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Dlk1
Gene Detail
Symbol

Name
ID
Dlk1
delta-like 1 homolog (Drosophila)
MGI:94900
Synonyms
DlkI, FA1, Peg9, pG2, pref-1, SCP1, ZOG
Feature Type
protein coding gene
Genetic Map
Chromosome 12
60.17 cM, cytoband E-F1
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr12:109452823-109463336 bp, + strand
From VEGA annotation of GRCm38

  10514 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2846  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: DLK1
Protein SuperFamily: preadipocyte factor 1
Gene Tree: Dlk1

Human
homologs
DLK1, delta-like 1 homolog (Drosophila)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 8788
neXtProt AC: NX_P80370

Human Synonyms: Delta1, DLK, DLK-1, FA1, pG2, Pref-1, PREF1, ZOG

Human Chr (Location): 14q32; chr14:100726865-100735130 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygote null mice have reduced fetal growth and 50% lethality 2 days after birth. Survivors are small but have enlarged fat pad masses. Homozygotes for another null allele have abnormal B cell development. Paternally-inherited null alleles phenocopy homozygotes due to maternal imprinting.
 
Interactions
Dlk1 interacts with 304 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process cell differentiation, embryo development, ...
Component external side of plasma membrane, extracellular space, ...
Function calcium ion binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (89 records)
Data Summary: Results (262)    Tissues (184)    Images (37)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 13
RNA in situ 135
Northern blot 22
Western blot 1
RT-PCR 91
cDNA source data(22)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase dlk1    NEW 
Molecular
reagents
All nucleic(43) Genomic(4) cDNA(22) Primer pair(14) Other(3)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000022851 (Evidence)
Ensembl Gene Model ENSMUSG00000040856 (Evidence)
Entrez Gene 13386 (Evidence)
DFCI TC1574610
DoTS DT.101393155, DT.102556252, DT.50317281
NIA Mouse Gene Index U014380
Consensus CDS Project CCDS26168.1, CCDS49173.1, CCDS49174.1, CCDS56863.1
International Mouse Phenotyping Consortium Status Dlk1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022851 VEGA Gene Model | MGI Sequence Detail 10514 C57BL/6J ±  kb
transcript OTTMUST00000054941 VEGA | MGI Sequence Detail 4653 Not Applicable 
polypeptide OTTMUSP00000026246 VEGA | MGI Sequence Detail 385 Not Applicable 

For the selected sequences
All sequences(96) RefSeq(17) UniProt(13)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(59 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
Protein Ontology PR:000006521 protein delta homolog 1
References
(Earliest) J:3994 Laborda J, et al., dlk, a putative mammalian homeotic gene differentially expressed in small cell lung carcinoma and neuroendocrine tumor cell line. J Biol Chem. 1993 Feb 25;268(6):3817-20
(Latest) J:220807 Shamis Y, et al., Maternal and zygotic Zfp57 modulate NOTCH signaling in cardiac development. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):E2020-9
All references(158)
Other
accession IDs
MGD-MRK-8856, MGI:2145055

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory