Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes F2RL1
  • Mouse genes F2rl1
  • Rat genes F2rl1
  • Zfish genes f2rl1.1,f2rl1.2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set F2rl1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004930	G protein-coupled receptor activity	F2RL1	IMP		Human	PMID:18622013
Molecular Function	GO:0004930	G protein-coupled receptor activity	F2RL1	IMP		Human	PMID:28445455
Molecular Function	GO:0004930	G protein-coupled receptor activity	F2rl1	IMP		Mouse	MGI:MGI:5285163|PMID:20215560
Molecular Function	GO:0001965	G-protein alpha-subunit binding	F2rl1	IDA		Mouse	MGI:MGI:5285163|PMID:20215560
Molecular Function	GO:0031681	G-protein beta-subunit binding	F2rl1	IDA		Mouse	MGI:MGI:5285163|PMID:20215560
Molecular Function	GO:0140677	molecular function activator activity	F2rl1	IMP	MGI:MGI:2179844	Mouse	PMID:17992256
Molecular Function	GO:0002020	protease binding	F2RL1	IPI	UniProtKB:B2LSD2	Human	PMID:18434511
Molecular Function	GO:0005515	protein binding	F2RL1	IPI	UniProtKB:P29066	Human	PMID:10725339
Molecular Function	GO:0005515	protein binding	F2RL1	IPI	UniProtKB:P22681	Human	PMID:15708858
Molecular Function	GO:0005515	protein binding	F2RL1	IPI	UniProtKB:Q92905	Human	PMID:16410250
Molecular Function	GO:0005515	protein binding	F2RL1	IPI	UniProtKB:P13726	Human	PMID:16959886
Molecular Function	GO:0005515	protein binding	F2RL1	IPI	UniProtKB:Q15363	Human	PMID:17693410
Molecular Function	GO:0005515	protein binding	F2RL1	IPI	UniProtKB:Q14868	Human	PMID:20826780
Molecular Function	GO:0005515	protein binding	F2RL1	IPI	UniProtKB:Q15363	Human	PMID:21219331
Molecular Function	GO:0005515	protein binding	F2RL1	IPI	UniProtKB:P04156	Human	PMID:28298427
Molecular Function	GO:0005515	protein binding	F2RL1	IPI	UniProtKB:P0DMV9	Human	PMID:28298427
Molecular Function	GO:0005515	protein binding	F2RL1	IPI	UniProtKB:P16615	Human	PMID:28298427
Molecular Function	GO:0005515	protein binding	F2rl1	IPI	UniProtKB:Q63524	Rat	PMID:17693410|RGD:8554006
Molecular Function	GO:0001648	proteinase-activated receptor activity	F2rl1	IMP	MGI:MGI:2179844	Mouse	PMID:17992256
Molecular Function	GO:0001648	proteinase-activated receptor activity	f2rl1.2	IDA		Zfish	PMID:21181945
Cellular Component	GO:0005769	early endosome	F2RL1	IDA		Human	PMID:22547407
Cellular Component	GO:0005886	plasma membrane	F2RL1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	F2RL1	IDA		Human	PMID:17848177
Cellular Component	GO:0005886	plasma membrane	F2RL1	IDA		Human	PMID:22547407
Cellular Component	GO:0005886	plasma membrane	F2RL1	IDA		Human	PMID:28445455
Cellular Component	GO:0031143	pseudopodium	F2rl1	IDA		Mouse	MGI:MGI:2673740|PMID:12821670
Biological Process	GO:0008283	cell population proliferation	f2rl1.2	IGI	ZFIN:ZDB-GENE-040426-2169	Zfish	PMID:29301867
Biological Process	GO:0008283	cell population proliferation	f2rl1.2	IMP	ZFIN:ZDB-GENO-200109-5	Zfish	PMID:29301867
Biological Process	GO:0045217	cell-cell junction maintenance	F2RL1	IMP		Human	PMID:23202369
Biological Process	GO:0051607	defense response to virus	F2RL1	IDA		Human	PMID:18453611
Biological Process	GO:0051607	defense response to virus	F2RL1	IDA		Human	PMID:19494303
Biological Process	GO:0051607	defense response to virus	F2rl1	IDA		Mouse	MGI:MGI:3848267|PMID:19494303
Biological Process	GO:0061028	establishment of endothelial barrier	F2RL1	IDA		Human	PMID:20826780
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	F2RL1	IMP		Human	PMID:28445455
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	F2rl1	IMP	MGI:MGI:2179844	Mouse	MGI:MGI:3772319|PMID:17992256
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	f2rl1.2	IDA		Zfish	PMID:21181945|ZFIN:ZDB-PUB-110103-12
Biological Process	GO:0050900	leukocyte migration	F2RL1	IDA		Human	PMID:15155775
Biological Process	GO:0070661	leukocyte proliferation	F2rl1	IDA		Mouse	MGI:MGI:3848267|PMID:19494303
Biological Process	GO:0097029	mature conventional dendritic cell differentiation	F2RL1	IDA		Human	PMID:16478888
Biological Process	GO:0097029	mature conventional dendritic cell differentiation	F2rl1	IDA		Mouse	MGI:MGI:4839888|PMID:19845798
Biological Process	GO:0002009	morphogenesis of an epithelium	f2rl1.2	IGI	ZFIN:ZDB-GENE-040426-2169	Zfish	PMID:29301867
Biological Process	GO:0002009	morphogenesis of an epithelium	f2rl1.2	IMP	ZFIN:ZDB-GENO-200109-5	Zfish	PMID:29301867
Biological Process	GO:0032682	negative regulation of chemokine production	F2RL1	IDA		Human	PMID:19865078
Biological Process	GO:0046676	negative regulation of insulin secretion	F2rl1	IMP	MGI:MGI:2179844	Mouse	PMID:17992256
Biological Process	GO:0046329	negative regulation of JNK cascade	F2RL1	IDA		Human	PMID:19781631
Biological Process	GO:0034140	negative regulation of toll-like receptor 3 signaling pathway	F2RL1	IMP		Human	PMID:19865078
Biological Process	GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway	F2RL1	IDA		Human	PMID:19781631
Biological Process	GO:0042119	neutrophil activation	F2RL1	IDA		Human	PMID:15155775
Biological Process	GO:0030836	positive regulation of actin filament depolymerization	F2RL1	IDA		Human	PMID:17500066
Biological Process	GO:0030335	positive regulation of cell migration	F2rl1	IDA		Mouse	MGI:MGI:5285163|PMID:20215560
Biological Process	GO:0032722	positive regulation of chemokine production	F2RL1	IDA		Human	PMID:19494303
Biological Process	GO:0032722	positive regulation of chemokine production	F2RL1	IDA		Human	PMID:21501162
Biological Process	GO:0032722	positive regulation of chemokine production	F2rl1	IDA		Mouse	MGI:MGI:3848267|PMID:19494303
Biological Process	GO:0050921	positive regulation of chemotaxis	F2rl1	IDA		Mouse	MGI:MGI:2673740|PMID:12821670
Biological Process	GO:0002720	positive regulation of cytokine production involved in immune response	F2RL1	IDA		Human	PMID:11441110
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	F2RL1	IDA		Human	PMID:10725339
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	F2rl1	IDA		Mouse	MGI:MGI:5285163|PMID:20215560
Biological Process	GO:0043311	positive regulation of eosinophil degranulation	F2RL1	IDA		Human	PMID:11714832
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	F2RL1	IDA		Human	PMID:10725339
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	F2rl1	IDA		Mouse	MGI:MGI:5285163|PMID:20215560
Biological Process	GO:0003104	positive regulation of glomerular filtration	F2rl1	IDA		Rat	PMID:12644441|RGD:1582293
Biological Process	GO:0043547	positive regulation of GTPase activity	F2RL1	IMP		Human	PMID:23202369
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	F2RL1	IDA		Human	PMID:11413129
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	F2RL1	IDA		Human	PMID:15155775
Biological Process	GO:0032733	positive regulation of interleukin-10 production	F2RL1	IDA		Human	PMID:18453611
Biological Process	GO:0032755	positive regulation of interleukin-6 production	F2RL1	IDA		Human	PMID:11447194
Biological Process	GO:0032755	positive regulation of interleukin-6 production	F2RL1	IDA		Human	PMID:15155775
Biological Process	GO:0032757	positive regulation of interleukin-8 production	F2RL1	IDA		Human	PMID:15155775
Biological Process	GO:0032757	positive regulation of interleukin-8 production	F2RL1	IDA		Human	PMID:17404307
Biological Process	GO:0032757	positive regulation of interleukin-8 production	F2RL1	IDA		Human	PMID:18622013
Biological Process	GO:0032757	positive regulation of interleukin-8 production	F2RL1	IDA		Human	PMID:19865078
Biological Process	GO:0046330	positive regulation of JNK cascade	F2RL1	IDA		Human	PMID:11413129
Biological Process	GO:0002690	positive regulation of leukocyte chemotaxis	F2RL1	IDA		Human	PMID:17991872
Biological Process	GO:0070963	positive regulation of neutrophil mediated killing of gram-negative bacterium	F2RL1	IDA		Human	PMID:21501162
Biological Process	GO:0060100	positive regulation of phagocytosis, engulfment	F2RL1	IDA		Human	PMID:21501162
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	F2rl1	IDA		Mouse	MGI:MGI:5285163|PMID:20215560
Biological Process	GO:0050927	positive regulation of positive chemotaxis	F2RL1	IDA		Human	PMID:17991872
Biological Process	GO:0031274	positive regulation of pseudopodium assembly	F2rl1	IDA		Mouse	MGI:MGI:2673740|PMID:12821670
Biological Process	GO:1900135	positive regulation of renin secretion into blood stream	F2rl1	IDA		Mouse	MGI:MGI:5315674|PMID:21859963
Biological Process	GO:0035025	positive regulation of Rho protein signal transduction	F2RL1	IMP		Human	PMID:20826780
Biological Process	GO:0035025	positive regulation of Rho protein signal transduction	F2rl1	IDA		Mouse	MGI:MGI:5285163|PMID:20215560
Biological Process	GO:0032930	positive regulation of superoxide anion generation	F2RL1	IDA		Human	PMID:11714832
Biological Process	GO:0034137	positive regulation of toll-like receptor 2 signaling pathway	F2RL1	IMP		Human	PMID:19865078
Biological Process	GO:0034141	positive regulation of toll-like receptor 3 signaling pathway	F2RL1	IMP		Human	PMID:19865078
Biological Process	GO:0034145	positive regulation of toll-like receptor 4 signaling pathway	F2RL1	IDA		Human	PMID:18622013
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	F2RL1	IDA		Human	PMID:16410250
Biological Process	GO:0032729	positive regulation of type II interferon production	F2rl1	IDA		Mouse	MGI:MGI:3848267|PMID:19494303
Biological Process	GO:0099109	potassium channel activating, G protein-coupled receptor signaling pathway	F2rl1	IMP	MGI:MGI:2179844	Mouse	PMID:17992256
Biological Process	GO:0030193	regulation of blood coagulation	F2RL1	IDA		Human	PMID:17848177
Biological Process	GO:2000341	regulation of chemokine (C-X-C motif) ligand 2 production	F2RL1	IDA		Human	PMID:21501162
Biological Process	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	F2RL1	IDA		Human	PMID:18453611
Biological Process	GO:0046328	regulation of JNK cascade	F2RL1	IDA		Human	PMID:16410250
Biological Process	GO:0002286	T cell activation involved in immune response	F2rl1	IDA		Mouse	MGI:MGI:4839888|PMID:19845798
Biological Process	GO:0042311	vasodilation	F2rl1	IDA		Mouse	MGI:MGI:5315674|PMID:21859963
Biological Process	GO:0042311	vasodilation	F2rl1	IMP		Mouse	MGI:MGI:3530059|PMID:9918574
Biological Process	GO:0042311	vasodilation	F2rl1	IDA		Rat	PMID:11884377|RGD:8553406
Biological Process	GO:0042311	vasodilation	F2rl1	IDA		Rat	PMID:12644441|RGD:1582293

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern