Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ETS2
  • Mouse genes Ets2
  • Rat genes Ets2
  • Zfish genes ets2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ets2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Ets2	IDA		Rat	PMID:11279115|RGD:1300077
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	ETS2	IDA		Human	PMID:12637547
Molecular Function	GO:0035259	nuclear glucocorticoid receptor binding	Ets2	IDA		Rat	PMID:11279115|RGD:1300077
Molecular Function	GO:0005515	protein binding	ETS2	IPI	UniProtKB:Q15131	Human	PMID:18242510
Molecular Function	GO:0005515	protein binding	ETS2	IPI	UniProtKB:Q15672	Human	PMID:18598946
Molecular Function	GO:0005515	protein binding	ETS2	IPI	UniProtKB:Q8WVJ9	Human	PMID:18598946
Molecular Function	GO:0005515	protein binding	ETS2	IPI	UniProtKB:Q8NHY2	Human	PMID:25117710
Molecular Function	GO:0005515	protein binding	ETS2	IPI	UniProtKB:P04637	Human	PMID:26331536
Molecular Function	GO:0005515	protein binding	ETS2	IPI	UniProtKB:Q8NHY2	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	ETS2	IPI	UniProtKB:P17612	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ETS2	IPI	UniProtKB:P37173	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ETS2	IPI	UniProtKB:P50454	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ETS2	IPI	UniProtKB:Q16236	Human	PMID:32911434
Molecular Function	GO:0019904	protein domain specific binding	ETS2	IPI	UniProtKB:P45481	Human	PMID:11583620
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ETS2	IDA		Human	PMID:12637547
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	Ets2	IDA		Mouse	PMID:20176728
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ETS2	IDA		Human	PMID:11909962
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ETS2	IPI	UniProtKB:P23497-2	Human	PMID:11909962
Molecular Function	GO:0043565	sequence-specific DNA binding	Ets2	IDA		Mouse	PMID:1409581
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ETS2	IDA		Human	PMID:28473536
Cellular Component	GO:0005829	cytosol	ETS2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	ETS2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	ETS2	HDA		Human	PMID:16780588
Cellular Component	GO:0005886	plasma membrane	ETS2	IDA		Human	GO_REF:0000052
Biological Process	GO:0001712	ectodermal cell fate commitment	Ets2	IGI	MGI:MGI:1335079	Mouse	PMID:25446535
Biological Process	GO:0007498	mesoderm development	Ets2	IMP	MGI:MGI:1891557	Mouse	PMID:23552073
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ETS2	IDA		Human	PMID:12637547
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ETS2	IDA		Human	PMID:11909962
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Ets2	IMP		Rat	PMID:11279115|RGD:1300077
Biological Process	GO:0090009	primitive streak formation	Ets2	IMP	MGI:MGI:1891557	Mouse	PMID:23552073

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern