Ets2
Gene Detail

Symbol Name ID

Ets2 E26 avian leukemia oncogene 2, 3' domain MGI:95456

Synonyms

Ets-2

Feature Type

protein coding gene

Genetic Map

Chromosome 16

56.64 cM, cytoband C3-qter
Detailed Genetic Map ± 1 cM


Mapping data(56)

Sequence Map

Chr16:95702075-95721051 bp, + strand From VEGA annotation of GRCm38   18977 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3838  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: transforming factor C-ets
Gene Tree: Ets2

Human homologs

Human Homolog		ETS2, v-ets avian erythroblastosis virus E26 oncogene homolog 2
NCBI Gene ID		2114
neXtProt AC		NX_P15036
Human Synonyms		ETS2IT1
Human Chr (Location)		21q22.2; chr21:38805307-38824955 (+)  GRCh38

Alleles and phenotypes

All alleles(13) : Gene trapped(6) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygotes for targeted null mutations exhibit defective trophoblast formation and die by embryonic day 8.5, but tetraploid chimeric rescue results in viable and fertile mutants with wavy hair. Mammary tumors induced in carriers are reduced in size.

 

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	cell differentiation, negative regulation of transcription from RNA polymerase II promoter, ...
Component	nucleus
Function	DNA binding, glucocorticoid receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (27 records)

Data Summary: Results (439)    Tissues (272)    Images (42)
Theiler Stages: 2, 3, 4, 5, 13, 15, 17, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	401
RT-PCR	33
RNase protection	5

cDNA source data(163)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(176) Genomic(7) cDNA(163) Primer pair(4) Other(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000027024 (Evidence)
Ensembl Gene Model	ENSMUSG00000022895 (Evidence)
Entrez Gene	23872 (Evidence)
UniGene	290207
DFCI	TC1572035, TC1688250
DoTS	DT.101228253, DT.101378435, DT.55100486, DT.94222107
NIA Mouse Gene Index	U017415
Consensus CDS Project	CCDS37412.1
International Mouse Knockout Project Status	Ets2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000027024	VEGA Gene Model | MGI Sequence Detail	18977	C57BL/6J
transcript	OTTMUST00000066803	VEGA | MGI Sequence Detail	3890	Not Applicable
polypeptide	OTTMUSP00000033528	VEGA | MGI Sequence Detail	468	Not Applicable

All sequences(65) RefSeq(2) UniProt(9)

Polymorphisms

RFLP(15) : SNPs within 2kb(110 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR000418	Ets domain
InterPro	IPR003118	Pointed domain
InterPro	IPR013761	Sterile alpha motif/pointed domain
InterPro	IPR016311	Transforming protein C-ets
InterPro	IPR027276	Transforming protein C-ets-2
InterPro	IPR011991	Winged helix-turn-helix DNA-binding domain
Protein Ontology	PR:000007222	protein C-ets-2

References

(Earliest) J:8218 Watson DK, et al., Conserved chromosomal positions of dual domains of the ets protooncogene in cats, mice, and humans. Proc Natl Acad Sci U S A. 1986 Mar;83(6):1792-6
(Latest) J:206347 Wallace JA, et al., Ets2 in tumor fibroblasts promotes angiogenesis in breast cancer. PLoS One. 2013;8(8):e71533
All references(127)

Other accession IDs

MGD-MRK-9664, MGD-MRK-9666, MGI:2146567