Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DLK1
  • Mouse genes Dlk1
  • Rat genes Dlk1
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dlk1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	DLK1	IPI	UniProtKB:P28799-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	DLK1	IPI	UniProtKB:Q7Z699	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Dlk1	IPI	PR:Q6PHU5	Mouse	PMID:24928897
Molecular Function	GO:0005515	protein binding	Dlk1	IPI	UniProtKB:Q498M5	Rat	PMID:22128169|RGD:13673844
Cellular Component	GO:0009897	external side of plasma membrane	Dlk1	IDA		Mouse	PMID:18988804
Cellular Component	GO:0005615	extracellular space	DLK1	IDA		Human	PMID:25093684
Cellular Component	GO:0005615	extracellular space	DLK1	IDA		Human	PMID:7925474
Biological Process	GO:0030282	bone mineralization	Dlk1	IMP	MGI:MGI:3526402	Mouse	PMID:21308776
Biological Process	GO:0030154	cell differentiation	Dlk1	IDA		Rat	PMID:9645708|RGD:632565
Biological Process	GO:0009790	embryo development	Dlk1	IDA		Mouse	PMID:19247431
Biological Process	GO:0048706	embryonic skeletal system development	Dlk1	IDA		Mouse	PMID:19247431
Biological Process	GO:0035264	multicellular organism growth	Dlk1	IMP	MGI:MGI:3526402	Mouse	PMID:21308776
Biological Process	GO:0045599	negative regulation of fat cell differentiation	Dlk1	IDA		Mouse	MGI:MGI:69412|PMID:8500166
Biological Process	GO:0045746	negative regulation of Notch signaling pathway	DLK1	IDA		Human	PMID:25093684
Biological Process	GO:0045746	negative regulation of Notch signaling pathway	Dlk1	IGI	MGI:MGI:97363	Mouse	PMID:21419176
Biological Process	GO:1905563	negative regulation of vascular endothelial cell proliferation	Dlk1	IDA		Mouse	MGI:MGI:5569873|PMID:24584117
Biological Process	GO:0001503	ossification	Dlk1	IMP	MGI:MGI:3526402	Mouse	PMID:21308776
Biological Process	GO:0001649	osteoblast differentiation	Dlk1	IMP	MGI:MGI:3526402	Mouse	PMID:21308776
Biological Process	GO:0045780	positive regulation of bone resorption	Dlk1	IMP	MGI:MGI:3526402	Mouse	PMID:21308776
Biological Process	GO:0001819	positive regulation of cytokine production	Dlk1	IDA		Mouse	PMID:21308776
Biological Process	GO:0009791	post-embryonic development	Dlk1	IDA		Mouse	PMID:19247431
Biological Process	GO:0010468	regulation of gene expression	Dlk1	IMP		Mouse	PMID:19515692

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern