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Ets2 Gene Detail
Summary
  • Symbol
    Ets2
  • Name
    E26 avian leukemia oncogene 2, 3' domain
  • Synonyms
    Ets-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:95456
    NCBI Gene: 23872
  • Gene Overview
    MyGene.info: ETS2
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr16:95702075-95721051 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      18977 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 56.64 cM, cytoband C3-qter
  • Mapping Data
    56 experiments
Homology
more
  • Human Ortholog
    ETS2, ETS proto-oncogene 2, transcription factor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ETS2, ETS proto-oncogene 2, transcription factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ETS2IT1
  • Links
    NCBI Gene ID: 2114
    neXtProt AC: NX_P15036
    UniProt: P15036

  • Chr Location
    21q22.2; chr21:38805307-38824955 (+)  GRCh38.p7
Human Diseases
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  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 6 alleles in 9 genetic backgrounds
    15 phenotypes from multigenic genotypes
    53 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit defective trophoblast formation and die by embryonic day 8.5, but tetraploid chimeric rescue results in viable and fertile mutants with wavy hair. Mammary tumors induced in carriers are reduced in size.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    23
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    520
  • Tissues
    330
  • cDNA Data
    163
  • Literature Summary
    35
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027024 VEGA Gene Model | MGI Sequence Detail 18977 C57BL/6J ±  kb
transcript OTTMUST00000066803 VEGA | MGI Sequence Detail 3890 Not Applicable  
polypeptide OTTMUSP00000033528 VEGA | MGI Sequence Detail 468 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    110 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 178
    Genomic 7
    cDNA 163
    Primer pair 4
    Other 4

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-9664, MGD-MRK-9666, MGI:2146567
References
more
  • Summaries
    All 167
    Developmental Gene Expression 35
    Diseases 3
    Gene Ontology 9
    Phenotypes 53
  • Earliest
    J:8218 Watson DK, et al., Conserved chromosomal positions of dual domains of the ets protooncogene in cats, mice, and humans. Proc Natl Acad Sci U S A. 1986 Mar;83(6):1792-6
  • Latest
    J:258794 Pourebrahim R, et al., Integrative genome analysis of somatic p53 mutant osteosarcomas identifies Ets2-dependent regulation of small nucleolar RNAs by mutant p53 protein. Genes Dev. 2017 Sep 15;31(18):1847-1857
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/17/2018
MGI 6.11 		The Jackson Laboratory