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Fbxo4 Gene Detail
Summary
  • Symbol
    Fbxo4
  • Name
    F-box protein 4
  • Synonyms
    1700096C12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2146220
    NCBI Gene: 106052
  • Gene Overview
    MyGene.info: FBXO4
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:3965445-3979573 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 1.84 cM, cytoband A1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    40 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2146220
protein coding gene Chr15:3963564-3979573 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021683
protein coding gene Chr15:829758-844399 (-)
A/J MGP_AJ_G0021643
protein coding gene Chr15:859188-873427 (-)
AKR/J MGP_AKRJ_G0021621
protein coding gene Chr15:844389-858638 (-)
BALB/cJ MGP_BALBcJ_G0021650
protein coding gene Chr15:820408-833778 (-)
C3H/HeJ MGP_C3HHeJ_G0021426
protein coding gene Chr15:850421-866445 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022089
protein coding gene Chr15:910843-932284 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019627
protein coding gene Chr15:707567-721627 (-)
CAST/EiJ MGP_CASTEiJ_G0020942
protein coding gene Chr15:850278-863927 (-)
CBA/J MGP_CBAJ_G0021395
protein coding gene Chr15:895748-914091 (-)
DBA/2J MGP_DBA2J_G0021519
protein coding gene Chr15:811411-846200 (-)
FVB/NJ MGP_FVBNJ_G0021497
protein coding gene Chr15:783542-797269 (-)
LP/J MGP_LPJ_G0021586
protein coding gene Chr15:811005-827032 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021523
protein coding gene Chr15:949938-968632 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022112
protein coding gene Chr15:826313-840135 (-)
PWK/PhJ MGP_PWKPhJ_G0020686
protein coding gene Chr15:840829-854027 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020524
protein coding gene Chr15:893189-906873 (-)
WSB/EiJ MGP_WSBEiJ_G0020998
protein coding gene Chr15:808376-825488 (-)



Homology
more
  • Human Ortholog
    FBXO4, F-box protein 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FBXO4, F-box protein 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FBX4
  • Links
    NCBI Gene ID: 26272
    neXtProt AC: NX_Q9UKT5
    UniProt: Q9UKT5

  • Chr Location
    5p13.1; chr5:41925249-42040230 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 8134
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: FBXO4
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous or heterozygous for a knock-out allele exhibit increased tumor incidence of lymphoblastic lineage and premature death. Mice homozygous for a different knock-out allele are indistinguishable from wild-type mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022184 Ensembl Gene Model | MGI Sequence Detail 14129 C57BL/6J ±  kb
    transcript ENSMUST00000022791 Ensembl | MGI Sequence Detail 1565 Not Applicable  
    polypeptide ENSMUSP00000022791 Ensembl | MGI Sequence Detail 385 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 24

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1914771, MGI:2146089
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 1
      Gene Ontology 3
      Phenotypes 8
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:255973 Qie S, et al., Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis in head and neck squamous cell carcinoma. Nat Commun. 2017 Nov 16;8(1):1534

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory