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Etv4
Gene Detail
Symbol

Name
ID
Etv4
ets variant 4
MGI:99423
Synonyms
Pea3, Pea-3
Feature Type
protein coding gene
Genetic Map
Chromosome 11
65.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr11:101769747-101785371 bp, - strand
From VEGA annotation of GRCm38

  15625 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1504  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

HCOP human homology predictions: ETV4
Protein SuperFamily: transcription factor ER81
Gene Tree: Etv4

Human
homologs
ETV4, ets variant 4
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 2118
neXtProt AC: NX_P43268

Human Synonyms: E1AF, E1A-F, PEA3, PEAS3

Human Chr (Location): 17q21; chr17:43527843-43546432 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(36) : Gene trapped(31) Targeted(5)
Genomic Mutations involving Etv4 (1)
Incidental mutations (data from APF )
 
Homozygotes for targeted null mutations exhibit male infertility due to failure to ejaculate, impaired branching of motor neurons, and abnormal mammary gland terminal differentiation.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Etv4 interacts with 108 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (130 records)
Data Summary: Results (336)    Tissues (225)    Images (40)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 261
In situ reporter (knock in) 15
Northern blot 11
RT-PCR 44
cDNA source data(48)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA ETV4 ZFIN etv4    NEW 
Molecular
reagents
All nucleic(57) Genomic(1) cDNA(48) Primer pair(4) Other(4)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000002089 (Evidence)
Ensembl Gene Model ENSMUSG00000017724 (Evidence)
Entrez Gene 18612 (Evidence)
UniGene 5025
DFCI TC1582450, TC1628960
DoTS DT.101191916, DT.101307029, DT.102548943, DT.40154619, DT.91333908, DT.99854468
NIA Mouse Gene Index U033457
Consensus CDS Project CCDS48937.1
International Mouse Phenotyping Consortium Status Etv4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002089 VEGA Gene Model | MGI Sequence Detail 15625 C57BL/6J ±  kb
transcript OTTMUST00000004229 VEGA | MGI Sequence Detail 2395 Not Applicable 
polypeptide OTTMUSP00000002013 VEGA | MGI Sequence Detail 486 Not Applicable 

For the selected sequences
All sequences(75) RefSeq(16) UniProt(5)
Polymorphisms
PCR(1) : SNPs within 2kb(94 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000418 Ets domain
InterPro IPR006715 PEA3-type ETS-domain transcription factor, N-terminal
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000007227 ETS translocation variant 4
References
(Earliest) J:588 Martin ME, et al., Expression of a 91-kilodalton PEA3-binding protein is down-regulated during differentiation of F9 embryonal carcinoma cells. Mol Cell Biol. 1992 May;12(5):2213-21
(Latest) J:221158 Okazawa M, et al., Region-specific regulation of cell proliferation by FGF receptor signaling during the Wolffian duct development. Dev Biol. 2015 Apr 1;400(1):139-47
All references(188)
Other
accession IDs
MGD-MRK-13225, MGD-MRK-16186, MGI:2144527

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory