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Fbxo4
Gene Detail
 Symbol
Name
ID
Fbxo4
F-box protein 4
MGI:2146220
Synonyms 1700096C12Rik
Feature Type protein coding gene
Genetic Map
Chromosome 15
1.84 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:3965445-3979573 bp, - strand
From VEGA annotation of GRCm38

  14129 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8134  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Fbxo4

Human
homologs
Human Homolog FBXO4, F-box protein 4
NCBI Gene ID 26272
neXtProt AC  NX_Q9UKT5
Human Synonyms  FBX4
Human Chr (Location)  5p12; chr5:41925252-41941570 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from APF )
 
Mice homozygous or heterozygous for a knock-out allele exhibit increased tumor incidence of lymphoblastic lineage and premature death. Mice homozygous for a different knock-out allele are indistinguishable from wild-type mice.
 
Interactions
Fbxo4 interacts with 73 markers (Mir16-1, Mir17, Mir19a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process positive regulation of protein ubiquitination, protein polyubiquitination, ...
Component cytoplasm, SCF ubiquitin ligase complex, ...
Function protein binding, protein homodimerization activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (74)    Tissues (11)    Images (21)
Theiler Stages: 23
Assay TypeResults
RNA in situ 74
cDNA source data(21)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) cDNA(23)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000027965 (Evidence)
Ensembl Gene ModelENSMUSG00000022184 (Evidence)
Entrez Gene106052 (Evidence)
UniGene234191
DFCITC1582258, TC1769966
DoTSDT.525508
NIA Mouse Gene IndexU035970
Consensus CDS ProjectCCDS27359.1
International Mouse Knockout Project StatusFbxo4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027965 VEGA Gene Model | MGI Sequence Detail 14129 C57BL/6J ±  kb
transcript OTTMUST00000069277 VEGA | MGI Sequence Detail 1565 Not Applicable 
polypeptide OTTMUSP00000035163 VEGA | MGI Sequence Detail 385 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(40 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001810 F-box domain, cyclin-like
Protein Ontology PR:000007408 F-box only protein 4
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:206100 Lee EK, et al., The FBXO4 tumor suppressor functions as a barrier to BRAFV600E-dependent metastatic melanoma. Mol Cell Biol. 2013 Nov;33(22):4422-33
All references(36)
Other
accession IDs
MGI:1914771, MGI:2146089

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory