Etv4
Gene Detail

Symbol Name ID

Etv4 ets variant gene 4 (E1A enhancer binding protein, E1AF) MGI:99423

Synonyms

Pea3, Pea-3

Feature Type

protein coding gene

Genetic Map

Chromosome 11

65.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr11:101769747-101785371 bp, - strand From VEGA annotation of GRCm38   15625 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1504  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: transcription factor ER81
Gene Tree: Etv4

Human homologs

Human Homolog		ETV4, ets variant 4
NCBI Gene ID		2118
neXtProt AC		NX_P43268
Human Synonyms		E1AF, E1A-F, PEA3, PEAS3
Human Chr (Location)		17q21; chr17:41605211-41623800 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(34) : Targeted(3) Gene trapped(31)
 

Homozygotes for targeted null mutations exhibit male infertility due to failure to ejaculate, impaired branching of motor neurons, and abnormal mammary gland terminal differentiation.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	branching involved in mammary gland duct morphogenesis, motor neuron axon guidance, ...
Component	intracellular, nucleolus, ...
Function	DNA binding, sequence-specific DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (108 records)
Data Summary: Results (315)    Tissues (212)    Images (23)
Theiler Stages: 2, 3, 4, 5, 9, 11, 12, 13, 14, 15, 17, 18, 19, 20, 21, 22, 23, 28

Assay Type	Results
Immunohistochemistry	5
RNA in situ	234
In situ reporter (knock in)	14
Northern blot	11
RT-PCR	51

cDNA source data(45)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(52) Genomic(1) cDNA(45) Primer pair(4) Other(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000002089 (Evidence)
Ensembl Gene Model	ENSMUSG00000017724 (Evidence)
Entrez Gene	18612 (Evidence)
UniGene	5025
DFCI	TC1582450, TC1628960
DoTS	DT.101191916, DT.101307029, DT.102548943, DT.40154619, DT.91333908, DT.99854468
NIA Mouse Gene Index	U033457
Consensus CDS Project	CCDS48937.1
International Mouse Knockout Project Status	Etv4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000002089	VEGA Gene Model | MGI Sequence Detail	15625	C57BL/6J
transcript	OTTMUST00000004229	VEGA | MGI Sequence Detail	2395	Not Applicable
polypeptide	OTTMUSP00000002013	VEGA | MGI Sequence Detail	486	Not Applicable

All sequences(62) RefSeq(2) UniProt(6)

Polymorphisms

PCR(1) : SNPs(66 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000418	Ets
InterPro	IPR006715	PEA3-type ETS-domain transcription factor, N-terminal
InterPro	IPR011991	Winged helix-turn-helix transcription repressor DNA-binding
Protein Ontology	PR:000007227	ETS translocation variant 4

References

(Earliest) J:588 Martin ME, et al., Expression of a 91-kilodalton PEA3-binding protein is down-regulated during differentiation of F9 embryonal carcinoma cells. Mol Cell Biol. 1992 May;12(5):2213-21
(Latest) J:194074 Ahn Y, et al., Lrp4 and Wise interplay controls the formation and patterning of mammary and other skin appendage placodes by modulating Wnt signaling. Development. 2013 Feb 1;140(3):583-93
All references(165)

Other accession IDs

MGD-MRK-13225, MGD-MRK-16186, MGI:2144527