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Dlk1 Gene Detail
Summary
  • Symbol
    Dlk1
  • Name
    delta-like 1 homolog (Drosophila)
  • Synonyms
    DlkI, FA1, Peg9, pG2, pref-1, SCP1, ZOG
  • Feature Type
    protein coding gene
  • IDs
    MGI:94900
    NCBI Gene: 13386
Location & Maps
more
  • Sequence Map
    Chr12:109452823-109463336 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10514 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    DLK1, delta-like 1 homolog (Drosophila)
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DLK1, delta-like 1 homolog (Drosophila)
    Orthology source: HGNC, HomoloGene
  • Synonyms
    Delta1, DLK, DLK-1, FA1, pG2, Pref-1, PREF1, ZOG
  • Links
    NCBI Gene ID: 8788
    neXtProt AC: NX_P80370

  • Chr Location
    14q32; chr14:100726865-100735130 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    50 phenotypes from 4 alleles in 7 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Gene trapped
    1
  • Targeted
    5
  • Incidental Mutations
Homozygote null mice have reduced fetal growth and 50% lethality 2 days after birth. Survivors are small but have enlarged fat pad masses. Homozygotes for another null allele have abnormal B cell development. Paternally-inherited null alleles phenocopy homozygotes due to maternal imprinting.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022851 VEGA Gene Model | MGI Sequence Detail 10514 C57BL/6J ±  kb
transcript OTTMUST00000054941 VEGA | MGI Sequence Detail 4653 Not Applicable  
polypeptide OTTMUSP00000026246 VEGA | MGI Sequence Detail 385 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    59 from dbSNP Build 137
  • PCR
  • RFLP
Protein
Information
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  • UniProt
    13 Sequences
  • Protein Ontology
    PR:000029766 sushi, nidogen and EGF-like domain-containing protein 1
  • InterPro Domains
    IPR001881 EGF-like calcium-binding domain
    IPR013032 EGF-like, conserved site
    IPR000742 EGF-like domain
    IPR000152 EGF-type aspartate/asparagine hydroxylation site
Molecular
Reagents
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  • All nucleic 43
    Genomic 4
    cDNA 22
    Primer pair 14
    Other 3

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-8856, MGI:2145055
References
more
  • Summaries
    All 160
    Developmental Gene Expression 92
    Gene Ontology 10
    Phenotypes 19
  • Earliest
    J:3994 Laborda J, et al., dlk, a putative mammalian homeotic gene differentially expressed in small cell lung carcinoma and neuroendocrine tumor cell line. J Biol Chem. 1993 Feb 25;268(6):3817-20
  • Latest
    J:226683 Rataj-Baniowska M, et al., Retinoic Acid Receptor beta Controls Development of Striatonigral Projection Neurons through FGF-Dependent and Meis1-Dependent Mechanisms. J Neurosci. 2015 Oct 28;35(43):14467-75

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory