Etv4
Gene Detail

Symbol

Name
ID

Etv4
ets variant 4
MGI:99423

Synonyms

Pea3, Pea-3

Feature Type

protein coding gene

Genetic Map

Chromosome 11
65.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr11:101769747-101785371 bp, - strand From VEGA annotation of GRCm38   15625 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:1504  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: transcription factor ER81
Gene Tree: Etv4

Human
homologs

Human Homolog		ETV4, ets variant 4
NCBI Gene ID		2118
neXtProt AC		NX_P43268
Human Synonyms		E1AF, E1A-F, PEA3, PEAS3
Human Chr (Location)		17q21; chr17:43527843-43546432 (-)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(36) : Gene trapped(31) Targeted(5)
Genomic Mutations involving Etv4 (1)
Incidental mutations (data from APF )
 

Homozygotes for targeted null mutations exhibit male infertility due to failure to ejaculate, impaired branching of motor neurons, and abnormal mammary gland terminal differentiation.

 
Mutations Annotated to Human Diseases (1)   

Interactions

Etv4 interacts with 108 markers (Mir15a, Mir15b, Mir16-1, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (24 annotations)

Process	branching involved in mammary gland duct morphogenesis, motor neuron axon guidance, ...
Component	intracellular, nucleolus, ...
Function	DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (127 records)

Data Summary: Results (336)    Tissues (225)    Images (40)    Tissue x Stage Matrix (view)

Assay Type	Results
Immunohistochemistry	5
RNA in situ	261
In situ reporter (knock in)	15
Northern blot	11
RT-PCR	44

cDNA source data(48)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(57) Genomic(1) cDNA(48) Primer pair(4) Other(4)
Microarray probesets(4)

Other database
links

VEGA Gene Model	OTTMUSG00000002089 (Evidence)
Ensembl Gene Model	ENSMUSG00000017724 (Evidence)
Entrez Gene	18612 (Evidence)
UniGene	5025
DFCI	TC1582450, TC1628960
DoTS	DT.101191916, DT.101307029, DT.102548943, DT.40154619, DT.91333908, DT.99854468
NIA Mouse Gene Index	U033457
Consensus CDS Project	CCDS48937.1
International Mouse Knockout Project Status	Etv4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000002089	VEGA Gene Model | MGI Sequence Detail	15625	C57BL/6J
transcript	OTTMUST00000004229	VEGA | MGI Sequence Detail	2395	Not Applicable
polypeptide	OTTMUSP00000002013	VEGA | MGI Sequence Detail	486	Not Applicable

All sequences(75) RefSeq(16) UniProt(5)

Polymorphisms

PCR(1) : SNPs within 2kb(94 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR000418	Ets domain
InterPro	IPR006715	PEA3-type ETS-domain transcription factor, N-terminal
InterPro	IPR011991	Winged helix-turn-helix DNA-binding domain
Protein Ontology	PR:000007227	ETS translocation variant 4

References

(Earliest) J:588 Martin ME, et al., Expression of a 91-kilodalton PEA3-binding protein is down-regulated during differentiation of F9 embryonal carcinoma cells. Mol Cell Biol. 1992 May;12(5):2213-21
(Latest) J:216935 Xu B, et al., PTEN signaling through RAF1 proto-oncogene serine/threonine kinase (RAF1)/ERK in the epididymis is essential for male fertility. Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18643-8
All references(186)

Other
accession IDs

MGD-MRK-13225, MGD-MRK-16186, MGI:2144527