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Dach1 Gene Detail
Summary
  • Symbol
    Dach1
  • Name
    dachshund family transcription factor 1
  • Synonyms
    D6, Dac, E130112M23Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277991
    NCBI Gene: 13134
  • Gene Overview
    MyGene.info: DACH1
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:97786853-98169765 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 48.25 cM, cytoband E3
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3569 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1277991
protein coding gene Chr14:97786846-98169765 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021613
protein coding gene Chr14:94008188-94413665 (-)
A/J MGP_AJ_G0021571
protein coding gene Chr14:91050995-91436197 (-)
AKR/J MGP_AKRJ_G0021547
protein coding gene Chr14:93685812-94079498 (-)
BALB/cJ MGP_BALBcJ_G0021577
protein coding gene Chr14:91321389-91705472 (-)
C3H/HeJ MGP_C3HHeJ_G0021355
protein coding gene Chr14:93595742-93984179 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022017
protein coding gene Chr14:97837457-98236460 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019557
protein coding gene Chr14:88111804-88494753 (-)
CAST/EiJ MGP_CASTEiJ_G0020872
protein coding gene Chr14:90852932-91268960 (-)
CBA/J MGP_CBAJ_G0021323
protein coding gene Chr14:101446135-101888063 (-)
DBA/2J MGP_DBA2J_G0021447
protein coding gene Chr14:90507795-90901269 (-)
FVB/NJ MGP_FVBNJ_G0021423
protein coding gene Chr14:89514299-89928757 (-)
LP/J MGP_LPJ_G0021515
protein coding gene Chr14:94792658-95214900 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021451
protein coding gene Chr14:104071452-104605031 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022040
protein coding gene Chr14:93221744-93623005 (-)
PWK/PhJ MGP_PWKPhJ_G0020615
protein coding gene Chr14:87466004-87859960 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020453
protein coding gene Chr14:89145406-89555608 (-)
WSB/EiJ MGP_WSBEiJ_G0020925
protein coding gene Chr14:93773047-94180190 (-)



Homology
more
  • Human Ortholog
    DACH1, dachshund family transcription factor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DACH1, dachshund family transcription factor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DACH
  • Links
    NCBI Gene ID: 1602
    neXtProt AC: NX_Q9UI36
    UniProt: Q9UI36

  • Chr Location
    13q21.33; chr13:71437966-71868068 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 7288
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: DACH1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 3 alleles in 4 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
In spite of normal gross morphology, mice homozygous for targeted mutations that inactivate this gene die within 1 day of birth.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000055639 Ensembl Gene Model | MGI Sequence Detail 382913 C57BL/6J ±  kb
    transcript ENSMUST00000071533 Ensembl | MGI Sequence Detail 5219 Not Applicable  
    polypeptide ENSMUSP00000071464 Ensembl | MGI Sequence Detail 751 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR009061 Putative DNA-binding domain superfamily
      IPR037000 Ski-like, DNA-binding domain superfamily
      IPR003380 SKI/SNO/DAC domain
    Molecular
    Reagents
    less
    • All nucleic 44
      Genomic 2
      cDNA 36
      Primer pair 1
      Other 5

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2145601, MGI:2442731
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 30
      Gene Ontology 15
      Phenotypes 14
    • Earliest
      J:38305 Stewart GJ, et al., Sequence analysis of 497 mouse brain ESTs expressed in the substantia nigra. Genomics. 1997 Jan 15;39(2):147-53
    • Latest
      J:255744 Rhee S, et al., Endothelial deletion of Ino80 disrupts coronary angiogenesis and causes congenital heart disease. Nat Commun. 2018 Jan 25;9(1):368

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory