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Epo
Gene Detail
Symbol

Name
ID
Epo
erythropoietin
MGI:95407
STS
Feature Type
protein coding gene
Genetic Map
Chromosome 5
76.50 cM, cytoband G
Detailed Genetic Map ± 1 cM


Mapping data(36)
Sequence Map
Chr5:137483020-137533242 bp, - strand
From VEGA annotation of GRCm38

  50223 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:624  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: EPO
Protein SuperFamily: erythropoietin
Gene Tree: Epo

Human
homologs
EPO, erythropoietin
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 2056
neXtProt AC: NX_P01588

Human Synonyms: EP, MVCD2

Human Chr (Location): 7q22; chr7:100720800-100723700 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human EPO

Mutations,
alleles, and
phenotypes
All mutations/alleles(24) : Gene trapped(17) Targeted(5) Transgenic(2)
 
Homozygotes for a targeted null mutation exhibit reduced primitive erythropoiesis and die around embryonic day 13 due to impaired fetal liver erythropoiesis.
 
Interactions
Epo interacts with 107 markers (Mir7-1, Mir22, Mir26a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (38 annotations)
Process activation of protein kinase activity, angiogenesis, ...
Component cell surface, extracellular region, ...
Function erythropoietin receptor binding, hormone activity, ...
External Resources: FuncBase
Expression
Literature Summary: (43 records)
Data Summary: Results (96)    Tissues (35)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 10
Western blot 7
RT-PCR 79
cDNA source data(8)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN epo    NEW 
Molecular
reagents
All nucleic(31) Genomic(9) cDNA(8) Primer pair(10) Other(4)
Microarray probesets(1)
Other database
links
VEGA Gene Model OTTMUSG00000021944 (Evidence)
Ensembl Gene Model ENSMUSG00000029711 (Evidence)
Entrez Gene 13856 (Evidence)
UniGene 349116
DFCI TC1761920
DoTS DT.101312972
Consensus CDS Project CCDS39332.1
International Mouse Phenotyping Consortium Status Epo
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021944 VEGA Gene Model | MGI Sequence Detail 50223 C57BL/6J ±  kb
transcript OTTMUST00000052085 VEGA | MGI Sequence Detail 715 Not Applicable 
polypeptide OTTMUSP00000024625 VEGA | MGI Sequence Detail 192 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(2) UniProt(3)
Polymorphisms
All PCR and RFLP(10) : PCR(4) RFLP(6) SNPs within 2kb(106 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003013 Erythropoietin
InterPro IPR001323 Erythropoietin/thrombopoeitin
InterPro IPR019767 Erythropoietin/thrombopoeitin, conserved site
InterPro IPR012351 Four-helical cytokine, core
InterPro IPR009079 Four-helical cytokine-like, core
Protein Ontology PR:000007141 erythropoietin
References
(Earliest) J:8454 McDonald JD, et al., Cloning, sequencing, and evolutionary analysis of the mouse erythropoietin gene. Mol Cell Biol. 1986 Mar;6(3):842-8
(Latest) J:201436 Chang I, et al., Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice. J Clin Invest. 2013 Jun 3;123(6):2643-53
All references(164)
Other
accession IDs
MGD-MRK-9566

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory