Epo
Gene Detail

Symbol Name ID

Epo erythropoietin MGI:95407

STS

D5Mit46

Feature Type

protein coding gene

Genetic Map

Chromosome 5

76.50 cM, cytoband G
Detailed Genetic Map ± 1 cM


Mapping data(36)

Sequence Map

Chr5:137482259-137533242 bp, - strand From VEGA annotation of GRCm38   50984 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:624  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 zebrafish

Protein SuperFamily: erythropoietin
Gene Tree: Epo

Human homologs

Human Homolog		EPO, erythropoietin
NCBI Gene ID		2056
neXtProt AC		NX_P01588
Human Synonyms		EP, MVCD2
Human Chr (Location)		7q22; chr7:100318423-100321323 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human EPO

Alleles and phenotypes

All alleles(22) : Targeted(4) Gene trapped(17) Transgenic(1)
 

Homozygotes for a targeted null mutation exhibit reduced primitive erythropoiesis and die around embryonic day 13 due to impaired fetal liver erythropoiesis.

 

Gene Ontology (GO) classifications

All GO classifications: (36 annotations)

Process	angiogenesis, apoptotic process, ...
Component	extracellular region, extracellular space
Function	erythropoietin receptor binding, eukaryotic cell surface binding, ...

External Resources: FuncBase

Expression

Literature Summary: (39 records)
Data Summary: Results (88)    Tissues (27)    Images (3)
Theiler Stages: 11, 13, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	2
Western blot	7
RT-PCR	79

cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(30) Genomic(9) cDNA(7) Primer pair(10) Other(4)
Microarray probesets(1)

Other database links

VEGA Gene Model	OTTMUSG00000021944 (Evidence)
Ensembl Gene Model	ENSMUSG00000029711 (Evidence)
Entrez Gene	13856 (Evidence)
UniGene	349116
DFCI	TC1761920
DoTS	DT.101312972
Consensus CDS Project	CCDS39332.1
International Mouse Knockout Project Status	Epo

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021944	VEGA Gene Model | MGI Sequence Detail	50984	C57BL/6J
transcript	OTTMUST00000052085	VEGA | MGI Sequence Detail	1583	Not Applicable
polypeptide	OTTMUSP00000024625	VEGA | MGI Sequence Detail	192	Not Applicable

All sequences(33) RefSeq(2) UniProt(3)

Polymorphisms

All PCR and RFLP(10) : PCR(4) RFLP(6) SNPs(4 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003013	Erythropoietin
InterPro	IPR001323	Erythropoietin/thrombopoeitin
InterPro	IPR019767	Erythropoietin/thrombopoeitin, conserved site
InterPro	IPR012351	Four-helical cytokine, core
InterPro	IPR009079	Four-helical cytokine-like, core
Protein Ontology	PR:000007141	erythropoietin

References

(Earliest) J:8454 McDonald JD, et al., Cloning, sequencing, and evolutionary analysis of the mouse erythropoietin gene. Mol Cell Biol. 1986 Mar;6(3):842-8
(Latest) J:193997 Liu Q, et al., Hypoxia-inducible factor regulates hepcidin via erythropoietin-induced erythropoiesis. J Clin Invest. 2012 Dec 3;122(12):4635-44
All references(162)

Other accession IDs

MGD-MRK-9566