Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Dnmt3a

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes DNMT3A
- Mouse genes Dnmt3a
- Rat genes Dnmt3a
- Zfish genes dnmt3aa,dnmt3ab
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dnmt3a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Dnmt3a	IDA		Mouse	PMID:16322236
Molecular Function	GO:0003682	chromatin binding	Dnmt3a	IDA		Rat	PMID:23671328\|RGD:9590112
Molecular Function	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	DNMT3A	IDA		Human	PMID:12138111
Molecular Function	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	DNMT3A	IDA		Human	PMID:19786833
Molecular Function	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	Dnmt3a	IDA		Mouse	PMID:9662389
Molecular Function	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	Dnmt3a	IGI	MGI:MGI:1261819	Mouse	PMID:17938196
Molecular Function	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	Dnmt3a	IDA		Mouse	PMID:11399089
Molecular Function	GO:0003677	DNA binding	DNMT3A	IDA		Human	PMID:12138111
Molecular Function	GO:0003677	DNA binding	Dnmt3a	IDA		Mouse	PMID:11399089
Molecular Function	GO:0042802	identical protein binding	DNMT3A	IPI	UniProtKB:Q9Y6K1	Human	PMID:24656771
Molecular Function	GO:0005515	protein binding	DNMT3A	IPI	UniProtKB:O75530	Human	PMID:16357870
Molecular Function	GO:0005515	protein binding	DNMT3A	IPI	UniProtKB:Q15910	Human	PMID:16357870
Molecular Function	GO:0005515	protein binding	DNMT3A	IPI	UniProtKB:Q15047	Human	PMID:16682412
Molecular Function	GO:0005515	protein binding	DNMT3A	IPI	UniProtKB:Q9QR71	Human	PMID:16983096
Molecular Function	GO:0005515	protein binding	DNMT3A	IPI	UniProtKB:Q9UJW3	Human	PMID:17713477
Molecular Function	GO:0005515	protein binding	DNMT3A	IPI	UniProtKB:O14744	Human	PMID:19234465
Molecular Function	GO:0005515	protein binding	DNMT3A	IPI	UniProtKB:Q96T88	Human	PMID:19798101
Molecular Function	GO:0005515	protein binding	DNMT3A	IPI	UniProtKB:P84243	Human	PMID:19834512
Molecular Function	GO:0005515	protein binding	DNMT3A	IPI	UniProtKB:Q03060	Human	PMID:21976679
Molecular Function	GO:0005515	protein binding	DNMT3A	IPI	UniProtKB:Q15910	Human	PMID:24074865
Molecular Function	GO:0005515	protein binding	DNMT3A	IPI	UniProtKB:Q9UJW3-1	Human	PMID:25383530
Molecular Function	GO:0005515	protein binding	DNMT3A	IPI	UniProtKB:P23497	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	DNMT3A	IPI	UniProtKB:P56279	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	DNMT3A	IPI	UniProtKB:P56279	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	DNMT3A	IPI	UniProtKB:O14978	Human	PMID:32051553
Molecular Function	GO:0005515	protein binding	DNMT3A	IPI	UniProtKB:P32242	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DNMT3A	IPI	UniProtKB:P56279	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DNMT3A	IPI	UniProtKB:Q6FHY5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DNMT3A	IPI	UniProtKB:Q8N8E2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DNMT3A	IPI	UniProtKB:Q99750	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DNMT3A	IPI	UniProtKB:O76024	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	DNMT3A	IPI	UniProtKB:Q9UBC3	Human	PMID:32968275
Molecular Function	GO:0005515	protein binding	Dnmt3a	IPI	UniProtKB:Q9CWR8	Mouse	MGI:MGI:5919006\|PMID:17713477
Molecular Function	GO:0005515	protein binding	Dnmt3a	IPI	UniProtKB:Q13547\|UniProtKB:Q92769	Mouse	MGI:MGI:3852310\|PMID:14752048
Molecular Function	GO:0005515	protein binding	Dnmt3a	IPI	UniProtKB:O75925\|UniProtKB:O75928\|UniProtKB:P63279	Mouse	MGI:MGI:3852310\|PMID:14752048
Molecular Function	GO:0005515	protein binding	Dnmt3a	IPI	UniProtKB:Q9Z148-2	Mouse	MGI:MGI:5915592\|PMID:18953337
Molecular Function	GO:0005515	protein binding	Dnmt3a	IPI	UniProtKB:Q9CWR8	Mouse	MGI:MGI:3719491\|PMID:17687327
Molecular Function	GO:0005515	protein binding	Dnmt3a	IPI	UniProtKB:Q9CWR8	Mouse	MGI:MGI:5553039\|PMID:24074865
Molecular Function	GO:0005515	protein binding	Dnmt3a	IPI	UniProtKB:P51608-1	Mouse	MGI:MGI:6201034\|PMID:30102379
Molecular Function	GO:0005515	protein binding	Dnmt3a	IPI	UniProtKB:Q60848	Mouse	MGI:MGI:5508259\|PMID:16395332
Molecular Function	GO:0005515	protein binding	Dnmt3a	IPI	UniProtKB:B1ASB6	Mouse	MGI:MGI:6453929\|PMID:32674113
Molecular Function	GO:0005515	protein binding	Dnmt3a	IPI	PR:Q9CWR8	Mouse	PMID:17938196
Molecular Function	GO:0005515	protein binding	Dnmt3a	IPI	PR:Q3TKT4	Mouse	PMID:16322236
Molecular Function	GO:0005515	protein binding	Dnmt3a	IPI	PR:Q9CZJ6	Mouse	PMID:22516971
Molecular Function	GO:0106363	protein-cysteine methyltransferase activity	Dnmt3a	IDA		Mouse	MGI:MGI:5467213\|PMID:21481189
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	DNMT3A	IDA		Human	PMID:19786833
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	DNMT3A	IDA		Human	PMID:23042785
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	DNMT3A	IPI	UniProtKB:P01106	Human	PMID:19786833
Cellular Component	GO:1902494	catalytic complex	DNMT3A	IPI		Human	PMID:25383530
Cellular Component	GO:0000775	chromosome, centromeric region	Dnmt3a	IDA		Mouse	MGI:MGI:3056853\|PMID:15456878
Cellular Component	GO:0005737	cytoplasm	DNMT3A	IDA		Human	PMID:12138111
Cellular Component	GO:0005737	cytoplasm	Dnmt3a	IDA		Mouse	PMID:15739230
Cellular Component	GO:0005737	cytoplasm	Dnmt3a	IDA		Rat	PMID:19660178\|RGD:9588289
Cellular Component	GO:0000791	euchromatin	DNMT3A	IDA		Human	PMID:12138111
Cellular Component	GO:0000792	heterochromatin	Dnmt3a	IDA		Mouse	PMID:16322236
Cellular Component	GO:0000792	heterochromatin	Dnmt3a	IDA		Mouse	PMID:11934864
Cellular Component	GO:0016363	nuclear matrix	DNMT3A	IDA		Human	PMID:12138111
Cellular Component	GO:0005654	nucleoplasm	DNMT3A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	DNMT3A	IDA		Human	PMID:12138111
Cellular Component	GO:0005634	nucleus	DNMT3A	IDA		Human	PMID:25743254
Cellular Component	GO:0005634	nucleus	Dnmt3a	IDA		Mouse	MGI:MGI:3852310\|PMID:14752048
Cellular Component	GO:0005634	nucleus	Dnmt3a	IDA		Mouse	PMID:20577743
Cellular Component	GO:0005634	nucleus	Dnmt3a	IDA		Rat	PMID:11844796\|RGD:2289670
Cellular Component	GO:0001741	XY body	Dnmt3a	IDA		Mouse	PMID:20577743
Biological Process	GO:0007568	aging	Dnmt3a	IEP		Rat	PMID:16702315\|RGD:9588248
Biological Process	GO:0090116	C-5 methylation of cytosine	DNMT3A	IDA		Human	PMID:25383530
Biological Process	GO:0071230	cellular response to amino acid stimulus	Dnmt3a	IDA		Mouse	PMID:20548288
Biological Process	GO:1903926	cellular response to bisphenol A	Dnmt3a	IDA		Mouse	PMID:21980460
Biological Process	GO:0071361	cellular response to ethanol	Dnmt3a	IEP		Rat	PMID:24117907\|RGD:9588613
Biological Process	GO:0071456	cellular response to hypoxia	Dnmt3a	IEP		Rat	PMID:24282625\|RGD:9589039
Biological Process	GO:0006306	DNA methylation	DNMT3A	IDA		Human	PMID:12138111
Biological Process	GO:0006306	DNA methylation	DNMT3A	IDA		Human	PMID:19786833
Biological Process	GO:0006306	DNA methylation	DNMT3A	IDA		Human	PMID:23042785
Biological Process	GO:0006306	DNA methylation	DNMT3A	IMP		Human	PMID:30478443
Biological Process	GO:0006306	DNA methylation	Dnmt3a	IGI	MGI:MGI:1261819	Mouse	PMID:17938196
Biological Process	GO:0006306	DNA methylation	Dnmt3a	IGI	MGI:MGI:1261819,MGI:MGI:94912	Mouse	PMID:27841881
Biological Process	GO:0006306	DNA methylation	Dnmt3a	IDA		Mouse	PMID:11399089
Biological Process	GO:0006306	DNA methylation	Dnmt3a	IDA		Mouse	PMID:11934864
Biological Process	GO:0043045	DNA methylation involved in embryo development	Dnmt3a	IMP		Mouse	MGI:MGI:3045942\|PMID:15215868
Biological Process	GO:0043045	DNA methylation involved in embryo development	Dnmt3a	IGI	MGI:MGI:1261819	Mouse	PMID:10555141
Biological Process	GO:0043045	DNA methylation involved in embryo development	Dnmt3a	IGI	MGI:MGI:1261819,MGI:MGI:94912	Mouse	PMID:27841881
Biological Process	GO:0043045	DNA methylation involved in embryo development	Dnmt3a	IMP		Mouse	PMID:20385583
Biological Process	GO:0043046	DNA methylation involved in gamete generation	Dnmt3a	IMP		Mouse	MGI:MGI:3045942\|PMID:15215868
Biological Process	GO:0032776	DNA methylation on cytosine	Dnmt3a	IDA		Rat	PMID:22880885\|RGD:9588218
Biological Process	GO:0006346	DNA methylation-dependent heterochromatin formation	Dnmt3a	IGI	MGI:MGI:1261819	Mouse	PMID:17938196
Biological Process	GO:0006346	DNA methylation-dependent heterochromatin formation	Dnmt3a	IDA		Mouse	PMID:16322236
Biological Process	GO:0097284	hepatocyte apoptotic process	Dnmt3a	IEP		Rat	PMID:19833194\|RGD:9588622
Biological Process	GO:0000278	mitotic cell cycle	Dnmt3a	IEP		Rat	PMID:24282625\|RGD:9589039
Biological Process	GO:0044027	negative regulation of gene expression via CpG island methylation	Dnmt3a	IDA		Mouse	MGI:MGI:5009774\|PMID:21047779
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	DNMT3A	IMP		Human	PMID:19786833
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	DNMT3A	IDA		Human	PMID:23042785
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Dnmt3a	IDA		Mouse	PMID:16322236
Biological Process	GO:0030182	neuron differentiation	Dnmt3a	IEP		Rat	PMID:19660178\|RGD:9588289
Biological Process	GO:1900039	positive regulation of cellular response to hypoxia	Dnmt3a	IMP		Rat	PMID:23516428\|RGD:9589049
Biological Process	GO:2000983	regulation of ATP citrate synthase activity	dnmt3aa	IMP	ZFIN:ZDB-GENO-221216-1	Zfish	PMID:33478487
Biological Process	GO:2000983	regulation of ATP citrate synthase activity	dnmt3ab	IGI	ZFIN:ZDB-GENO-221216-1,ZFIN:ZDB-CRISPR-210927-2	Zfish	PMID:33478487
Biological Process	GO:2000983	regulation of ATP citrate synthase activity	dnmt3aa	IGI	ZFIN:ZDB-GENO-221216-1,ZFIN:ZDB-CRISPR-210927-2	Zfish	PMID:33478487
Biological Process	GO:0006349	regulation of gene expression by genomic imprinting	Dnmt3a	IDA		Mouse	MGI:MGI:5009774\|PMID:21047779
Biological Process	GO:0006349	regulation of gene expression by genomic imprinting	Dnmt3a	IMP	MGI:MGI:3047824	Mouse	PMID:15215868
Biological Process	GO:0006349	regulation of gene expression by genomic imprinting	Dnmt3a	IMP	MGI:MGI:3047552	Mouse	PMID:15215868
Biological Process	GO:0006349	regulation of gene expression by genomic imprinting	Dnmt3a	IMP	MGI:MGI:2182412	Mouse	PMID:11934864
Biological Process	GO:0042220	response to cocaine	Dnmt3a	IEP		Rat	PMID:23688924\|RGD:9589062
Biological Process	GO:0032355	response to estradiol	Dnmt3a	IEP		Rat	PMID:22334722\|RGD:9588258
Biological Process	GO:0045471	response to ethanol	Dnmt3a	IEP		Rat	PMID:24968059\|RGD:9588611
Biological Process	GO:0010212	response to ionizing radiation	Dnmt3a	IEP		Rat	PMID:17148264\|RGD:1601086
Biological Process	GO:0010288	response to lead ion	Dnmt3a	IEP		Rat	PMID:23246732\|RGD:9588316
Biological Process	GO:0031667	response to nutrient levels	Dnmt3a	IEP		Rat	PMID:16702315\|RGD:9588248
Biological Process	GO:0009266	response to temperature stimulus	dnmt3aa	IMP	ZFIN:ZDB-GENO-221216-1	Zfish	PMID:33478487
Biological Process	GO:0009266	response to temperature stimulus	dnmt3ab	IGI	ZFIN:ZDB-GENO-221216-1,ZFIN:ZDB-CRISPR-210927-2	Zfish	PMID:33478487
Biological Process	GO:0009266	response to temperature stimulus	dnmt3aa	IGI	ZFIN:ZDB-GENO-221216-1,ZFIN:ZDB-CRISPR-210927-2	Zfish	PMID:33478487
Biological Process	GO:0009636	response to toxic substance	Dnmt3a	IEP		Rat	PMID:23433207\|RGD:9588261
Biological Process	GO:0033189	response to vitamin A	Dnmt3a	IEP		Rat	PMID:23333085\|RGD:9588314
Biological Process	GO:0009410	response to xenobiotic stimulus	Dnmt3a	IEP		Rat	PMID:16632870\|RGD:1601088
Biological Process	GO:0009410	response to xenobiotic stimulus	Dnmt3a	IEP		Rat	PMID:21682946\|RGD:9588311
Biological Process	GO:0007283	spermatogenesis	Dnmt3a	IMP	MGI:MGI:2182412	Mouse	PMID:11934864
Biological Process	GO:0036269	swimming behavior	dnmt3aa	IGI	ZFIN:ZDB-GENO-221216-1,ZFIN:ZDB-CRISPR-210927-2	Zfish	PMID:33478487
Biological Process	GO:0036269	swimming behavior	dnmt3ab	IGI	ZFIN:ZDB-GENO-221216-1,ZFIN:ZDB-CRISPR-210927-2	Zfish	PMID:33478487
Biological Process	GO:0036269	swimming behavior	dnmt3aa	IMP	ZFIN:ZDB-GENO-221216-1	Zfish	PMID:33478487

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/14/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.