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Etv4
Gene Detail
 Symbol
Name
ID
Etv4
ets variant 4
MGI:99423
Synonyms Pea3, Pea-3
Feature Type protein coding gene
Genetic Map
Chromosome 11
65.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr11:101769747-101785371 bp, - strand
From VEGA annotation of GRCm38

  15625 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1504  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: transcription factor ER81
Gene Tree: Etv4

Human
homologs
Human Homolog ETV4, ets variant 4
NCBI Gene ID 2118
neXtProt AC  NX_P43268
Human Synonyms  E1AF, E1A-F, PEA3, PEAS3
Human Chr (Location)  17q21; chr17:43527843-43546432 (-)  GRCh38
Alleles
and
phenotypes
All alleles(34) : Gene trapped(31) Targeted(3)
Incidental mutations (data from APF )
 
Homozygotes for targeted null mutations exhibit male infertility due to failure to ejaculate, impaired branching of motor neurons, and abnormal mammary gland terminal differentiation.
 
Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process branching involved in mammary gland duct morphogenesis, motor neuron axon guidance, ...
Component intracellular, nucleolus, ...
Function DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (118 records)
Data Summary: Results (335)    Tissues (227)    Images (34)
Theiler Stages: 2, 3, 4, 5, 9, 11, 12, 13, 14, 15, 17, 18, 19, 20, 21, 22, 23, 26, 28
Assay TypeResults
Immunohistochemistry 5
RNA in situ 253
In situ reporter (knock in) 15
Northern blot 11
RT-PCR 51
cDNA source data(48)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(56) Genomic(1) cDNA(48) Primer pair(4) Other(3)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000002089 (Evidence)
Ensembl Gene ModelENSMUSG00000017724 (Evidence)
Entrez Gene18612 (Evidence)
UniGene5025
DFCITC1582450, TC1628960
DoTSDT.101191916, DT.101307029, DT.102548943, DT.40154619, DT.91333908, DT.99854468
NIA Mouse Gene IndexU033457
Consensus CDS ProjectCCDS48937.1
International Mouse Knockout Project StatusEtv4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002089 VEGA Gene Model | MGI Sequence Detail 15625 C57BL/6J ±  kb
transcript OTTMUST00000004229 VEGA | MGI Sequence Detail 2395 Not Applicable 
polypeptide OTTMUSP00000002013 VEGA | MGI Sequence Detail 486 Not Applicable 

For the selected sequences
All sequences(79) RefSeq(20) UniProt(5)
Polymorphisms PCR(1) : SNPs within 2kb(94 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000418 Ets domain
InterPro IPR006715 PEA3-type ETS-domain transcription factor, N-terminal
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000007227 ETS translocation variant 4
References (Earliest) J:588 Martin ME, et al., Expression of a 91-kilodalton PEA3-binding protein is down-regulated during differentiation of F9 embryonal carcinoma cells. Mol Cell Biol. 1992 May;12(5):2213-21
(Latest) J:203791 Kuracha MR, et al., Spry1 and Spry2 are necessary for eyelid closure. Dev Biol. 2013 Nov 15;383(2):227-38
All references(177)
Other
accession IDs
MGD-MRK-13225, MGD-MRK-16186, MGI:2144527

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/01/2014
MGI 5.18
The Jackson Laboratory