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Gene Ontology Browser
Term Detail
GO term:mature dendritic cell differentiation
GO id:GO:0097029
Definition:The process in which antigen-activated dendritic cells acquire the specialized features of a mature dendritic cell. Mature dendritic cells upregulate the surface expression of MHC molecules, chemokine receptors and adhesion molecules, and increase the number of dendrites (cytoplasmic protrusions) in preparation for migration to lymphoid organs where they present antigen to T cells.
CommentsNote that immunologists typically use the word 'maturation' to refer to dendritic cells undergoing the process that GO describes as 'cell differentiation'.
Number of paths to term: 18

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acellular developmental process
                                        is-acell differentiation
                                                is-aleukocyte differentiation
                                                        is-adendritic cell differentiation
                                                                is-amature dendritic cell differentiation [GO:0097029] (3 genes, 4 annotations)
                                                                is-amyeloid dendritic cell differentiation +
                                                                negatively-regulatesnegative regulation of dendritic cell differentiation
                                                                is-aplasmacytoid dendritic cell differentiation +
                                                                positively-regulatespositive regulation of dendritic cell differentiation
                                                                regulatesregulation of dendritic cell differentiation +


Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-aanatomical structure development
                                is-aorgan development
                                        is-ahematopoietic or lymphoid organ development
                                                is-ahemopoiesis
                                                        part-ofleukocyte differentiation
                                                                is-adendritic cell differentiation
                                                                        is-amature dendritic cell differentiation [GO:0097029] (3 genes, 4 annotations)
                                                                        is-amyeloid dendritic cell differentiation +
                                                                        negatively-regulatesnegative regulation of dendritic cell differentiation
                                                                        is-aplasmacytoid dendritic cell differentiation +
                                                                        positively-regulatespositive regulation of dendritic cell differentiation
                                                                        regulatesregulation of dendritic cell differentiation +


Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-aanatomical structure development
                                is-asystem development
                                        is-aimmune system development
                                                part-ofhematopoietic or lymphoid organ development
                                                        is-ahemopoiesis
                                                                part-ofleukocyte differentiation
                                                                        is-adendritic cell differentiation
                                                                                is-amature dendritic cell differentiation [GO:0097029] (3 genes, 4 annotations)
                                                                                is-amyeloid dendritic cell differentiation +
                                                                                negatively-regulatesnegative regulation of dendritic cell differentiation
                                                                                is-aplasmacytoid dendritic cell differentiation +
                                                                                positively-regulatespositive regulation of dendritic cell differentiation
                                                                                regulatesregulation of dendritic cell differentiation +


Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-aanatomical structure development
                                is-asystem development
                                        part-oforgan development
                                                is-ahematopoietic or lymphoid organ development
                                                        is-ahemopoiesis
                                                                part-ofleukocyte differentiation
                                                                        is-adendritic cell differentiation
                                                                                is-amature dendritic cell differentiation [GO:0097029] (3 genes, 4 annotations)
                                                                                is-amyeloid dendritic cell differentiation +
                                                                                negatively-regulatesnegative regulation of dendritic cell differentiation
                                                                                is-aplasmacytoid dendritic cell differentiation +
                                                                                positively-regulatespositive regulation of dendritic cell differentiation
                                                                                regulatesregulation of dendritic cell differentiation +


Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-asingle-organism developmental process
                                is-acellular developmental process
                                        is-acell differentiation
                                                is-aleukocyte differentiation
                                                        is-adendritic cell differentiation
                                                                is-amature dendritic cell differentiation [GO:0097029] (3 genes, 4 annotations)
                                                                is-amyeloid dendritic cell differentiation +
                                                                negatively-regulatesnegative regulation of dendritic cell differentiation
                                                                is-aplasmacytoid dendritic cell differentiation +
                                                                positively-regulatespositive regulation of dendritic cell differentiation
                                                                regulatesregulation of dendritic cell differentiation +


Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-asingle-organism developmental process
                                is-ahematopoietic or lymphoid organ development
                                        is-ahemopoiesis
                                                part-ofleukocyte differentiation
                                                        is-adendritic cell differentiation
                                                                is-amature dendritic cell differentiation [GO:0097029] (3 genes, 4 annotations)
                                                                is-amyeloid dendritic cell differentiation +
                                                                negatively-regulatesnegative regulation of dendritic cell differentiation
                                                                is-aplasmacytoid dendritic cell differentiation +
                                                                positively-regulatespositive regulation of dendritic cell differentiation
                                                                regulatesregulation of dendritic cell differentiation +


Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-asingle-organism developmental process
                                is-amulticellular organismal development
                                        part-ofsystem development
                                                is-aimmune system development
                                                        part-ofhematopoietic or lymphoid organ development
                                                                is-ahemopoiesis
                                                                        part-ofleukocyte differentiation
                                                                                is-adendritic cell differentiation
                                                                                        is-amature dendritic cell differentiation [GO:0097029] (3 genes, 4 annotations)
                                                                                        is-amyeloid dendritic cell differentiation +
                                                                                        negatively-regulatesnegative regulation of dendritic cell differentiation
                                                                                        is-aplasmacytoid dendritic cell differentiation +
                                                                                        positively-regulatespositive regulation of dendritic cell differentiation
                                                                                        regulatesregulation of dendritic cell differentiation +


Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-asingle-organism developmental process
                                is-amulticellular organismal development
                                        part-ofsystem development
                                                part-oforgan development
                                                        is-ahematopoietic or lymphoid organ development
                                                                is-ahemopoiesis
                                                                        part-ofleukocyte differentiation
                                                                                is-adendritic cell differentiation
                                                                                        is-amature dendritic cell differentiation [GO:0097029] (3 genes, 4 annotations)
                                                                                        is-amyeloid dendritic cell differentiation +
                                                                                        negatively-regulatesnegative regulation of dendritic cell differentiation
                                                                                        is-aplasmacytoid dendritic cell differentiation +
                                                                                        positively-regulatespositive regulation of dendritic cell differentiation
                                                                                        regulatesregulation of dendritic cell differentiation +


Gene_Ontology
        is-abiological_process
                is-aimmune system process
                        is-aimmune system development
                                part-ofhematopoietic or lymphoid organ development
                                        is-ahemopoiesis
                                                part-ofleukocyte differentiation
                                                        is-adendritic cell differentiation
                                                                is-amature dendritic cell differentiation [GO:0097029] (3 genes, 4 annotations)
                                                                is-amyeloid dendritic cell differentiation +
                                                                negatively-regulatesnegative regulation of dendritic cell differentiation
                                                                is-aplasmacytoid dendritic cell differentiation +
                                                                positively-regulatespositive regulation of dendritic cell differentiation
                                                                regulatesregulation of dendritic cell differentiation +


Gene_Ontology
        is-abiological_process
                is-amulticellular organismal process
                        is-asingle-multicellular organism process
                                is-amulticellular organismal development
                                        part-ofsystem development
                                                is-aimmune system development
                                                        part-ofhematopoietic or lymphoid organ development
                                                                is-ahemopoiesis
                                                                        part-ofleukocyte differentiation
                                                                                is-adendritic cell differentiation
                                                                                        is-amature dendritic cell differentiation [GO:0097029] (3 genes, 4 annotations)
                                                                                        is-amyeloid dendritic cell differentiation +
                                                                                        negatively-regulatesnegative regulation of dendritic cell differentiation
                                                                                        is-aplasmacytoid dendritic cell differentiation +
                                                                                        positively-regulatespositive regulation of dendritic cell differentiation
                                                                                        regulatesregulation of dendritic cell differentiation +


Gene_Ontology
        is-abiological_process
                is-amulticellular organismal process
                        is-asingle-multicellular organism process
                                is-amulticellular organismal development
                                        part-ofsystem development
                                                part-oforgan development
                                                        is-ahematopoietic or lymphoid organ development
                                                                is-ahemopoiesis
                                                                        part-ofleukocyte differentiation
                                                                                is-adendritic cell differentiation
                                                                                        is-amature dendritic cell differentiation [GO:0097029] (3 genes, 4 annotations)
                                                                                        is-amyeloid dendritic cell differentiation +
                                                                                        negatively-regulatesnegative regulation of dendritic cell differentiation
                                                                                        is-aplasmacytoid dendritic cell differentiation +
                                                                                        positively-regulatespositive regulation of dendritic cell differentiation
                                                                                        regulatesregulation of dendritic cell differentiation +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-multicellular organism process
                                is-amulticellular organismal development
                                        part-ofsystem development
                                                is-aimmune system development
                                                        part-ofhematopoietic or lymphoid organ development
                                                                is-ahemopoiesis
                                                                        part-ofleukocyte differentiation
                                                                                is-adendritic cell differentiation
                                                                                        is-amature dendritic cell differentiation [GO:0097029] (3 genes, 4 annotations)
                                                                                        is-amyeloid dendritic cell differentiation +
                                                                                        negatively-regulatesnegative regulation of dendritic cell differentiation
                                                                                        is-aplasmacytoid dendritic cell differentiation +
                                                                                        positively-regulatespositive regulation of dendritic cell differentiation
                                                                                        regulatesregulation of dendritic cell differentiation +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-multicellular organism process
                                is-amulticellular organismal development
                                        part-ofsystem development
                                                part-oforgan development
                                                        is-ahematopoietic or lymphoid organ development
                                                                is-ahemopoiesis
                                                                        part-ofleukocyte differentiation
                                                                                is-adendritic cell differentiation
                                                                                        is-amature dendritic cell differentiation [GO:0097029] (3 genes, 4 annotations)
                                                                                        is-amyeloid dendritic cell differentiation +
                                                                                        negatively-regulatesnegative regulation of dendritic cell differentiation
                                                                                        is-aplasmacytoid dendritic cell differentiation +
                                                                                        positively-regulatespositive regulation of dendritic cell differentiation
                                                                                        regulatesregulation of dendritic cell differentiation +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acellular developmental process
                                        is-acell differentiation
                                                is-aleukocyte differentiation
                                                        is-adendritic cell differentiation
                                                                is-amature dendritic cell differentiation [GO:0097029] (3 genes, 4 annotations)
                                                                is-amyeloid dendritic cell differentiation +
                                                                negatively-regulatesnegative regulation of dendritic cell differentiation
                                                                is-aplasmacytoid dendritic cell differentiation +
                                                                positively-regulatespositive regulation of dendritic cell differentiation
                                                                regulatesregulation of dendritic cell differentiation +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism developmental process
                                is-acellular developmental process
                                        is-acell differentiation
                                                is-aleukocyte differentiation
                                                        is-adendritic cell differentiation
                                                                is-amature dendritic cell differentiation [GO:0097029] (3 genes, 4 annotations)
                                                                is-amyeloid dendritic cell differentiation +
                                                                negatively-regulatesnegative regulation of dendritic cell differentiation
                                                                is-aplasmacytoid dendritic cell differentiation +
                                                                positively-regulatespositive regulation of dendritic cell differentiation
                                                                regulatesregulation of dendritic cell differentiation +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism developmental process
                                is-ahematopoietic or lymphoid organ development
                                        is-ahemopoiesis
                                                part-ofleukocyte differentiation
                                                        is-adendritic cell differentiation
                                                                is-amature dendritic cell differentiation [GO:0097029] (3 genes, 4 annotations)
                                                                is-amyeloid dendritic cell differentiation +
                                                                negatively-regulatesnegative regulation of dendritic cell differentiation
                                                                is-aplasmacytoid dendritic cell differentiation +
                                                                positively-regulatespositive regulation of dendritic cell differentiation
                                                                regulatesregulation of dendritic cell differentiation +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism developmental process
                                is-amulticellular organismal development
                                        part-ofsystem development
                                                is-aimmune system development
                                                        part-ofhematopoietic or lymphoid organ development
                                                                is-ahemopoiesis
                                                                        part-ofleukocyte differentiation
                                                                                is-adendritic cell differentiation
                                                                                        is-amature dendritic cell differentiation [GO:0097029] (3 genes, 4 annotations)
                                                                                        is-amyeloid dendritic cell differentiation +
                                                                                        negatively-regulatesnegative regulation of dendritic cell differentiation
                                                                                        is-aplasmacytoid dendritic cell differentiation +
                                                                                        positively-regulatespositive regulation of dendritic cell differentiation
                                                                                        regulatesregulation of dendritic cell differentiation +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism developmental process
                                is-amulticellular organismal development
                                        part-ofsystem development
                                                part-oforgan development
                                                        is-ahematopoietic or lymphoid organ development
                                                                is-ahemopoiesis
                                                                        part-ofleukocyte differentiation
                                                                                is-adendritic cell differentiation
                                                                                        is-amature dendritic cell differentiation [GO:0097029] (3 genes, 4 annotations)
                                                                                        is-amyeloid dendritic cell differentiation +
                                                                                        negatively-regulatesnegative regulation of dendritic cell differentiation
                                                                                        is-aplasmacytoid dendritic cell differentiation +
                                                                                        positively-regulatespositive regulation of dendritic cell differentiation
                                                                                        regulatesregulation of dendritic cell differentiation +


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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory