IX biosynthetic process +
                                                                is-asuccinyl-CoA pathway
                                                                is-auroporphyrinogen III biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-aorganic cyclic compound metabolic process
                                        is-aorganic cyclic compound biosynthetic process
                                                is-atetrapyrrole biosynthetic process
                                                        is-aporphyrin-containing compound biosynthetic process
                                                                is-achlorophyll biosynthetic process +
                                                                is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                                        is-aheme a biosynthetic process
                                                                        is-aheme b biosynthetic process
                                                                        is-aheme c biosynthetic process
                                                                        is-aheme O biosynthetic process
                                                                        negatively-regulatesnegative regulation of heme biosynthetic process
                                                                        positively-regulatespositive regulation of heme biosynthetic process
                                                                        part-ofprotoporphyrinogen IX biosynthetic process +
                                                                        regulatesregulation of heme biosynthetic process +
                                                                        is-asiroheme biosynthetic process
                                                                is-aprotoporphyrinogen IX biosynthetic process +
                                                                is-asuccinyl-CoA pathway
                                                                is-auroporphyrinogen III biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-aorganic cyclic compound metabolic process
                                        is-atetrapyrrole metabolic process
                                                is-aporphyrin-containing compound metabolic process
                                                        is-aheme metabolic process
                                                                is-aheme a metabolic process +
                                                                is-aheme b metabolic process +
                                                                is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                                        is-aheme a biosynthetic process
                                                                        is-aheme b biosynthetic process
                                                                        is-aheme c biosynthetic process
                                                                        is-aheme O biosynthetic process
                                                                        negatively-regulatesnegative regulation of heme biosynthetic process
                                                                        positively-regulatespositive regulation of heme biosynthetic process
                                                                        part-ofprotoporphyrinogen IX biosynthetic process +
                                                                        regulatesregulation of heme biosynthetic process +
                                                                        is-asiroheme biosynthetic process
                                                                is-aheme c metabolic process +
                                                                is-aheme catabolic process +
                                                                is-aheme o metabolic process +
                                                                is-aheme oxidation
                                                                is-asiroheme metabolic process +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-aorganic cyclic compound metabolic process
                                        is-atetrapyrrole metabolic process
                                                is-aporphyrin-containing compound metabolic process
                                                        is-aporphyrin-containing compound biosynthetic process
                                                                is-achlorophyll biosynthetic process +
                                                                is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                                        is-aheme a biosynthetic process
                                                                        is-aheme b biosynthetic process
                                                                        is-aheme c biosynthetic process
                                                                        is-aheme O biosynthetic process
                                                                        negatively-regulatesnegative regulation of heme biosynthetic process
                                                                        positively-regulatespositive regulation of heme biosynthetic process
                                                                        part-ofprotoporphyrinogen IX biosynthetic process +
                                                                        regulatesregulation of heme biosynthetic process +
                                                                        is-asiroheme biosynthetic process
                                                                is-aprotoporphyrinogen IX biosynthetic process +
                                                                is-asuccinyl-CoA pathway
                                                                is-auroporphyrinogen III biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-aorganic cyclic compound metabolic process
                                        is-atetrapyrrole metabolic process
                                                is-atetrapyrrole biosynthetic process
                                                        is-aporphyrin-containing compound biosynthetic process
                                                                is-achlorophyll biosynthetic process +
                                                                is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                                        is-aheme a biosynthetic process
                                                                        is-aheme b biosynthetic process
                                                                        is-aheme c biosynthetic process
                                                                        is-aheme O biosynthetic process
                                                                        negatively-regulatesnegative regulation of heme biosynthetic process
                                                                        positively-regulatespositive regulation of heme biosynthetic process
                                                                        part-ofprotoporphyrinogen IX biosynthetic process +
                                                                        regulatesregulation of heme biosynthetic process +
                                                                        is-asiroheme biosynthetic process
                                                                is-aprotoporphyrinogen IX biosynthetic process +
                                                                is-asuccinyl-CoA pathway
                                                                is-auroporphyrinogen III biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-aorganic substance biosynthetic process
                                        is-aorganic cyclic compound biosynthetic process
                                                is-atetrapyrrole biosynthetic process
                                                        is-aporphyrin-containing compound biosynthetic process
                                                                is-achlorophyll biosynthetic process +
                                                                is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                                        is-aheme a biosynthetic process
                                                                        is-aheme b biosynthetic process
                                                                        is-aheme c biosynthetic process
                                                                        is-aheme O biosynthetic process
                                                                        negatively-regulatesnegative regulation of heme biosynthetic process
                                                                        positively-regulatespositive regulation of heme biosynthetic process
                                                                        part-ofprotoporphyrinogen IX biosynthetic process +
                                                                        regulatesregulation of heme biosynthetic process +
                                                                        is-asiroheme biosynthetic process
                                                                is-aprotoporphyrinogen IX biosynthetic process +
                                                                is-asuccinyl-CoA pathway
                                                                is-auroporphyrinogen III biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-aorganic substance biosynthetic process
                                        is-aorganonitrogen compound biosynthetic process
                                                is-atetrapyrrole biosynthetic process
                                                        is-aporphyrin-containing compound biosynthetic process
                                                                is-achlorophyll biosynthetic process +
                                                                is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                                        is-aheme a biosynthetic process
                                                                        is-aheme b biosynthetic process
                                                                        is-aheme c biosynthetic process
                                                                        is-aheme O biosynthetic process
                                                                        negatively-regulatesnegative regulation of heme biosynthetic process
                                                                        positively-regulatespositive regulation of heme biosynthetic process
                                                                        part-ofprotoporphyrinogen IX biosynthetic process +
                                                                        regulatesregulation of heme biosynthetic process +
                                                                        is-asiroheme biosynthetic process
                                                                is-aprotoporphyrinogen IX biosynthetic process +
                                                                is-asuccinyl-CoA pathway
                                                                is-auroporphyrinogen III biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-aorganonitrogen compound metabolic process
                                        is-aorganonitrogen compound biosynthetic process
                                                is-atetrapyrrole biosynthetic process
                                                        is-aporphyrin-containing compound biosynthetic process
                                                                is-achlorophyll biosynthetic process +
                                                                is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                                        is-aheme a biosynthetic process
                                                                        is-aheme b biosynthetic process
                                                                        is-aheme c biosynthetic process
                                                                        is-aheme O biosynthetic process
                                                                        negatively-regulatesnegative regulation of heme biosynthetic process
                                                                        positively-regulatespositive regulation of heme biosynthetic process
                                                                        part-ofprotoporphyrinogen IX biosynthetic process +
                                                                        regulatesregulation of heme biosynthetic process +
                                                                        is-asiroheme biosynthetic process
                                                                is-aprotoporphyrinogen IX biosynthetic process +
                                                                is-asuccinyl-CoA pathway
                                                                is-auroporphyrinogen III biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-aorganonitrogen compound metabolic process
                                        is-atetrapyrrole metabolic process
                                                is-aporphyrin-containing compound metabolic process
                                                        is-aheme metabolic process
                                                                is-aheme a metabolic process +
                                                                is-aheme b metabolic process +
                                                                is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                                        is-aheme a biosynthetic process
                                                                        is-aheme b biosynthetic process
                                                                        is-aheme c biosynthetic process
                                                                        is-aheme O biosynthetic process
                                                                        negatively-regulatesnegative regulation of heme biosynthetic process
                                                                        positively-regulatespositive regulation of heme biosynthetic process
                                                                        part-ofprotoporphyrinogen IX biosynthetic process +
                                                                        regulatesregulation of heme biosynthetic process +
                                                                        is-asiroheme biosynthetic process
                                                                is-aheme c metabolic process +
                                                                is-aheme catabolic process +
                                                                is-aheme o metabolic process +
                                                                is-aheme oxidation
                                                                is-asiroheme metabolic process +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-aorganonitrogen compound metabolic process
                                        is-atetrapyrrole metabolic process
                                                is-aporphyrin-containing compound metabolic process
                                                        is-aporphyrin-containing compound biosynthetic process
                                                                is-achlorophyll biosynthetic process +
                                                                is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                                        is-aheme a biosynthetic process
                                                                        is-aheme b biosynthetic process
                                                                        is-aheme c biosynthetic process
                                                                        is-aheme O biosynthetic process
                                                                        negatively-regulatesnegative regulation of heme biosynthetic process
                                                                        positively-regulatespositive regulation of heme biosynthetic process
                                                                        part-ofprotoporphyrinogen IX biosynthetic process +
                                                                        regulatesregulation of heme biosynthetic process +
                                                                        is-asiroheme biosynthetic process
                                                                is-aprotoporphyrinogen IX biosynthetic process +
                                                                is-asuccinyl-CoA pathway
                                                                is-auroporphyrinogen III biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-aorganonitrogen compound metabolic process
                                        is-atetrapyrrole metabolic process
                                                is-atetrapyrrole biosynthetic process
                                                        is-aporphyrin-containing compound biosynthetic process
                                                                is-achlorophyll biosynthetic process +
                                                                is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                                        is-aheme a biosynthetic process
                                                                        is-aheme b biosynthetic process
                                                                        is-aheme c biosynthetic process
                                                                        is-aheme O biosynthetic process
                                                                        negatively-regulatesnegative regulation of heme biosynthetic process
                                                                        positively-regulatespositive regulation of heme biosynthetic process
                                                                        part-ofprotoporphyrinogen IX biosynthetic process +
                                                                        regulatesregulation of heme biosynthetic process +
                                                                        is-asiroheme biosynthetic process
                                                                is-aprotoporphyrinogen IX biosynthetic process +
                                                                is-asuccinyl-CoA pathway
                                                                is-auroporphyrinogen III biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-asingle-organism metabolic process
                                is-apigment metabolic process
                                        is-aheme metabolic process
                                                is-aheme a metabolic process +
                                                is-aheme b metabolic process +
                                                is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                        is-aheme a biosynthetic process
                                                        is-aheme b biosynthetic process
                                                        is-aheme c biosynthetic process
                                                        is-aheme O biosynthetic process
                                                        negatively-regulatesnegative regulation of heme biosynthetic process
                                                        positively-regulatespositive regulation of heme biosynthetic process
                                                        part-ofprotoporphyrinogen IX biosynthetic process +
                                                        regulatesregulation of heme biosynthetic process +
                                                        is-asiroheme biosynthetic process
                                                is-aheme c metabolic process +
                                                is-aheme catabolic process +
                                                is-aheme o metabolic process +
                                                is-aheme oxidation
                                                is-asiroheme metabolic process +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-asingle-organism metabolic process
                                is-apigment metabolic process
                                        is-apigment biosynthetic process
                                                is-aanthocyanin-containing compound biosynthetic process +
                                                is-aaurone biosynthetic process
                                                is-acarotenoid biosynthetic process +
                                                is-achlorophyll biosynthetic process +
                                                is-aeye pigment biosynthetic process +
                                                is-aflavone biosynthetic process +
                                                is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                        is-aheme a biosynthetic process
                                                        is-aheme b biosynthetic process
                                                        is-aheme c biosynthetic process
                                                        is-aheme O biosynthetic process
                                                        negatively-regulatesnegative regulation of heme biosynthetic process
                                                        positively-regulatespositive regulation of heme biosynthetic process
                                                        part-ofprotoporphyrinogen IX biosynthetic process +
                                                        regulatesregulation of heme biosynthetic process +
                                                        is-asiroheme biosynthetic process
                                                is-amelanin biosynthetic process +
                                                is-aocellus pigment biosynthetic process +
                                                is-aphlobaphene biosynthetic process
                                                is-aphytochrome chromophore biosynthetic process
                                                is-apigment biosynthetic process involved in pigment accumulation +
                                                is-apteridine biosynthetic process
                                                is-apurine nucleobase biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-asingle-organism metabolic process
                                is-asingle-organism biosynthetic process
                                        is-apigment biosynthetic process
                                                is-aanthocyanin-containing compound biosynthetic process +
                                                is-aaurone biosynthetic process
                                                is-acarotenoid biosynthetic process +
                                                is-achlorophyll biosynthetic process +
                                                is-aeye pigment biosynthetic process +
                                                is-aflavone biosynthetic process +
                                                is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                        is-aheme a biosynthetic process
                                                        is-aheme b biosynthetic process
                                                        is-aheme c biosynthetic process
                                                        is-aheme O biosynthetic process
                                                        negatively-regulatesnegative regulation of heme biosynthetic process
                                                        positively-regulatespositive regulation of heme biosynthetic process
                                                        part-ofprotoporphyrinogen IX biosynthetic process +
                                                        regulatesregulation of heme biosynthetic process +
                                                        is-asiroheme biosynthetic process
                                                is-amelanin biosynthetic process +
                                                is-aocellus pigment biosynthetic process +
                                                is-aphlobaphene biosynthetic process
                                                is-aphytochrome chromophore biosynthetic process
                                                is-apigment biosynthetic process involved in pigment accumulation +
                                                is-apteridine biosynthetic process
                                                is-apurine nucleobase biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-aheme metabolic process
                                        is-aheme a metabolic process +
                                        is-aheme b metabolic process +
                                        is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                is-aheme a biosynthetic process
                                                is-aheme b biosynthetic process
                                                is-aheme c biosynthetic process
                                                is-aheme O biosynthetic process
                                                negatively-regulatesnegative regulation of heme biosynthetic process
                                                positively-regulatespositive regulation of heme biosynthetic process
                                                part-ofprotoporphyrinogen IX biosynthetic process +
                                                regulatesregulation of heme biosynthetic process +
                                                is-asiroheme biosynthetic process
                                        is-aheme c metabolic process +
                                        is-aheme catabolic process +
                                        is-aheme o metabolic process +
                                        is-aheme oxidation
                                        is-asiroheme metabolic process +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism metabolic process
                                is-apigment metabolic process
                                        is-aheme metabolic process
                                                is-aheme a metabolic process +
                                                is-aheme b metabolic process +
                                                is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                        is-aheme a biosynthetic process
                                                        is-aheme b biosynthetic process
                                                        is-aheme c biosynthetic process
                                                        is-aheme O biosynthetic process
                                                        negatively-regulatesnegative regulation of heme biosynthetic process
                                                        positively-regulatespositive regulation of heme biosynthetic process
                                                        part-ofprotoporphyrinogen IX biosynthetic process +
                                                        regulatesregulation of heme biosynthetic process +
                                                        is-asiroheme biosynthetic process
                                                is-aheme c metabolic process +
                                                is-aheme catabolic process +
                                                is-aheme o metabolic process +
                                                is-aheme oxidation
                                                is-asiroheme metabolic process +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism metabolic process
                                is-apigment metabolic process
                                        is-apigment biosynthetic process
                                                is-aanthocyanin-containing compound biosynthetic process +
                                                is-aaurone biosynthetic process
                                                is-acarotenoid biosynthetic process +
                                                is-achlorophyll biosynthetic process +
                                                is-aeye pigment biosynthetic process +
                                                is-aflavone biosynthetic process +
                                                is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                        is-aheme a biosynthetic process
                                                        is-aheme b biosynthetic process
                                                        is-aheme c biosynthetic process
                                                        is-aheme O biosynthetic process
                                                        negatively-regulatesnegative regulation of heme biosynthetic process
                                                        positively-regulatespositive regulation of heme biosynthetic process
                                                        part-ofprotoporphyrinogen IX biosynthetic process +
                                                        regulatesregulation of heme biosynthetic process +
                                                        is-asiroheme biosynthetic process
                                                is-amelanin biosynthetic process +
                                                is-aocellus pigment biosynthetic process +
                                                is-aphlobaphene biosynthetic process
                                                is-aphytochrome chromophore biosynthetic process
                                                is-apigment biosynthetic process involved in pigment accumulation +
                                                is-apteridine biosynthetic process
                                                is-apurine nucleobase biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism metabolic process
                                is-asingle-organism biosynthetic process
                                        is-apigment biosynthetic process
                                                is-aanthocyanin-containing compound biosynthetic process +
                                                is-aaurone biosynthetic process
                                                is-acarotenoid biosynthetic process +
                                                is-achlorophyll biosynthetic process +
                                                is-aeye pigment biosynthetic process +
                                                is-aflavone biosynthetic process +
                                                is-aheme biosynthetic process [GO:0006783] (20 genes, 32 annotations)
                                                        is-aheme a biosynthetic process
                                                        is-aheme b biosynthetic process
                                                        is-aheme c biosynthetic process
                                                        is-aheme O biosynthetic process
                                                        negatively-regulatesnegative regulation of heme biosynthetic process
                                                        positively-regulatespositive regulation of heme biosynthetic process
                                                        part-ofprotoporphyrinogen IX biosynthetic process +
                                                        regulatesregulation of heme biosynthetic process +
                                                        is-asiroheme biosynthetic process
                                                is-amelanin biosynthetic process +
                                                is-aocellus pigment biosynthetic process +
                                                is-aphlobaphene biosynthetic process
                                                is-aphytochrome chromophore biosynthetic process
                                                is-apigment biosynthetic process involved in pigment accumulation +
                                                is-apteridine biosynthetic process
                                                is-apurine nucleobase biosynthetic process +


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory