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Epo Gene Detail
Summary
  • Symbol
    Epo
  • Name
    erythropoietin
Location &
Maps
more
  • Sequence Map
    Chr5:137481282-137484078 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 76.50 cM, cytoband G
  • Mapping Data
    36 experiments
Strain
Comparison
more
  • SNPs within 2kb
    165 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    4
  • RFLP
    6
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95407
 protein coding gene Chr5:137481282-137531504 (-)
129S1/SvImJ ENSMUSG00200043132
 protein coding gene Chr5:131275771-131278604 (-)
A/J ENSMUSG00195046724
 protein coding gene Chr5:130779007-130781839 (-)
AKR/J ENSMUSG00220048860
 protein coding gene Chr5:130254084-130256913 (-)
BALB/cJ ENSMUSG00180039239
 protein coding gene Chr5:130875551-130878383 (-)
C3H/HeJ ENSMUSG00175045913
 protein coding gene Chr5:132803089-132805921 (-)
C57BL/6NJ ENSMUSG00215044145
 protein coding gene Chr5:130924429-130927261 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027875
 protein coding gene Chr5:130287697-130336637 (-)
CAST/EiJ ENSTCUG00005010102
 protein coding gene Chr5:130147061-130149902 (-)
CBA/J ENSMUSG00210006873
 protein coding gene Chr5:131620667-131623499 (-)
DBA/2J ENSMUSG00185052748
 protein coding gene Chr5:134636039-134638871 (-)
FVB/NJ ENSMUSG00205038012
 protein coding gene Chr5:130520505-130523337 (-)
JF1/MsJ ENSUMUG00000039548
 protein coding gene Chr5:137527313-137530168 (-)
LP/J ENSMUSG00230040995
 protein coding gene Chr5:138749512-138752344 (-)
NOD/ShiLtJ ENSMUSG00190031995
 protein coding gene Chr5:130575335-130578167 (-)
NZO/HlLtJ ENSMUSG00225023498
 protein coding gene Chr5:146424204-146427033 (-)
PWK/PhJ ENSLUMG00010017001
 protein coding gene Chr5:129384056-129386897 (-)
SPRET/EiJ ENSMSPG00010036654
 protein coding gene Chr5:132781786-132784607 (-)
WSB/EiJ ENSIUOG00005034452
 protein coding gene Chr5:133225462-133228295 (-)



Homology
more
  • Human Ortholog
    EPO, erythropoietin
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EPO, erythropoietin
  • Synonyms
    DBAL, ECYT5, EP, MVCD2
  • Links
    NCBI Gene ID: 2056
    UniProt: P01588

  • Chr Location
    7q22.1; chr7:100720468-100723700 (+)  GRCh38
  • MGI Vertebrate Homology
    Epo stringent orthology
    1 human;1 mouse;1 rat;2 zebrafish
  • HCOP
    vertebrate homology predictions: EPO
  • Protein SuperFamily
    EPO
  • Gene Tree
    Epo
Human Diseases
more
  • Diseases
    19 with human EPO associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    36 phenotypes from 3 alleles in 6 genetic backgrounds
    7 phenotypes from multigenic genotypes
    3 images
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit reduced primitive erythropoiesis and die around embryonic day 13 due to impaired fetal liver erythropoiesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    97
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    847
  • Tissues
    116
  • cDNA Data
    9
  • Literature Summary
    66
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13856 NCBI Gene Model | MGI Sequence Detail 2797 C57BL/6J ±  kb
    transcript NM_007942 RefSeq | MGI Sequence Detail 715 Not Specified  
    polypeptide P07321 UniProt | EBI | MGI Sequence Detail 192 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 45
      Genomic 9
      cDNA 10
      Primer pair 19
      Other 7
      Antibodies 3

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-9566
    References
    more
    • Summaries
      All 264
      Developmental Gene Expression 66
      Gene Ontology 14
      Phenotypes 33
    • Earliest
      J:8454 McDonald JD, et al., Cloning, sequencing, and evolutionary analysis of the mouse erythropoietin gene. Mol Cell Biol. 1986 Mar;6(3):842-8
    • Latest
      J:382980 Lu IL, et al., Hypoxia-inducible factor signaling regulates embryonic interneuron development, GRIN2B expression and adult cortical function. Dev Cell. 2026 Apr 8;61(4):773-786.e6
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory