Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ETV4
  • Mouse genes Etv4
  • Rat genes Etv4
  • Zfish genes etv4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Etv4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Etv4	IDA		Mouse	PMID:12527199
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ETV4	IDA		Human	PMID:24983502
Molecular Function	GO:0005515	protein binding	ETV4	IPI	UniProtKB:P14079	Human	PMID:22458338
Molecular Function	GO:0005515	protein binding	ETV4	IPI	UniProtKB:Q16236	Human	PMID:32911434
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ETV4	IDA		Human	PMID:14625302
Molecular Function	GO:0043565	sequence-specific DNA binding	etv4	IDA		Zfish	PMID:18177854
Molecular Function	GO:0043565	sequence-specific DNA binding	etv4	IDA		Zfish	PMID:9671318
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ETV4	IDA		Human	PMID:28473536
Cellular Component	GO:0005694	chromosome	ETV4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005622	intracellular anatomical structure	Etv4	IDA		Mouse	PMID:10482234
Cellular Component	GO:0005730	nucleolus	ETV4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Etv4	IDA		Mouse	PMID:25512490
Biological Process	GO:0060444	branching involved in mammary gland duct morphogenesis	Etv4	IDA		Mouse	PMID:12871699
Biological Process	GO:0060444	branching involved in mammary gland duct morphogenesis	Etv4	IMP	MGI:MGI:2445834	Mouse	PMID:18977342
Biological Process	GO:0035108	limb morphogenesis	etv4	IGI	ZFIN:ZDB-MRPHLNO-100617-9,ZFIN:ZDB-MRPHLNO-100621-3,ZFIN:ZDB-MRPHLNO-100621-4	Zfish	PMID:19386268
Biological Process	GO:0008045	motor neuron axon guidance	Etv4	IMP	MGI:MGI:2387770	Mouse	PMID:12372283
Biological Process	GO:0033600	negative regulation of mammary gland epithelial cell proliferation	Etv4	IMP	MGI:MGI:2445834	Mouse	PMID:18977342
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Etv4	IPI	UniProtKB:Q61069	Mouse	PMID:15466854
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Etv4	IDA		Mouse	PMID:15466854
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	etv4	IDA		Zfish	PMID:9671318|ZFIN:ZDB-PUB-980729-36
Biological Process	GO:0010628	positive regulation of gene expression	Etv4	IDA		Mouse	MGI:MGI:5447623|PMID:15253939
Biological Process	GO:0045618	positive regulation of keratinocyte differentiation	ETV4	IMP		Human	PMID:31552090
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ETV4	IDA		Human	PMID:24983502
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Etv4	IMP		Mouse	PMID:22014525
Biological Process	GO:0035778	pronephric nephron tubule epithelial cell differentiation	etv4	IGI	ZFIN:ZDB-MRPHLNO-100617-9,ZFIN:ZDB-MRPHLNO-100621-4	Zfish	PMID:26827902
Biological Process	GO:0035778	pronephric nephron tubule epithelial cell differentiation	etv4	IMP	ZFIN:ZDB-MRPHLNO-100617-9	Zfish	PMID:26827902
Biological Process	GO:0048793	pronephros development	etv4	IGI	ZFIN:ZDB-MRPHLNO-080311-1,ZFIN:ZDB-MRPHLNO-080311-2	Zfish	PMID:21184241
Biological Process	GO:0006355	regulation of DNA-templated transcription	etv4	IDA		Zfish	PMID:9671318|ZFIN:ZDB-PUB-980729-36
Biological Process	GO:0048863	stem cell differentiation	Etv4	IMP	MGI:MGI:2445834	Mouse	PMID:18977342
Biological Process	GO:0006366	transcription by RNA polymerase II	Etv4	IMP		Mouse	PMID:22014525

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern