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Dach1 Gene Detail
Summary
  • Symbol
    Dach1
  • Name
    dachshund family transcription factor 1
  • Synonyms
    D6, Dac, E130112M23Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277991
    NCBI Gene: 13134
  • Gene Overview
    MyGene.info: DACH1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr14:97786853-98169765 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      382913 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 48.25 cM, cytoband E3
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    DACH1, dachshund family transcription factor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DACH1, dachshund family transcription factor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DACH
  • Links
    NCBI Gene ID: 1602
    neXtProt AC: NX_Q9UI36
    UniProt: Q9UI36

  • Chr Location
    13q21.33; chr13:71437966-71868068 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 7288
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: DACH1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 3 alleles in 4 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
In spite of normal gross morphology, mice homozygous for targeted mutations that inactivate this gene die within 1 day of birth.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000022525 VEGA Gene Model | MGI Sequence Detail 382913 C57BL/6J ±  kb
    transcript OTTMUST00000053950 VEGA | MGI Sequence Detail 5219 Not Applicable  
    polypeptide OTTMUSP00000025692 VEGA | MGI Sequence Detail 751 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      3569 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR009061 Putative DNA-binding domain superfamily
      IPR037000 Ski-like, DNA-binding domain superfamily
      IPR003380 SKI/SNO/DAC domain
    Molecular
    Reagents
    less
    • All nucleic 44
      Genomic 2
      cDNA 36
      Primer pair 1
      Other 5

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2145601, MGI:2442731
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 30
      Gene Ontology 13
      Phenotypes 14
    • Earliest
      J:38305 Stewart GJ, et al., Sequence analysis of 497 mouse brain ESTs expressed in the substantia nigra. Genomics. 1997 Jan 15;39(2):147-53
    • Latest
      J:255744 Rhee S, et al., Endothelial deletion of Ino80 disrupts coronary angiogenesis and causes congenital heart disease. Nat Commun. 2018 Jan 25;9(1):368

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory