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Ets2
Gene Detail
 Symbol
Name
ID
Ets2
E26 avian leukemia oncogene 2, 3' domain
MGI:95456
Synonyms Ets-2
Feature Type protein coding gene
Genetic Map
Chromosome 16
56.64 cM, cytoband C3-qter
Detailed Genetic Map ± 1 cM


Mapping data(56)
Sequence Map
Chr16:95702075-95721051 bp, + strand
From VEGA annotation of GRCm38

  18977 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3838  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: transforming factor C-ets
Gene Tree: Ets2

Human
homologs
Human Homolog ETS2, v-ets avian erythroblastosis virus E26 oncogene homolog 2
NCBI Gene ID 2114
neXtProt AC  NX_P15036
Human Synonyms  ETS2IT1
Human Chr (Location)  21q22.2; chr21:38805307-38824955 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(6) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit defective trophoblast formation and die by embryonic day 8.5, but tetraploid chimeric rescue results in viable and fertile mutants with wavy hair. Mammary tumors induced in carriers are reduced in size.
 
Interactions
Ets2 interacts with 257 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process cell differentiation, negative regulation of transcription from RNA polymerase II promoter, ...
Component nucleus
Function DNA binding, glucocorticoid receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (28 records)
Data Summary: Results (432)    Tissues (268)    Images (42)
Theiler Stages: 2, 3, 4, 5, 13, 15, 17, 19, 20, 21, 22, 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 401
RT-PCR 26
RNase protection 5
cDNA source data(163)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(176) Genomic(7) cDNA(163) Primer pair(4) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000027024 (Evidence)
Ensembl Gene ModelENSMUSG00000022895 (Evidence)
Entrez Gene23872 (Evidence)
UniGene290207
DFCITC1572035, TC1688250
DoTSDT.101228253, DT.101378435, DT.55100486, DT.94222107
NIA Mouse Gene IndexU017415
Consensus CDS ProjectCCDS37412.1
International Mouse Knockout Project StatusEts2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027024 VEGA Gene Model | MGI Sequence Detail 18977 C57BL/6J ±  kb
transcript OTTMUST00000066803 VEGA | MGI Sequence Detail 3890 Not Applicable 
polypeptide OTTMUSP00000033528 VEGA | MGI Sequence Detail 468 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(2) UniProt(9)
Polymorphisms RFLP(15) : SNPs within 2kb(110 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000418 Ets domain
InterPro IPR003118 Pointed domain
InterPro IPR013761 Sterile alpha motif/pointed domain
InterPro IPR016311 Transforming protein C-ets
InterPro IPR027276 Transforming protein C-ets-2
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000007222 protein C-ets-2
References (Earliest) J:8218 Watson DK, et al., Conserved chromosomal positions of dual domains of the ets protooncogene in cats, mice, and humans. Proc Natl Acad Sci U S A. 1986 Mar;83(6):1792-6
(Latest) J:208416 Holt JE, et al., The APC/C activator FZR1 is essential for meiotic prophase I in mice. Development. 2014 Mar;141(6):1354-65
All references(128)
Other
accession IDs
MGD-MRK-9664, MGD-MRK-9666, MGI:2146567

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory