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Dlk1 Gene Detail
Summary
  • Symbol
    Dlk1
  • Name
    delta-like 1 homolog (Drosophila)
  • Synonyms
    DlkI, FA1, Peg9, pG2, pref-1, SCP1, ZOG
  • Feature Type
    protein coding gene
  • IDs
    MGI:94900
    NCBI Gene: 13386
  • Gene Overview
    MyGene.info: DLK1
Location & Maps
more
  • Sequence Map
    Chr12:109452823-109463336 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10514 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 60.17 cM, cytoband E-F1
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    DLK1, delta like non-canonical Notch ligand 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DLK1, delta like non-canonical Notch ligand 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    Delta1, DLK, DLK-1, FA1, pG2, Pref-1, PREF1, ZOG
  • Links
    NCBI Gene ID: 8788
    neXtProt AC: NX_P80370

  • Chr Location
    14q32; chr14:100726865-100735130 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    50 phenotypes from 4 alleles in 7 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Gene trapped
    1
  • Targeted
    5
  • Incidental Mutations
Homozygote null mice have reduced fetal growth and 50% lethality 2 days after birth. Survivors are small but have enlarged fat pad masses. Homozygotes for another null allele have abnormal B cell development. Paternally-inherited null alleles phenocopy homozygotes due to maternal imprinting.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022851 VEGA Gene Model | MGI Sequence Detail 10514 C57BL/6J ±  kb
transcript OTTMUST00000054941 VEGA | MGI Sequence Detail 4653 Not Applicable  
polypeptide OTTMUSP00000026246 VEGA | MGI Sequence Detail 385 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    58 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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  • UniProt
    13 Sequences
  • Protein Ontology
    PR:000029766 sushi, nidogen and EGF-like domain-containing protein 1
  • InterPro Domains
    IPR001881 EGF-like calcium-binding domain
    IPR013032 EGF-like, conserved site
    IPR000742 EGF-like domain
    IPR000152 EGF-type aspartate/asparagine hydroxylation site
Molecular
Reagents
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  • All nucleic 44
    Genomic 4
    cDNA 22
    Primer pair 15
    Other 3

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-8856, MGI:2145055
References
more
  • Summaries
    All 165
    Developmental Gene Expression 95
    Gene Ontology 11
    Phenotypes 20
  • Earliest
    J:3994 Laborda J, et al., dlk, a putative mammalian homeotic gene differentially expressed in small cell lung carcinoma and neuroendocrine tumor cell line. J Biol Chem. 1993 Feb 25;268(6):3817-20
  • Latest
    J:228807 Umansky KB, et al., Runx1 Transcription Factor Is Required for Myoblasts Proliferation during Muscle Regeneration. PLoS Genet. 2015 Aug;11(8):e1005457

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory