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Dach1 Gene Detail
Summary
  • Symbol
    Dach1
  • Name
    dachshund 1 (Drosophila)
  • Synonyms
    D6, Dac, E130112M23Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277991
    NCBI Gene: 13134
  • Gene Overview
    MyGene.info: DACH1
Location & Maps
more
  • Sequence Map
    Chr14:97786853-98169765 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      382913 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 48.25 cM, cytoband E3
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    DACH1, dachshund family transcription factor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DACH1, dachshund family transcription factor 1
    Orthology source: HomoloGene
  • Synonyms
    DACH
  • Links
    NCBI Gene ID: 1602
    neXtProt AC: NX_Q9UI36

  • Chr Location
    13q22; chr13:71437966-71869113 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 7288
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: DACH1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 3 alleles in 4 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Targeted
    5
  • Genomic Mutations
    1 involving Dach1
  • Incidental Mutations
In spite of normal gross morphology, mice homozygous for targeted mutations that inactivate this gene die within 1 day of birth.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022525 VEGA Gene Model | MGI Sequence Detail 382913 C57BL/6J ±  kb
transcript OTTMUST00000053950 VEGA | MGI Sequence Detail 5219 Not Applicable  
polypeptide OTTMUSP00000025692 VEGA | MGI Sequence Detail 751 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    3569 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000006261 dachshund homolog 1
  • InterPro Domains
    IPR009061 Putative DNA-binding domain
    IPR003380 Transforming protein Ski
Molecular
Reagents
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  • All nucleic 40
    Genomic 2
    cDNA 33
    Primer pair 1
    Other 4

    Microarray probesets 7
Other
Accession IDs
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MGI:2145601, MGI:2442731
References
more
  • Summaries
    All 58
    Developmental Gene Expression 26
    Gene Ontology 13
    Phenotypes 12
  • Earliest
    J:38305 Stewart GJ, et al., Sequence analysis of 497 mouse brain ESTs expressed in the substantia nigra. Genomics. 1997 Jan 15;39(2):147-53
  • Latest
    J:229484 Conte D, et al., The apical ectodermal ridge of the mouse model of ectrodactyly Dlx5;Dlx6-/- shows altered stratification and cell polarity, which are restored by exogenous Wnt5a ligand. Hum Mol Genet. 2016 Feb 15;25(4):740-54

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory