Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CSF2
  • Mouse genes Csf2
  • Rat genes Csf2
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Csf2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005125	cytokine activity	CSF2	IDA		Human	PMID:3925454
Molecular Function	GO:0005125	cytokine activity	Csf2	IDA		Mouse	PMID:1350248
Molecular Function	GO:0005125	cytokine activity	Csf2	IDA		Mouse	PMID:10652277
Molecular Function	GO:0005125	cytokine activity	Csf2	IDA		Rat	PMID:8535150|RGD:5131521
Molecular Function	GO:0005515	protein binding	CSF2	IPI	UniProtKB:P32927	Human	PMID:18692472
Molecular Function	GO:0005515	protein binding	CSF2	IPI	UniProtKB:P50222	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CSF2	IPI	UniProtKB:P50222	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	CSF2	IPI	UniProtKB:P01023	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CSF2	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CSF2	IPI	UniProtKB:P50570-2	Human	PMID:32814053
Cellular Component	GO:0005576	extracellular region	Csf2	IDA		Rat	PMID:16673407|RGD:151665782
Cellular Component	GO:0005615	extracellular space	CSF2	IDA		Human	PMID:3925454
Cellular Component	GO:0005615	extracellular space	Csf2	IDA		Mouse	PMID:7690439
Cellular Component	GO:0005615	extracellular space	Csf2	IDA		Mouse	PMID:21148126
Cellular Component	GO:0005615	extracellular space	Csf2	IDA		Rat	PMID:21442011|RGD:5131471
Cellular Component	GO:0030526	granulocyte macrophage colony-stimulating factor receptor complex	CSF2	IDA		Human	PMID:27396825
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	CSF2	IDA		Human	GO_REF:0000052
Biological Process	GO:0008283	cell population proliferation	Csf2	IDA		Mouse	PMID:1350248
Biological Process	GO:0008283	cell population proliferation	Csf2	IDA		Mouse	PMID:10652277
Biological Process	GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus	CSF2	IDA		Human	PMID:24942581
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Csf2	IEP		Rat	PMID:18387647|RGD:5131517
Biological Process	GO:0097028	dendritic cell differentiation	CSF2	IDA		Human	PMID:21149635
Biological Process	GO:0097028	dendritic cell differentiation	Csf2	IDA		Rat	PMID:20628067|RGD:5131511
Biological Process	GO:0097028	dendritic cell differentiation	Csf2	IDA		Rat	PMID:8535150|RGD:5131521
Biological Process	GO:0001892	embryonic placenta development	Csf2	IMP	MGI:MGI:1930997	Mouse	PMID:19228596
Biological Process	GO:0042045	epithelial fluid transport	Csf2	IDA		Rat	PMID:14504066|RGD:727979
Biological Process	GO:0038157	granulocyte-macrophage colony-stimulating factor signaling pathway	CSF2	IDA		Human	PMID:18692472
Biological Process	GO:0001821	histamine secretion	Csf2	IDA		Rat	PMID:9685678|RGD:10449533
Biological Process	GO:0042116	macrophage activation	Csf2	IMP		Rat	PMID:21326109|RGD:5131507
Biological Process	GO:0030225	macrophage differentiation	CSF2	IDA		Human	PMID:24942581
Biological Process	GO:0030224	monocyte differentiation	Csf2	IDA		Mouse	PMID:19109256
Biological Process	GO:0043011	myeloid dendritic cell differentiation	CSF2	IDA		Human	PMID:16116184
Biological Process	GO:0043011	myeloid dendritic cell differentiation	Csf2	IDA		Mouse	PMID:12021780
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	CSF2	IDA		Human	PMID:16606666
Biological Process	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	CSF2	IDA		Human	PMID:10666185
Biological Process	GO:0030223	neutrophil differentiation	Csf2	IDA		Mouse	PMID:19109256
Biological Process	GO:0030335	positive regulation of cell migration	Csf2	IMP		Rat	PMID:8304053|RGD:151665809
Biological Process	GO:0008284	positive regulation of cell population proliferation	CSF2	IDA		Human	PMID:9722506
Biological Process	GO:0008284	positive regulation of cell population proliferation	Csf2	IDA		Mouse	PMID:1350248
Biological Process	GO:0008284	positive regulation of cell population proliferation	Csf2	IDA		Mouse	PMID:10652277
Biological Process	GO:0010628	positive regulation of gene expression	CSF2	IDA		Human	PMID:10666185
Biological Process	GO:0032747	positive regulation of interleukin-23 production	CSF2	IDA		Human	PMID:20027291
Biological Process	GO:0070665	positive regulation of leukocyte proliferation	CSF2	IDA		Human	PMID:18692472
Biological Process	GO:0010744	positive regulation of macrophage derived foam cell differentiation	CSF2	IDA		Human	PMID:19032770
Biological Process	GO:0071803	positive regulation of podosome assembly	CSF2	IDA		Human	PMID:15220135
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	CSF2	IDA		Human	PMID:9722506
Biological Process	GO:0006468	protein phosphorylation	CSF2	IDA		Human	PMID:18692472
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	CSF2	IDA		Human	PMID:18692472
Biological Process	GO:0042127	regulation of cell population proliferation	Csf2	IGI	MGI:MGI:97306	Mouse	PMID:10678181
Biological Process	GO:0045187	regulation of circadian sleep/wake cycle, sleep	Csf2	IMP		Rat	PMID:12047622|RGD:10449529
Biological Process	GO:0010468	regulation of gene expression	Csf2	IMP	MGI:MGI:1930997	Mouse	PMID:19228596
Biological Process	GO:0010468	regulation of gene expression	Csf2	IDA		Mouse	PMID:9697835
Biological Process	GO:0034405	response to fluid shear stress	Csf2	IEP		Rat	PMID:15010288|RGD:10450246
Biological Process	GO:0034021	response to silicon dioxide	Csf2	IEP		Rat	PMID:21505002|RGD:10450467

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern