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Etv4 Gene Detail
Summary
  • Symbol
    Etv4
  • Name
    ets variant 4
  • Synonyms
    Pea3, Pea-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:99423
    NCBI Gene: 18612
  • Gene Overview
    MyGene.info: ETV4
Location & Maps
more
  • Sequence Map
    Chr11:101769747-101785371 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15625 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ETV4, ETS variant 4
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ETV4, ETS variant 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    E1AF, E1A-F, PEA3, PEAS3
  • Links
    NCBI Gene ID: 2118
    neXtProt AC: NX_P43268

  • Chr Location
    17q21.31; chr17:43527843-43546432 (-)  GRCh38.p2

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 3 alleles in 4 genetic backgrounds
    24 phenotypes from multigenic genotypes
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    36
  • Gene trapped
    31
  • Targeted
    5
  • Genomic Mutations
    1 involving Etv4
  • Incidental Mutations
    APF
Homozygotes for targeted null mutations exhibit male infertility due to failure to ejaculate, impaired branching of motor neurons, and abnormal mammary gland terminal differentiation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002089 VEGA Gene Model | MGI Sequence Detail 15625 C57BL/6J ±  kb
transcript OTTMUST00000004229 VEGA | MGI Sequence Detail 2395 Not Applicable  
polypeptide OTTMUSP00000002013 VEGA | MGI Sequence Detail 486 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    93 from dbSNP Build 142
  • PCR
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000007227 ETS translocation variant 4
  • InterPro Domains
    IPR000418 Ets domain
    IPR006715 PEA3-type ETS-domain transcription factor, N-terminal
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
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  • All nucleic 58
    Genomic 1
    cDNA 48
    Primer pair 4
    Other 5

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-13225, MGD-MRK-16186, MGI:2144527
References
more
  • Summaries
    All 194
    Developmental Gene Expression 137
    Diseases 1
    Gene Ontology 13
    Phenotypes 30
  • Earliest
    J:588 Martin ME, et al., Expression of a 91-kilodalton PEA3-binding protein is down-regulated during differentiation of F9 embryonal carcinoma cells. Mol Cell Biol. 1992 May;12(5):2213-21
  • Latest
    J:229163 Blake J, et al., Urogenital development in Pallister-Hall syndrome is disrupted in a cell-lineage-specific manner by constitutive expression of GLI3 repressor. Hum Mol Genet. 2016 Feb 1;25(3):437-47

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory