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Dlk1
Gene Detail
 Symbol
Name
ID
Dlk1
delta-like 1 homolog (Drosophila)
MGI:94900
Synonyms DlkI, FA1, Peg9, pG2, pref-1, SCP1, ZOG
Feature Type protein coding gene
Genetic Map
Chromosome 12
60.17 cM, cytoband E-F1
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr12:109452823-109463336 bp, + strand
From VEGA annotation of GRCm38

  10514 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2846  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: preadipocyte factor 1
Gene Tree: Dlk1

Human
homologs
Human Homolog DLK1, delta-like 1 homolog (Drosophila)
NCBI Gene ID 8788
neXtProt AC  NX_P80370
Human Synonyms  Delta1, DLK, DLK-1, FA1, pG2, Pref-1, PREF1, ZOG
Human Chr (Location)  14q32; chr14:100726865-100735130 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygote null mice have reduced fetal growth and 50% lethality 2 days after birth. Survivors are small but have enlarged fat pad masses. Homozygotes for another null allele have abnormal B cell development. Paternally-inherited null alleles phenocopy homozygotes due to maternal imprinting.
 
Interactions
Dlk1 interacts with 305 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process cell differentiation, embryo development, ...
Component external side of plasma membrane, integral component of membrane, ...
Function calcium ion binding
External Resources: FuncBase
Expression
Literature Summary: (75 records)
Data Summary: Results (249)    Tissues (176)    Images (21)
Theiler Stages: 10, 15, 17, 18, 19, 20, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 135
Northern blot 22
Western blot 1
RT-PCR 91
cDNA source data(22)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(43) Genomic(4) cDNA(22) Primer pair(14) Other(3)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000022851 (Evidence)
Ensembl Gene ModelENSMUSG00000040856 (Evidence)
Entrez Gene13386 (Evidence)
DFCITC1574610
DoTSDT.101393155, DT.102556252, DT.50317281
NIA Mouse Gene IndexU014380
Consensus CDS ProjectCCDS26168.1, CCDS49173.1, CCDS49174.1, CCDS56863.1
International Mouse Knockout Project StatusDlk1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022851 VEGA Gene Model | MGI Sequence Detail 10514 C57BL/6J ±  kb
transcript OTTMUST00000054941 VEGA | MGI Sequence Detail 4653 Not Applicable 
polypeptide OTTMUSP00000026246 VEGA | MGI Sequence Detail 385 Not Applicable 

For the selected sequences
All sequences(90) RefSeq(13) UniProt(12)
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(59 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
Protein Ontology PR:000006521 protein delta homolog 1
References (Earliest) J:3994 Laborda J, et al., dlk, a putative mammalian homeotic gene differentially expressed in small cell lung carcinoma and neuroendocrine tumor cell line. J Biol Chem. 1993 Feb 25;268(6):3817-20
(Latest) J:210259 Schober A, et al., MicroRNA-126-5p promotes endothelial proliferation and limits atherosclerosis by suppressing Dlk1. Nat Med. 2014 Apr;20(4):368-76
All references(147)
Other
accession IDs
MGD-MRK-8856, MGI:2145055

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory