Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DACH1
  • Mouse genes Dach1
  • Rat genes Dach1
  • Zfish genes dachc,dachd
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dach1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Dach1	IDA		Mouse	PMID:14628042
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Dach1	IDA		Mouse	PMID:20869363
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	DACH1	IDA		Human	PMID:20956529
Molecular Function	GO:0005515	protein binding	DACH1	IPI	UniProtKB:O75376	Human	PMID:14525983
Molecular Function	GO:0005515	protein binding	DACH1	IPI	UniProtKB:Q13485	Human	PMID:14525983
Molecular Function	GO:0005515	protein binding	DACH1	IPI	UniProtKB:Q9UJ70	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	DACH1	IPI	UniProtKB:O14776	Human	PMID:20956529
Molecular Function	GO:0005515	protein binding	DACH1	IPI	UniProtKB:Q9UJ70	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	Dach1	IPI	UniProtKB:Q60974	Mouse	MGI:MGI:3611682|PMID:12130660
Molecular Function	GO:0005515	protein binding	Dach1	IPI	PR:P63280	Mouse	PMID:11025202
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	DACH1	IDA		Human	PMID:20956529
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	DACH1	IDA		Human	PMID:20956529
Cellular Component	GO:0005737	cytoplasm	Dach1	IDA		Mouse	PMID:16024294
Cellular Component	GO:0005737	cytoplasm	Dach1	IDA		Mouse	PMID:11025202
Cellular Component	GO:0005829	cytosol	DACH1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005794	Golgi apparatus	DACH1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016607	nuclear speck	DACH1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	DACH1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Dach1	IDA		Mouse	PMID:11025202
Cellular Component	GO:0005634	nucleus	Dach1	IDA		Mouse	PMID:16024294
Cellular Component	GO:0005634	nucleus	Dach1	IDA		Mouse	PMID:12203718
Cellular Component	GO:0005634	nucleus	Dach1	IDA		Mouse	PMID:11543628
Cellular Component	GO:0005667	transcription regulator complex	Dach1	IPI	PR:Q60974	Mouse	PMID:17182846
Cellular Component	GO:0005667	transcription regulator complex	Dach1	IPI	PR:P05627	Mouse	PMID:17182846
Cellular Component	GO:0005667	transcription regulator complex	Dach1	IDA		Mouse	PMID:14628042
Cellular Component	GO:0005667	transcription regulator complex	Dach1	IPI	PR:Q60520	Mouse	PMID:17182846
Cellular Component	GO:0005667	transcription regulator complex	Dach1	IPI	PR:P70288	Mouse	PMID:17182846
Cellular Component	GO:0005667	transcription regulator complex	Dach1	IPI	PR:O09106	Mouse	PMID:17182846
Biological Process	GO:0046545	development of primary female sexual characteristics	Dach1	IGI	MGI:MGI:1890446	Mouse	PMID:18395837
Biological Process	GO:0050673	epithelial cell proliferation	Dach1	IMP	MGI:MGI:2448366	Mouse	PMID:20869363
Biological Process	GO:0003094	glomerular filtration	dachd	IMP	ZFIN:ZDB-MRPHLNO-180905-3	Zfish	PMID:29498212
Biological Process	GO:0003094	glomerular filtration	dachd	IMP	ZFIN:ZDB-MRPHLNO-180905-4	Zfish	PMID:29498212
Biological Process	GO:0030336	negative regulation of cell migration	DACH1	IDA		Human	PMID:20956529
Biological Process	GO:0060244	negative regulation of cell proliferation involved in contact inhibition	Dach1	IGI	MGI:MGI:96646	Mouse	PMID:17182846
Biological Process	GO:2000279	negative regulation of DNA biosynthetic process	DACH1	IDA		Human	PMID:16980615
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	DACH1	IMP		Human	PMID:21750150
Biological Process	GO:0048147	negative regulation of fibroblast proliferation	Dach1	IGI	MGI:MGI:96646	Mouse	PMID:17182846
Biological Process	GO:0048147	negative regulation of fibroblast proliferation	Dach1	IDA		Mouse	PMID:17182846
Biological Process	GO:0010944	negative regulation of transcription by competitive promoter binding	DACH1	IMP		Human	PMID:20956529
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	DACH1	IDA		Human	PMID:20956529
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Dach1	IMP	MGI:MGI:2448366	Mouse	PMID:20869363
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Dach1	IGI	MGI:MGI:96646	Mouse	PMID:17182846
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Dach1	IDA		Mouse	PMID:17182846
Biological Process	GO:0006355	regulation of DNA-templated transcription	Dach1	IDA		Mouse	PMID:14628042
Biological Process	GO:0006355	regulation of DNA-templated transcription	Dach1	IMP		Mouse	PMID:14628042
Biological Process	GO:0033262	regulation of nuclear cell cycle DNA replication	Dach1	IMP		Mouse	MGI:MGI:5619482|PMID:16980615
Biological Process	GO:0007585	respiratory gaseous exchange by respiratory system	Dach1	IMP	MGI:MGI:2182311	Mouse	PMID:11238885
Biological Process	GO:0001967	suckling behavior	Dach1	IMP	MGI:MGI:2182311	Mouse	PMID:11238885
Biological Process	GO:0044342	type B pancreatic cell proliferation	Dach1	IMP	MGI:MGI:2448366	Mouse	PMID:20869363

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern