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Etv4 Gene Detail
Summary
  • Symbol
    Etv4
  • Name
    ets variant 4
  • Synonyms
    Pea3, Pea-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:99423
    NCBI Gene: 18612
  • Gene Overview
    MyGene.info: ETV4
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr11:101769747-101785371 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      15625 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 65.48 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    ETV4, ETS variant 4
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ETV4, ETS variant 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    E1AF, E1A-F, PEA3, PEAS3
  • Links
    NCBI Gene ID: 2118
    neXtProt AC: NX_P43268
    UniProt: P43268

  • Chr Location
    17q21.31; chr17:43527843-43546432 (-)  GRCh38.p7
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 3 alleles in 4 genetic backgrounds
    24 phenotypes from multigenic genotypes
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit male infertility due to failure to ejaculate, impaired branching of motor neurons, and abnormal mammary gland terminal differentiation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    26
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    353
  • Tissues
    237
  • cDNA Data
    48
  • Literature Summary
    170
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000002089 VEGA Gene Model | MGI Sequence Detail 15625 C57BL/6J ±  kb
    transcript OTTMUST00000004229 VEGA | MGI Sequence Detail 2395 Not Applicable  
    polypeptide OTTMUSP00000002013 VEGA | MGI Sequence Detail 486 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      93 from dbSNP Build 142
    • PCR
      1
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR000418 Ets domain
      IPR006715 PEA3-type ETS-domain transcription factor, N-terminal
      IPR036390 Winged helix DNA-binding domain superfamily
      IPR036388 Winged helix-like DNA-binding domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 59
      Genomic 2
      cDNA 48
      Primer pair 4
      Other 5

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13225, MGD-MRK-16186, MGI:2144527
    References
    more
    • Summaries
      All 240
      Developmental Gene Expression 170
      Diseases 1
      Gene Ontology 13
      Phenotypes 36
    • Earliest
      J:588 Martin ME, et al., Expression of a 91-kilodalton PEA3-binding protein is down-regulated during differentiation of F9 embryonal carcinoma cells. Mol Cell Biol. 1992 May;12(5):2213-21
    • Latest
      J:263230 Helmbacher F, Tissue-specific activities of the Fat1 cadherin cooperate to control neuromuscular morphogenesis. PLoS Biol. 2018 May;16(5):e2004734
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/16/2018
    MGI 6.12     		The Jackson Laboratory