Dlk1
Gene Detail

Symbol Name ID

Dlk1 delta-like 1 homolog (Drosophila) MGI:94900

Synonyms

DlkI, FA1, Peg9, pG2, pref-1, SCP1, ZOG

Feature Type

protein coding gene

Genetic Map

Chromosome 12

60.17 cM, cytoband E-F1
Detailed Genetic Map ± 1 cM


Mapping data(9)

Sequence Map

Chr12:109452823-109463336 bp, + strand From VEGA annotation of GRCm38   10514 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2846  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

Protein SuperFamily: preadipocyte factor 1
Gene Tree: Dlk1

Human homologs

Human Homolog		DLK1, delta-like 1 homolog (Drosophila)
NCBI Gene ID		8788
neXtProt AC		NX_P80370
Human Synonyms		Delta1, DLK, DLK-1, FA1, pG2, Pref-1, PREF1, ZOG
Human Chr (Location)		14q32; chr14:101193202-101201467 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(5) Gene trapped(1)
 

Homozygote null mice have reduced fetal growth and 50% lethality 2 days after birth. Survivors are small but have enlarged fat pad masses. Homozygotes for another null allele have abnormal B cell development. Paternally-inherited null alleles phenocopy homozygotes due to maternal imprinting.

 

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	cell differentiation, embryo development, ...
Component	external side of plasma membrane, integral to membrane, ...
Function	calcium ion binding

External Resources: FuncBase

Expression

Literature Summary: (66 records)
Data Summary: Results (249)    Tissues (173)    Images (21)
Theiler Stages: 10, 15, 17, 18, 19, 20, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	135
Northern blot	22
Western blot	1
RT-PCR	91

cDNA source data(22)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(43) Genomic(4) cDNA(22) Primer pair(14) Other(3)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000022851 (Evidence)
Ensembl Gene Model	ENSMUSG00000040856 (Evidence)
Entrez Gene	13386 (Evidence)
DFCI	TC1574610
DoTS	DT.101393155, DT.102556252, DT.50317281
NIA Mouse Gene Index	U014380
Consensus CDS Project	CCDS26168.1, CCDS49173.1, CCDS49174.1, CCDS56863.1
International Mouse Knockout Project Status	Dlk1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022851	VEGA Gene Model | MGI Sequence Detail	10514	C57BL/6J
transcript	OTTMUST00000054941	VEGA | MGI Sequence Detail	4653	Not Applicable
polypeptide	OTTMUSP00000026246	VEGA | MGI Sequence Detail	385	Not Applicable

All sequences(86) RefSeq(9) UniProt(12)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(28 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001881	EGF-like calcium-binding
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000152	EGF-type aspartate/asparagine hydroxylation site
InterPro	IPR000742	Epidermal growth factor-like domain
Protein Ontology	PR:000006521	protein delta 1

References

(Earliest) J:3994 Laborda J, et al., dlk, a putative mammalian homeotic gene differentially expressed in small cell lung carcinoma and neuroendocrine tumor cell line. J Biol Chem. 1993 Feb 25;268(6):3817-20
(Latest) J:194131 Sugiyama D, et al., TGF-beta-1 up-regulates extra-cellular matrix production in mouse hepatoblasts. Mech Dev. 2013 Feb;130(2-3):195-206
All references(133)

Other accession IDs

MGD-MRK-8856, MGI:2145055