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Ets2 Gene Detail
Summary
  • Symbol
    Ets2
  • Name
    E26 avian leukemia oncogene 2, 3' domain
  • Synonyms
    Ets-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:95456
    NCBI Gene: 23872
  • Gene Overview
    MyGene.info: ETS2
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:95702407-95721049 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 56.64 cM, cytoband C3-qter
  • Mapping Data
    56 experiments
Strain
Comparison
more
  • SNPs within 2kb
    110 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95456
 protein coding gene Chr16:95702075-95721051 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023077
 protein coding gene Chr16:97031231-97051566 (+)
A/J MGP_AJ_G0023045
 protein coding gene Chr16:92437176-92455871 (+)
AKR/J MGP_AKRJ_G0023015
 protein coding gene Chr16:95278143-95299291 (+)
BALB/cJ MGP_BALBcJ_G0023047
 protein coding gene Chr16:92982544-93001635 (+)
C3H/HeJ MGP_C3HHeJ_G0022808
 protein coding gene Chr16:95805462-95825532 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023494
 protein coding gene Chr16:100107713-100128323 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020996
 protein coding gene Chr16:90302384-90320198 (+)
CAST/EiJ MGP_CASTEiJ_G0022327
 protein coding gene Chr16:96595421-96615413 (+)
CBA/J MGP_CBAJ_G0022777
 protein coding gene Chr16:104383572-104405244 (+)
DBA/2J MGP_DBA2J_G0022911
 protein coding gene Chr16:92327508-92346556 (+)
FVB/NJ MGP_FVBNJ_G0022885
 protein coding gene Chr16:91496325-91515902 (+)
LP/J MGP_LPJ_G0022981
 protein coding gene Chr16:96663279-96681631 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022906
 protein coding gene Chr16:108676227-108695616 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023512
 protein coding gene Chr16:95812390-95831167 (+)
PWK/PhJ MGP_PWKPhJ_G0022072
 protein coding gene Chr16:92613129-92670816 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021902
 protein coding gene Chr16:95349672-95408988 (+)
WSB/EiJ MGP_WSBEiJ_G0022378
 protein coding gene Chr16:96073078-96093116 (+)



Homology
more
  • Human Ortholog
    ETS2, ETS proto-oncogene 2, transcription factor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ETS2, ETS proto-oncogene 2, transcription factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ETS2IT1
  • Links
    NCBI Gene ID: 2114
    neXtProt AC: NX_P15036
    UniProt: P15036

  • Chr Location
    21q22.2; chr21:38805307-38824955 (+)  GRCh38.p7
Human Diseases
less
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 6 alleles in 9 genetic backgrounds
    15 phenotypes from multigenic genotypes
    57 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit defective trophoblast formation and die by embryonic day 8.5, but tetraploid chimeric rescue results in viable and fertile mutants with wavy hair. Mammary tumors induced in carriers are reduced in size.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1161
  • Tissues
    333
  • cDNA Data
    165
  • Literature Summary
    37
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 23872 NCBI Gene Model | MGI Sequence Detail 18643 C57BL/6J ±  kb
    transcript NM_011809 RefSeq | MGI Sequence Detail 3560 C57BL/6  
    polypeptide P15037 UniProt | EBI | MGI Sequence Detail 468 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 182
      Genomic 7
      cDNA 165
      Primer pair 5
      Other 5

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-9664, MGD-MRK-9666, MGI:2146567
    References
    more
    • Summaries
      All 173
      Developmental Gene Expression 37
      Diseases 3
      Gene Ontology 8
      Phenotypes 57
    • Earliest
      J:8218 Watson DK, et al., Conserved chromosomal positions of dual domains of the ets protooncogene in cats, mice, and humans. Proc Natl Acad Sci U S A. 1986 Mar;83(6):1792-6
    • Latest
      J:296478 Ma X, et al., Ets2 suppresses inflammatory cytokines through MAPK/NF-kappaB signaling and directly binds to the IL-6 promoter in macrophages. Aging (Albany NY). 2019 Nov 27;11(22):10610-10625
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    02/16/2021
    MGI 6.16     		The Jackson Laboratory