Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes EPO
  • Mouse genes Epo
  • Rat genes Epo
  • Zfish genes epoa,epob
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Epo

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005125	cytokine activity	EPO	IDA		Human	PMID:28283061
Molecular Function	GO:0005128	erythropoietin receptor binding	EPO	IMP		Human	PMID:28283061
Molecular Function	GO:0005515	protein binding	EPO	IPI	UniProtKB:P54760	Human	PMID:26481148
Molecular Function	GO:0005515	protein binding	EPO	IPI	UniProtKB:P19235	Human	PMID:29997244
Molecular Function	GO:0005515	protein binding	EPO	IPI	UniProtKB:P19235	Human	PMID:9774108
Molecular Function	GO:0030295	protein kinase activator activity	Epo	IDA		Mouse	MGI:MGI:5009772|PMID:21095239
Cellular Component	GO:0044297	cell body	Epo	IDA		Rat	PMID:17554621|RGD:11041649
Cellular Component	GO:0009986	cell surface	EPO	IDA		Human	PMID:14569084
Cellular Component	GO:0005615	extracellular space	EPO	IDA		Human	PMID:14569084
Cellular Component	GO:0005615	extracellular space	Epo	IDA		Mouse	PMID:15016652
Cellular Component	GO:0005615	extracellular space	Epo	IDA		Rat	PMID:15470751|RGD:1601067
Cellular Component	GO:0005615	extracellular space	Epo	IDA		Rat	PMID:19136608|RGD:2313644
Cellular Component	GO:0048471	perinuclear region of cytoplasm	epoa	IDA		Zfish	PMID:17706649
Biological Process	GO:0006953	acute-phase response	Epo	IEP		Rat	PMID:19840250|RGD:10395370
Biological Process	GO:0007568	aging	Epo	IEP		Rat	PMID:19330822|RGD:2313640
Biological Process	GO:0006915	apoptotic process	Epo	IDA		Mouse	PMID:17300687
Biological Process	GO:0071474	cellular hyperosmotic response	EPO	IDA		Human	PMID:14569084
Biological Process	GO:0007566	embryo implantation	Epo	IDA		Mouse	PMID:17300687
Biological Process	GO:0030218	erythrocyte differentiation	EPO	IDA		Human	PMID:15084469
Biological Process	GO:0030218	erythrocyte differentiation	EPO	IMP		Human	PMID:28283061
Biological Process	GO:0030218	erythrocyte differentiation	Epo	IDA		Mouse	PMID:15591122
Biological Process	GO:0038162	erythropoietin-mediated signaling pathway	EPO	IMP		Human	PMID:28283061
Biological Process	GO:0042541	hemoglobin biosynthetic process	Epo	IDA		Mouse	PMID:17300687
Biological Process	GO:0030097	hemopoiesis	epoa	IDA		Zfish	PMID:17579187
Biological Process	GO:0030097	hemopoiesis	epoa	IMP	ZFIN:ZDB-MRPHLNO-070921-1	Zfish	PMID:17706649
Biological Process	GO:0033028	myeloid cell apoptotic process	Epo	IDA		Mouse	PMID:17981124
Biological Process	GO:0043066	negative regulation of apoptotic process	Epo	IDA		Mouse	MGI:MGI:5009772|PMID:21095239
Biological Process	GO:0010523	negative regulation of calcium ion transport into cytosol	EPO	IDA		Human	PMID:14569084
Biological Process	GO:2001258	negative regulation of cation channel activity	EPO	IDA		Human	PMID:14569084
Biological Process	GO:1902251	negative regulation of erythrocyte apoptotic process	EPO	IDA		Human	PMID:14569084
Biological Process	GO:1902219	negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress	EPO	IDA		Human	PMID:14569084
Biological Process	GO:0033033	negative regulation of myeloid cell apoptotic process	Epo	IDA		Mouse	PMID:17981124
Biological Process	GO:1901215	negative regulation of neuron death	Epo	IDA		Rat	PMID:20580927|RGD:10400908
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	EPO	IMP		Human	PMID:16497104
Biological Process	GO:0048823	nucleate erythrocyte development	epoa	IDA		Zfish	PMID:24869937
Biological Process	GO:0018105	peptidyl-serine phosphorylation	Epo	IDA		Mouse	MGI:MGI:5009772|PMID:21095239
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	Epo	IDA		Rat	PMID:21649646|RGD:10401062
Biological Process	GO:0008284	positive regulation of cell population proliferation	EPO	IDA		Human	PMID:9722506
Biological Process	GO:0008284	positive regulation of cell population proliferation	Epo	IMP		Rat	PMID:21749867|RGD:10400910
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	EPO	IDA		Human	PMID:9722506
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Epo	IMP		Rat	PMID:21749867|RGD:10400910
Biological Process	GO:0045666	positive regulation of neuron differentiation	Epo	IDA		Rat	PMID:12876482|RGD:2313656
Biological Process	GO:0010976	positive regulation of neuron projection development	Epo	IDA		Rat	PMID:22469063|RGD:10401068
Biological Process	GO:0045860	positive regulation of protein kinase activity	Epo	IDA		Mouse	MGI:MGI:5009772|PMID:21095239
Biological Process	GO:0046579	positive regulation of Ras protein signal transduction	EPO	IDA		Human	PMID:9722506
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	EPO	IDA		Human	PMID:9722506
Biological Process	GO:0048793	pronephros development	epoa	IMP	ZFIN:ZDB-CRISPR-180626-1	Zfish	PMID:29203238
Biological Process	GO:0048793	pronephros development	epoa	IMP	ZFIN:ZDB-MRPHLNO-070921-1	Zfish	PMID:29203238
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Epo	IDA		Mouse	PMID:17300687
Biological Process	GO:0014823	response to activity	epoa	IDA		Zfish	PMID:16966387
Biological Process	GO:0048678	response to axon injury	Epo	IEP		Rat	PMID:15470751|RGD:1601067
Biological Process	GO:0071548	response to dexamethasone	Epo	IEP		Rat	PMID:21540288|RGD:11049535
Biological Process	GO:0051602	response to electrical stimulus	Epo	IEP		Rat	PMID:19185286|RGD:2313642
Biological Process	GO:0043627	response to estrogen	Epo	IEP		Rat	PMID:15784734|RGD:2313654
Biological Process	GO:0055093	response to hyperoxia	Epo	IEP		Rat	PMID:19768476|RGD:2313637
Biological Process	GO:0001666	response to hypoxia	Epo	IDA		Mouse	PMID:15016652
Biological Process	GO:0001666	response to hypoxia	Epo	IEP		Rat	PMID:19497871|RGD:2313639
Biological Process	GO:0070555	response to interleukin-1	Epo	IEP		Rat	PMID:9321887|RGD:2313657
Biological Process	GO:0032496	response to lipopolysaccharide	Epo	IEP		Rat	PMID:9321887|RGD:2313657
Biological Process	GO:0007584	response to nutrient	Epo	IEP		Rat	PMID:19136608|RGD:2313644
Biological Process	GO:0009651	response to salt stress	Epo	IEP		Rat	PMID:16815869|RGD:2313666
Biological Process	GO:0033574	response to testosterone	Epo	IEP		Rat	PMID:15778925|RGD:2313655
Biological Process	GO:0033189	response to vitamin A	Epo	IEP		Rat	PMID:9027729|RGD:2313658

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern