Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FBXO4
  • Mouse genes Fbxo4
  • Rat genes Fbxo4
  • Zfish genes fbxo4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fbxo4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	FBXO4	IPI	UniProtKB:P63208	Human	PMID:16278047
Molecular Function	GO:0005515	protein binding	FBXO4	IPI	UniProtKB:Q13616	Human	PMID:16278047
Molecular Function	GO:0005515	protein binding	FBXO4	IPI	UniProtKB:P54274	Human	PMID:19487455
Molecular Function	GO:0005515	protein binding	FBXO4	IPI	UniProtKB:P54274	Human	PMID:20159592
Molecular Function	GO:0005515	protein binding	FBXO4	IPI	UniProtKB:P54274	Human	PMID:20181953
Molecular Function	GO:0005515	protein binding	FBXO4	IPI	UniProtKB:P63208	Human	PMID:20181953
Molecular Function	GO:0005515	protein binding	FBXO4	IPI	UniProtKB:P62258	Human	PMID:21242966
Molecular Function	GO:0005515	protein binding	FBXO4	IPI	UniProtKB:P62260	Human	PMID:21242966
Molecular Function	GO:0005515	protein binding	FBXO4	IPI	UniProtKB:P63208	Human	PMID:21242966
Molecular Function	GO:0005515	protein binding	FBXO4	IPI	UniProtKB:Q13616	Human	PMID:23108047
Molecular Function	GO:0005515	protein binding	FBXO4	IPI	UniProtKB:P54274	Human	PMID:24389012
Molecular Function	GO:0005515	protein binding	FBXO4	IPI	UniProtKB:P63208	Human	PMID:27705803
Molecular Function	GO:0005515	protein binding	FBXO4	IPI	UniProtKB:P63208	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	FBXO4	IPI	UniProtKB:Q13616	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	FBXO4	IPI	UniProtKB:P63208	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FBXO4	IPI	UniProtKB:Q59H18	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FBXO4	IPI	UniProtKB:O76024	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	FBXO4	IPI	UniProtKB:Q13148	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Fbxo4	IPI	UniProtKB:P62259	Mouse	MGI:MGI:5285136|PMID:21242966
Molecular Function	GO:0042803	protein homodimerization activity	FBXO4	IPI	UniProtKB:Q9UKT5	Human	PMID:20181953
Molecular Function	GO:1990756	ubiquitin ligase-substrate adaptor activity	FBXO4	IDA		Human	PMID:29142209
Molecular Function	GO:1990756	ubiquitin ligase-substrate adaptor activity	Fbxo4	IDA		Mouse	MGI:MGI:6106241|PMID:29142209
Molecular Function	GO:0061630	ubiquitin protein ligase activity	Fbxo4	IDA		Mouse	PMID:21911473
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	FBXO4	IDA		Human	PMID:10531035
Cellular Component	GO:0005737	cytoplasm	FBXO4	IDA		Human	PMID:21378169
Cellular Component	GO:0019005	SCF ubiquitin ligase complex	FBXO4	IDA		Human	PMID:20181953
Cellular Component	GO:0019005	SCF ubiquitin ligase complex	Fbxo4	IDA		Mouse	PMID:21911473
Cellular Component	GO:0000151	ubiquitin ligase complex	FBXO4	IDA		Human	PMID:10531035
Biological Process	GO:0019725	cellular homeostasis	Fbxo4	IMP	MGI:MGI:5301830	Mouse	PMID:21911473
Biological Process	GO:0071479	cellular response to ionizing radiation	Fbxo4	IDA		Mouse	PMID:21911473
Biological Process	GO:0090398	cellular senescence	Fbxo4	IMP	MGI:MGI:5301830	Mouse	PMID:21911473
Biological Process	GO:0035726	common myeloid progenitor cell proliferation	Fbxo4	IMP	MGI:MGI:5301830	Mouse	PMID:21911473
Biological Process	GO:0048147	negative regulation of fibroblast proliferation	Fbxo4	IMP	MGI:MGI:5301830	Mouse	PMID:21911473
Biological Process	GO:1900181	negative regulation of protein localization to nucleus	Fbxo4	IMP	MGI:MGI:5301830	Mouse	PMID:21911473
Biological Process	GO:1902916	positive regulation of protein polyubiquitination	Fbxo4	IMP	MGI:MGI:5301830	Mouse	PMID:21911473
Biological Process	GO:0031398	positive regulation of protein ubiquitination	FBXO4	IDA		Human	PMID:24389012
Biological Process	GO:0032212	positive regulation of telomere maintenance via telomerase	FBXO4	IMP		Human	PMID:16275645
Biological Process	GO:0010608	post-transcriptional regulation of gene expression	Fbxo4	IMP	MGI:MGI:5301830	Mouse	PMID:21911473
Biological Process	GO:0031648	protein destabilization	Fbxo4	IMP	MGI:MGI:5301830	Mouse	PMID:21911473
Biological Process	GO:0000209	protein polyubiquitination	FBXO4	IDA		Human	PMID:20181953
Biological Process	GO:0016567	protein ubiquitination	FBXO4	IDA		Human	PMID:10531035
Biological Process	GO:0016567	protein ubiquitination	FBXO4	IDA		Human	PMID:16275645
Biological Process	GO:2000001	regulation of DNA damage checkpoint	Fbxo4	IMP	MGI:MGI:5301830	Mouse	PMID:21911473
Biological Process	GO:0031647	regulation of protein stability	FBXO4	IMP		Human	PMID:16275645
Biological Process	GO:0031647	regulation of protein stability	FBXO4	IDA		Human	PMID:24389012
Biological Process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	FBXO4	IDA		Human	PMID:20159592
Biological Process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	FBXO4	IDA		Human	PMID:29142209

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern