Etv4 MGI Mouse Gene Detail - MGI:99423

Etv4 Gene Detail

Symbol

Etv4
Name

ets variant 4
Synonyms

Pea3, Pea-3

Feature Type

protein coding gene
IDs

MGI:99423
NCBI Gene: 18612
Gene Overview

MyGene.info: ETV4

Sequence Map

Chr11:101769747-101785371 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

15625 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 65.48 cM
Mapping Data

5 experiments

Human Ortholog

ETV4, ETS variant 4

Vertebrate Orthologs

8

Human Ortholog

ETV4, ETS variant 4
Orthology source: HomoloGene, HGNC
Synonyms

E1AF, E1A-F, PEA3, PEAS3
Links

HGNC:3493

NCBI Gene ID: 2118

neXtProt AC: NX_P43268

UniProt: P43268
Chr Location

17q21.31; chr17:43527843-43546432 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 1504
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 macaque, rhesus
HCOP

human homology predictions: ETV4
Protein SuperFamily

transcription factor ER81
Gene Tree

Etv4

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Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

17 phenotypes from 3 alleles in 4 genetic backgrounds
24 phenotypes from multigenic genotypes
32 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

36
Gene trapped

31
Targeted

5
Genomic Mutations

1 involving Etv4
Incidental Mutations

APF
Find Mice (IMSR)

24 strains or lines available

Homozygotes for targeted null mutations exhibit male infertility due to failure to ejaculate, impaired branching of motor neurons, and abnormal mammary gland terminal differentiation.

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All GO Annotations

21
GO References

13

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

338
Tissues

225
cDNA Data

48
Literature Summary

153

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ETV4

ZFIN etv4

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Etv4 interacts with 108 markers (Mir15a, Mir15b, Mir16-1, ...) View All

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All Sequences

67
RefSeq

16
UniProt

5
CCDS

CCDS48937.1, CCDS83902.1, CCDS83903.1
UniGene

5025

			Length	Strain/Species	Flank
genomic	OTTMUSG00000002089	VEGA Gene Model \| MGI Sequence Detail	15625	C57BL/6J	± kb
transcript	OTTMUST00000004229	VEGA \| MGI Sequence Detail	2395	Not Applicable
polypeptide	OTTMUSP00000002013	VEGA \| MGI Sequence Detail	486	Not Applicable

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SNPs within 2kb

93 from dbSNP Build 142

PCR

1

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UniProt

5 Sequences
Protein Ontology

PR:000007227 ETS translocation variant 4

(term hierarchy)
InterPro Domains

IPR000418 Ets domain

IPR006715 PEA3-type ETS-domain transcription factor, N-terminal

IPR011991 Winged helix-turn-helix DNA-binding domain

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All nucleic 58

Genomic 1

cDNA 48

Primer pair 4

Other 5

Microarray probesets 4

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MGD-MRK-13225, MGD-MRK-16186, MGI:2144527

Summaries

All 218

Developmental Gene Expression 153

Diseases 1

Gene Ontology 13

Phenotypes 32
Earliest

J:588 Martin ME, et al., Expression of a 91-kilodalton PEA3-binding protein is down-regulated during differentiation of F9 embryonal carcinoma cells. Mol Cell Biol. 1992 May;12(5):2213-21
Latest

J:243411 Rutledge EA, et al., Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development. Development. 2017 Sep 01;144(17):3177-3188

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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